JP2004509061A5 - - Google Patents
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- Publication number
- JP2004509061A5 JP2004509061A5 JP2001559475A JP2001559475A JP2004509061A5 JP 2004509061 A5 JP2004509061 A5 JP 2004509061A5 JP 2001559475 A JP2001559475 A JP 2001559475A JP 2001559475 A JP2001559475 A JP 2001559475A JP 2004509061 A5 JP2004509061 A5 JP 2004509061A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- hepatitis
- virus
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18267600P | 2000-02-15 | 2000-02-15 | |
| US60/182,676 | 2000-02-15 | ||
| US09/595,365 | 2000-06-16 | ||
| US09/595,365 US6455508B1 (en) | 2000-02-15 | 2000-10-05 | Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides |
| PCT/US2001/040148 WO2001060379A1 (en) | 2000-02-15 | 2001-02-15 | Nucleoside analogs with carboxamidine modified monocyclic base |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009018382A Division JP5253204B2 (ja) | 2000-02-15 | 2009-01-29 | カルボキサミジンで修飾した単環式塩基を有するヌクレオシドアナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004509061A JP2004509061A (ja) | 2004-03-25 |
| JP2004509061A5 true JP2004509061A5 (OSRAM) | 2006-01-05 |
| JP4975930B2 JP4975930B2 (ja) | 2012-07-11 |
Family
ID=26878297
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001559477A Pending JP2004510691A (ja) | 2000-02-15 | 2001-02-15 | カルボキサミジンで修飾した二環式塩基を有するヌクレオシドアナログ |
| JP2001559475A Expired - Fee Related JP4975930B2 (ja) | 2000-02-15 | 2001-02-15 | カルボキサミジンで修飾した単環式塩基を有するヌクレオシドアナログ |
| JP2009018382A Expired - Fee Related JP5253204B2 (ja) | 2000-02-15 | 2009-01-29 | カルボキサミジンで修飾した単環式塩基を有するヌクレオシドアナログ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001559477A Pending JP2004510691A (ja) | 2000-02-15 | 2001-02-15 | カルボキサミジンで修飾した二環式塩基を有するヌクレオシドアナログ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009018382A Expired - Fee Related JP5253204B2 (ja) | 2000-02-15 | 2009-01-29 | カルボキサミジンで修飾した単環式塩基を有するヌクレオシドアナログ |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6455508B1 (OSRAM) |
| EP (3) | EP1257281B8 (OSRAM) |
| JP (3) | JP2004510691A (OSRAM) |
| KR (2) | KR20030005190A (OSRAM) |
| CN (2) | CN1420779A (OSRAM) |
| AT (1) | ATE377422T1 (OSRAM) |
| AU (2) | AU3845001A (OSRAM) |
| BR (2) | BR0108402A (OSRAM) |
| CA (2) | CA2399208C (OSRAM) |
| CY (1) | CY1107103T1 (OSRAM) |
| CZ (2) | CZ302327B6 (OSRAM) |
| DE (1) | DE60131250T8 (OSRAM) |
| DK (1) | DK1257281T3 (OSRAM) |
| ES (2) | ES2528429T3 (OSRAM) |
| HR (2) | HRP20020583A2 (OSRAM) |
| HU (2) | HU229480B1 (OSRAM) |
| IL (3) | IL150555A0 (OSRAM) |
| MX (2) | MXPA02007931A (OSRAM) |
| NO (2) | NO20023852L (OSRAM) |
| NZ (2) | NZ520877A (OSRAM) |
| PL (2) | PL200140B1 (OSRAM) |
| PT (1) | PT1257281E (OSRAM) |
| RS (1) | RS20090086A (OSRAM) |
| RU (2) | RU2259831C2 (OSRAM) |
| SI (2) | SI21076A (OSRAM) |
| SK (2) | SK287765B6 (OSRAM) |
| WO (2) | WO2001060381A1 (OSRAM) |
| YU (1) | YU61502A (OSRAM) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6831069B2 (en) * | 1999-08-27 | 2004-12-14 | Ribapharm Inc. | Pyrrolo[2,3-d]pyrimidine nucleoside analogs |
| US7056895B2 (en) * | 2000-02-15 | 2006-06-06 | Valeant Pharmaceuticals International | Tirazole nucleoside analogs and methods for using same |
| US7638496B2 (en) * | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| YU92202A (sh) | 2000-05-26 | 2006-01-16 | Idenix (Cayman) Limited | Metode i smeše za lečenje flavi virusa i pesti virusa |
| CN1267446C (zh) | 2001-01-22 | 2006-08-02 | 默克公司 | 作为依赖于rna的rna病毒聚合酶的抑制剂的核苷衍生物 |
| WO2003037908A1 (en) * | 2001-10-31 | 2003-05-08 | Ribapharm Inc. | Antiviral combination therapy and compositions |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| PT1576138T (pt) | 2002-11-15 | 2017-05-03 | Idenix Pharmaceuticals Llc | 2'-metil-nucleósidos em combinação com interferão e mutação de flaviviridae |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
| US20050049204A1 (en) * | 2003-03-28 | 2005-03-03 | Otto Michael J. | Compounds for the treatment of flaviviridae infections |
| US20040197292A1 (en) * | 2003-04-04 | 2004-10-07 | The Procter & Gamble Company | Personal care composition containing an antidandruff component and a nonionic surfactant |
| US20040202636A1 (en) * | 2003-04-11 | 2004-10-14 | Kaczvinsky Joseph Robert | Personal care composition containing an antidandruff component and a nonionic surfactant |
| US20040197287A1 (en) * | 2003-04-04 | 2004-10-07 | The Procter & Gamble Company | Personal care composition containing an antidandruff component and a nonionic surfactant |
| US20050009848A1 (en) * | 2003-07-10 | 2005-01-13 | Icn Pharmaceuticals Switzerland Ltd. | Use of antivirals against inflammatory bowel diseases |
| US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
| WO2005018330A1 (en) * | 2003-08-18 | 2005-03-03 | Pharmasset, Inc. | Dosing regimen for flaviviridae therapy |
| US20050095218A1 (en) * | 2003-10-29 | 2005-05-05 | The Procter & Gamble Company | Personal care composition containing a detersive surfactant, an antidandruff component, and ketoamide surfactants |
| US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| CA2568379A1 (en) | 2004-06-15 | 2005-12-29 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase |
| JP4516863B2 (ja) * | 2005-03-11 | 2010-08-04 | 株式会社ケンウッド | 音声合成装置、音声合成方法及びプログラム |
| AU2006242475B2 (en) | 2005-05-02 | 2011-07-07 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
| AR057456A1 (es) | 2005-07-20 | 2007-12-05 | Merck & Co Inc | Inhibidores de la proteasa ns3 del vhc |
| RU2008107972A (ru) | 2005-08-01 | 2009-09-10 | Мерк энд Ко., Инк. (US) | Макроциклические пептиды в качестве ингибиторов ns3-протеазы hcv |
| WO2007075876A2 (en) | 2005-12-23 | 2007-07-05 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| EP1971690B1 (en) * | 2005-12-28 | 2018-10-17 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| US8497292B2 (en) | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| GB0612423D0 (en) | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| WO2008005542A2 (en) * | 2006-07-07 | 2008-01-10 | Gilead Sciences, Inc., | Antiviral phosphinate compounds |
| US8138164B2 (en) | 2006-10-24 | 2012-03-20 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
| AU2007309546A1 (en) | 2006-10-24 | 2008-05-02 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | HCV NS3 protease inhibitors |
| US8309540B2 (en) | 2006-10-24 | 2012-11-13 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
| EP2086982B1 (en) | 2006-10-27 | 2018-08-29 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
| EP2083844B1 (en) | 2006-10-27 | 2013-11-27 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
| CN103224506A (zh) | 2006-12-20 | 2013-07-31 | P.安杰莱蒂分子生物学研究所 | 抗病毒的吲哚 |
| GB0625349D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| GB0625345D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| AU2008277442A1 (en) | 2007-07-17 | 2009-01-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Macrocyclic indole derivatives for the treatment of hepatitis C infections |
| WO2009010804A1 (en) | 2007-07-19 | 2009-01-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic compounds as antiviral agents |
| CA2720850A1 (en) | 2008-04-28 | 2009-11-05 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
| PL2310095T3 (pl) | 2008-07-22 | 2013-03-29 | Msd Italia Srl | Makrocykliczne związki chinoksaliny jako inhibitory proteazy NS3 HCV |
| WO2010082050A1 (en) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections |
| GB0900914D0 (en) | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
| WO2011014487A1 (en) | 2009-07-30 | 2011-02-03 | Merck Sharp & Dohme Corp. | Hepatitis c virus ns3 protease inhibitors |
| EP2780026B1 (en) | 2011-11-15 | 2019-10-23 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
| US20140356325A1 (en) | 2012-01-12 | 2014-12-04 | Ligand Pharmaceuticals Incorporated | Novel 2'-c-methyl nucleoside derivative compounds |
| CN102978264B (zh) * | 2012-11-14 | 2014-12-10 | 广东肇庆星湖生物科技股份有限公司 | 一种他立韦林的制备方法 |
| WO2014121417A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
| WO2014121418A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
| WO2015123352A1 (en) | 2014-02-13 | 2015-08-20 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| WO2016003812A1 (en) | 2014-07-02 | 2016-01-07 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
| WO2017024310A1 (en) | 2015-08-06 | 2017-02-09 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents |
| WO2019060692A1 (en) | 2017-09-21 | 2019-03-28 | Chimerix, Inc. | MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES |
| RU2020126177A (ru) | 2018-01-09 | 2022-02-10 | Лиганд Фармасьютикалз, Инк. | Ацетальные соединения и их терапевтическое применение |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3798209A (en) | 1971-06-01 | 1974-03-19 | Icn Pharmaceuticals | 1,2,4-triazole nucleosides |
| US3984396A (en) | 1971-06-01 | 1976-10-05 | Icn Pharmaceuticals, Inc. | 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters |
| US3991078A (en) | 1971-06-01 | 1976-11-09 | Icn Pharmaceuticals, Inc. | N-substituted 1,2,4-triazoles |
| USRE29835E (en) | 1971-06-01 | 1978-11-14 | Icn Pharmaceuticals | 1,2,4-Triazole nucleosides |
| US3962211A (en) * | 1975-01-13 | 1976-06-08 | The University Of Utah | 7-substituted nucleoside compounds |
| US4093624A (en) | 1977-01-31 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 1,2,4-Thiadiazolidine-3,5-dione |
| SU1124559A1 (ru) * | 1983-06-08 | 1986-07-07 | Институт молекулярной биологии АН СССР | 1-(2-Оксиэтоксиметил)-1,2,4-триазол-5-карбоксамид,обладающий активностью противвируса герпеса |
| JPS6426593A (en) | 1987-07-21 | 1989-01-27 | Asahi Glass Co Ltd | Nucleoside derivative |
| US4892865A (en) * | 1987-12-01 | 1990-01-09 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents |
| US5405837A (en) * | 1993-05-18 | 1995-04-11 | Indiana University Foundation | Method for the treatment of neoplastic disease utilizing tiazofurin and ribavirin |
| US5767097A (en) * | 1996-01-23 | 1998-06-16 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes |
| PL187439B1 (pl) * | 1996-01-23 | 2004-07-30 | Icn Pharmaceuticals | Zastosowanie rybawiryny |
| AU738170B2 (en) * | 1996-10-16 | 2001-09-13 | Icn Pharmaceuticals, Inc. | Monocyclic L-nucleosides, analogs and uses thereof |
| JP2003511454A (ja) * | 1999-08-27 | 2003-03-25 | アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド | ピロロ［２，３−ｄ］ピリミジンヌクレオシド類似化合物 |
-
2000
- 2000-10-05 US US09/595,365 patent/US6455508B1/en not_active Expired - Lifetime
-
2001
- 2001-02-15 PL PL357945A patent/PL200140B1/pl unknown
- 2001-02-15 JP JP2001559477A patent/JP2004510691A/ja active Pending
- 2001-02-15 NZ NZ52087701A patent/NZ520877A/xx not_active IP Right Cessation
- 2001-02-15 CA CA2399208A patent/CA2399208C/en not_active Expired - Fee Related
- 2001-02-15 EP EP01920996A patent/EP1257281B8/en not_active Expired - Lifetime
- 2001-02-15 ES ES07107588.1T patent/ES2528429T3/es not_active Expired - Lifetime
- 2001-02-15 AU AU38450/01A patent/AU3845001A/en not_active Abandoned
- 2001-02-15 BR BR0108402-0A patent/BR0108402A/pt not_active Application Discontinuation
- 2001-02-15 IL IL15055501A patent/IL150555A0/xx unknown
- 2001-02-15 AT AT01920996T patent/ATE377422T1/de active
- 2001-02-15 AU AU47988/01A patent/AU783142B2/en not_active Ceased
- 2001-02-15 RU RU2002120922/15A patent/RU2259831C2/ru active
- 2001-02-15 EP EP01910892A patent/EP1278528A4/en not_active Withdrawn
- 2001-02-15 HU HU0300027A patent/HU229480B1/hu unknown
- 2001-02-15 RU RU2002120483/14A patent/RU2002120483A/ru not_active Application Discontinuation
- 2001-02-15 CZ CZ20022798A patent/CZ302327B6/cs not_active IP Right Cessation
- 2001-02-15 DK DK01920996T patent/DK1257281T3/da active
- 2001-02-15 CN CN01805036A patent/CN1420779A/zh active Pending
- 2001-02-15 HU HU0300912A patent/HUP0300912A2/hu unknown
- 2001-02-15 MX MXPA02007931A patent/MXPA02007931A/es active IP Right Grant
- 2001-02-15 SI SI200120010A patent/SI21076A/sl not_active IP Right Cessation
- 2001-02-15 HR HR20020583A patent/HRP20020583A2/xx not_active Application Discontinuation
- 2001-02-15 HR HR20020657A patent/HRP20020657A2/hr not_active Application Discontinuation
- 2001-02-15 KR KR1020027010593A patent/KR20030005190A/ko not_active Withdrawn
- 2001-02-15 CN CNB018077455A patent/CN1268335C/zh not_active Expired - Fee Related
- 2001-02-15 EP EP07107588.1A patent/EP1813278B9/en not_active Expired - Lifetime
- 2001-02-15 JP JP2001559475A patent/JP4975930B2/ja not_active Expired - Fee Related
- 2001-02-15 CZ CZ20022799A patent/CZ20022799A3/cs unknown
- 2001-02-15 WO PCT/US2001/005172 patent/WO2001060381A1/en not_active Ceased
- 2001-02-15 KR KR1020027010417A patent/KR100811927B1/ko not_active Expired - Fee Related
- 2001-02-15 IL IL15099001A patent/IL150990A0/xx unknown
- 2001-02-15 MX MXPA02007932A patent/MXPA02007932A/es unknown
- 2001-02-15 BR BR0108401-1A patent/BR0108401A/pt not_active IP Right Cessation
- 2001-02-15 RS RSP-2009/0086A patent/RS20090086A/sr unknown
- 2001-02-15 SK SK1149-2002A patent/SK287765B6/sk not_active IP Right Cessation
- 2001-02-15 NZ NZ521390A patent/NZ521390A/en unknown
- 2001-02-15 PT PT01920996T patent/PT1257281E/pt unknown
- 2001-02-15 WO PCT/US2001/040148 patent/WO2001060379A1/en not_active Ceased
- 2001-02-15 PL PL01365239A patent/PL365239A1/xx unknown
- 2001-02-15 SK SK1157-2002A patent/SK11572002A3/sk unknown
- 2001-02-15 SI SI200120011A patent/SI21077A/sl not_active IP Right Cessation
- 2001-02-15 ES ES01920996T patent/ES2295148T3/es not_active Expired - Lifetime
- 2001-02-15 CA CA002395854A patent/CA2395854A1/en not_active Abandoned
- 2001-02-15 YU YU61502A patent/YU61502A/sh unknown
- 2001-02-15 DE DE60131250T patent/DE60131250T8/de active Active
-
2002
- 2002-07-30 IL IL150990A patent/IL150990A/en not_active IP Right Cessation
- 2002-08-14 NO NO20023852A patent/NO20023852L/no not_active Application Discontinuation
- 2002-08-14 NO NO20023855A patent/NO329927B1/no not_active IP Right Cessation
-
2007
- 2007-12-19 CY CY20071101614T patent/CY1107103T1/el unknown
-
2009
- 2009-01-29 JP JP2009018382A patent/JP5253204B2/ja not_active Expired - Fee Related