AU2001265008A1 - Caspase inhibitors and uses thereof - Google Patents

Caspase inhibitors and uses thereof

Info

Publication number
AU2001265008A1
AU2001265008A1 AU2001265008A AU6500801A AU2001265008A1 AU 2001265008 A1 AU2001265008 A1 AU 2001265008A1 AU 2001265008 A AU2001265008 A AU 2001265008A AU 6500801 A AU6500801 A AU 6500801A AU 2001265008 A1 AU2001265008 A1 AU 2001265008A1
Authority
AU
Australia
Prior art keywords
caspase inhibitors
caspase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001265008A
Other languages
English (en)
Inventor
Julian Golec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2001265008A1 publication Critical patent/AU2001265008A1/en
Abandoned legal-status Critical Current

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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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AU2001265008A 2000-05-23 2001-05-23 Caspase inhibitors and uses thereof Abandoned AU2001265008A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20636200P 2000-05-23 2000-05-23
US60206362 2000-05-23
US21700600P 2000-07-10 2000-07-10
US60217006 2000-07-10
PCT/US2001/017075 WO2001090070A2 (en) 2000-05-23 2001-05-23 Caspase inhibitors and uses thereof

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AU2001265008A1 true AU2001265008A1 (en) 2001-12-03

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US (1) US7053057B2 (https=)
EP (1) EP1283827A2 (https=)
JP (1) JP2003534325A (https=)
KR (1) KR20020025959A (https=)
AP (1) AP2002002407A0 (https=)
AR (1) AR028619A1 (https=)
AU (1) AU2001265008A1 (https=)
CA (1) CA2380935A1 (https=)
MX (1) MXPA02000823A (https=)
NO (1) NO20020343L (https=)
NZ (1) NZ516918A (https=)
PE (1) PE20020058A1 (https=)
PL (1) PL357713A1 (https=)
SK (1) SK1192002A3 (https=)
TR (1) TR200200767T1 (https=)
WO (1) WO2001090070A2 (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355618B1 (en) 1999-04-09 2002-03-12 Cytovia, Inc. Caspase inhibitors and the use thereof
DE60010675T2 (de) 1999-08-06 2005-06-16 Vertex Pharmaceuticals Inc., Cambridge Caspase inhibitoren und deren verwendung
US6495522B1 (en) 1999-08-27 2002-12-17 Cytovia, Inc. Substituted alpha-hydroxy acid caspase inhibitors and the use thereof
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
WO2003024955A2 (en) 2001-09-18 2003-03-27 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
US7410956B2 (en) 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
AU2003225088A1 (en) 2002-04-19 2003-11-03 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
EP1549224A1 (en) * 2002-10-10 2005-07-06 Becton Dickinson and Company Sample collection system with caspase inhibitor
EP1626732B1 (en) * 2003-05-22 2013-04-03 CHIESI FARMACEUTICI S.p.A. Means for preventing and treating cellular death and their biological applications
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