JP2004516013A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004516013A5 JP2004516013A5 JP2002514188A JP2002514188A JP2004516013A5 JP 2004516013 A5 JP2004516013 A5 JP 2004516013A5 JP 2002514188 A JP2002514188 A JP 2002514188A JP 2002514188 A JP2002514188 A JP 2002514188A JP 2004516013 A5 JP2004516013 A5 JP 2004516013A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- nucleic acid
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920001184 polypeptide Polymers 0.000 description 25
- 108090000765 processed proteins & peptides Proteins 0.000 description 25
- 102000004196 processed proteins & peptides Human genes 0.000 description 25
- 150000007523 nucleic acids Chemical class 0.000 description 14
- 239000003814 drug Substances 0.000 description 13
- 125000003275 alpha amino acid group Chemical group 0.000 description 11
- 108020004707 nucleic acids Proteins 0.000 description 9
- 102000039446 nucleic acids Human genes 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- 108010076504 Protein Sorting Signals Proteins 0.000 description 6
- 241000124008 Mammalia Species 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 230000002491 angiogenic effect Effects 0.000 description 4
- 230000002526 effect on cardiovascular system Effects 0.000 description 4
- 230000003511 endothelial effect Effects 0.000 description 4
- 108091026890 Coding region Proteins 0.000 description 3
- 239000000556 agonist Substances 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 206010007572 Cardiac hypertrophy Diseases 0.000 description 2
- 208000006029 Cardiomegaly Diseases 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 239000003966 growth inhibitor Substances 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Applications Claiming Priority (36)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21955600P | 2000-07-20 | 2000-07-20 | |
US22062400P | 2000-07-25 | 2000-07-25 | |
US22066400P | 2000-07-25 | 2000-07-25 | |
PCT/US2000/020710 WO2001009327A2 (en) | 1999-07-28 | 2000-07-28 | Method of preventing the injury or death of retinal cells and treating ocular diseases |
US22269500P | 2000-08-02 | 2000-08-02 | |
US09/643,657 US6642024B1 (en) | 1998-01-29 | 2000-08-17 | Guanylate-binding protein |
PCT/US2000/023522 WO2001016319A2 (en) | 1999-08-31 | 2000-08-23 | Compositions and methods for the treatment of immune related diseases |
PCT/US2000/023328 WO2001016318A2 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US23097800P | 2000-09-07 | 2000-09-07 | |
US66535000A | 2000-09-18 | 2000-09-18 | |
US66461000A | 2000-09-18 | 2000-09-18 | |
US24292200P | 2000-10-24 | 2000-10-24 | |
US70923800A | 2000-11-08 | 2000-11-08 | |
PCT/US2000/030952 WO2001049715A2 (en) | 2000-01-06 | 2000-11-08 | Methods and compositions for inhibiting neoplastic cell growth |
PCT/US2000/030873 WO2001040465A2 (en) | 1999-11-30 | 2000-11-10 | Compositions and methods for the treatment of immune related diseases |
PCT/US2000/032678 WO2001040466A2 (en) | 1999-12-01 | 2000-12-01 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
PCT/US2000/034956 WO2001046420A2 (en) | 1999-12-23 | 2000-12-20 | Il-17 and il-17r homologous polypeptides and therapeutic uses thereof |
US09/747,259 US6569645B2 (en) | 1999-05-14 | 2000-12-20 | IL-17 homologous polypeptides and therapeutic uses thereof |
US09/767,609 US20020042367A1 (en) | 1997-11-25 | 2001-01-22 | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
US79649801A | 2001-02-28 | 2001-02-28 | |
PCT/US2001/006520 WO2001068848A2 (en) | 2000-03-01 | 2001-02-28 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
PCT/US2001/006666 WO2001066740A2 (en) | 2000-03-03 | 2001-03-01 | Compositions and methods for the treatment of immune related diseases |
US80270601A | 2001-03-09 | 2001-03-09 | |
US80868901A | 2001-03-14 | 2001-03-14 | |
US09/816,744 US6579520B2 (en) | 1998-05-15 | 2001-03-22 | IL-17 related mammalian cytokine polypeptides (IL-17E) |
US09/828,366 US20020010137A1 (en) | 1997-09-18 | 2001-04-05 | Methods and compositions for inhibiting neoplastic cell growth |
US09/854,280 US7115398B2 (en) | 1998-05-15 | 2001-05-10 | IL-17 homologous polypeptides and therapeutic uses thereof |
US09/854,208 US7217412B2 (en) | 1998-05-15 | 2001-05-10 | IL-17C related mammalian cytokine polypeptides |
US09/866,034 US20030170864A1 (en) | 2000-05-30 | 2001-05-25 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
PCT/US2001/017092 WO2001092331A2 (en) | 2000-05-30 | 2001-05-25 | Compositions and methods for the treatment of immune related diseases |
US09/866,028 US6642360B2 (en) | 1997-12-03 | 2001-05-25 | Secreted polypeptides that stimulate release of proteoglycans from cartilage |
PCT/US2001/017443 WO2002016611A2 (en) | 2000-08-24 | 2001-05-30 | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders |
US09/870,574 US6551799B2 (en) | 1999-12-07 | 2001-05-30 | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders |
PCT/US2001/017800 WO2001093983A1 (en) | 2000-06-02 | 2001-06-01 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
PCT/US2001/019692 WO2002000690A2 (en) | 2000-06-23 | 2001-06-20 | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
PCT/US2001/021735 WO2002008284A2 (en) | 2000-07-20 | 2001-07-09 | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008194764A Division JP2009039119A (ja) | 2000-07-20 | 2008-07-29 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2008194678A Division JP2009039117A (ja) | 2000-07-20 | 2008-07-29 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2008194721A Division JP2009039118A (ja) | 2000-07-20 | 2008-07-29 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2011173336A Division JP6033531B2 (ja) | 2000-07-20 | 2011-08-08 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004516013A JP2004516013A (ja) | 2004-06-03 |
JP2004516013A5 true JP2004516013A5 (ro) | 2010-07-15 |
Family
ID=56290165
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002514188A Withdrawn JP2004516013A (ja) | 2000-07-20 | 2001-07-09 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2008194678A Withdrawn JP2009039117A (ja) | 2000-07-20 | 2008-07-29 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2008194721A Withdrawn JP2009039118A (ja) | 2000-07-20 | 2008-07-29 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2008194764A Withdrawn JP2009039119A (ja) | 2000-07-20 | 2008-07-29 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2011173336A Expired - Fee Related JP6033531B2 (ja) | 2000-07-20 | 2011-08-08 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008194678A Withdrawn JP2009039117A (ja) | 2000-07-20 | 2008-07-29 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2008194721A Withdrawn JP2009039118A (ja) | 2000-07-20 | 2008-07-29 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2008194764A Withdrawn JP2009039119A (ja) | 2000-07-20 | 2008-07-29 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
JP2011173336A Expired - Fee Related JP6033531B2 (ja) | 2000-07-20 | 2011-08-08 | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1309685A2 (ro) |
JP (5) | JP2004516013A (ro) |
AU (1) | AU2001271973A1 (ro) |
CA (1) | CA2416538A1 (ro) |
WO (1) | WO2002008284A2 (ro) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002000690A2 (en) * | 2000-06-23 | 2002-01-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
DE69837606T2 (de) | 1997-09-12 | 2008-02-14 | Biogen Idec Ma Inc., Cambridge | Cystein-reiche rezeptoren-train |
US7419663B2 (en) | 1998-03-20 | 2008-09-02 | Genentech, Inc. | Treatment of complement-associated disorders |
US8088386B2 (en) | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
US8007798B2 (en) | 1997-11-21 | 2011-08-30 | Genentech, Inc. | Treatment of complement-associated disorders |
US7192589B2 (en) | 1998-09-16 | 2007-03-20 | Genentech, Inc. | Treatment of inflammatory disorders with STIgMA immunoadhesins |
US7771719B1 (en) | 2000-01-11 | 2010-08-10 | Genentech, Inc. | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E |
EP2333069A3 (en) | 1998-05-15 | 2011-09-14 | Genentech, Inc. | Therapeutic uses of IL-17 homologous polypeptides |
US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
US7109292B2 (en) | 1999-03-08 | 2006-09-19 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030119113A1 (en) | 1999-07-20 | 2003-06-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
EP1892249A1 (en) * | 1999-09-01 | 2008-02-27 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20040043397A1 (en) | 2000-01-11 | 2004-03-04 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
EP2258848B1 (en) * | 1999-12-23 | 2014-03-05 | Genentech, Inc. | Il-17 homologous polypeptide and therapeutic uses thereof |
US7718397B2 (en) | 2000-03-21 | 2010-05-18 | Genentech, Inc. | Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof |
WO2001081401A1 (fr) | 2000-04-21 | 2001-11-01 | Fuso Pharmaceutical Industries, Ltd. | Nouvelles collectines |
US20030096969A1 (en) | 2000-06-02 | 2003-05-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
CA2709771A1 (en) * | 2000-06-23 | 2002-01-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
DK2042597T3 (da) * | 2000-06-23 | 2014-08-11 | Genentech Inc | Sammensætninger og fremgangsmåder til diagnose og behandling af sygdomme, der involverer angiogenese |
US7265210B2 (en) | 2000-09-15 | 2007-09-04 | Genentech, Inc. | Anti-PRO9821 antibodies |
US6630325B1 (en) * | 2000-10-19 | 2003-10-07 | Maine Medical Center Research Institute | Compositions, methods and kits relating to remodel |
US20020115610A1 (en) | 2000-11-03 | 2002-08-22 | Qun-Yong Zhou | Prokineticin polypeptides, related compositions and methods |
EP1334179A2 (en) | 2000-11-14 | 2003-08-13 | Bristol-Myers Squibb Company | A human serpin secreted from lymphoid cells lsi-01 |
US7250495B2 (en) | 2001-06-20 | 2007-07-31 | Genentech, Inc. | PRO20044 polypeptides |
EP1530590A2 (en) * | 2002-03-22 | 2005-05-18 | Bioxell S.p.a. | Triggering receptors expressed on myeloid cells (trem)-4 and -5 and uses thereof |
JPWO2003083114A1 (ja) * | 2002-03-28 | 2005-08-04 | アステラス製薬株式会社 | アンジオポエチン関連増殖因子 |
EP2011886A3 (en) * | 2002-04-16 | 2009-02-11 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
EP2305710A3 (en) | 2002-06-03 | 2013-05-29 | Genentech, Inc. | Synthetic antibody phage libraries |
WO2004022087A1 (ja) * | 2002-09-04 | 2004-03-18 | Takeda Pharmaceutical Company Limited | 疾患関連遺伝子の用途 |
CA2497661A1 (en) * | 2002-09-11 | 2004-03-25 | Genentech, Inc. | Compositions and methods for the diagnosis of immune related diseases using pro71061 |
JP2006513700A (ja) * | 2002-09-25 | 2006-04-27 | ジェネンテック・インコーポレーテッド | 乾癬の治療のための新規組成物と方法 |
EP2526960A1 (en) | 2003-03-12 | 2012-11-28 | Genentech, Inc. | Use of BV8 and/or EG-VEGF to promote hematopoiesis |
NZ544317A (en) | 2003-07-08 | 2009-05-31 | Genentech Inc | IL-17 A/F heterologous polypeptides and therapeutic uses thereof |
US20100031378A1 (en) | 2008-08-04 | 2010-02-04 | Edwards Joel A | Novel gene disruptions, compositions and methods relating thereto |
AU2005249377A1 (en) | 2004-04-14 | 2005-12-15 | Genentech, Inc. | Compositions and methods comprising an EGFL7 antagonist for modulating vascular development |
SI1781682T1 (sl) | 2004-06-24 | 2013-05-31 | Mayo Foundation For Medical Education And Research | B7-H5, so-stimulatorni polipeptid |
US7410772B2 (en) | 2004-07-02 | 2008-08-12 | Genentech, Inc. | Compositions and methods for treatment of non-Hodgkin's lymphoma |
JP5060293B2 (ja) | 2004-08-03 | 2012-10-31 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 神経機能におけるtaj |
US7906116B2 (en) | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
KR20150055628A (ko) | 2005-11-04 | 2015-05-21 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
PL2097455T3 (pl) | 2006-11-02 | 2015-04-30 | Genentech Inc | Humanizowane przeciwciała przeciw czynnikowi D |
AR066660A1 (es) | 2007-05-23 | 2009-09-02 | Genentech Inc | Prevencion y tratamiento de condiciones del ojo asociadas con su complemento |
CN101925611A (zh) * | 2007-11-21 | 2010-12-22 | 安姆根有限公司 | Wise结合剂和表位 |
CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
NZ623706A (en) | 2008-05-05 | 2015-12-24 | Novimmune Sa | Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof |
SG190596A1 (en) | 2008-05-06 | 2013-06-28 | Genentech Inc | Affinity matured crig variants |
CN107028969A (zh) | 2009-02-20 | 2017-08-11 | 加尼梅德药物公司 | 用于癌症诊断和治疗的方法和组合物 |
MX348013B (es) | 2009-05-05 | 2017-05-23 | Novimmune Sa | Anticuerpos anti il-17f y metodos de uso de los mismos. |
BRPI1007706A2 (pt) | 2009-05-08 | 2019-04-02 | Genentech, Inc. | anticorpo anti-egfl7, anticorpo biespecífico, ácido nucléico, vetor, célula hospedeira, composição, método para produzir um anticorpo anti-egfl7, método de redução ou inibição da angiogênese em um indivíduo, método de acentuação da eficácia de um agente antiangiogênese em um indivíduo e método de redução ou inibição da perfusão e permeabilidade de um tumor em um indivíduo |
AT508569A1 (de) | 2009-07-23 | 2011-02-15 | Affiris Ag | Pharmaceutical compound |
ES2649389T3 (es) | 2009-11-11 | 2018-01-11 | Ganymed Pharmaceuticals Gmbh | Anticuerpos específicos para claudina 6 (CLDN6) |
EP2404936A1 (en) | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
RS54627B1 (en) | 2011-05-13 | 2016-08-31 | Ganymed Pharmaceuticals Ag | CANCER EXPRESSION ANTIBODIES THAT EXPLAIN CLAUDINE 6 |
MY163674A (en) | 2011-07-01 | 2017-10-13 | Ngm Biopharmaceuticals Inc | Compositions, uses and method for treatment of metabolic disorders and diseases |
US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
AU2013352363B2 (en) | 2012-11-28 | 2018-04-12 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
DK2938740T3 (da) | 2012-12-27 | 2022-06-20 | Ngm Biopharmaceuticals Inc | Kimære fgf19-peptider til anvendelse til behandling af galdesyrelidelser |
US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
CN110922468A (zh) * | 2013-01-17 | 2020-03-27 | 汉诺威医学院 | 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂 |
WO2015014376A1 (en) | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
MX2016001854A (es) | 2013-08-12 | 2016-09-06 | Genentech Inc | Composiciones y metodo para tratar condiciones asociadas con el complemento. |
SG11201602870YA (en) | 2013-10-28 | 2016-05-30 | Ngm Biopharmaceuticals Inc | Cancer models and associated methods |
UA119863C2 (uk) | 2014-01-24 | 2019-08-27 | Нгм Біофармасьютікалс, Інк. | Антитіло або його фрагмент, що зв'язується з бета-клото |
TW201623337A (zh) | 2014-05-01 | 2016-07-01 | 建南德克公司 | 抗-因子d抗體變異體及其用途 |
WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
AU2015277438B2 (en) | 2014-06-16 | 2020-02-27 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
CN107108711B (zh) | 2014-10-23 | 2021-11-23 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
US10407510B2 (en) | 2015-10-30 | 2019-09-10 | Genentech, Inc. | Anti-factor D antibodies and conjugates |
JP2018536650A (ja) | 2015-10-30 | 2018-12-13 | ジェネンテック, インコーポレイテッド | 抗d因子抗体変異体コンジュゲート及びその使用 |
JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
AU2017315459B2 (en) | 2016-08-26 | 2023-06-29 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
GB201906052D0 (en) * | 2019-04-30 | 2019-06-12 | Int Centre For Genetic Engineering And Biotechnology | Proteins with cardioprotective activity |
JP7064179B2 (ja) | 2020-11-30 | 2022-05-10 | 富士電機株式会社 | 水分吸着材 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000015792A2 (en) * | 1998-09-14 | 2000-03-23 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
WO2000053756A2 (en) * | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
WO2002000690A2 (en) * | 2000-06-23 | 2002-01-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
WO2000053751A1 (en) * | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
EP1017707A4 (en) * | 1997-08-29 | 2004-04-28 | Human Genome Sciences Inc | 29 HUMAN SECRETED PROTEINS |
WO1999043802A2 (en) * | 1998-02-27 | 1999-09-02 | Sagami Chemical Research Center | HUMAN PROTEINS HAVING TRANSMEMBRANE DOMAINS AND DNAs ENCODING THESE PROTEINS |
NZ507435A (en) * | 1998-03-10 | 2003-12-19 | Genentech Inc | Novel polypeptides and nucleic acids with homology to cornichon |
JP2002509722A (ja) * | 1998-03-31 | 2002-04-02 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌蛋白およびそれらをコードするポリヌクレオチド |
CA2347835A1 (en) * | 1998-12-01 | 2000-06-08 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
KR100543857B1 (ko) * | 1999-09-01 | 2006-01-23 | 제넨테크, 인크. | 혈관신생 및 심혈관형성의 촉진 또는 억제 |
-
2001
- 2001-07-09 JP JP2002514188A patent/JP2004516013A/ja not_active Withdrawn
- 2001-07-09 AU AU2001271973A patent/AU2001271973A1/en not_active Abandoned
- 2001-07-09 WO PCT/US2001/021735 patent/WO2002008284A2/en active Search and Examination
- 2001-07-09 EP EP01951036A patent/EP1309685A2/en not_active Withdrawn
- 2001-07-09 CA CA002416538A patent/CA2416538A1/en not_active Abandoned
-
2008
- 2008-07-29 JP JP2008194678A patent/JP2009039117A/ja not_active Withdrawn
- 2008-07-29 JP JP2008194721A patent/JP2009039118A/ja not_active Withdrawn
- 2008-07-29 JP JP2008194764A patent/JP2009039119A/ja not_active Withdrawn
-
2011
- 2011-08-08 JP JP2011173336A patent/JP6033531B2/ja not_active Expired - Fee Related
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2004516013A5 (ro) | ||
EP0617126B1 (en) | Polypeptide capable of inhibiting the binding between human IL-6 and its receptor | |
EP2510009B1 (en) | Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof | |
JP4840939B2 (ja) | Dkk−1に対する抗体 | |
CN105143267B (zh) | 人pac1抗体 | |
RU2183215C2 (ru) | Конъюгат для стимулирования иммунной реакции против клетки-мишени, способ лечения злокачественных опухолей у млекопитающего | |
KR20200123782A (ko) | 암치료를 위해 화학치료제와 병용된 다중결합 항-dr5 결합분자의 용도 | |
JP2008508858A (ja) | マクロファージ−刺激タンパク質受容体(ron)の阻害 | |
JP4308322B2 (ja) | インターフェロンアルファ/ベータ受容体に対する抗体 | |
WO2006046661A1 (ja) | インターロイキン-6阻害剤 | |
JP2020509737A5 (ro) | ||
AU750296B2 (en) | Antibodies against SEMP1, methods for their production and uses thereof | |
BG107613A (bg) | Фузионен протеин от инхибитор на антитяло-цитокин-цитокин като продрога със специфична мишена | |
TW416960B (en) | Reshaped human antibody to human interleukin-8 | |
JP2003530871A (ja) | インテグリン/接着因子アンタゴニスト | |
KR100277769B1 (ko) | 항-파스 재조합 항체 및 이에 대한 디엔에이 | |
CN116917326A (zh) | 抗her-2/trop-2构建体及其用途 | |
KR102669444B1 (ko) | Etar 항체 및 이의 약학 조성물 및 용도 | |
WO2023222035A1 (zh) | 抗tigit抗体与il2的融合蛋白或其变体及其应用 | |
KR100382628B1 (ko) | 인터페론α/β결합단백질과이의제조및용도 | |
JP7300008B2 (ja) | 低免疫原性かつ低ADCC/CDC機能の抗TNF-αヒト化モノクローナル抗体TCX060およびその使用 | |
KR101946779B1 (ko) | 마이코플라스마 중화 에피토프 및 이에 대한 항체 | |
US20090148440A1 (en) | Antibodies against interleukin-22 binding protein and its uses for the treatment of metabolic disorders | |
JP2003529370A5 (ro) | ||
JP2002522021A5 (ro) |