JP2003528042A5 - - Google Patents
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- Publication number
- JP2003528042A5 JP2003528042A5 JP2001536502A JP2001536502A JP2003528042A5 JP 2003528042 A5 JP2003528042 A5 JP 2003528042A5 JP 2001536502 A JP2001536502 A JP 2001536502A JP 2001536502 A JP2001536502 A JP 2001536502A JP 2003528042 A5 JP2003528042 A5 JP 2003528042A5
- Authority
- JP
- Japan
- Prior art keywords
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- composition
- chch
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 description 31
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 description 24
- 101150065749 Churc1 gene Proteins 0.000 description 24
- 102100038239 Protein Churchill Human genes 0.000 description 24
- -1 2, 3,4,5-tetrazol-1-yl Chemical group 0.000 description 12
- 150000002148 esters Chemical group 0.000 description 12
- 125000002887 hydroxy group Chemical class [H]O* 0.000 description 12
- 125000000524 functional group Chemical group 0.000 description 9
- 125000003277 amino group Chemical class 0.000 description 6
- 150000001768 cations Chemical class 0.000 description 6
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 4
- 206010013774 Dry eye Diseases 0.000 description 4
- 0 CC(C)*C(C=*)=NC Chemical compound CC(C)*C(C=*)=NC 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 150000007970 thio esters Chemical group 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16437199P | 1999-11-09 | 1999-11-09 | |
| US16438699P | 1999-11-09 | 1999-11-09 | |
| US16436999P | 1999-11-09 | 1999-11-09 | |
| US60/164,371 | 1999-11-09 | ||
| US60/164,369 | 1999-11-09 | ||
| US60/164,386 | 1999-11-09 | ||
| PCT/US2000/029243 WO2001034551A1 (en) | 1999-11-09 | 2000-10-23 | Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003528042A JP2003528042A (ja) | 2003-09-24 |
| JP2003528042A5 true JP2003528042A5 (https=) | 2007-11-08 |
| JP4663193B2 JP4663193B2 (ja) | 2011-03-30 |
Family
ID=27389011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001536502A Expired - Fee Related JP4663193B2 (ja) | 1999-11-09 | 2000-10-23 | ヒドロキシエイコサテトラエン酸アナログおよびドライアイ障害の処置におけるその使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1228029B1 (https=) |
| JP (1) | JP4663193B2 (https=) |
| KR (1) | KR100781354B1 (https=) |
| CN (1) | CN1390191A (https=) |
| AR (1) | AR029769A1 (https=) |
| AT (2) | ATE271534T1 (https=) |
| AU (1) | AU776254B2 (https=) |
| BR (1) | BR0015424A (https=) |
| CA (1) | CA2386627C (https=) |
| DE (2) | DE60017810T2 (https=) |
| DK (1) | DK1228029T3 (https=) |
| ES (2) | ES2233921T3 (https=) |
| HK (1) | HK1045983B (https=) |
| MX (1) | MXPA02004704A (https=) |
| PL (1) | PL202040B1 (https=) |
| PT (2) | PT1418167E (https=) |
| TW (1) | TWI281395B (https=) |
| WO (1) | WO2001034551A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030109508A1 (en) * | 2001-10-11 | 2003-06-12 | Alcon, Inc. | Methods for treating dry eye |
| US8710252B2 (en) * | 2006-04-19 | 2014-04-29 | Cecil Pace-Asciak | Hepodxilin analog enantiomers |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4906467A (en) | 1988-03-24 | 1990-03-06 | New York Medical College | Novel, long-duration treatment for glaucoma |
| US5696166A (en) * | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
-
2000
- 2000-10-23 PT PT04003004T patent/PT1418167E/pt unknown
- 2000-10-23 ES ES04003004T patent/ES2233921T3/es not_active Expired - Lifetime
- 2000-10-23 DE DE60017810T patent/DE60017810T2/de not_active Expired - Lifetime
- 2000-10-23 DK DK00973791T patent/DK1228029T3/da active
- 2000-10-23 WO PCT/US2000/029243 patent/WO2001034551A1/en not_active Ceased
- 2000-10-23 HK HK02107320.4A patent/HK1045983B/en not_active IP Right Cessation
- 2000-10-23 PL PL356105A patent/PL202040B1/pl unknown
- 2000-10-23 AU AU12262/01A patent/AU776254B2/en not_active Ceased
- 2000-10-23 MX MXPA02004704A patent/MXPA02004704A/es active IP Right Grant
- 2000-10-23 JP JP2001536502A patent/JP4663193B2/ja not_active Expired - Fee Related
- 2000-10-23 ES ES00973791T patent/ES2220559T3/es not_active Expired - Lifetime
- 2000-10-23 AT AT00973791T patent/ATE271534T1/de active
- 2000-10-23 DE DE60012358T patent/DE60012358T2/de not_active Expired - Lifetime
- 2000-10-23 CN CN00815492A patent/CN1390191A/zh active Pending
- 2000-10-23 CA CA002386627A patent/CA2386627C/en not_active Expired - Fee Related
- 2000-10-23 EP EP00973791A patent/EP1228029B1/en not_active Expired - Lifetime
- 2000-10-23 PT PT00973791T patent/PT1228029E/pt unknown
- 2000-10-23 KR KR1020027004596A patent/KR100781354B1/ko not_active Expired - Fee Related
- 2000-10-23 BR BR0015424-5A patent/BR0015424A/pt not_active Application Discontinuation
- 2000-10-23 AT AT04003004T patent/ATE287866T1/de active
- 2000-11-07 TW TW089123506A patent/TWI281395B/zh not_active IP Right Cessation
- 2000-11-08 AR ARP000105868A patent/AR029769A1/es not_active Application Discontinuation
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