JP2003533470A5 - - Google Patents
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- Publication number
- JP2003533470A5 JP2003533470A5 JP2001583741A JP2001583741A JP2003533470A5 JP 2003533470 A5 JP2003533470 A5 JP 2003533470A5 JP 2001583741 A JP2001583741 A JP 2001583741A JP 2001583741 A JP2001583741 A JP 2001583741A JP 2003533470 A5 JP2003533470 A5 JP 2003533470A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical dosage
- dosage form
- region
- toxic
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 description 32
- 239000007788 liquid Substances 0.000 description 18
- 238000000034 method Methods 0.000 description 18
- 239000000843 powder Substances 0.000 description 15
- 230000007704 transition Effects 0.000 description 15
- 239000013543 active substance Substances 0.000 description 14
- 231100000331 toxic Toxicity 0.000 description 13
- 230000002588 toxic effect Effects 0.000 description 13
- 239000000546 pharmaceutical excipient Substances 0.000 description 10
- 239000003814 drug Substances 0.000 description 8
- 239000012530 fluid Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 239000002245 particle Substances 0.000 description 4
- 230000003389 potentiating effect Effects 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 3
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 description 2
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 description 2
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 2
- 230000003444 anaesthetic effect Effects 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940127093 camptothecin Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 description 2
- 229940050521 gelatin agent Drugs 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229950008325 levothyroxine Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 description 2
- 229950009213 rubitecan Drugs 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 2
- 229940035722 triiodothyronine Drugs 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 101100379079 Emericella variicolor andA gene Proteins 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20589600P | 2000-05-18 | 2000-05-18 | |
| US60/205,896 | 2000-05-18 | ||
| PCT/US2001/040763 WO2001087272A2 (en) | 2000-05-18 | 2001-05-18 | Encapsulating a toxic core within a non-toxic region in an oral dosage form |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012012834A Division JP2012082224A (ja) | 2000-05-18 | 2012-01-25 | 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003533470A JP2003533470A (ja) | 2003-11-11 |
| JP2003533470A5 true JP2003533470A5 (enExample) | 2008-07-17 |
| JP5178982B2 JP5178982B2 (ja) | 2013-04-10 |
Family
ID=22764098
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001583741A Expired - Fee Related JP5178982B2 (ja) | 2000-05-18 | 2001-05-18 | 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化 |
| JP2012012834A Withdrawn JP2012082224A (ja) | 2000-05-18 | 2012-01-25 | 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012012834A Withdrawn JP2012082224A (ja) | 2000-05-18 | 2012-01-25 | 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7276252B2 (enExample) |
| EP (1) | EP1286663B1 (enExample) |
| JP (2) | JP5178982B2 (enExample) |
| AT (1) | ATE315930T1 (enExample) |
| AU (1) | AU2001263506A1 (enExample) |
| CA (1) | CA2408956C (enExample) |
| DE (1) | DE60116758T2 (enExample) |
| ES (1) | ES2257412T3 (enExample) |
| WO (1) | WO2001087272A2 (enExample) |
Families Citing this family (90)
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| US6046177A (en) * | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| US6294199B1 (en) * | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
-
2001
- 2001-05-18 ES ES01937808T patent/ES2257412T3/es not_active Expired - Lifetime
- 2001-05-18 DE DE60116758T patent/DE60116758T2/de not_active Expired - Lifetime
- 2001-05-18 AU AU2001263506A patent/AU2001263506A1/en not_active Abandoned
- 2001-05-18 CA CA2408956A patent/CA2408956C/en not_active Expired - Fee Related
- 2001-05-18 EP EP01937808A patent/EP1286663B1/en not_active Expired - Lifetime
- 2001-05-18 WO PCT/US2001/040763 patent/WO2001087272A2/en not_active Ceased
- 2001-05-18 JP JP2001583741A patent/JP5178982B2/ja not_active Expired - Fee Related
- 2001-05-18 US US09/861,480 patent/US7276252B2/en not_active Expired - Lifetime
- 2001-05-18 AT AT01937808T patent/ATE315930T1/de not_active IP Right Cessation
-
2005
- 2005-10-07 US US11/246,910 patent/US7875290B2/en not_active Expired - Fee Related
-
2012
- 2012-01-25 JP JP2012012834A patent/JP2012082224A/ja not_active Withdrawn
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