JP2003525880A5 - - Google Patents
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- JP2003525880A5 JP2003525880A5 JP2001559832A JP2001559832A JP2003525880A5 JP 2003525880 A5 JP2003525880 A5 JP 2003525880A5 JP 2001559832 A JP2001559832 A JP 2001559832A JP 2001559832 A JP2001559832 A JP 2001559832A JP 2003525880 A5 JP2003525880 A5 JP 2003525880A5
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- Prior art keywords
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- 150000001875 compounds Chemical class 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 9
- 229910052799 carbon Inorganic materials 0.000 description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 8
- 208000010668 atopic eczema Diseases 0.000 description 7
- 201000004624 Dermatitis Diseases 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000000172 allergic effect Effects 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 4
- 125000006239 protecting group Chemical group 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 3
- 208000006011 Stroke Diseases 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 206010027654 Allergic conditions Diseases 0.000 description 1
- 208000036490 Arterial inflammations Diseases 0.000 description 1
- 206010003225 Arteriospasm coronary Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000015943 Coeliac disease Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 description 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 206010034972 Photosensitivity reaction Diseases 0.000 description 1
- 206010036774 Proctitis Diseases 0.000 description 1
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 1
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010057011 Rectal spasm Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 201000002661 Spondylitis Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 208000002205 allergic conjunctivitis Diseases 0.000 description 1
- 208000002029 allergic contact dermatitis Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 208000024998 atopic conjunctivitis Diseases 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 208000002528 coronary thrombosis Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 208000001286 intracranial vasospasm Diseases 0.000 description 1
- 201000004614 iritis Diseases 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 208000001875 irritant dermatitis Diseases 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- 208000002440 photoallergic dermatitis Diseases 0.000 description 1
- 208000007578 phototoxic dermatitis Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000006934 radiodermatitis Diseases 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000016160 smooth muscle contraction Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18307800P | 2000-02-16 | 2000-02-16 | |
| US60/183,078 | 2000-02-16 | ||
| US23881400P | 2000-10-06 | 2000-10-06 | |
| US60/238,814 | 2000-10-06 | ||
| PCT/US2001/005196 WO2001060778A2 (en) | 2000-02-16 | 2001-02-16 | Aspirin-triggered lipid mediators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010134989A Division JP2010248213A (ja) | 2000-02-16 | 2010-06-14 | アスピリン誘発脂質メディエータ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003525880A JP2003525880A (ja) | 2003-09-02 |
| JP2003525880A5 true JP2003525880A5 (https=) | 2009-06-25 |
| JP4932116B2 JP4932116B2 (ja) | 2012-05-16 |
Family
ID=26878731
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001559832A Expired - Lifetime JP4932116B2 (ja) | 2000-02-16 | 2001-02-16 | アスピリン誘発脂質メディエータ |
| JP2010134989A Pending JP2010248213A (ja) | 2000-02-16 | 2010-06-14 | アスピリン誘発脂質メディエータ |
| JP2014140321A Expired - Lifetime JP5973503B2 (ja) | 2000-02-16 | 2014-07-08 | アスピリン誘発脂質メディエータ |
| JP2015137034A Withdrawn JP2016006057A (ja) | 2000-02-16 | 2015-07-08 | アスピリン誘発脂質メディエータ |
| JP2019030694A Pending JP2019108348A (ja) | 2000-02-16 | 2019-02-22 | アスピリン誘発脂質メディエータ |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010134989A Pending JP2010248213A (ja) | 2000-02-16 | 2010-06-14 | アスピリン誘発脂質メディエータ |
| JP2014140321A Expired - Lifetime JP5973503B2 (ja) | 2000-02-16 | 2014-07-08 | アスピリン誘発脂質メディエータ |
| JP2015137034A Withdrawn JP2016006057A (ja) | 2000-02-16 | 2015-07-08 | アスピリン誘発脂質メディエータ |
| JP2019030694A Pending JP2019108348A (ja) | 2000-02-16 | 2019-02-22 | アスピリン誘発脂質メディエータ |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US6670396B2 (https=) |
| EP (2) | EP1296923B3 (https=) |
| JP (5) | JP4932116B2 (https=) |
| CN (4) | CN1951899B (https=) |
| AT (2) | ATE344226T1 (https=) |
| AU (4) | AU2001238468B2 (https=) |
| CA (1) | CA2400462C (https=) |
| DE (2) | DE60144401D1 (https=) |
| IL (1) | IL151299A0 (https=) |
| MX (1) | MXPA02007915A (https=) |
| WO (1) | WO2001060778A2 (https=) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4932116B2 (ja) * | 2000-02-16 | 2012-05-16 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | アスピリン誘発脂質メディエータ |
| AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
| ITMI20010129A1 (it) | 2001-01-25 | 2002-07-25 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco |
| US6638543B2 (en) * | 2001-02-27 | 2003-10-28 | Regents Of The University Of Michigan | Use of natural EGFR inhibitors to prevent side effects due to retinoid therapy, soaps, and other stimuli that activate the epidermal growth factor receptor |
| PT1406698E (pt) * | 2001-03-02 | 2009-01-12 | Brigham & Womens Hospital | Análogos de lipoxina como novos inibidores da angiogénese |
| DE60236467D1 (de) | 2001-03-02 | 2010-07-01 | Brigham And Women S Hospital B | Lipoxinanaloge als neuartige Restenose-Hemmer |
| GB0111282D0 (en) * | 2001-05-09 | 2001-06-27 | Laxdale Ltd | Potentiation of therapeutic effects of fatty acids |
| JPWO2002102364A1 (ja) * | 2001-06-18 | 2004-09-30 | 山田 幸子 | ＰＰＡＲγ作動性医薬組成物 |
| ITMI20012384A1 (it) * | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
| AU2002365167A1 (en) * | 2001-12-18 | 2003-07-09 | The Brigham And Women's Hospital | Inhibition or prevention of infection by bacteria with epa, dha or analogs |
| WO2003051350A1 (en) * | 2001-12-18 | 2003-06-26 | The Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| WO2003084305A2 (en) * | 2002-04-01 | 2003-10-16 | University Of Southern California | Trihydroxy polyunsaturated eicosanoids |
| US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| JP2005529945A (ja) | 2002-06-17 | 2005-10-06 | リソルヴィックス ファーマシューティカルズ | オメガ−３ｐｕｆａ由来の脂質メディエーターの類似体及び使用方法 |
| DE60330154D1 (de) * | 2002-08-12 | 2009-12-31 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004028470A2 (en) * | 2002-09-27 | 2004-04-08 | Martek Biosciences Corporation | Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| JP2007525201A (ja) * | 2003-07-07 | 2007-09-06 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | コンパニオンアニマルにおいて改良された酸化的状態を得るための組成物 |
| US20050238589A1 (en) * | 2004-04-14 | 2005-10-27 | Van Dyke Thomas E | Methods and compositions for preventing or treating periodontal diseases |
| US20060002985A1 (en) * | 2004-07-02 | 2006-01-05 | Zicker Steven C | Compositions and methods for decreasing age-related deterioration in mental activities in companion animals |
| LT2801354T (lt) * | 2004-10-08 | 2017-06-26 | Forward Pharma A/S | Kontroliuojamo atpalaidavimo farmacinės kompozicijos, apimančios fumaro rūgšties esterį |
| US20090318394A1 (en) * | 2004-11-19 | 2009-12-24 | Julie Nauroth | Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same |
| US7893106B2 (en) * | 2004-11-19 | 2011-02-22 | Martek Biosciences, Corporation | Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same |
| WO2006055965A2 (en) * | 2004-11-19 | 2006-05-26 | Martek Biosciences Corporation | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
| US20060194723A1 (en) * | 2005-02-28 | 2006-08-31 | Rabinoff Michael D | Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement |
| US8273792B2 (en) | 2005-10-03 | 2012-09-25 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers |
| US8636986B2 (en) | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| EP1983977A4 (en) * | 2006-01-31 | 2011-11-30 | Martek Biosciences Corp | OXYLIPINES FROM STEARIDONIC ACID AND GAMMA-LINOLIC ACID AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| CA2650607A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| JP2009545527A (ja) * | 2006-07-19 | 2009-12-24 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 粘膜炎の治療用の組成物及び方法 |
| EP2131833A2 (en) * | 2006-10-26 | 2009-12-16 | Resolvyx Pharmaceuticals, Inc. | Use of resolvins for inhibition of bone loss |
| WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| AU2008274876A1 (en) * | 2007-02-05 | 2009-01-15 | Children, Youth And Women's Health Service | Modulators of antigen-dependent T cell proliferation |
| EP2120920A4 (en) * | 2007-02-20 | 2011-06-15 | Martek Biosciences Corp | OXYLIPINES OF LONG-CHAIN MULTIPLE-UNSATURATED FATTY ACIDS AND METHOD FOR THEIR PREPARATION AND USE |
| EP2679224A1 (en) | 2007-08-01 | 2014-01-01 | University of Pittsburgh of the Commonwealth System of Higher Education | Nitro oleic acid modulation of type II diabetes |
| CA2699483A1 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
| JP5421272B2 (ja) * | 2007-10-12 | 2014-02-19 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 眼病治療のための組成物及び方法 |
| US20110027841A1 (en) * | 2007-12-21 | 2011-02-03 | Martek Biosciences Corporation | Method for preparation of oxylipins |
| CN102083787A (zh) | 2008-05-01 | 2011-06-01 | 康普雷克萨公司 | 乙烯基取代的脂肪酸 |
| US20140024713A1 (en) | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| US20110152223A1 (en) * | 2008-08-22 | 2011-06-23 | Junichi Hirahashi | Therapeutic agent for anca-related vasculitis |
| ES2792676T3 (es) | 2008-09-16 | 2020-11-11 | Brigham & Womens Hospital Inc | Compuestos del ácido 14-hidroxi-docosahexaenoico |
| US20110190242A1 (en) * | 2008-09-23 | 2011-08-04 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| EP2415748A4 (en) | 2009-02-20 | 2013-08-07 | Univ Tokyo | NEW INFLAMMATORY COMPOUNDS |
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| EP2459189A4 (en) * | 2009-07-31 | 2013-01-16 | Univ Pittsburgh | FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS |
| WO2011041639A2 (en) | 2009-10-02 | 2011-04-07 | Miller Raymond A | Heteroatom containing substituted fatty acids |
| US20130137767A1 (en) * | 2010-02-02 | 2013-05-30 | Dsm Ip Assets B.V. | Methods and Compositions for Treating Arthritis with Docosahexaenoic Acid |
| JP5909183B2 (ja) * | 2010-08-19 | 2016-04-26 | 国立大学法人 東京大学 | オメガ３系脂肪酸由来の新規抗炎症性代謝物 |
| EP2744491B1 (en) | 2011-08-19 | 2020-07-29 | The University of Utah Research Foundation | Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system |
| FR2979824A1 (fr) * | 2011-09-13 | 2013-03-15 | Vetinnov | Composition a usage humain ou veterinaire. |
| JP5969186B2 (ja) * | 2011-09-15 | 2016-08-17 | 出光興産株式会社 | Ｇｐｒ１１９アゴニスト並びにそれを含むインスリン分泌促進剤、血糖降下剤および糖尿病の治療または予防剤 |
| WO2013044176A2 (en) * | 2011-09-23 | 2013-03-28 | University Of Southern California | Methods and compositions for the treatment of ischemic stroke |
| US9340483B2 (en) | 2012-02-15 | 2016-05-17 | Anida Pharma Inc. | Methods of treating amyotrophic lateral sclerosis |
| DK2858496T3 (da) | 2012-05-10 | 2023-07-24 | Solutex Na Llc | Olier med anti-inflammatorisk aktivitet, som indeholder naturlige specialiserede pro-afhjælpningsmediatorer og deres forløbere |
| GB201213484D0 (en) * | 2012-07-30 | 2012-09-12 | Dignity Sciences Ltd | Pharmaceutical compositions comprising 15-OHEPA and methods of using the same |
| PL2887923T3 (pl) | 2012-08-24 | 2023-08-14 | Sun Pharmaceutical Industries Limited | Preparat okulistyczny polioksylipidu lub polioksylowego kwasu tłuszczowego i leczenie chorób oczu |
| GB201301626D0 (en) * | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| CA2902232C (en) * | 2013-02-22 | 2020-12-29 | University Of Southern California | Methods for treatment of ophthalmic diseases and disorders |
| USRE48077E1 (en) | 2013-02-28 | 2020-07-07 | Anida Pharma Inc. | Methods of treating ototoxicity |
| EP3068757B1 (en) | 2013-11-15 | 2019-02-27 | DS Biopharma Limited | Lysine salt of 15-hydroxy-8(z),11(z),13(e)-eicosatrienoic acid |
| SG10202000496XA (en) * | 2014-01-10 | 2020-03-30 | Afimmune Ltd | Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same |
| ES2784240T3 (es) | 2014-06-04 | 2020-09-23 | Ds Biopharma Ltd | Composiciones farmacéuticas que comprenden DGLA y uso de las mismas |
| MA41120A (fr) | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| EP3270693B1 (en) | 2015-03-18 | 2021-06-30 | Forsyth Dental Infirmary for Children | Methods for stabilizing atherosclerotic plaques using lipoxins, resolvins, and analogs thereof |
| CN117402059A (zh) | 2015-05-13 | 2024-01-16 | Ds生物制药有限公司 | 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法 |
| HRP20240082T1 (hr) | 2015-07-07 | 2024-03-29 | H. Lundbeck A/S | Inhibitor pde9 s okosnicom imidazopirazinona za liječenje perifernih bolesti |
| JP2018520197A (ja) * | 2015-07-21 | 2018-07-26 | アフィミューン リミテッド | 癌及び神経疾患の治療または予防において使用するための、１５−ｈｅｐｅを含む組成物 |
| US10653703B2 (en) | 2015-09-03 | 2020-05-19 | Solutex Na Llc | Compositions comprising omega-3 fatty acids, 17-HDHA and 18-HEPE and methods of using same |
| IL258476B2 (en) | 2015-10-02 | 2023-04-01 | Complexa Inc | Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids |
| WO2017077528A2 (en) * | 2015-11-02 | 2017-05-11 | Salzman Lovelace Investments, Ltd. | Methods and pharmaceutical compositions for treatment of lung inflammation |
| EP3373976B1 (en) | 2015-11-10 | 2024-01-03 | Sun Pharmaceutical Industries Limited | Topical formulations and uses thereof |
| KR20180094516A (ko) | 2015-12-18 | 2018-08-23 | 애피뮨 리미티드 | 15-hepe를 포함하는 조성물 및 이를 사용하는 방법 |
| EP3463419A4 (en) | 2016-05-27 | 2020-03-25 | Forsyth Dental Infirmary for Children | COMPOSITIONS AND METHODS FOR TREATING CANCER USING LIPID AGONISTS AND RECEPTORS THEREOF |
| ES2827796T3 (es) | 2016-06-03 | 2021-05-24 | Thetis Pharmaceuticals Llc | Composiciones y procedimientos relativos a sales de mediadores pro-resolutivos especializados de inflamación |
| CN105924338B (zh) * | 2016-06-17 | 2019-03-01 | 中科瑞奥能源科技股份有限公司 | 丁醇尾气回收工艺与系统 |
| EP3475442B1 (en) * | 2016-06-23 | 2024-10-23 | The Regents of The University of Michigan | 12(s)-hydroxyeicosatrienoic acid compounds and their use as therapeutic agents |
| CA3055093A1 (en) | 2017-03-09 | 2018-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
| WO2019182191A1 (ko) | 2018-03-21 | 2019-09-26 | 경북대학교 산학협력단 | C0x2 아세틸화제를 유효성분으로 포함하는 퇴행성 신경질환의 예방 또는 치료용 약학적 조성물 |
| FI3801526T3 (fi) | 2018-05-25 | 2024-03-20 | Cardurion Pharmaceuticals Inc | 6-[(3s,4s)-4-metyyli-1-(pyrimidin-2-yylimetyyli)pyrrolidin-3-yyli]-3-tetrahydropyran-4-yyli-7h-imidatso[1,5-a]pyratsin-8-onin monohydraattimuotoja ja kiteisiä muotoja |
| EP3843737A4 (en) | 2018-08-31 | 2022-06-01 | Imara Inc. | PDE9 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE |
| US20220040136A1 (en) | 2018-10-09 | 2022-02-10 | University Of Rochester | Treatment of vulvovaginal disorders |
| CA3121033C (en) * | 2018-11-30 | 2023-06-13 | Evonik Operations Gmbh | Preparation comprising a probiotic strain of the genus bacillus megaterium and a polyunsaturated fatty acid component |
| US20220226270A1 (en) * | 2019-04-04 | 2022-07-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Very-long-chain polyunsaturated fatty acids, elovanoid hydroxylated derivatives, and methods of use |
| KR102442204B1 (ko) * | 2019-09-20 | 2022-09-08 | 경북대학교 산학협력단 | Cox2 단백질의 아세틸화 검출용 항체 및 이의 용도 |
| JP7734686B2 (ja) * | 2020-04-03 | 2025-09-05 | アフィミューン リミテッド | 血液障害及び／又は関連疾患を治療する、又は予防するための１５－ｈｅｐｅを含む組成物 |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
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