JP2004514150A - 蛍光媒介式分子断層撮影法 - Google Patents

蛍光媒介式分子断層撮影法 Download PDF

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Publication number
JP2004514150A
JP2004514150A JP2002543944A JP2002543944A JP2004514150A JP 2004514150 A JP2004514150 A JP 2004514150A JP 2002543944 A JP2002543944 A JP 2002543944A JP 2002543944 A JP2002543944 A JP 2002543944A JP 2004514150 A JP2004514150 A JP 2004514150A
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light
signal
measurement result
array
fluorescence
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Pending
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JP2002543944A
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English (en)
Japanese (ja)
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JP2004514150A5 (enExample
Inventor
ニツィアクリストス　バシリス
ワイスレーダー　ラルフ
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General Hospital Corp
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General Hospital Corp
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Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of JP2004514150A publication Critical patent/JP2004514150A/ja
Publication of JP2004514150A5 publication Critical patent/JP2004514150A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Luminescent Compositions (AREA)
JP2002543944A 2000-11-27 2001-11-27 蛍光媒介式分子断層撮影法 Pending JP2004514150A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/723,033 US6615063B1 (en) 2000-11-27 2000-11-27 Fluorescence-mediated molecular tomography
PCT/US2001/044764 WO2002041760A2 (en) 2000-11-27 2001-11-27 Fluorescence-mediated molecular tomography

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008004715A Division JP5134977B2 (ja) 2000-11-27 2008-01-11 蛍光媒介式分子断層撮影法

Publications (2)

Publication Number Publication Date
JP2004514150A true JP2004514150A (ja) 2004-05-13
JP2004514150A5 JP2004514150A5 (enExample) 2005-09-02

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ID=24904527

Family Applications (2)

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JP2002543944A Pending JP2004514150A (ja) 2000-11-27 2001-11-27 蛍光媒介式分子断層撮影法
JP2008004715A Expired - Lifetime JP5134977B2 (ja) 2000-11-27 2008-01-11 蛍光媒介式分子断層撮影法

Family Applications After (1)

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JP2008004715A Expired - Lifetime JP5134977B2 (ja) 2000-11-27 2008-01-11 蛍光媒介式分子断層撮影法

Country Status (8)

Country Link
US (1) US6615063B1 (enExample)
EP (3) EP1349490B1 (enExample)
JP (2) JP2004514150A (enExample)
AT (2) ATE420592T1 (enExample)
AU (2) AU2867302A (enExample)
CA (2) CA2428462C (enExample)
DE (1) DE60137453D1 (enExample)
WO (1) WO2002041760A2 (enExample)

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JP2007222669A (ja) * 2003-10-28 2007-09-06 Veralight Inc 組織の蛍光発光を用いた糖化最終産物または疾病状態の尺度の決定
JPWO2008010604A1 (ja) * 2006-07-19 2009-12-17 学校法人北里研究所 血管撮影装置及び血管分布解析システム
JP2010509976A (ja) * 2006-11-21 2010-04-02 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 解剖構造における組織のイメージングのためのシステム、方法、コンピュータ読取可能媒体及び使用
JP2010512904A (ja) * 2006-12-19 2010-04-30 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 不透明媒体のイメージング
WO2010087478A1 (ja) * 2009-01-30 2010-08-05 富士フイルム株式会社 光断層情報の生成方法、光断層情報生成装置及び記憶媒体
WO2010087477A1 (ja) * 2009-01-30 2010-08-05 富士フイルム株式会社 計測対象保持具、生体保持具及び光計測装置
JP2010236903A (ja) * 2009-03-30 2010-10-21 Fujifilm Corp 計測対象保持具
JP2011505954A (ja) * 2007-12-17 2011-03-03 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 混濁媒体の内部における不均質性の存在を検出するための方法及び、混濁媒体の内部を画像化するための装置
JP2011196693A (ja) * 2010-03-17 2011-10-06 Kitasato Institute オプティカル・コヒーレンス・トモグラフィー装置及び断層像の撮影方法
JP2012515920A (ja) * 2009-01-23 2012-07-12 ジェファソン サイエンス アソシエーツ リミテッド ライアビリティ カンパニー 挿入可能な経直腸プローブを有する専用のモバイル高解像前立腺ｐｅｔイメージャ
CN102781307A (zh) * 2009-09-22 2012-11-14 文森医学公司 用于漫射性介质虚拟折射率匹配的系统和方法
JP2013530426A (ja) * 2010-06-14 2013-07-25 ハミルトン−ソーン インコーポレイテッド 生細胞操作用の装置及び方法
JP2014039818A (ja) * 2012-08-15 2014-03-06 Aspect Imaging Ltd 臨床診断及び臨床前診断用の複数の異種撮像システム
JP2014039816A (ja) * 2012-08-15 2014-03-06 Aspect Imaging Ltd レンダリングされた画像を発生するｍｒｉ画像処理システム
WO2015037055A1 (ja) * 2013-09-10 2015-03-19 株式会社島津製作所 蛍光画像取得装置
JP2016540537A (ja) * 2013-10-23 2016-12-28 ヴェリリー ライフ サイエンシズ エルエルシー 変調源を有する非侵襲的な分析物検出システム
JP2016540539A (ja) * 2013-10-23 2016-12-28 ヴェリリー ライフ サイエンシズ エルエルシー 外部磁界による血管系内の磁性粒子の空間変調
JP2016540534A (ja) * 2013-10-23 2016-12-28 ヴェリリー ライフ サイエンシズ エルエルシー 分析物と背景信号とを区別するための応答信号の変調
JP2017116555A (ja) * 2007-12-19 2017-06-29 シンギュレックス・インコーポレイテッド 単一分子検出走査分析器およびその使用方法
JP2022179782A (ja) * 2016-04-01 2022-12-02 ブラック ライト サージカル， インコーポレイテッド 時間分解蛍光分光法のためのシステム、デバイス、および方法

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7328059B2 (en) 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
US7865230B1 (en) 1997-02-07 2011-01-04 Texas A&M University System Method and system for detecting sentinel lymph nodes
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US7107116B2 (en) * 1999-03-29 2006-09-12 Genex Technologies, Inc. Diffuse optical tomography system and method of use
US7054002B1 (en) 1999-10-08 2006-05-30 The Texas A&M University System Characterization of luminescence in a scattering medium
US6614452B1 (en) * 1999-11-15 2003-09-02 Xenogen Corporation Graphical user interface for in-vivo imaging
US7581191B2 (en) * 1999-11-15 2009-08-25 Xenogen Corporation Graphical user interface for 3-D in-vivo imaging
US6775567B2 (en) 2000-02-25 2004-08-10 Xenogen Corporation Imaging apparatus
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
WO2002093143A2 (en) * 2001-05-17 2002-11-21 Xenogen Corporation Method and apparatus for determining target depth, brightness and size within a body region
US6919919B2 (en) * 2002-02-06 2005-07-19 Xenogen Corporation Light calibration device for use in low level light imaging systems
US7116354B2 (en) * 2001-06-20 2006-10-03 Xenogen Corporation Absolute intensity determination for a light source in low level light imaging systems
US7113217B2 (en) * 2001-07-13 2006-09-26 Xenogen Corporation Multi-view imaging apparatus
US7298415B2 (en) * 2001-07-13 2007-11-20 Xenogen Corporation Structured light imaging apparatus
CN1543325A (zh) * 2001-07-16 2004-11-03 ART�Ƚ��о��Ƽ���˾ 高度混浊介质的多波长成像
AU2003207438A1 (en) * 2002-01-02 2003-07-24 Visen Medical, Inc. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
US7649185B2 (en) * 2002-02-06 2010-01-19 Xenogen Corporation Fluorescent phantom device
US7629573B2 (en) * 2002-02-06 2009-12-08 Xenogen Corporation Tissue phantom calibration device for low level light imaging systems
US7503323B2 (en) * 2002-02-20 2009-03-17 Xenogen Corporation Multiple output anesthesia system
US7474398B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Illumination system for an imaging apparatus with low profile output device
US7474399B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Dual illumination system for an imaging apparatus and method
US6922246B2 (en) 2002-02-22 2005-07-26 Xenogen Corporation Bottom fluorescence illumination assembly for an imaging apparatus
AU2003225763A1 (en) * 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
EP2410315B1 (en) 2002-06-04 2020-04-01 Visen Medical, Inc. Imaging volumes with arbitrary geometries in contact and non-contact tomography
US7218959B2 (en) * 2002-06-05 2007-05-15 Research Foundation Of City University Hybrid-dual-fourier tomographic algorithm for a fast three-dimensionial optical image reconstruction in turbid media
US7616985B2 (en) * 2002-07-16 2009-11-10 Xenogen Corporation Method and apparatus for 3-D imaging of internal light sources
US7599731B2 (en) * 2002-07-16 2009-10-06 Xenogen Corporation Fluorescent light tomography
WO2004027028A2 (en) * 2002-09-18 2004-04-01 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture
CA2505677C (en) * 2002-11-11 2011-11-01 Art, Advanced Research Technologies Inc. Method and apparatus for time resolved optical imaging of biological tissues as part of animals
US6992762B2 (en) * 2002-11-11 2006-01-31 Art Advanced Research Technologies Inc. Method and apparatus for time resolved optical imaging of biological tissues as part of animals
DE10255013B4 (de) * 2002-11-25 2004-12-09 Siemens Ag Verfahren und Vorrichtung zur Lokalisierung von Licht emittierenden Bereichen
US7647091B2 (en) * 2003-02-05 2010-01-12 The General Hospital Corporation Method and system for free space optical tomography of diffuse media
US7720525B2 (en) 2003-03-12 2010-05-18 New Art Advanced Research Technologies Inc. Method and apparatus for combining continuous wave and time domain optical imaging
US20040267335A1 (en) * 2003-04-23 2004-12-30 John Tulip Switched photodynamic therapy apparatus and method
CA2533621C (en) * 2003-06-20 2013-12-10 The Texas A & M University System Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
US7190991B2 (en) * 2003-07-01 2007-03-13 Xenogen Corporation Multi-mode internal imaging
EP1682878A1 (en) * 2003-10-31 2006-07-26 Art Advanced Research Technologies Inc. A time-domain method and apparatus for determining the depth and concentration of a fluorophore in a turbid medium
US7155274B1 (en) 2003-11-21 2006-12-26 Imaging Diagnostic Systems, Inc. Optical computed tomography scanner for small laboratory animals
NO20035748D0 (no) * 2003-12-19 2003-12-19 Amersham Health As Optisk avbildning av sårbar arteriosklerose
US7693318B1 (en) 2004-01-12 2010-04-06 Pme Ip Australia Pty Ltd Method and apparatus for reconstruction of 3D image volumes from projection images
DE102004009657A1 (de) * 2004-02-27 2005-06-09 Siemens Ag Vorrichtung für die optische Tomographie
DE102004009655A1 (de) * 2004-02-27 2005-06-09 Siemens Ag Vorrichtung für die optische Tomographie
DE102004009656A1 (de) * 2004-02-27 2005-06-09 Siemens Ag Vorrichtung für die optische Tomographie
EP1797818A3 (en) * 2004-03-11 2008-02-13 The General Hospital Corporation Method and system for tomographic imaging using fluorescent proteins
JP2007528500A (ja) 2004-03-11 2007-10-11 ザ・ゼネラル・ホスピタル・コーポレーション 蛍光タンパク質を使用する断層撮影イメージングのための方法およびシステム
DE102004015682B4 (de) * 2004-03-26 2008-07-31 Bundesrepublik Deutschland, vertr. d. d. Bundesministerium für Wirtschaft und Technologie, dieses vertr. d. d. Präsidenten der Physikalisch-Technischen Bundesanstalt Verfahren und Gerät zur Detektion eines in den Körper eines Lebewesens injizierten Farbstoff-Bolus
ATE441459T1 (de) * 2004-06-30 2009-09-15 Univ Rochester Fotodynamische therapie mit räumlich aufgelíster dualspektroskopieüberwachung
US20060018525A1 (en) * 2004-07-21 2006-01-26 Barbour Randall L Method and system for temporal spectral imaging
EP1806999A1 (en) 2004-09-24 2007-07-18 ART Advanced Research Technologies Inc. Method for fluorescence tomographic imaging
US8189002B1 (en) 2004-10-29 2012-05-29 PME IP Australia Pty, Ltd. Method and apparatus for visualizing three-dimensional and higher-dimensional image data sets
US7778392B1 (en) 2004-11-02 2010-08-17 Pme Ip Australia Pty Ltd Method of reconstructing computed tomography (CT) volumes suitable for execution on commodity central processing units (CPUs) and graphics processors, and apparatus operating in accord with those methods (rotational X-ray on GPUs)
US20070016078A1 (en) * 2004-12-06 2007-01-18 Hoyt Clifford C Systems and methods for in-vivo optical imaging and measurement
US20080312540A1 (en) * 2004-12-08 2008-12-18 Vasilis Ntziachristos System and Method for Normalized Flourescence or Bioluminescence Imaging
US7609884B1 (en) 2004-12-23 2009-10-27 Pme Ip Australia Pty Ltd Mutual information based registration of 3D-image volumes on GPU using novel accelerated methods of histogram computation
DE102005013042A1 (de) 2005-03-18 2006-09-28 Siemens Ag Einrichtung zur Erzeugung von 3D-Fluoreszenz-oder Lumineszenz-Scans
US7725169B2 (en) * 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
US7623732B1 (en) 2005-04-26 2009-11-24 Mercury Computer Systems, Inc. Method and apparatus for digital image filtering with discrete filter kernels using graphics hardware
US7962198B2 (en) * 2005-04-27 2011-06-14 The Trustees Of Dartmouth College System and method for spectral-encoded high-rate hemodynamic tomography
US8044996B2 (en) * 2005-05-11 2011-10-25 Xenogen Corporation Surface construction using combined photographic and structured light information
EP1743658A1 (en) * 2005-07-14 2007-01-17 Schering Aktiengesellschaft Optical imaging of rheumatoid arthritis
WO2007028118A2 (en) 2005-09-02 2007-03-08 Visen Medical, Inc. Nicotinic acid and picolinic acid derived near-infrared fluorophores
US8041409B2 (en) * 2005-09-08 2011-10-18 Carestream Health, Inc. Method and apparatus for multi-modal imaging
US20090281383A1 (en) * 2005-09-08 2009-11-12 Rao Papineni Apparatus and method for external fluorescence imaging of internal regions of interest in a small animal using an endoscope for internal illumination
US8203132B2 (en) * 2005-09-08 2012-06-19 Carestream Health, Inc. Apparatus and method for imaging ionizing radiation
US20100220836A1 (en) 2005-09-08 2010-09-02 Feke Gilbert D Apparatus and method for multi-modal imaging
US8050735B2 (en) * 2005-09-08 2011-11-01 Carestream Health, Inc. Apparatus and method for multi-modal imaging
US8660631B2 (en) * 2005-09-08 2014-02-25 Bruker Biospin Corporation Torsional support apparatus and method for craniocaudal rotation of animals
US8170302B1 (en) * 2005-09-30 2012-05-01 Ut-Battelle, Llc System and method for generating motion corrected tomographic images
US20080269617A1 (en) * 2005-11-10 2008-10-30 Koninklijke Philips Electronics, N.V. Absorption and Scattering Map Reconstruction For Optical Fluorescence Tomography
JP2009517115A (ja) * 2005-11-25 2009-04-30 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学蛍光トモグラフィ
WO2007111669A2 (en) † 2005-12-22 2007-10-04 Visen Medical, Inc. Combined x-ray and optical tomographic imaging system
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
FR2895897B1 (fr) * 2006-01-12 2008-10-17 Commissariat Energie Atomique Procede et dispositif de reconstruction d'image de tomographie optique de fluorescence par double mesure
US7787129B2 (en) * 2006-01-31 2010-08-31 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US7865226B2 (en) * 2006-02-03 2011-01-04 Chiodo Chris D Specimen positioning system for imaging machines
US20070282404A1 (en) * 2006-04-10 2007-12-06 University Of Rochester Side-firing linear optic array for interstitial optical therapy and monitoring using compact helical geometry
US8433384B2 (en) * 2006-05-03 2013-04-30 Covidien Lp Method and apparatus for cerebral oximetry
US8755866B2 (en) * 2006-05-03 2014-06-17 Covidien Lp Method and apparatus for lymph node mapping
WO2007143141A2 (en) * 2006-06-01 2007-12-13 The General Hospital Corporation In-vivo optical imaging method including analysis of dynamic images
JP2009540327A (ja) 2006-06-14 2009-11-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学的蛍光トモグラフィー（ｔｏｍｏｇｒａｐｈｙ）較正
EP2029020A4 (en) * 2006-06-22 2010-04-21 Wisconsin Alumni Res Found USE OF STROMA COLLAGEN IN THE DIAGNOSIS AND CHARACTERIZATION OF BREAST CANCER
WO2008005554A2 (en) * 2006-07-06 2008-01-10 University Of Connecticut Method and apparatus for medical imaging using near-infrared optical tomography, fluorence tomography combined with ultrasound
RU2454921C2 (ru) * 2006-07-07 2012-07-10 Конинклейке Филипс Электроникс Н.В. Оптическая отображающая система и способ
US8078265B2 (en) * 2006-07-11 2011-12-13 The General Hospital Corporation Systems and methods for generating fluorescent light images
WO2008011112A2 (en) * 2006-07-19 2008-01-24 University Of Connecticut Method and apparatus for medical imaging using combined near-infrared optical tomography, fluorescent tomography and ultrasound
US10335038B2 (en) * 2006-08-24 2019-07-02 Xenogen Corporation Spectral unmixing for in-vivo imaging
US10775308B2 (en) * 2006-08-24 2020-09-15 Xenogen Corporation Apparatus and methods for determining optical tissue properties
US20080086051A1 (en) * 2006-09-20 2008-04-10 Ethicon Endo-Surgery, Inc. System, storage medium for a computer program, and method for displaying medical images
BRPI0721489A2 (pt) 2006-11-17 2014-02-11 Koninkl Philips Electronics Nv Sistema para formação de imagem de um interior de um meio túrbido, sistema de aquisição de imagem médica para formação de imagem de um interior de um meio túrbido, método para formação de imagem de um interior de um meio túrbido, e, marcador para uso em um método para formação de imagem de um interior de um meio túrbido.
WO2008065580A2 (en) 2006-11-28 2008-06-05 Koninklijke Philips Electronics N.V. Method, device, medical image acquisition device for imaging an interior of a turbid medium with darkness level measurement
EP1943941A1 (en) * 2006-12-21 2008-07-16 Koninklijke Philips Electronics N.V. Method for optically imaging an interior of a turbid medium, method for reconstructing an image of an interior of a turbid medium, device for imaging an interior of a turbid medium, medical image acquisition device and computer program products for use in said methods and devices
US7983740B2 (en) * 2006-12-22 2011-07-19 Washington University High performance imaging system for diffuse optical tomography and associated method of use
EP2118640A1 (en) 2007-02-05 2009-11-18 Koninklijke Philips Electronics N.V. Device and method for acquiring image data from a turbid medium
DK2118206T3 (en) * 2007-02-09 2018-06-18 Visen Medical Inc POLYCYCLOF COLORS AND APPLICATION THEREOF
US8144966B2 (en) * 2007-03-02 2012-03-27 Wisconsin Alumni Research Foundation Use of endogenous fluorescence to identify invading metastatic breast tumor cells
US8155728B2 (en) * 2007-08-22 2012-04-10 Ethicon Endo-Surgery, Inc. Medical system, method, and storage medium concerning a natural orifice transluminal medical procedure
US20080319307A1 (en) * 2007-06-19 2008-12-25 Ethicon Endo-Surgery, Inc. Method for medical imaging using fluorescent nanoparticles
US8457718B2 (en) * 2007-03-21 2013-06-04 Ethicon Endo-Surgery, Inc. Recognizing a real world fiducial in a patient image data
US20080221434A1 (en) * 2007-03-09 2008-09-11 Voegele James W Displaying an internal image of a body lumen of a patient
US20080234544A1 (en) * 2007-03-20 2008-09-25 Ethicon Endo-Sugery, Inc. Displaying images interior and exterior to a body lumen of a patient
US8081810B2 (en) 2007-03-22 2011-12-20 Ethicon Endo-Surgery, Inc. Recognizing a real world fiducial in image data of a patient
WO2008134649A1 (en) * 2007-04-27 2008-11-06 Children's Medical Center Corporation Polymer blend phantoms
US20100331927A1 (en) * 2007-05-02 2010-12-30 Cottrell William J Feedback-controlled method for delivering photodynamic therapy and related instrumentation
CN101301192B (zh) * 2007-05-10 2010-06-23 中国科学院自动化研究所 一种多模态自发荧光断层分子影像仪器及重建方法
US7952706B2 (en) * 2007-05-17 2011-05-31 Prescient Medical, Inc. Multi-channel fiber optic spectroscopy systems employing integrated optics modules
US7692160B2 (en) * 2007-05-31 2010-04-06 General Electric Company Method and system of optical imaging for target detection in a scattering medium
US7952719B2 (en) 2007-06-08 2011-05-31 Prescient Medical, Inc. Optical catheter configurations combining raman spectroscopy with optical fiber-based low coherence reflectometry
US8019151B2 (en) * 2007-06-11 2011-09-13 Visualization Sciences Group, Inc. Methods and apparatus for image compression and decompression using graphics processing unit (GPU)
WO2009005748A1 (en) 2007-06-29 2009-01-08 The Trustees Of Columbia University In The City Ofnew York Optical imaging or spectroscopy systems and methods
WO2009006758A1 (en) * 2007-07-10 2009-01-15 Tsinghua University Continuous and dynamical acquisition-type imaging system for small animal induced fluorescence molecule imaging
US8392529B2 (en) 2007-08-27 2013-03-05 Pme Ip Australia Pty Ltd Fast file server methods and systems
WO2009055095A1 (en) 2007-10-19 2009-04-30 Visen Medical, Inc. Imaging systems featuring waveguiding compensation
US8319781B2 (en) 2007-11-23 2012-11-27 Pme Ip Australia Pty Ltd Multi-user multi-GPU render server apparatus and methods
WO2009067675A1 (en) 2007-11-23 2009-05-28 Mercury Computer Systems, Inc. Client-server visualization system with hybrid data processing
WO2009067680A1 (en) 2007-11-23 2009-05-28 Mercury Computer Systems, Inc. Automatic image segmentation methods and apparartus
US9904969B1 (en) 2007-11-23 2018-02-27 PME IP Pty Ltd Multi-user multi-GPU render server apparatus and methods
US10311541B2 (en) 2007-11-23 2019-06-04 PME IP Pty Ltd Multi-user multi-GPU render server apparatus and methods
RU2368306C2 (ru) * 2007-12-03 2009-09-27 Институт прикладной физики РАН Устройство получения флуоресцентных томографических изображений
US8983580B2 (en) 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
EP2732826B1 (en) 2008-01-18 2017-11-08 Visen Medical, Inc. Fluorescent imaging agents
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
EP2110076A1 (en) * 2008-02-19 2009-10-21 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Method and device for near-field dual-wave modality imaging
WO2009114776A2 (en) 2008-03-14 2009-09-17 Visen Medical, Inc. Integrin targeting agents and methods of using same
US20090240139A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
US20090240138A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
CA2719839C (en) * 2008-03-25 2017-08-22 Visen Medical, Inc. Animal holder for in vivo tomographic imaging with multiple modalities
US9480425B2 (en) * 2008-04-17 2016-11-01 Washington University Task-less optical mapping of dynamic brain function using resting state functional connectivity
WO2009140757A1 (en) 2008-05-20 2009-11-26 University Health Network Device and method for fluorescence-based imaging and monitoring
US8107710B2 (en) * 2008-05-23 2012-01-31 University Of Rochester Automated placental measurement
US9339191B2 (en) 2008-07-08 2016-05-17 Hitachi, Ltd. Optical measurement apparatus
CN102292029B (zh) 2008-07-18 2014-11-05 罗切斯特大学 用于c扫描光声成像的低成本设备
US9572497B2 (en) 2008-07-25 2017-02-21 Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) Quantitative multi-spectral opto-acoustic tomography (MSOT) of tissue biomarkers
US20100094134A1 (en) * 2008-10-14 2010-04-15 The University Of Connecticut Method and apparatus for medical imaging using near-infrared optical tomography combined with photoacoustic and ultrasound guidance
US20100298688A1 (en) * 2008-10-15 2010-11-25 Dogra Vikram S Photoacoustic imaging using a versatile acoustic lens
WO2010062787A1 (en) * 2008-11-03 2010-06-03 Washington University Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor
CN101485560B (zh) * 2008-11-17 2011-04-27 清华大学 一种非接触固定式荧光分子断层成像方法及装置
US8864821B2 (en) * 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
EP2208460A1 (de) * 2009-01-19 2010-07-21 BrainLAB AG Erkennung und Lokalisierung von Gewebe durch Lichtanalyse
WO2010099137A2 (en) 2009-02-26 2010-09-02 Osi Pharmaceuticals, Inc. In situ methods for monitoring the emt status of tumor cells in vivo
JP2012525883A (ja) 2009-05-05 2012-10-25 ルミト・アーベー 散乱媒体の拡散ルミネセンスイメージングまたは断層撮影の改善のためのシステム、方法、およびルミネセンスマーカー
JP5566456B2 (ja) 2009-06-29 2014-08-06 ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー） 被写体を熱音響撮像するための撮像装置及び撮像方法、コンピュータプログラム並びにコンピュータで読み取り可能な記憶媒体を備える装置
EP2459987A1 (en) 2009-07-27 2012-06-06 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Imaging device and method for optoacoustic imaging of small animals
JP5426026B2 (ja) 2009-07-28 2014-02-26 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 非侵襲性インビボ光学イメージング方法
AU2010286592B2 (en) 2009-08-28 2015-08-13 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
FR2950431B1 (fr) * 2009-09-24 2011-12-09 Commissariat Energie Atomique Dispositif et procede de reconstruction spatiale d'une cartographie de fluorescence
JP5268846B2 (ja) * 2009-09-25 2013-08-21 富士フイルム株式会社 計測データの補正方法、光断層計測装置及びプログラム
US8619237B2 (en) 2009-12-04 2013-12-31 The Trustees Of Columbia University In The City Of New York Laser-scanning intersecting plane tomography such as for high speed volumetric optical imaging
US8192429B2 (en) 2010-06-29 2012-06-05 Theravant, Inc. Abnormality eradication through resonance
WO2012050896A2 (en) 2010-09-29 2012-04-19 Kansas State University Research Foundation Protease selective supramolecular assemblies
CN103140757A (zh) * 2010-09-30 2013-06-05 日本电气株式会社 信息处理设备、信息处理系统、信息处理方法、程序和记录介质
US9063074B2 (en) 2010-12-30 2015-06-23 Empire Technology Development Llc Analyzing tissue morphology in three dimensions
WO2012090035A1 (en) * 2010-12-30 2012-07-05 Empire Technology Development Llc Spectral analysis of tissue morphology in three dimensions
US20140099264A1 (en) 2011-03-07 2014-04-10 F. Hoffman-La Roche Ag Means and methods for in vivo testing of therapeutic antibodies
EP2683413A1 (en) 2011-03-07 2014-01-15 F.Hoffmann-La Roche Ag In vivo selection of therapeutically active antibodies
CA2835286C (en) 2011-05-09 2021-03-23 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
US8810640B2 (en) 2011-05-16 2014-08-19 Ut-Battelle, Llc Intrinsic feature-based pose measurement for imaging motion compensation
CN102551671B (zh) * 2011-12-23 2013-08-28 天津大学 光子计数型动态扩散荧光断层成像方法及装置
WO2013102144A2 (en) 2011-12-30 2013-07-04 Halozyme, Inc. Ph20 polypeptede variants, formulations and uses thereof
WO2013112709A1 (en) * 2012-01-24 2013-08-01 Niedre Mark Systems and methods for sensing, enumerating and imaging rare cells with diffuse light
CN102579011B (zh) * 2012-03-01 2013-10-16 天津大学 一种基于电子倍增ccd的扩散光学层析成像系统及方法
CN104245954A (zh) 2012-03-30 2014-12-24 文森医学公司 细菌成像剂及其使用方法
IL221489A0 (en) * 2012-08-15 2012-12-31 Aspect Imaging Ltd Imaging system for generating a rendered image
WO2014028057A1 (en) 2012-08-15 2014-02-20 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
US20140051974A1 (en) * 2012-08-15 2014-02-20 Aspect Imaging Ltd. System and method for mri imaging using polarized light
RU2515203C1 (ru) * 2012-10-12 2014-05-10 Федеральное государственное бюджетное учреждение науки Институт прикладной физики Российской академии наук (ИПФ РАН) Устройство получения томографических флуоресцентных изображений
CN104853669B (zh) 2012-10-15 2017-07-21 文森医学公司 具有荧光及生物发光源的交叉形态加权特征的漫射介质成像的系统、方法及设备
CA2794226C (en) 2012-10-31 2020-10-20 Queen's University At Kingston Automated intraoperative ultrasound calibration
EP2742854B1 (en) 2012-12-11 2021-03-10 iThera Medical GmbH Handheld device and method for tomographic optoacoustic imaging of an object
EP2754388B1 (en) 2013-01-15 2020-09-09 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH System and method for quality-enhanced high-rate optoacoustic imaging of an object
US9696393B2 (en) * 2013-01-28 2017-07-04 The Regents Of The University Of California MRI receiver coil providing an enhanced signal-to-noise ratio
WO2014160037A2 (en) 2013-03-14 2014-10-02 The Regents Of The University Of California Activatable membrane-interacting peptides and methods of use
US10070839B2 (en) 2013-03-15 2018-09-11 PME IP Pty Ltd Apparatus and system for rule based visualization of digital breast tomosynthesis and other volumetric images
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
US10540803B2 (en) 2013-03-15 2020-01-21 PME IP Pty Ltd Method and system for rule-based display of sets of images
CA2901000C (en) 2013-03-15 2023-03-14 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
US9509802B1 (en) 2013-03-15 2016-11-29 PME IP Pty Ltd Method and system FPOR transferring data to improve responsiveness when sending large data sets
US11244495B2 (en) 2013-03-15 2022-02-08 PME IP Pty Ltd Method and system for rule based display of sets of images using image content derived parameters
US8976190B1 (en) 2013-03-15 2015-03-10 Pme Ip Australia Pty Ltd Method and system for rule based display of sets of images
US11183292B2 (en) 2013-03-15 2021-11-23 PME IP Pty Ltd Method and system for rule-based anonymized display and data export
US9486163B2 (en) * 2014-02-21 2016-11-08 Verily Life Sciences Llc Silicon-vacancy-doped nanodiamonds for molecular and cellular imaging
US10039491B2 (en) * 2014-06-30 2018-08-07 Verily Life Sciences Llc Methods for reducing noise in optical biological sensors
US9910035B1 (en) 2014-07-16 2018-03-06 Verily Life Sciences Llc Polyvalent functionalized nanoparticle-based in vivo diagnostic system
US9874554B1 (en) 2014-07-16 2018-01-23 Verily Life Sciences Llc Aptamer-based in vivo diagnostic system
EP3171765B1 (en) 2014-07-24 2021-09-01 University Health Network Collection and analysis of data for diagnostic purposes
JP6355127B2 (ja) * 2014-07-25 2018-07-11 一般財団法人電力中央研究所 蛍光観察システム
CN106331442B (zh) 2015-07-02 2021-01-15 松下知识产权经营株式会社 摄像装置
US9984478B2 (en) 2015-07-28 2018-05-29 PME IP Pty Ltd Apparatus and method for visualizing digital breast tomosynthesis and other volumetric images
US11599672B2 (en) 2015-07-31 2023-03-07 PME IP Pty Ltd Method and apparatus for anonymized display and data export
CN106725347A (zh) * 2017-02-16 2017-05-31 西北大学 基于随机变量交替方向乘子法荧光分子断层成像重建方法
CN107242860B (zh) * 2017-07-25 2021-01-19 京东方科技集团股份有限公司 荧光分子层析成像系统及方法
US10909679B2 (en) 2017-09-24 2021-02-02 PME IP Pty Ltd Method and system for rule based display of sets of images using image content derived parameters
US11549017B2 (en) 2017-09-29 2023-01-10 Perkinelmer Health Sciences, Inc. NIR to SWIR fluorescent compounds for imaging and detection
US10928617B1 (en) 2018-05-18 2021-02-23 GDH Enterprises, LLC Portable three-dimensional virtual imaging device
CN111481164B (zh) * 2019-01-25 2023-04-07 宏碁股份有限公司 用以获取荧光眼底图的方法及其装置
WO2021258069A2 (en) 2020-06-19 2021-12-23 The General Hospital Corporation Near-infrared autofluorescence imaging systems and methods
RU203175U1 (ru) * 2020-06-19 2021-03-24 Федеральное государственное бюджетное учреждение науки федеральный исследовательский центр "Институт общей физики им. А.М. Прохорова Российской академии наук"(ИОФ РАН) Видеофлуоресцентное устройство для анализа внутритканевого распределения фотосенсибилизаторов дальнего красного и ближнего инфракрасного диапазонов злокачественных новообразований головы и шеи
WO2022147171A1 (en) 2020-12-30 2022-07-07 Hawkeye Bio, Limited Pristine graphene based biosensor for biomarker detection and related core particles, materials compositions methods and systems
RU206470U1 (ru) * 2021-02-11 2021-09-13 Акционерное Общество "Наука И Инновации" Устройство с возможностью видеофлуоресцентного и спектроскопического анализа для контроля и оценки распределения фотосенсибилизаторов в биотканях
CN113951831B (zh) * 2021-11-19 2023-08-29 复旦大学 基于随机重构策略的超高分辨荧光分子断层成像方法
CN114027802A (zh) * 2022-01-10 2022-02-11 杭州纬壹医疗科技有限公司 一种扩散光学层析成像系统
CN115844365B (zh) * 2023-02-07 2023-04-28 北京航空航天大学 小动物磁粒子成像和荧光分子断层成像多模态成像系统
CN120199343B (zh) * 2025-05-26 2025-08-01 齐鲁工业大学(山东省科学院) 近红外二区分子荧光探针发光性能评价方法及系统

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281645A (en) * 1977-06-28 1981-08-04 Duke University, Inc. Method and apparatus for monitoring metabolism in body organs
JPS62180241A (ja) * 1986-02-04 1987-08-07 Hamamatsu Photonics Kk 断層像観察装置
US5090415A (en) * 1989-02-14 1992-02-25 Hamamatsu Photonics Kabushiki Kaisha Examination apparatus
US5136373A (en) 1989-06-22 1992-08-04 Hamamatsu Photonics K. K. Image processing apparatus
JPH0483149A (ja) * 1990-07-26 1992-03-17 Res Dev Corp Of Japan 蛍光像画像化装置
US5699798A (en) * 1990-08-10 1997-12-23 University Of Washington Method for optically imaging solid tumor tissue
JPH04122248A (ja) * 1990-09-13 1992-04-22 Res Dev Corp Of Japan 光断層像画像化装置
JP3217107B2 (ja) * 1992-02-14 2001-10-09 科学技術振興事業団 蛍光断層像測定装置
US6397099B1 (en) * 1992-05-18 2002-05-28 Non-Invasive Technology, Inc. Non-invasive imaging of biological tissue
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
US6304771B1 (en) 1993-10-29 2001-10-16 The Trustees Of The University Of Pennsylvania Systems and methods for imaging fluorophores
US5391877A (en) * 1994-01-26 1995-02-21 Marks; Michael A. Combined imaging scanner
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
US5685313A (en) * 1994-05-31 1997-11-11 Brain Monitor Ltd. Tissue monitor
US6217847B1 (en) 1994-07-01 2001-04-17 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5650135A (en) 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
JPH08131445A (ja) * 1994-11-14 1996-05-28 Hitachi Ltd 光計測装置
AU1130797A (en) 1995-08-24 1997-03-19 Purdue Research Foundation Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media
JP3917731B2 (ja) * 1996-11-21 2007-05-23 オリンパス株式会社 レーザ走査顕微鏡
US5952664A (en) 1997-01-17 1999-09-14 Imaging Diagnostic Systems, Inc. Laser imaging apparatus using biomedical markers that bind to cancer cells
JP3654325B2 (ja) * 1997-02-13 2005-06-02 富士写真フイルム株式会社 蛍光検出装置
US5762607A (en) * 1997-03-19 1998-06-09 Schotland; John Carl Emission tomography system and method using direct reconstruction of scattered radiation
US6081322A (en) * 1997-10-16 2000-06-27 Research Foundation Of State Of New York NIR clinical opti-scan system
JP3771364B2 (ja) * 1997-12-12 2006-04-26 浜松ホトニクス株式会社 光ｃｔ装置及び画像再構成方法
WO1999040841A1 (en) * 1998-02-11 1999-08-19 Non-Invasive Technology, Inc. Imaging and characterization of brain tissue
US6205347B1 (en) * 1998-02-27 2001-03-20 Picker International, Inc. Separate and combined multi-modality diagnostic imaging system
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
CA2341359A1 (en) * 1998-08-21 2000-03-02 Ian Walton Novel optical architectures for microvolume laser-scanning cytometers
US6377842B1 (en) * 1998-09-22 2002-04-23 Aurora Optics, Inc. Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
AT410718B (de) * 1998-10-28 2003-07-25 Schindler Hansgeorg Dr Vorrichtung zur visualisierung von molekülen
US6377841B1 (en) 2000-03-31 2002-04-23 Vanderbilt University Tumor demarcation using optical spectroscopy

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007222669A (ja) * 2003-10-28 2007-09-06 Veralight Inc 組織の蛍光発光を用いた糖化最終産物または疾病状態の尺度の決定
JPWO2008010604A1 (ja) * 2006-07-19 2009-12-17 学校法人北里研究所 血管撮影装置及び血管分布解析システム
JP2010509976A (ja) * 2006-11-21 2010-04-02 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 解剖構造における組織のイメージングのためのシステム、方法、コンピュータ読取可能媒体及び使用
JP2010512904A (ja) * 2006-12-19 2010-04-30 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 不透明媒体のイメージング
JP2011505954A (ja) * 2007-12-17 2011-03-03 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 混濁媒体の内部における不均質性の存在を検出するための方法及び、混濁媒体の内部を画像化するための装置
JP2017116555A (ja) * 2007-12-19 2017-06-29 シンギュレックス・インコーポレイテッド 単一分子検出走査分析器およびその使用方法
JP2012515920A (ja) * 2009-01-23 2012-07-12 ジェファソン サイエンス アソシエーツ リミテッド ライアビリティ カンパニー 挿入可能な経直腸プローブを有する専用のモバイル高解像前立腺ｐｅｔイメージャ
WO2010087477A1 (ja) * 2009-01-30 2010-08-05 富士フイルム株式会社 計測対象保持具、生体保持具及び光計測装置
JP2010175466A (ja) * 2009-01-30 2010-08-12 Fujifilm Corp 光断層情報の生成方法、光断層情報生成装置及び光断層情報の生成プログラム
JP2010197381A (ja) * 2009-01-30 2010-09-09 Fujifilm Corp 計測対象保持具、生体保持具及び光計測装置
WO2010087478A1 (ja) * 2009-01-30 2010-08-05 富士フイルム株式会社 光断層情報の生成方法、光断層情報生成装置及び記憶媒体
US8742371B2 (en) 2009-01-30 2014-06-03 Fujifilm Corporation Method for generating optical tomographic information, optical tomographic information generating apparatus, and storage medium
US8327804B2 (en) 2009-01-30 2012-12-11 Fujifilm Corporation Measurement object holder, living body holder, and optical measurement instrument
JP2010236903A (ja) * 2009-03-30 2010-10-21 Fujifilm Corp 計測対象保持具
JP2013505468A (ja) * 2009-09-22 2013-02-14 ビセン メディカル， インコーポレイテッド 拡散媒質の仮想屈折率整合のためのシステムおよび方法
CN102781307A (zh) * 2009-09-22 2012-11-14 文森医学公司 用于漫射性介质虚拟折射率匹配的系统和方法
JP2011196693A (ja) * 2010-03-17 2011-10-06 Kitasato Institute オプティカル・コヒーレンス・トモグラフィー装置及び断層像の撮影方法
JP2013530426A (ja) * 2010-06-14 2013-07-25 ハミルトン−ソーン インコーポレイテッド 生細胞操作用の装置及び方法
US9040272B2 (en) 2010-06-14 2015-05-26 Hamilton Thorne, Inc. Apparatus and method for living cell manipulation
JP2014039818A (ja) * 2012-08-15 2014-03-06 Aspect Imaging Ltd 臨床診断及び臨床前診断用の複数の異種撮像システム
JP2014039816A (ja) * 2012-08-15 2014-03-06 Aspect Imaging Ltd レンダリングされた画像を発生するｍｒｉ画像処理システム
JPWO2015037055A1 (ja) * 2013-09-10 2017-03-02 株式会社島津製作所 蛍光画像取得装置
WO2015037055A1 (ja) * 2013-09-10 2015-03-19 株式会社島津製作所 蛍光画像取得装置
JP2016540539A (ja) * 2013-10-23 2016-12-28 ヴェリリー ライフ サイエンシズ エルエルシー 外部磁界による血管系内の磁性粒子の空間変調
JP2016540534A (ja) * 2013-10-23 2016-12-28 ヴェリリー ライフ サイエンシズ エルエルシー 分析物と背景信号とを区別するための応答信号の変調
JP2016540537A (ja) * 2013-10-23 2016-12-28 ヴェリリー ライフ サイエンシズ エルエルシー 変調源を有する非侵襲的な分析物検出システム
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
US11464429B2 (en) 2013-10-23 2022-10-11 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
JP2022179782A (ja) * 2016-04-01 2022-12-02 ブラック ライト サージカル， インコーポレイテッド 時間分解蛍光分光法のためのシステム、デバイス、および方法
JP7671725B2 (ja) 2016-04-01 2025-05-02 ブラック ライト サージカル， インコーポレイテッド 時間分解蛍光分光法のためのシステム、デバイス、および方法

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