CN1390191A - 羟基二十碳四烯酸类似物及其用于治疗干眼病的方法 - Google Patents

羟基二十碳四烯酸类似物及其用于治疗干眼病的方法 Download PDF

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Publication number
CN1390191A
CN1390191A CN00815492A CN00815492A CN1390191A CN 1390191 A CN1390191 A CN 1390191A CN 00815492 A CN00815492 A CN 00815492A CN 00815492 A CN00815492 A CN 00815492A CN 1390191 A CN1390191 A CN 1390191A
Authority
CN
China
Prior art keywords
trans
compound
ch2ch2
co2r
ophthalmically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00815492A
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English (en)
Chinese (zh)
Inventor
P·G·科林寇
M·R·赫勒贝格
J·R·福尔科
R·E·康洛吾
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of CN1390191A publication Critical patent/CN1390191A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN00815492A 1999-11-09 2000-10-23 羟基二十碳四烯酸类似物及其用于治疗干眼病的方法 Pending CN1390191A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US16437199P 1999-11-09 1999-11-09
US16438699P 1999-11-09 1999-11-09
US16436999P 1999-11-09 1999-11-09
US60/164,371 1999-11-09
US60/164,369 1999-11-09
US60/164,386 1999-11-09

Publications (1)

Publication Number Publication Date
CN1390191A true CN1390191A (zh) 2003-01-08

Family

ID=27389011

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00815492A Pending CN1390191A (zh) 1999-11-09 2000-10-23 羟基二十碳四烯酸类似物及其用于治疗干眼病的方法

Country Status (18)

Country Link
EP (1) EP1228029B1 (https=)
JP (1) JP4663193B2 (https=)
KR (1) KR100781354B1 (https=)
CN (1) CN1390191A (https=)
AR (1) AR029769A1 (https=)
AT (2) ATE271534T1 (https=)
AU (1) AU776254B2 (https=)
BR (1) BR0015424A (https=)
CA (1) CA2386627C (https=)
DE (2) DE60017810T2 (https=)
DK (1) DK1228029T3 (https=)
ES (2) ES2233921T3 (https=)
HK (1) HK1045983B (https=)
MX (1) MXPA02004704A (https=)
PL (1) PL202040B1 (https=)
PT (2) PT1418167E (https=)
TW (1) TWI281395B (https=)
WO (1) WO2001034551A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030109508A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
US8710252B2 (en) * 2006-04-19 2014-04-29 Cecil Pace-Asciak Hepodxilin analog enantiomers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906467A (en) 1988-03-24 1990-03-06 New York Medical College Novel, long-duration treatment for glaucoma
US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

Also Published As

Publication number Publication date
DE60017810D1 (de) 2005-03-03
ES2220559T3 (es) 2004-12-16
DE60012358D1 (de) 2004-08-26
PL356105A1 (en) 2004-06-14
BR0015424A (pt) 2002-07-16
PT1418167E (pt) 2005-05-31
AU1226201A (en) 2001-06-06
ATE287866T1 (de) 2005-02-15
ATE271534T1 (de) 2004-08-15
HK1045983A1 (en) 2002-12-20
PT1228029E (pt) 2004-10-29
KR100781354B1 (ko) 2007-11-30
TWI281395B (en) 2007-05-21
DE60017810T2 (de) 2005-08-25
MXPA02004704A (es) 2004-09-10
ES2233921T3 (es) 2005-06-16
KR20020040849A (ko) 2002-05-30
JP4663193B2 (ja) 2011-03-30
CA2386627A1 (en) 2001-05-17
CA2386627C (en) 2008-12-23
PL202040B1 (pl) 2009-05-29
DE60012358T2 (de) 2005-02-17
AR029769A1 (es) 2003-07-16
DK1228029T3 (da) 2004-10-25
JP2003528042A (ja) 2003-09-24
HK1045983B (en) 2004-12-24
WO2001034551A1 (en) 2001-05-17
HK1063623A1 (en) 2005-01-07
EP1228029B1 (en) 2004-07-21
EP1228029A1 (en) 2002-08-07
AU776254B2 (en) 2004-09-02

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication