JP2003535891A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003535891A5 JP2003535891A5 JP2002503267A JP2002503267A JP2003535891A5 JP 2003535891 A5 JP2003535891 A5 JP 2003535891A5 JP 2002503267 A JP2002503267 A JP 2002503267A JP 2002503267 A JP2002503267 A JP 2002503267A JP 2003535891 A5 JP2003535891 A5 JP 2003535891A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- methyl
- pyrrol
- carbonyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0015447.6A GB0015447D0 (en) | 2000-06-23 | 2000-06-23 | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0015447.6 | 2000-06-23 | ||
| PCT/EP2001/007064 WO2001097790A2 (en) | 2000-06-23 | 2001-06-20 | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003535891A JP2003535891A (ja) | 2003-12-02 |
| JP2003535891A5 true JP2003535891A5 (https=) | 2008-08-07 |
Family
ID=9894288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002503267A Withdrawn JP2003535891A (ja) | 2000-06-23 | 2001-06-20 | 置換アクリロイルジスタマイシン誘導体及びアルキル化剤を含む腫瘍に対する併用療法 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8642580B2 (https=) |
| EP (1) | EP1303307B1 (https=) |
| JP (1) | JP2003535891A (https=) |
| KR (1) | KR100869037B1 (https=) |
| CN (1) | CN100479860C (https=) |
| AT (1) | ATE362365T1 (https=) |
| AU (2) | AU8186701A (https=) |
| BR (1) | BR0111740A (https=) |
| CA (1) | CA2410160C (https=) |
| CY (1) | CY1106713T1 (https=) |
| CZ (1) | CZ301053B6 (https=) |
| DE (1) | DE60128472T2 (https=) |
| DK (1) | DK1303307T3 (https=) |
| EA (1) | EA008502B1 (https=) |
| EE (1) | EE05300B1 (https=) |
| ES (1) | ES2284674T3 (https=) |
| GB (1) | GB0015447D0 (https=) |
| HK (1) | HK1054335B (https=) |
| HU (1) | HUP0301234A2 (https=) |
| IL (2) | IL152956A0 (https=) |
| MX (1) | MXPA02012209A (https=) |
| NO (1) | NO329782B1 (https=) |
| NZ (1) | NZ522999A (https=) |
| PL (1) | PL202053B1 (https=) |
| PT (1) | PT1303307E (https=) |
| SK (1) | SK18342002A3 (https=) |
| WO (1) | WO2001097790A2 (https=) |
| ZA (1) | ZA200209836B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2263835T3 (es) * | 2002-01-02 | 2006-12-16 | Nerviano Medical Sciences S.R.L. | Terapia combinada contra tumores que comprende derivados de distamicina acriloil sustituidos e inhibidores proteina quinasa (serina/treonina quinasa). |
| BR0308976A (pt) * | 2002-04-02 | 2005-01-11 | Pharmacia Italia Spa | Terapia combinada contra tumores compreendendo derivados de acriloil distamicina substituìda e radioterapia |
| MD36Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare |
| MD24Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare |
| MD23Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare |
| MD35Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare |
| EP2836494B1 (en) * | 2012-04-05 | 2019-08-21 | Nerviano Medical Sciences S.r.l. | New alkylating agents |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56154493A (en) * | 1980-04-30 | 1981-11-30 | Shionogi & Co Ltd | Novel platinum complex |
| CN85103908A (zh) * | 1985-07-16 | 1986-11-05 | 法米塔利·卡洛·埃尔巴有限公司 | 制备4′-表多克索红菌素的新方法 |
| SE468642B (sv) | 1985-07-16 | 1993-02-22 | Erba Farmitalia | Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition |
| GB8612218D0 (en) * | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
| DE3768419D1 (de) | 1986-10-07 | 1991-04-11 | Boehringer Biochemia Srl | Pharmazeutische zusammensetzungen mit antineoplastischer wirkung. |
| GB8906709D0 (en) | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
| JP2919867B2 (ja) | 1989-09-27 | 1999-07-19 | 千寿製薬株式会社 | 抗腫瘍剤 |
| GB9000644D0 (en) * | 1990-01-11 | 1990-03-14 | Erba Carlo Spa | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
| IT1272234B (it) | 1994-05-02 | 1997-06-16 | Consiglio Nazionale Ricerche | Derivati glutationici delle antracicline e procedimento per ottenerli. |
| GB9416005D0 (en) | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
| US5880097A (en) | 1996-01-04 | 1999-03-09 | Terrapin Techologies, Inc. | Tethered prodrugs |
| JP2000503999A (ja) | 1996-02-02 | 2000-04-04 | フアルマシア・エ・アツプジヨン・エツセ・ピー・アー | ジスタマイシン誘導体、その調製方法、および抗腫瘍および抗ウイルス剤としてのその使用 |
| GB9610079D0 (en) | 1996-05-14 | 1996-07-17 | Pharmacia Spa | Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents |
| GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GB9623522D0 (en) * | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
| GB9727524D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
| GB9806692D0 (en) | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
| GB9806689D0 (en) | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
| GB9816652D0 (en) | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
| GB9816653D0 (en) | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
| GB9928703D0 (en) | 1999-12-03 | 2000-02-02 | Pharmacia & Upjohn Spa | Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents |
| GB0011059D0 (en) | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015444D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
| US6576612B1 (en) * | 2000-10-02 | 2003-06-10 | Pharmacia Italia S.P.A. | Antitumor therapy comprising distamycin derivatives |
-
2000
- 2000-06-23 GB GBGB0015447.6A patent/GB0015447D0/en not_active Ceased
-
2001
- 2001-06-20 JP JP2002503267A patent/JP2003535891A/ja not_active Withdrawn
- 2001-06-20 ES ES01960355T patent/ES2284674T3/es not_active Expired - Lifetime
- 2001-06-20 HK HK03106772.8A patent/HK1054335B/zh not_active IP Right Cessation
- 2001-06-20 AU AU8186701A patent/AU8186701A/xx active Pending
- 2001-06-20 DK DK01960355T patent/DK1303307T3/da active
- 2001-06-20 CN CNB018114776A patent/CN100479860C/zh not_active Expired - Fee Related
- 2001-06-20 AU AU2001281867A patent/AU2001281867B2/en not_active Ceased
- 2001-06-20 EP EP01960355A patent/EP1303307B1/en not_active Expired - Lifetime
- 2001-06-20 CZ CZ20024106A patent/CZ301053B6/cs not_active IP Right Cessation
- 2001-06-20 US US10/311,995 patent/US8642580B2/en not_active Expired - Fee Related
- 2001-06-20 HU HU0301234A patent/HUP0301234A2/hu unknown
- 2001-06-20 DE DE60128472T patent/DE60128472T2/de not_active Expired - Lifetime
- 2001-06-20 PL PL365158A patent/PL202053B1/pl not_active IP Right Cessation
- 2001-06-20 SK SK1834-2002A patent/SK18342002A3/sk unknown
- 2001-06-20 CA CA002410160A patent/CA2410160C/en not_active Expired - Fee Related
- 2001-06-20 NZ NZ522999A patent/NZ522999A/en unknown
- 2001-06-20 EE EEP200200660A patent/EE05300B1/xx not_active IP Right Cessation
- 2001-06-20 AT AT01960355T patent/ATE362365T1/de not_active IP Right Cessation
- 2001-06-20 IL IL15295601A patent/IL152956A0/xx unknown
- 2001-06-20 MX MXPA02012209A patent/MXPA02012209A/es active IP Right Grant
- 2001-06-20 WO PCT/EP2001/007064 patent/WO2001097790A2/en not_active Ceased
- 2001-06-20 BR BR0111740-8A patent/BR0111740A/pt not_active Application Discontinuation
- 2001-06-20 KR KR1020027017565A patent/KR100869037B1/ko not_active Expired - Fee Related
- 2001-06-20 PT PT01960355T patent/PT1303307E/pt unknown
- 2001-06-20 EA EA200300061A patent/EA008502B1/ru not_active IP Right Cessation
-
2002
- 2002-11-20 IL IL152956A patent/IL152956A/en not_active IP Right Cessation
- 2002-12-04 ZA ZA200209836A patent/ZA200209836B/en unknown
- 2002-12-18 NO NO20026077A patent/NO329782B1/no not_active IP Right Cessation
-
2007
- 2007-07-09 CY CY20071100908T patent/CY1106713T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006524222A5 (https=) | ||
| JP2011524422A5 (https=) | ||
| JP2022520061A5 (https=) | ||
| JP2005519908A5 (https=) | ||
| CA2389681A1 (en) | Npy y5 antagonist | |
| JP2006515858A5 (https=) | ||
| JP2010500415A5 (https=) | ||
| JP2007505877A5 (https=) | ||
| JP2001526218A5 (https=) | ||
| JP2013538213A5 (https=) | ||
| JP2003535891A5 (https=) | ||
| RU2007131435A (ru) | Противоопухолевое средство | |
| JP2005532269A5 (https=) | ||
| JP2003516994A5 (https=) | ||
| CA2410160C (en) | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents | |
| CA2523253A1 (en) | Methyl indoles and methyl pyrrolopyridines as alpha-1 adrenergic agonists | |
| JP2003535874A5 (https=) | ||
| AU2001281867A1 (en) | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents | |
| JP2006506319A5 (https=) | ||
| ES2317913T3 (es) | Tratamiento antitumoral combinado que comprende un derivado de la distamicina sustituida por acriloilo y un antimetabolito. | |
| EP4198017A1 (en) | Benzylamine derivative, preparation method therefor and use thereof | |
| RU2004123641A (ru) | Комбинированная противоопухолевая терапия замещенными производными акрилоилдистамицина и ингибиторами протеинкиназ (серин- /треонинкиназы) | |
| RU2004130283A (ru) | Комбинации, включающие производные эпотилона и алкилирующие агенты |