JP2004512328A5 - - Google Patents
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- Publication number
- JP2004512328A5 JP2004512328A5 JP2002537718A JP2002537718A JP2004512328A5 JP 2004512328 A5 JP2004512328 A5 JP 2004512328A5 JP 2002537718 A JP2002537718 A JP 2002537718A JP 2002537718 A JP2002537718 A JP 2002537718A JP 2004512328 A5 JP2004512328 A5 JP 2004512328A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- methylpiperazin
- ylamino
- pyrimidin
- ylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 12
- -1 4-methylpiperazin-1-ylmethyl Chemical group 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 5
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims description 3
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 description 5
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 241000272517 Anseriformes Species 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 150000003936 benzamides Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24381000P | 2000-10-27 | 2000-10-27 | |
| PCT/EP2001/012442 WO2002034727A2 (en) | 2000-10-27 | 2001-10-26 | Treatment of gastrointestinal stromal tumors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004512328A JP2004512328A (ja) | 2004-04-22 |
| JP2004512328A5 true JP2004512328A5 (https=) | 2009-02-19 |
| JP4386635B2 JP4386635B2 (ja) | 2009-12-16 |
Family
ID=22920224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002537718A Expired - Lifetime JP4386635B2 (ja) | 2000-10-27 | 2001-10-26 | 消化管間質腫瘍の処置 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6958335B2 (https=) |
| EP (1) | EP1332137B1 (https=) |
| JP (1) | JP4386635B2 (https=) |
| KR (1) | KR100885129B1 (https=) |
| CN (1) | CN1276754C (https=) |
| AT (1) | ATE321556T1 (https=) |
| AU (2) | AU1826202A (https=) |
| BR (1) | BRPI0114870B8 (https=) |
| CA (1) | CA2424470C (https=) |
| CY (1) | CY1105055T1 (https=) |
| CZ (1) | CZ303944B6 (https=) |
| DE (1) | DE60118430T2 (https=) |
| DK (1) | DK1332137T3 (https=) |
| ES (1) | ES2260317T3 (https=) |
| HU (1) | HU229106B1 (https=) |
| IL (2) | IL155029A0 (https=) |
| MX (1) | MXPA03003703A (https=) |
| NO (1) | NO324948B1 (https=) |
| NZ (1) | NZ525254A (https=) |
| PL (1) | PL209733B1 (https=) |
| PT (1) | PT1332137E (https=) |
| RU (1) | RU2301066C2 (https=) |
| SK (1) | SK287335B6 (https=) |
| WO (1) | WO2002034727A2 (https=) |
| ZA (1) | ZA200302155B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| CA2444867C (en) * | 2001-05-16 | 2010-08-17 | Novartis Ag | Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent |
| ES2266553T3 (es) * | 2001-06-29 | 2007-03-01 | Ab Science | Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias. |
| WO2003003006A2 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
| US20040266797A1 (en) * | 2001-06-29 | 2004-12-30 | Alain Moussy | Use of potent,selective and non toxic c-kit inhibitors for treating tumor angiogensis |
| ES2274993T3 (es) * | 2001-06-29 | 2007-06-01 | Ab Science | Utilizacion de inhibidores de tirosina cinasa para el tratamiento de enfermedades alergicas. |
| JP2004537542A (ja) * | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用 |
| EP1461032B1 (en) * | 2001-09-20 | 2008-07-16 | AB Science | Use of c-kit inhibitors for promoting hair growth |
| EP1427379B1 (en) * | 2001-09-20 | 2008-08-13 | AB Science | Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis |
| DE60307237T2 (de) * | 2002-02-27 | 2007-10-18 | Ab Science | Verwendung von tyrosine-kinase inhibitoren zur behandlung von cns krankheiten |
| FR2844452A1 (fr) * | 2002-09-18 | 2004-03-19 | Inst Gustave Roussy Igr | Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| CA2538523A1 (en) * | 2003-09-19 | 2005-03-31 | Novartis Ag | Treatment of gastrointestinal stromal tumors with imatinib and midostaurin |
| WO2007089716A2 (en) * | 2006-02-01 | 2007-08-09 | The Regents Of The University Of California | Use of aminopyrimidine compounds in the treatment of immune disorders |
| AU2007296743B2 (en) * | 2006-09-11 | 2012-02-16 | Curis, Inc. | Tyrosine kinase inhibitors containing a zinc binding moiety |
| WO2008033747A2 (en) * | 2006-09-11 | 2008-03-20 | Curis, Inc. | Multi-functional small molecules as anti-proliferative agents |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| US20090082361A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched imatinib |
| CN101584696A (zh) | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
| US8530492B2 (en) | 2009-04-17 | 2013-09-10 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| WO2012122058A2 (en) | 2011-03-04 | 2012-09-13 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compound and methods of use |
| WO2012155339A1 (zh) | 2011-05-17 | 2012-11-22 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
| US20160015708A1 (en) | 2012-02-21 | 2016-01-21 | Ranbaxy Laboratories Limited | Stable dosage forms of imatinib mesylate |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| JP6464084B2 (ja) | 2012-07-27 | 2019-02-06 | イズミ テクノロジー，エルエルシー | 排出阻害剤およびこれを用いる治療法 |
| EP3782604A1 (en) | 2013-07-31 | 2021-02-24 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| WO2019016673A2 (en) | 2017-07-20 | 2019-01-24 | Kashiv Pharma Llc | STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION OF IMATINIB |
| CN118416236A (zh) | 2018-01-31 | 2024-08-02 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| IL276398B2 (en) | 2018-01-31 | 2026-03-01 | Deciphera Pharmaceuticals Llc | Combination therapy for mastocytosis |
| WO2020185812A1 (en) | 2019-03-11 | 2020-09-17 | Teva Pharmaceuticals International Gmbh | Solid state forms of ripretinib |
| US12186393B2 (en) | 2019-08-02 | 2025-01-07 | Onehealthcompany, Inc. | Method of treating transitional cell carcinoma in a canine by administering lapatinib, wherein the carcinoma harbors a BRAF mutation |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| EP4013412B1 (en) | 2019-08-12 | 2026-01-28 | Deciphera Pharmaceuticals, LLC | Ripretinib for treating gastrointestinal stromal tumors |
| MX2022008103A (es) | 2019-12-30 | 2022-09-19 | Deciphera Pharmaceuticals Llc | Formulaciones de inhibidores de la cinasa amorfa y metodos de estas. |
| EP4084779B1 (en) | 2019-12-30 | 2024-10-09 | Deciphera Pharmaceuticals, LLC | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| KR102535840B1 (ko) | 2020-07-31 | 2023-05-23 | (주)파로스아이바이오 | 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1528449A1 (ru) * | 1985-06-05 | 1989-12-15 | Центральный институт усовершенствования врачей | Способ релаксации илеоцекального отдела кишечника |
| TW225528B (https=) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| JP2002523455A (ja) * | 1998-08-31 | 2002-07-30 | スージェン・インコーポレーテッド | 蛋白質キナーゼ活性の調節剤としての幾何学的に制限された２−インドリノン誘導体 |
-
2001
- 2001-10-26 CN CNB018178952A patent/CN1276754C/zh not_active Ceased
- 2001-10-26 HU HU0301512A patent/HU229106B1/hu unknown
- 2001-10-26 MX MXPA03003703A patent/MXPA03003703A/es active IP Right Grant
- 2001-10-26 US US10/415,015 patent/US6958335B2/en not_active Expired - Lifetime
- 2001-10-26 WO PCT/EP2001/012442 patent/WO2002034727A2/en not_active Ceased
- 2001-10-26 CA CA002424470A patent/CA2424470C/en not_active Expired - Lifetime
- 2001-10-26 PL PL362148A patent/PL209733B1/pl unknown
- 2001-10-26 DE DE60118430T patent/DE60118430T2/de not_active Expired - Lifetime
- 2001-10-26 PT PT01988712T patent/PT1332137E/pt unknown
- 2001-10-26 ES ES01988712T patent/ES2260317T3/es not_active Expired - Lifetime
- 2001-10-26 DK DK01988712T patent/DK1332137T3/da active
- 2001-10-26 JP JP2002537718A patent/JP4386635B2/ja not_active Expired - Lifetime
- 2001-10-26 KR KR1020037003903A patent/KR100885129B1/ko not_active Ceased
- 2001-10-26 NZ NZ525254A patent/NZ525254A/en not_active IP Right Cessation
- 2001-10-26 RU RU2003114752/15A patent/RU2301066C2/ru not_active IP Right Cessation
- 2001-10-26 SK SK518-2003A patent/SK287335B6/sk not_active IP Right Cessation
- 2001-10-26 AU AU1826202A patent/AU1826202A/xx active Pending
- 2001-10-26 EP EP01988712A patent/EP1332137B1/en not_active Expired - Lifetime
- 2001-10-26 IL IL15502901A patent/IL155029A0/xx unknown
- 2001-10-26 AT AT01988712T patent/ATE321556T1/de active
- 2001-10-26 CZ CZ20031152A patent/CZ303944B6/cs not_active IP Right Cessation
- 2001-10-26 BR BRPI0114870-2 patent/BRPI0114870B8/pt active IP Right Grant
- 2001-10-26 AU AU2002218262A patent/AU2002218262B2/en not_active Expired
-
2003
- 2003-03-18 ZA ZA200302155A patent/ZA200302155B/en unknown
- 2003-03-20 IL IL155029A patent/IL155029A/en active IP Right Grant
- 2003-04-24 NO NO20031833A patent/NO324948B1/no not_active IP Right Cessation
-
2006
- 2006-06-21 CY CY20061100839T patent/CY1105055T1/el unknown
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