JP2003534325A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003534325A5 JP2003534325A5 JP2001586259A JP2001586259A JP2003534325A5 JP 2003534325 A5 JP2003534325 A5 JP 2003534325A5 JP 2001586259 A JP2001586259 A JP 2001586259A JP 2001586259 A JP2001586259 A JP 2001586259A JP 2003534325 A5 JP2003534325 A5 JP 2003534325A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- ring
- optionally substituted
- pharmaceutical composition
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 150000001408 amides Chemical class 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical class C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 description 2
- 208000020084 Bone disease Diseases 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 208000034578 Multiple myelomas Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 125000003107 substituted aryl group Chemical group 0.000 description 2
- 125000003039 tetrahydroisoquinolinyl group Chemical class C1(NCCC2=CC=CC=C12)* 0.000 description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010055128 Autoimmune neutropenia Diseases 0.000 description 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 229940123169 Caspase inhibitor Drugs 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 208000001490 Dengue Diseases 0.000 description 1
- 206010012310 Dengue fever Diseases 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010014596 Encephalitis Japanese B Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 208000009329 Graft vs Host Disease Diseases 0.000 description 1
- 208000003807 Graves Disease Diseases 0.000 description 1
- 208000015023 Graves' disease Diseases 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 206010019773 Hepatitis G Diseases 0.000 description 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 description 1
- 206010019755 Hepatitis chronic active Diseases 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 201000005807 Japanese encephalitis Diseases 0.000 description 1
- 241000710842 Japanese encephalitis virus Species 0.000 description 1
- 208000007766 Kaposi sarcoma Diseases 0.000 description 1
- 208000027747 Kennedy disease Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 description 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000024777 Prion disease Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 206010049771 Shock haemorrhagic Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 206010043781 Thyroiditis chronic Diseases 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 description 1
- 208000003152 Yellow Fever Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000002353 alcoholic hepatitis Diseases 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 201000005000 autoimmune gastritis Diseases 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000025729 dengue disease Diseases 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 208000024908 graft versus host disease Diseases 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 208000021039 metastatic melanoma Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20636200P | 2000-05-23 | 2000-05-23 | |
| US60/206,362 | 2000-05-23 | ||
| US21700600P | 2000-07-10 | 2000-07-10 | |
| US60/217,006 | 2000-07-10 | ||
| PCT/US2001/017075 WO2001090070A2 (en) | 2000-05-23 | 2001-05-23 | Caspase inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003534325A JP2003534325A (ja) | 2003-11-18 |
| JP2003534325A5 true JP2003534325A5 (https=) | 2008-07-10 |
Family
ID=26901274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001586259A Pending JP2003534325A (ja) | 2000-05-23 | 2001-05-23 | カスパーゼインヒビター及びその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7053057B2 (https=) |
| EP (1) | EP1283827A2 (https=) |
| JP (1) | JP2003534325A (https=) |
| KR (1) | KR20020025959A (https=) |
| AP (1) | AP2002002407A0 (https=) |
| AR (1) | AR028619A1 (https=) |
| AU (1) | AU2001265008A1 (https=) |
| CA (1) | CA2380935A1 (https=) |
| MX (1) | MXPA02000823A (https=) |
| NO (1) | NO20020343L (https=) |
| NZ (1) | NZ516918A (https=) |
| PE (1) | PE20020058A1 (https=) |
| PL (1) | PL357713A1 (https=) |
| SK (1) | SK1192002A3 (https=) |
| TR (1) | TR200200767T1 (https=) |
| WO (1) | WO2001090070A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355618B1 (en) | 1999-04-09 | 2002-03-12 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
| DE60010675T2 (de) | 1999-08-06 | 2005-06-16 | Vertex Pharmaceuticals Inc., Cambridge | Caspase inhibitoren und deren verwendung |
| US6495522B1 (en) | 1999-08-27 | 2002-12-17 | Cytovia, Inc. | Substituted alpha-hydroxy acid caspase inhibitors and the use thereof |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| WO2003024955A2 (en) | 2001-09-18 | 2003-03-27 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
| US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| AU2003225088A1 (en) | 2002-04-19 | 2003-11-03 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
| EP1549224A1 (en) * | 2002-10-10 | 2005-07-06 | Becton Dickinson and Company | Sample collection system with caspase inhibitor |
| EP1626732B1 (en) * | 2003-05-22 | 2013-04-03 | CHIESI FARMACEUTICI S.p.A. | Means for preventing and treating cellular death and their biological applications |
| AU2003902704A0 (en) * | 2003-05-29 | 2003-06-19 | Crc For Waste Management And Pollution Control Limited Of Unsw | Process for producing a nanoscale zero-valent metal |
| US7652153B2 (en) * | 2004-02-27 | 2010-01-26 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| EP2399916B1 (en) * | 2004-03-12 | 2014-12-10 | Vertex Pharmaceuticals Incorporated | Process and intermediates for the preparation of aspartic acetal caspase ihnhibitors |
| DK2253614T3 (da) * | 2004-04-07 | 2013-01-07 | Novartis Ag | IAP-inhibitorer |
| EP1740614A2 (en) * | 2004-04-30 | 2007-01-10 | Theraptosis S.A. | Caspase-2 inhibitors and their biological applications |
| WO2005115362A1 (en) * | 2004-05-15 | 2005-12-08 | Vertex Pharmaceuticals Incorporated | Treating seizures using ice inhibitors |
| CA2567080A1 (en) | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| EP1791535B1 (en) | 2004-09-17 | 2008-07-30 | BioMAS Ltd. | Novel tellurium compounds and their use as immunomodulators |
| CN101268084A (zh) * | 2005-07-28 | 2008-09-17 | 沃泰克斯药物股份有限公司 | 天冬氨酸特异性半胱氨酸蛋白酶抑制剂前体药物 |
| PE20110220A1 (es) | 2006-08-02 | 2011-04-11 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
| KR20090057035A (ko) * | 2006-08-21 | 2009-06-03 | 유나이티드 세러퓨틱스 코오포레이션 | 바이러스 감염의 치료를 위한 병용 요법 |
| WO2008045905A1 (en) | 2006-10-12 | 2008-04-17 | Novartis Ag | Pyrrolydine derivatives as iap inhibitors |
| WO2008106167A1 (en) * | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases |
| WO2008137567A1 (en) * | 2007-05-01 | 2008-11-13 | Cedars-Sinai Medical Center | Caspase inhibitors in the treatment of infection-associated preterm delivery |
| US8791235B2 (en) | 2008-05-21 | 2014-07-29 | Novagenesis Foundation | Selective caspase inhibitors and uses thereof |
| WO2010133000A1 (en) | 2009-05-21 | 2010-11-25 | New World Laboratories Inc. | Selective caspase inhibitors and uses thereof |
| WO2012061786A1 (en) | 2010-11-05 | 2012-05-10 | Brandeis University | Ice cleaved alpha-synuclein a biomarker |
| US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| DK2697246T3 (en) | 2011-04-15 | 2018-05-28 | Genesis Tech Limited | SELECTIVE CYSTEIN PROTEASE INHIBITORS AND USES THEREOF |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| JP2017515854A (ja) | 2014-05-12 | 2017-06-15 | クオナトウス ファーマシューティカルズ，インコーポレイテッド | カスパーゼ阻害剤による慢性肝疾患の合併症の治療 |
| EP3247378B8 (en) | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
| EP4242304A3 (en) * | 2015-10-01 | 2024-02-07 | Revolution Medicines, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| CA3010286A1 (en) | 2015-12-31 | 2017-07-06 | Conatus Pharmaceuticals Inc. | Methods of using caspase inhibitors in treatment of liver disease |
| CN109641062A (zh) | 2016-04-12 | 2019-04-16 | 华普卓威生物公司 | 用于产生化合物的组合物和方法 |
| CN105853408B (zh) * | 2016-04-15 | 2018-12-04 | 浙江大学 | 苯酰胺衍生物在制备Caspase-1抑制剂中的应用 |
| TW201739734A (zh) * | 2016-05-11 | 2017-11-16 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Caspase抑制劑及其藥物組合物、用途和治療方法 |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
| US11479797B2 (en) | 2016-10-28 | 2022-10-25 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
| WO2018133870A1 (zh) * | 2017-01-23 | 2018-07-26 | 正大天晴药业集团股份有限公司 | 作为Caspase抑制剂的联环化合物 |
| CN109748843B (zh) * | 2017-11-06 | 2022-11-11 | 正大天晴药业集团股份有限公司 | Caspase抑制剂及其药物组合物、用途和治疗方法 |
| TW202132316A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| IL322454A (en) | 2019-11-04 | 2025-09-01 | Revolution Medicines Inc | ras inhibitors |
| AU2020377925A1 (en) | 2019-11-04 | 2022-05-05 | Revolution Medicines, Inc. | Ras inhibitors |
| CA3194067A1 (en) | 2020-09-15 | 2022-03-24 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| KR20240017811A (ko) | 2021-05-05 | 2024-02-08 | 레볼루션 메디슨즈, 인크. | 암의 치료를 위한 ras 억제제 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991015577A1 (en) | 1990-04-04 | 1991-10-17 | Black, Roy, A. | INTERLEUKIN 1'beta' PROTEASE |
| US5866545A (en) * | 1993-08-13 | 1999-02-02 | Merck & Co., Inc. | Substituted ketone derivatives as inhibitors of interleukin-1β converting enzyme |
| EP0900791A1 (en) * | 1995-12-27 | 1999-03-10 | Ono Pharmaceutical Co., Ltd. | Tetrazole derivatives and drugs containing the same as the active ingredient |
| CN1138472C (zh) | 1997-10-10 | 2004-02-18 | 西托维亚公司 | 二肽型编程性细胞死亡抑制剂及其用途 |
| KR20010041905A (ko) * | 1998-03-16 | 2001-05-25 | 시토비아 인크. | 디펩티드 카스파제 억제제 및 이의 용도 |
| US6045990A (en) * | 1998-07-09 | 2000-04-04 | Baust; John M. | Inclusion of apoptotic regulators in solutions for cell storage at low temperature |
-
2001
- 2001-05-23 KR KR1020027000995A patent/KR20020025959A/ko not_active Ceased
- 2001-05-23 JP JP2001586259A patent/JP2003534325A/ja active Pending
- 2001-05-23 NZ NZ516918A patent/NZ516918A/en unknown
- 2001-05-23 SK SK119-2002A patent/SK1192002A3/sk unknown
- 2001-05-23 AU AU2001265008A patent/AU2001265008A1/en not_active Abandoned
- 2001-05-23 US US09/863,649 patent/US7053057B2/en not_active Expired - Fee Related
- 2001-05-23 AR ARP010102477A patent/AR028619A1/es unknown
- 2001-05-23 AP APAP/P/2002/002407A patent/AP2002002407A0/en unknown
- 2001-05-23 PL PL01357713A patent/PL357713A1/xx not_active Application Discontinuation
- 2001-05-23 CA CA002380935A patent/CA2380935A1/en not_active Abandoned
- 2001-05-23 WO PCT/US2001/017075 patent/WO2001090070A2/en not_active Ceased
- 2001-05-23 MX MXPA02000823A patent/MXPA02000823A/es not_active Application Discontinuation
- 2001-05-23 EP EP01939497A patent/EP1283827A2/en not_active Withdrawn
- 2001-05-23 TR TR2002/00767T patent/TR200200767T1/xx unknown
- 2001-05-23 PE PE2001000468A patent/PE20020058A1/es not_active Application Discontinuation
-
2002
- 2002-01-22 NO NO20020343A patent/NO20020343L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003534325A5 (https=) | ||
| JP2003535865A5 (https=) | ||
| KR970015579A (ko) | 테트라졸 화합물 | |
| JP2005533825A5 (https=) | ||
| JP2004509120A5 (https=) | ||
| RU2005102094A (ru) | Ингибиторы каспазы и их применение | |
| JP2005509622A5 (https=) | ||
| JP2003506389A5 (https=) | ||
| CA2565660A1 (en) | Ortho substituted aryl or heteroaryl amide compounds | |
| RU2008134534A (ru) | 3,5-ди(арилили гетероарил)изоксазолы и 1,2,4-оксадиазолы в качестве агонистов рецентора s1p1, иммунодепрессантных и противовоспалительных агентов | |
| CA2709786A1 (en) | 4-(4-cyano-2-thioaryl)dihydropyrimidinones and use thereof | |
| WO2007123936A1 (en) | Novel heteroaryl-substituted arylaminopyridine derivatives as mek inhibitors | |
| JP2005514398A5 (https=) | ||
| CA2536870A1 (en) | Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists | |
| CA2749040A1 (en) | Triazolo and tetrazolo pyrimidine derivatives as hne inhibitors for treating copd | |
| JP2006513220A5 (https=) | ||
| JP2007534702A5 (https=) | ||
| CA2447999A1 (en) | Caspase inhibitors and uses thereof | |
| DK344882A (da) | Fremgangsmaade til fremstilling af substituerede 2-carbamimidoyl-1-carbadethiapen-2-em-carboxylsyrer | |
| EP2132196A1 (en) | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases | |
| WO2004020430A3 (fr) | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique | |
| JP2009502922A5 (https=) | ||
| JP2005529842A5 (https=) | ||
| RU2007132260A (ru) | Синтез арилпирролидонов | |
| RU2008107576A (ru) | Пролекарства ингибитора каспазы |