JP2003530317A5 - - Google Patents
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- Publication number
- JP2003530317A5 JP2003530317A5 JP2001550236A JP2001550236A JP2003530317A5 JP 2003530317 A5 JP2003530317 A5 JP 2003530317A5 JP 2001550236 A JP2001550236 A JP 2001550236A JP 2001550236 A JP2001550236 A JP 2001550236A JP 2003530317 A5 JP2003530317 A5 JP 2003530317A5
- Authority
- JP
- Japan
- Prior art keywords
- platinum
- composition
- polymer
- compound
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 32
- 229910052697 platinum Inorganic materials 0.000 description 21
- 108010038807 Oligopeptides Proteins 0.000 description 14
- 102000015636 Oligopeptides Human genes 0.000 description 14
- 150000003058 platinum compounds Chemical class 0.000 description 11
- 229920000642 polymer Polymers 0.000 description 11
- -1 platinum diamine Chemical class 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 6
- 230000000259 anti-tumor effect Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 229920001577 copolymer Polymers 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000004962 physiological condition Effects 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 230000008685 targeting Effects 0.000 description 3
- WEZDRVHTDXTVLT-GJZGRUSLSA-N 2-[[(2s)-2-[[(2s)-2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CN)CC1=CC=CC=C1 WEZDRVHTDXTVLT-GJZGRUSLSA-N 0.000 description 2
- 108010009504 Gly-Phe-Leu-Gly Proteins 0.000 description 2
- 108010020346 Polyglutamic Acid Proteins 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229940045985 antineoplastic platinum compound Drugs 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical compound NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 102000006815 folate receptor Human genes 0.000 description 1
- 108020005243 folate receptor Proteins 0.000 description 1
- 150000002224 folic acids Chemical class 0.000 description 1
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17443500P | 2000-01-04 | 2000-01-04 | |
| US60/174,435 | 2000-01-04 | ||
| PCT/US2001/000284 WO2001049696A1 (en) | 2000-01-04 | 2001-01-04 | N,o-amidomalonate platinum complexes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011086844A Division JP2011137046A (ja) | 2000-01-04 | 2011-04-08 | Ｎ，ｏ−アミドマロネート白金錯体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003530317A JP2003530317A (ja) | 2003-10-14 |
| JP2003530317A5 true JP2003530317A5 (https=) | 2008-02-28 |
| JP5025062B2 JP5025062B2 (ja) | 2012-09-12 |
Family
ID=22636134
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001550236A Expired - Fee Related JP5025062B2 (ja) | 2000-01-04 | 2001-01-04 | Ｎ，ｏ−アミドマロネート白金錯体 |
| JP2011086844A Withdrawn JP2011137046A (ja) | 2000-01-04 | 2011-04-08 | Ｎ，ｏ−アミドマロネート白金錯体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011086844A Withdrawn JP2011137046A (ja) | 2000-01-04 | 2011-04-08 | Ｎ，ｏ−アミドマロネート白金錯体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6692734B2 (https=) |
| EP (1) | EP1254145A1 (https=) |
| JP (2) | JP5025062B2 (https=) |
| KR (1) | KR100729015B1 (https=) |
| AU (1) | AU2762101A (https=) |
| CA (1) | CA2396702C (https=) |
| WO (1) | WO2001049696A1 (https=) |
| ZA (1) | ZA200205358B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7166733B2 (en) * | 2000-01-04 | 2007-01-23 | Access Pharmaceuticals, Inc. | O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes |
| US7138520B2 (en) * | 2003-01-13 | 2006-11-21 | Massachusetts Institute Of Technology | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same |
| WO2005002508A2 (en) * | 2003-06-11 | 2005-01-13 | Access Pharmaceuticals, Inc. | Macromolecular platinum chelates |
| CA2631704A1 (en) | 2005-12-05 | 2007-06-14 | Nitto Denko Corporation | Polyglutamate-amino acid conjugates and methods |
| JP2010528122A (ja) * | 2007-05-09 | 2010-08-19 | 日東電工株式会社 | 白金薬剤と結合されたポリマー |
| CN101855248B (zh) * | 2007-11-13 | 2012-08-22 | 生物技术通用（以色列）有限公司 | 用于粘弹性生物聚合物的稀释过滤灭菌方法 |
| CA2739757C (en) * | 2008-10-07 | 2016-07-05 | Rexahn Pharmaceuticals, Inc. | Hpma - docetaxel or gemcitabine conjugates and uses therefore |
| JP5281358B2 (ja) * | 2008-10-27 | 2013-09-04 | 学校法人常翔学園 | 高分子、経上皮吸収促進剤、及び医薬用製剤 |
| CA2777397C (en) * | 2009-10-13 | 2017-08-29 | Rexahn Pharmaceuticals, Inc. | Polymeric systems for the delivery of anticancer agents |
| JP5684056B2 (ja) | 2010-08-16 | 2015-03-11 | 株式会社マキタ | 手持ち工具 |
| US8946163B2 (en) | 2012-11-19 | 2015-02-03 | Mimedx Group, Inc. | Cross-linked collagen comprising metallic anticancer agents |
| US10335433B2 (en) * | 2013-04-10 | 2019-07-02 | Mimedx Group, Inc. | NDGA polymers and metal complexes thereof |
| WO2015035446A1 (en) * | 2013-09-10 | 2015-03-19 | Starpharma Pty Ltd | Macromolecules of dendrimer-platinum conjugates |
| CN107709286B (zh) | 2015-06-24 | 2021-02-19 | 日本化药株式会社 | 新型铂(ⅳ)络合物 |
| WO2017047497A1 (ja) | 2015-09-14 | 2017-03-23 | 日本化薬株式会社 | ６配位白金錯体の高分子結合体 |
| ES3062820T3 (en) * | 2017-11-08 | 2026-04-14 | L E A F Holdings Group Llc | Platinum complexes and uses thereof |
| US12071517B2 (en) | 2018-07-19 | 2024-08-27 | Starpharma Pty Ltd. | Therapeutic dendrimer |
| WO2020014750A1 (en) | 2018-07-19 | 2020-01-23 | Starpharma Pty Ltd | Therapeutic dendrimer |
| CN113018311A (zh) * | 2019-12-25 | 2021-06-25 | 沈阳药科大学 | 顺铂配合物以及顺铂配合物脂质体的制备方法 |
| CN117105797B (zh) * | 2023-08-25 | 2025-09-23 | 湖南科技大学 | 一种谷氨酸铂配合物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO146404C (no) * | 1979-10-26 | 1982-09-22 | Dyno Industrier As | Bygning for lyddempet skyting. |
| JPS5667326A (en) * | 1979-11-05 | 1981-06-06 | Hitachi Ltd | Imide type compound and production thereof |
| IL67789A (en) | 1983-01-31 | 1986-09-30 | Yissum Res Dev Co | Amino-substituted malonato platinum(ii)complexes and method for their preparation |
| EP0284197A1 (en) | 1987-02-20 | 1988-09-28 | Tanabe Seiyaku Co., Ltd. | Novel organic platinum complex and process for the preparation thereof |
| US4793986A (en) * | 1987-02-25 | 1988-12-27 | Johnson Matthey, Inc. | Macromolecular platinum antitumor compounds |
| JPS6494A (en) * | 1987-03-06 | 1989-01-05 | Tanabe Seiyaku Co Ltd | Novel organoplatinum complex |
| IL85595A0 (en) | 1987-03-06 | 1988-08-31 | Tanabe Seiyaku Co | Organic platinum complex and its preparation |
| JPH0256421A (ja) * | 1988-08-19 | 1990-02-26 | Tanabe Seiyaku Co Ltd | 抗腫瘍剤 |
| JPH0267217A (ja) * | 1988-09-01 | 1990-03-07 | Tanabe Seiyaku Co Ltd | 抗腫瘍剤 |
| US4946954A (en) | 1989-01-17 | 1990-08-07 | Georgetown University | Platinum pharmaceutical agents |
| KR0164460B1 (ko) | 1995-10-02 | 1999-03-20 | 김은영 | 고분자 백금 착화합물, 그의 제조방법 및 그를 유효성분으로 하는 항암제 |
| US5965118A (en) * | 1997-04-18 | 1999-10-12 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
-
2001
- 2001-01-04 US US09/755,220 patent/US6692734B2/en not_active Expired - Fee Related
- 2001-01-04 WO PCT/US2001/000284 patent/WO2001049696A1/en not_active Ceased
- 2001-01-04 EP EP01901752A patent/EP1254145A1/en not_active Withdrawn
- 2001-01-04 AU AU27621/01A patent/AU2762101A/en not_active Abandoned
- 2001-01-04 KR KR1020027008709A patent/KR100729015B1/ko not_active Expired - Fee Related
- 2001-01-04 JP JP2001550236A patent/JP5025062B2/ja not_active Expired - Fee Related
- 2001-01-04 CA CA2396702A patent/CA2396702C/en not_active Expired - Fee Related
-
2002
- 2002-07-04 ZA ZA200205358A patent/ZA200205358B/en unknown
-
2011
- 2011-04-08 JP JP2011086844A patent/JP2011137046A/ja not_active Withdrawn
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