JP2004511426A5 - - Google Patents

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Publication number
JP2004511426A5
JP2004511426A5 JP2001579774A JP2001579774A JP2004511426A5 JP 2004511426 A5 JP2004511426 A5 JP 2004511426A5 JP 2001579774 A JP2001579774 A JP 2001579774A JP 2001579774 A JP2001579774 A JP 2001579774A JP 2004511426 A5 JP2004511426 A5 JP 2004511426A5
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Japan
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composition
zeta potential
range
kcl
administration
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JP2001579774A
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English (en)
Japanese (ja)
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JP2004511426A (ja
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Priority claimed from PCT/IB2001/001206 external-priority patent/WO2001082899A2/en
Publication of JP2004511426A publication Critical patent/JP2004511426A/ja
Publication of JP2004511426A5 publication Critical patent/JP2004511426A5/ja
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JP2001579774A 2000-05-03 2001-05-03 活性化血管部位に関連する陽イオン性の診断薬、画像化剤、および治療薬 Pending JP2004511426A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20167300P 2000-05-03 2000-05-03
PCT/IB2001/001206 WO2001082899A2 (en) 2000-05-03 2001-05-03 Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites

Publications (2)

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JP2004511426A JP2004511426A (ja) 2004-04-15
JP2004511426A5 true JP2004511426A5 (https=) 2005-02-03

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JP2001579774A Pending JP2004511426A (ja) 2000-05-03 2001-05-03 活性化血管部位に関連する陽イオン性の診断薬、画像化剤、および治療薬

Country Status (10)

Country Link
US (1) US20020034537A1 (https=)
EP (1) EP1278512A2 (https=)
JP (1) JP2004511426A (https=)
AU (2) AU2001266272B2 (https=)
CA (1) CA2406650C (https=)
CZ (1) CZ20023913A3 (https=)
HU (1) HUP0301835A2 (https=)
MX (1) MXPA02010801A (https=)
PL (1) PL366025A1 (https=)
WO (1) WO2001082899A2 (https=)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8617514B2 (en) 1999-02-22 2013-12-31 Georgetown University Tumor-targeted nanodelivery systems to improve early MRI detection of cancer
WO2001074406A2 (en) * 2000-03-31 2001-10-11 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Dendrimer composition for magnetic resonance analysis
US6551344B2 (en) * 2000-04-26 2003-04-22 Ev3 Inc. Septal defect occluder
WO2004002455A1 (en) * 2002-06-26 2004-01-08 Medigene Oncology Gmbh Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system
EP1530465B2 (en) * 2002-06-26 2015-12-16 MediGene AG Method of producing a cationic liposomal preparation comprising a lipophilic compound
EP1374864A1 (en) * 2002-06-26 2004-01-02 Munich Biotech AG Amphiphilic taxane compositions
ES2611054T3 (es) * 2002-06-26 2017-05-04 Syncore Biotechnology Co., Ltd Método para producir una preparación de liposomas catiónicos que comprende un compuesto lipófilo
US20040024317A1 (en) * 2002-07-31 2004-02-05 Uzgiris Egidijus E. Method for assessing capillary permeability
JP4599292B2 (ja) * 2002-10-30 2010-12-15 エジソン ファーマシューティカルズ, インコーポレイテッド 物理的−化学的特性に基づく治療用化合物の同定
WO2004068405A2 (en) * 2003-01-25 2004-08-12 Oraevsky Alexander A High contrast optoacoustical imaging using nanoparticles
FR2855315B1 (fr) * 2003-05-23 2005-08-19 Centre Nat Rech Scient Ferrofluides stables en milieu neutre et ferrofluides modifies obtenus par modification de la surface des particules de ces ferrofluides
BRPI0414970A2 (pt) 2003-06-24 2012-12-11 Baxter Int método para transporte de drogas ao cérebro
US8986736B2 (en) 2003-06-24 2015-03-24 Baxter International Inc. Method for delivering particulate drugs to tissues
RU2006144851A (ru) 2004-06-15 2008-06-20 Бакстер Интернэшнл Инк. (Us) Применение терапевтических средств ex-vivo в виде твердых микрочастиц
KR20070052747A (ko) * 2004-09-10 2007-05-22 도레이 가부시끼가이샤 의약품제제
JP2006248978A (ja) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
EP3050963B1 (en) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
JP5700909B2 (ja) 2005-05-04 2015-04-15 メディゲーネ アクチエンゲゼルシャフトMediGene AG パクリタキセルを含む陽イオン性リポソーム製剤を投与する方法
AU2006304790B2 (en) * 2005-10-20 2013-06-27 Georgetown University Tumor-targeted nanodelivery systems to improve early MRI detection of cancer
MX2008011978A (es) 2006-03-22 2009-04-22 Medigene Ag Tratamiento del cancer de seno negativo al triple receptor.
US9670269B2 (en) 2006-03-31 2017-06-06 Chugai Seiyaku Kabushiki Kaisha Methods of modifying antibodies for purification of bispecific antibodies
ES2892925T3 (es) 2006-03-31 2022-02-07 Chugai Pharmaceutical Co Ltd Métodos para controlar la farmacocinética en sangre de anticuerpos
CA2977089A1 (en) * 2006-05-02 2007-11-15 University Of Miami Topical co-enzyme q10 formulations and treatment of pain, fatigue and wounds
JP5282031B2 (ja) * 2006-05-15 2013-09-04 ドミトリィ ビー カーポティン 有機物を含む磁性微粒子
US20090232731A1 (en) * 2006-05-18 2009-09-17 Martin Funk Cationic Liposomal Preparations for the Treatment of Rheumatoid Arthritis
CA2683137A1 (en) * 2006-10-10 2008-04-17 Squicor Compositions and methods for treating and diagnosing cancers
WO2008052766A2 (en) * 2006-11-03 2008-05-08 Medigene Ag Cationic colloidal carriers for delivery of active agents to the blood-brain barrier in the course of neuroinflammatory diseases
AU2008304748C1 (en) 2007-09-26 2014-06-12 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant region
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
CA2708532C (en) 2007-12-05 2018-06-05 Chugai Seiyaku Kabushiki Kaisha Anti-il31ra antibody and use thereof
RU2496482C2 (ru) 2008-03-05 2013-10-27 Бакстер Интернэшнл Инк. Композиции и способы для доставки лекарственных средств
KR102057826B1 (ko) 2008-04-11 2019-12-20 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복 결합하는 항원 결합 분자
US8329161B2 (en) * 2008-05-01 2012-12-11 National Health Research Institutes Red blood cell-derived vesicles as a nanoparticle drug delivery system
EP2299894B1 (en) * 2008-06-18 2020-09-02 Sarcos LC Transparent endoscope head defining a focal length
WO2010014792A2 (en) 2008-07-30 2010-02-04 Sterling Lc Method and device for incremental wavelength variation to analyze tissue
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
US9060704B2 (en) * 2008-11-04 2015-06-23 Sarcos Lc Method and device for wavelength shifted imaging
US20100135912A1 (en) * 2008-12-02 2010-06-03 Gambhir Sanjiv S Magnetotactic bacteria mri positive contrast enhancement agent and methods of use
TWI682995B (zh) 2009-03-19 2020-01-21 日商中外製藥股份有限公司 抗體恆定區域改變體
WO2010107110A1 (ja) 2009-03-19 2010-09-23 中外製薬株式会社 抗体定常領域改変体
US10952965B2 (en) * 2009-05-15 2021-03-23 Baxter International Inc. Compositions and methods for drug delivery
KR20120024763A (ko) 2009-05-15 2012-03-14 추가이 세이야쿠 가부시키가이샤 항axl 항체
DE102009031274A1 (de) * 2009-06-30 2011-01-13 Justus-Liebig-Universität Giessen Liposomen zur pulmonalen Applikation
US10150808B2 (en) 2009-09-24 2018-12-11 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant regions
US9144664B2 (en) 2009-10-01 2015-09-29 Sarcos Lc Method and apparatus for manipulating movement of a micro-catheter
WO2011041730A2 (en) * 2009-10-01 2011-04-07 Jacobsen Stephen C Light diffusion apparatus
US8828028B2 (en) 2009-11-03 2014-09-09 Raytheon Company Suture device and method for closing a planar opening
WO2011061259A1 (en) * 2009-11-18 2011-05-26 Nanobacterie Treatment of cancer or tumor induced by the release of heat generated by various chains of magnetosomes extracted from magnetotactic bacteria and submitted to an alternative magnetic field
JP5889181B2 (ja) 2010-03-04 2016-03-22 中外製薬株式会社 抗体定常領域改変体
EA027666B1 (ru) 2010-05-03 2017-08-31 ТЕИКОКУ ФАРМА ЮСЭй, ИНК. Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования
PH12016502073B1 (en) 2010-11-17 2024-04-05 Chugai Pharmaceutical Co Ltd Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
TWI812066B (zh) 2010-11-30 2023-08-11 日商中外製藥股份有限公司 具有鈣依存性的抗原結合能力之抗體
CN112812184A (zh) 2011-02-25 2021-05-18 中外制药株式会社 FcγRIIb特异性Fc抗体
US10029115B2 (en) * 2011-04-08 2018-07-24 Sanovas Intellectual Property, Llc Photodynamic therapy for tumors with localized delivery
CN102419370B (zh) * 2011-08-04 2014-08-27 武汉理工大学 用于检测小鼠组织内Bt杀虫蛋白的免疫磁小体及其制备方法
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TW201817744A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之FcRn結合域的治療性抗原結合分子
US10379026B2 (en) 2012-08-29 2019-08-13 Inguran, Llc Cell processing using magnetic particles
EP3563933B1 (en) * 2012-08-29 2022-03-02 Inguran, LLC Magnetic removal or identification of damaged or compromised cells or cellular structures
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
JP6534615B2 (ja) 2013-09-27 2019-06-26 中外製薬株式会社 ポリペプチド異種多量体の製造方法
EP3081234B1 (en) * 2013-12-13 2020-04-08 Mercury Asset Management Co., Ltd. Articular cartilage imaging composition
WO2015139051A2 (en) * 2014-03-14 2015-09-17 Rhode Island Hospital Nanocarriers and their processing for diagnostics and therapeutics
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
CN107207607B (zh) 2014-12-19 2021-05-04 中外制药株式会社 抗-c5抗体及使用方法
KR101860280B1 (ko) 2014-12-19 2018-05-21 추가이 세이야쿠 가부시키가이샤 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
CN114773470A (zh) 2015-02-05 2022-07-22 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用
JP6130983B2 (ja) 2015-02-27 2017-05-17 中外製薬株式会社 Il−6関連疾患治療用組成物
JP7082484B2 (ja) 2015-04-01 2022-06-08 中外製薬株式会社 ポリペプチド異種多量体の製造方法
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
CN108368166B (zh) 2015-12-28 2023-03-28 中外制药株式会社 提高含fc区多肽纯化效率的方法
US11072666B2 (en) 2016-03-14 2021-07-27 Chugai Seiyaku Kabushiki Kaisha Cell injury inducing therapeutic drug for use in cancer therapy
MA44780A (fr) 2016-04-28 2019-03-06 Chugai Pharmaceutical Co Ltd Préparation contenant un anticorps
TWI693940B (zh) 2016-08-05 2020-05-21 日商中外製藥股份有限公司 Il-8相關疾病之治療用或預防用組成物
EP3538546B1 (en) 2016-11-14 2025-01-08 Novartis AG Compositions, methods, and therapeutic uses related to fusogenic protein minion
CN110461358A (zh) 2017-03-31 2019-11-15 公立大学法人奈良县立医科大学 可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物
EP3620531A4 (en) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
DK3634391T3 (da) 2017-05-17 2025-03-31 Bpgbio Inc Anvendelse af coenzym q10-formuleringer i behandlingen og forebyggelsen af epidermolysis bullosa
AU2018361430B2 (en) 2017-11-01 2025-08-14 Chugai Seiyaku Kabushiki Kaisha Antibody variant and isoform with lowered biological activity
CN108751397A (zh) * 2018-05-31 2018-11-06 北京北华中清环境工程技术有限公司 添加功能化磁性微球利用mbr进行煤制气废水处理的方法
JP7738911B2 (ja) * 2020-04-30 2025-09-16 国立大学法人 長崎大学 ガン治療薬及びガン治療方法
CN112754996B (zh) * 2021-03-16 2023-03-31 江西省科学院生物资源研究所 一种鱼精蛋白短肽修饰的紫杉醇脂质体及其制备方法
WO2023064316A1 (en) * 2021-10-11 2023-04-20 Arizona Board Of Regents On Behalf Of Arizona State University Composite ink formulations for endoscopic imaging

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635180A (en) * 1988-02-17 1997-06-03 Neorx Corporation Alteration of pharmacokinetics of proteins by charge modification
US5230883A (en) * 1989-05-04 1993-07-27 Wisconsin Alumni Research Foundation Method for localization and treatment of tumors using polylysine complexes
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
IL101241A (en) * 1992-03-16 1997-11-20 Yissum Res Dev Co Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
DE4428851C2 (de) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
US5908635A (en) * 1994-08-05 1999-06-01 The United States Of America As Represented By The Department Of Health And Human Services Method for the liposomal delivery of nucleic acids
GB9416884D0 (en) * 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
AU687093B2 (en) * 1994-09-27 1998-02-19 Nycomed Imaging As Contrast agent
US5837283A (en) * 1997-03-12 1998-11-17 The Regents Of The University Of California Cationic lipid compositions targeting angiogenic endothelial cells
DE19912502A1 (de) * 1999-03-19 2000-09-21 Inst Neue Mat Gemein Gmbh Nanoskalige Teilchen, Komplexe mit Polynukleotiden und deren Verwendung
MXPA02002579A (es) * 1999-09-09 2003-10-14 Univ California Entrega de liposomas cationicas de taxanos a vasos sanguineos angiogenicos.

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