DE60017810T2 - Hydroxyeicosatetraensäureanaloge und Verfahren zu deren Verwendung zur Behandlung des trockenen Auges - Google Patents

Hydroxyeicosatetraensäureanaloge und Verfahren zu deren Verwendung zur Behandlung des trockenen Auges Download PDF

Info

Publication number
DE60017810T2
DE60017810T2 DE60017810T DE60017810T DE60017810T2 DE 60017810 T2 DE60017810 T2 DE 60017810T2 DE 60017810 T DE60017810 T DE 60017810T DE 60017810 T DE60017810 T DE 60017810T DE 60017810 T2 DE60017810 T2 DE 60017810T2
Authority
DE
Germany
Prior art keywords
trans
chch
compound
forms
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017810T
Other languages
German (de)
English (en)
Other versions
DE60017810D1 (de
Inventor
R. John FALCK
E. Raymond Crowley Conrow
R. Mark Arlington Hellberg
G. Peter KLIMKO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of DE60017810D1 publication Critical patent/DE60017810D1/de
Application granted granted Critical
Publication of DE60017810T2 publication Critical patent/DE60017810T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/655Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60017810T 1999-11-09 2000-10-23 Hydroxyeicosatetraensäureanaloge und Verfahren zu deren Verwendung zur Behandlung des trockenen Auges Expired - Lifetime DE60017810T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US16437199P 1999-11-09 1999-11-09
US16438699P 1999-11-09 1999-11-09
US16436999P 1999-11-09 1999-11-09
US164386P 1999-11-09
US164371P 1999-11-09
US164369P 1999-11-09

Publications (2)

Publication Number Publication Date
DE60017810D1 DE60017810D1 (de) 2005-03-03
DE60017810T2 true DE60017810T2 (de) 2005-08-25

Family

ID=27389011

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60017810T Expired - Lifetime DE60017810T2 (de) 1999-11-09 2000-10-23 Hydroxyeicosatetraensäureanaloge und Verfahren zu deren Verwendung zur Behandlung des trockenen Auges
DE60012358T Expired - Lifetime DE60012358T2 (de) 1999-11-09 2000-10-23 Hydroxyeicosatetraensäureanaloge und Verfahren zu deren Verwendung zur Behandlung des trockenen Auges

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60012358T Expired - Lifetime DE60012358T2 (de) 1999-11-09 2000-10-23 Hydroxyeicosatetraensäureanaloge und Verfahren zu deren Verwendung zur Behandlung des trockenen Auges

Country Status (18)

Country Link
EP (1) EP1228029B1 (https=)
JP (1) JP4663193B2 (https=)
KR (1) KR100781354B1 (https=)
CN (1) CN1390191A (https=)
AR (1) AR029769A1 (https=)
AT (2) ATE271534T1 (https=)
AU (1) AU776254B2 (https=)
BR (1) BR0015424A (https=)
CA (1) CA2386627C (https=)
DE (2) DE60017810T2 (https=)
DK (1) DK1228029T3 (https=)
ES (2) ES2233921T3 (https=)
HK (1) HK1045983B (https=)
MX (1) MXPA02004704A (https=)
PL (1) PL202040B1 (https=)
PT (2) PT1418167E (https=)
TW (1) TWI281395B (https=)
WO (1) WO2001034551A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030109508A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
US8710252B2 (en) * 2006-04-19 2014-04-29 Cecil Pace-Asciak Hepodxilin analog enantiomers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906467A (en) 1988-03-24 1990-03-06 New York Medical College Novel, long-duration treatment for glaucoma
US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

Also Published As

Publication number Publication date
DE60017810D1 (de) 2005-03-03
CN1390191A (zh) 2003-01-08
ES2220559T3 (es) 2004-12-16
DE60012358D1 (de) 2004-08-26
PL356105A1 (en) 2004-06-14
BR0015424A (pt) 2002-07-16
PT1418167E (pt) 2005-05-31
AU1226201A (en) 2001-06-06
ATE287866T1 (de) 2005-02-15
ATE271534T1 (de) 2004-08-15
HK1045983A1 (en) 2002-12-20
PT1228029E (pt) 2004-10-29
KR100781354B1 (ko) 2007-11-30
TWI281395B (en) 2007-05-21
MXPA02004704A (es) 2004-09-10
ES2233921T3 (es) 2005-06-16
KR20020040849A (ko) 2002-05-30
JP4663193B2 (ja) 2011-03-30
CA2386627A1 (en) 2001-05-17
CA2386627C (en) 2008-12-23
PL202040B1 (pl) 2009-05-29
DE60012358T2 (de) 2005-02-17
AR029769A1 (es) 2003-07-16
DK1228029T3 (da) 2004-10-25
JP2003528042A (ja) 2003-09-24
HK1045983B (en) 2004-12-24
WO2001034551A1 (en) 2001-05-17
HK1063623A1 (en) 2005-01-07
EP1228029B1 (en) 2004-07-21
EP1228029A1 (en) 2002-08-07
AU776254B2 (en) 2004-09-02

Similar Documents

Publication Publication Date Title
US6576663B2 (en) 6-Keto prostaglandin F1α and analogs for treating dry eye
DE60019322T2 (de) Heteroatomunterbrochene analoge von15-hydroxyeicosatetraensäure und verfahren zu deren verwendung
DE60007548T2 (de) Omega kettenmodifizierte hydroxyeicosatetraensäure derivate verwendbar in der behandlung der &#34;trockenes auge&#34; krankheit
DE60017810T2 (de) Hydroxyeicosatetraensäureanaloge und Verfahren zu deren Verwendung zur Behandlung des trockenen Auges
DE60010503T2 (de) Tri-heteroatom-substituierte und zwei kohlenstoff homologe von 15-hete und verfahren zur verwendung
US6552084B2 (en) Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
DE60020591T2 (de) Benzenoidderivate von 15-hydroxyeicosatetraesäure und verfahren zur verwendung zur behandlung des trockenen auges
US6803385B2 (en) Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
EP1418167B1 (en) Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
HK1063623B (en) Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
ZA200202279B (en) Hydroxyeicosatetraenoic acid and analogs and methods of their use in treating dry eye disorders.
ZA200202281B (en) Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition