JP5025062B2 - Ｎ，ｏ−アミドマロネート白金錯体 - Google Patents

Ｎ，ｏ−アミドマロネート白金錯体 Download PDF

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Publication number
JP5025062B2
JP5025062B2 JP2001550236A JP2001550236A JP5025062B2 JP 5025062 B2 JP5025062 B2 JP 5025062B2 JP 2001550236 A JP2001550236 A JP 2001550236A JP 2001550236 A JP2001550236 A JP 2001550236A JP 5025062 B2 JP5025062 B2 JP 5025062B2
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platinum
chelate
complex
polymer
ama
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Japanese (ja)
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JP2003530317A5 (https=
JP2003530317A (ja
Inventor
ドナルド アール． スチュワート，
ジョン アール． ライス，
ジョン ブイ． セイント．ジョン，
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アクセス ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2001550236A 2000-01-04 2001-01-04 Ｎ，ｏ−アミドマロネート白金錯体 Expired - Fee Related JP5025062B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17443500P 2000-01-04 2000-01-04
US60/174,435 2000-01-04
PCT/US2001/000284 WO2001049696A1 (en) 2000-01-04 2001-01-04 N,o-amidomalonate platinum complexes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011086844A Division JP2011137046A (ja) 2000-01-04 2011-04-08 Ｎ，ｏ−アミドマロネート白金錯体

Publications (3)

Publication Number Publication Date
JP2003530317A JP2003530317A (ja) 2003-10-14
JP2003530317A5 JP2003530317A5 (https=) 2008-02-28
JP5025062B2 true JP5025062B2 (ja) 2012-09-12

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ID=22636134

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001550236A Expired - Fee Related JP5025062B2 (ja) 2000-01-04 2001-01-04 Ｎ，ｏ−アミドマロネート白金錯体
JP2011086844A Withdrawn JP2011137046A (ja) 2000-01-04 2011-04-08 Ｎ，ｏ−アミドマロネート白金錯体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011086844A Withdrawn JP2011137046A (ja) 2000-01-04 2011-04-08 Ｎ，ｏ−アミドマロネート白金錯体

Country Status (8)

Country Link
US (1) US6692734B2 (https=)
EP (1) EP1254145A1 (https=)
JP (2) JP5025062B2 (https=)
KR (1) KR100729015B1 (https=)
AU (1) AU2762101A (https=)
CA (1) CA2396702C (https=)
WO (1) WO2001049696A1 (https=)
ZA (1) ZA200205358B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166733B2 (en) * 2000-01-04 2007-01-23 Access Pharmaceuticals, Inc. O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
WO2005002508A2 (en) * 2003-06-11 2005-01-13 Access Pharmaceuticals, Inc. Macromolecular platinum chelates
ATE465205T1 (de) 2005-12-05 2010-05-15 Nitto Denko Corp Polyglutamat-aminosäure-konjugate und verfahren
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
CA2705850C (en) * 2007-11-13 2016-07-19 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
BRPI0920655A2 (pt) * 2008-10-07 2019-07-09 Rexahn Pharmaceuticals, Inc. conjugados e hpma-docetaxel ou gencitabina e usos dos mesmos
JP5281358B2 (ja) * 2008-10-27 2013-09-04 学校法人常翔学園 高分子、経上皮吸収促進剤、及び医薬用製剤
KR101721865B1 (ko) * 2009-10-13 2017-04-03 렉산 파마슈티컬스, 인코포레이티드 항암제의 전달을 위한 폴리머 시스템
JP5684056B2 (ja) 2010-08-16 2015-03-11 株式会社マキタ 手持ち工具
US8946163B2 (en) 2012-11-19 2015-02-03 Mimedx Group, Inc. Cross-linked collagen comprising metallic anticancer agents
US10335433B2 (en) * 2013-04-10 2019-07-02 Mimedx Group, Inc. NDGA polymers and metal complexes thereof
WO2015035446A1 (en) * 2013-09-10 2015-03-19 Starpharma Pty Ltd Macromolecules of dendrimer-platinum conjugates
EP3315487B1 (en) 2015-06-24 2020-10-28 Nippon Kayaku Kabushiki Kaisha Novel platinum (iv) complex
AU2016324370B2 (en) 2015-09-14 2021-02-25 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of hexa-coordinated platinum complex
US20190231690A1 (en) * 2017-11-08 2019-08-01 L.E.A.F. Holdings Group Llc Platinum complexes and uses thereof
BR112021000658A2 (pt) 2018-07-19 2021-04-13 Starpharma Pty Ltd Dendrímero, composições, composição farmacêutica, método de tratamento de câncer, uso de dendrímero, método, uso, dendrímero ou composição, processo de produção de dendrímero e intermediários para a produção de dendrímero
US12071517B2 (en) 2018-07-19 2024-08-27 Starpharma Pty Ltd. Therapeutic dendrimer
CN113018311A (zh) * 2019-12-25 2021-06-25 沈阳药科大学 顺铂配合物以及顺铂配合物脂质体的制备方法
CN117105797B (zh) * 2023-08-25 2025-09-23 湖南科技大学 一种谷氨酸铂配合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63284134A (ja) * 1987-02-25 1988-11-21 ジョンソン　マセイ　インコーポレーテッド 抗腫瘍巨大分子白金化合物
JPS6494A (en) * 1987-03-06 1989-01-05 Tanabe Seiyaku Co Ltd Novel organoplatinum complex
WO1998047537A1 (en) * 1997-04-18 1998-10-29 Access Pharmaceuticals, Inc Polymer-platinum compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO146404C (no) * 1979-10-26 1982-09-22 Dyno Industrier As Bygning for lyddempet skyting.
JPS5667326A (en) * 1979-11-05 1981-06-06 Hitachi Ltd Imide type compound and production thereof
IL67789A (en) 1983-01-31 1986-09-30 Yissum Res Dev Co Amino-substituted malonato platinum(ii)complexes and method for their preparation
EP0284197A1 (en) * 1987-02-20 1988-09-28 Tanabe Seiyaku Co., Ltd. Novel organic platinum complex and process for the preparation thereof
IL85595A0 (en) * 1987-03-06 1988-08-31 Tanabe Seiyaku Co Organic platinum complex and its preparation
JPH0256421A (ja) * 1988-08-19 1990-02-26 Tanabe Seiyaku Co Ltd 抗腫瘍剤
JPH0267217A (ja) * 1988-09-01 1990-03-07 Tanabe Seiyaku Co Ltd 抗腫瘍剤
US4946954A (en) * 1989-01-17 1990-08-07 Georgetown University Platinum pharmaceutical agents
KR0164460B1 (ko) 1995-10-02 1999-03-20 김은영 고분자 백금 착화합물, 그의 제조방법 및 그를 유효성분으로 하는 항암제

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63284134A (ja) * 1987-02-25 1988-11-21 ジョンソン　マセイ　インコーポレーテッド 抗腫瘍巨大分子白金化合物
JPS6494A (en) * 1987-03-06 1989-01-05 Tanabe Seiyaku Co Ltd Novel organoplatinum complex
WO1998047537A1 (en) * 1997-04-18 1998-10-29 Access Pharmaceuticals, Inc Polymer-platinum compounds

Also Published As

Publication number Publication date
AU2762101A (en) 2001-07-16
US20010038830A1 (en) 2001-11-08
WO2001049696A1 (en) 2001-07-12
CA2396702C (en) 2010-03-23
KR20020082208A (ko) 2002-10-30
EP1254145A1 (en) 2002-11-06
US6692734B2 (en) 2004-02-17
CA2396702A1 (en) 2001-07-12
ZA200205358B (en) 2003-08-20
JP2011137046A (ja) 2011-07-14
JP2003530317A (ja) 2003-10-14
KR100729015B1 (ko) 2007-06-14

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