JP2003525880A5 - - Google Patents
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- JP2003525880A5 JP2003525880A5 JP2001559832A JP2001559832A JP2003525880A5 JP 2003525880 A5 JP2003525880 A5 JP 2003525880A5 JP 2001559832 A JP2001559832 A JP 2001559832A JP 2001559832 A JP2001559832 A JP 2001559832A JP 2003525880 A5 JP2003525880 A5 JP 2003525880A5
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- 150000001875 compounds Chemical class 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 9
- 229910052799 carbon Inorganic materials 0.000 description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 8
- 208000010668 atopic eczema Diseases 0.000 description 7
- 201000004624 Dermatitis Diseases 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000000172 allergic effect Effects 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 4
- 125000006239 protecting group Chemical group 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 3
- 208000006011 Stroke Diseases 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 206010027654 Allergic conditions Diseases 0.000 description 1
- 208000036490 Arterial inflammations Diseases 0.000 description 1
- 206010003225 Arteriospasm coronary Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000015943 Coeliac disease Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 description 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 206010034972 Photosensitivity reaction Diseases 0.000 description 1
- 206010036774 Proctitis Diseases 0.000 description 1
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 1
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010057011 Rectal spasm Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 201000002661 Spondylitis Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 208000002205 allergic conjunctivitis Diseases 0.000 description 1
- 208000002029 allergic contact dermatitis Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 208000024998 atopic conjunctivitis Diseases 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 208000002528 coronary thrombosis Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 208000001286 intracranial vasospasm Diseases 0.000 description 1
- 201000004614 iritis Diseases 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 208000001875 irritant dermatitis Diseases 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- 208000002440 photoallergic dermatitis Diseases 0.000 description 1
- 208000007578 phototoxic dermatitis Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000006934 radiodermatitis Diseases 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000016160 smooth muscle contraction Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18307800P | 2000-02-16 | 2000-02-16 | |
| US60/183,078 | 2000-02-16 | ||
| US23881400P | 2000-10-06 | 2000-10-06 | |
| US60/238,814 | 2000-10-06 | ||
| PCT/US2001/005196 WO2001060778A2 (en) | 2000-02-16 | 2001-02-16 | Aspirin-triggered lipid mediators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010134989A Division JP2010248213A (ja) | 2000-02-16 | 2010-06-14 | アスピリン誘発脂質メディエータ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003525880A JP2003525880A (ja) | 2003-09-02 |
| JP2003525880A5 true JP2003525880A5 (enExample) | 2009-06-25 |
| JP4932116B2 JP4932116B2 (ja) | 2012-05-16 |
Family
ID=26878731
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001559832A Expired - Lifetime JP4932116B2 (ja) | 2000-02-16 | 2001-02-16 | アスピリン誘発脂質メディエータ |
| JP2010134989A Pending JP2010248213A (ja) | 2000-02-16 | 2010-06-14 | アスピリン誘発脂質メディエータ |
| JP2014140321A Expired - Lifetime JP5973503B2 (ja) | 2000-02-16 | 2014-07-08 | アスピリン誘発脂質メディエータ |
| JP2015137034A Withdrawn JP2016006057A (ja) | 2000-02-16 | 2015-07-08 | アスピリン誘発脂質メディエータ |
| JP2019030694A Pending JP2019108348A (ja) | 2000-02-16 | 2019-02-22 | アスピリン誘発脂質メディエータ |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010134989A Pending JP2010248213A (ja) | 2000-02-16 | 2010-06-14 | アスピリン誘発脂質メディエータ |
| JP2014140321A Expired - Lifetime JP5973503B2 (ja) | 2000-02-16 | 2014-07-08 | アスピリン誘発脂質メディエータ |
| JP2015137034A Withdrawn JP2016006057A (ja) | 2000-02-16 | 2015-07-08 | アスピリン誘発脂質メディエータ |
| JP2019030694A Pending JP2019108348A (ja) | 2000-02-16 | 2019-02-22 | アスピリン誘発脂質メディエータ |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US6670396B2 (enExample) |
| EP (2) | EP1296923B3 (enExample) |
| JP (5) | JP4932116B2 (enExample) |
| CN (4) | CN102010324B (enExample) |
| AT (2) | ATE504557T1 (enExample) |
| AU (4) | AU3846801A (enExample) |
| CA (1) | CA2400462C (enExample) |
| DE (2) | DE60144401D1 (enExample) |
| IL (1) | IL151299A0 (enExample) |
| MX (1) | MXPA02007915A (enExample) |
| WO (1) | WO2001060778A2 (enExample) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL151299A0 (en) * | 2000-02-16 | 2003-04-10 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
| ITMI20010129A1 (it) | 2001-01-25 | 2002-07-25 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco |
| MXPA03007609A (es) * | 2001-02-27 | 2004-06-30 | Univ Michigan | Uso de inhibidores egfr naturales para evitar efectos secundarios debidos a terapia de retinoide, jabones y otros estimulos que activan el receptor del factor de crecimiento epidermico. |
| ES2344814T3 (es) | 2001-03-02 | 2010-09-07 | The Brigham And Women's Hospital | Analogos de lipoxina como nuevos inhibidores de la angiogenesis. |
| JP2005508282A (ja) * | 2001-03-02 | 2005-03-31 | ザ・ブリガム・アンド・ウイメンズ・ホスピタル | 新規な脈管形成抑制剤としてのリポキシン類似物 |
| GB0111282D0 (en) * | 2001-05-09 | 2001-06-27 | Laxdale Ltd | Potentiation of therapeutic effects of fatty acids |
| JPWO2002102364A1 (ja) * | 2001-06-18 | 2004-09-30 | 山田 幸子 | ＰＰＡＲγ作動性医薬組成物 |
| ITMI20012384A1 (it) * | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
| WO2003053423A2 (en) * | 2001-12-18 | 2003-07-03 | The Brigham And Women's Hospital | Inhibition or prevention of infection by bacteria with epa, dha or analogs |
| WO2003051350A1 (en) * | 2001-12-18 | 2003-06-26 | The Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US7902257B2 (en) * | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| SI2022775T1 (sl) * | 2002-04-01 | 2015-03-31 | University Of Southern California | Trihidroksi polinenasiäśeni eikosanoidi |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| DE60318456T2 (de) | 2002-06-17 | 2008-12-24 | Resolvyx Pharmaceuticals, Bedford | ANALOGA VON OMEGA-3-PUFAs ABGELEITETEN LIPIDMEDIATOREN UND ANWENDUNGSVERFAHREN |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| DK2216318T3 (en) | 2002-08-12 | 2018-12-10 | Brigham & Womens Hospital | Resolvins: Bio templates for therapeutic interventions |
| AU2003270909A1 (en) * | 2002-09-27 | 2004-04-19 | Martek Biosciences Corporation | Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| EP1641352B2 (en) * | 2003-07-07 | 2019-06-19 | Hill's Pet Nutrition, Inc. | Compositions for improved oxidative status in cats |
| EP1755537A4 (en) * | 2004-04-14 | 2009-12-09 | Univ Boston | METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA |
| US20060002985A1 (en) * | 2004-07-02 | 2006-01-05 | Zicker Steven C | Compositions and methods for decreasing age-related deterioration in mental activities in companion animals |
| DE14172396T1 (de) * | 2004-10-08 | 2015-01-08 | Forward Pharma A/S | Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester |
| KR20070090928A (ko) * | 2004-11-19 | 2007-09-06 | 마텍 바이오싸이언스스 코포레이션 | 장쇄 다가불포화 지방산으로부터의 옥시리핀, 및 이의 제조방법 및 사용 방법 |
| US7893106B2 (en) * | 2004-11-19 | 2011-02-22 | Martek Biosciences, Corporation | Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same |
| US20090318394A1 (en) * | 2004-11-19 | 2009-12-24 | Julie Nauroth | Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same |
| US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
| US20060194723A1 (en) * | 2005-02-28 | 2006-08-31 | Rabinoff Michael D | Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement |
| WO2007041440A2 (en) * | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| WO2007090162A2 (en) * | 2006-01-31 | 2007-08-09 | Martek Biosciences Corporation | OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME |
| CA2650607A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| WO2008011085A1 (en) * | 2006-07-19 | 2008-01-24 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of mucositis |
| US20080161274A1 (en) * | 2006-10-26 | 2008-07-03 | Resolvyx Pharmaceuticals, Inc. | Compounds and methods for inhibition of bone loss |
| WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| WO2009006668A1 (en) * | 2007-02-05 | 2009-01-15 | Children, Youth And Women's Health Service | Modulators of antigen-dependent t cell proliferation |
| US20110190389A1 (en) * | 2007-02-20 | 2011-08-04 | Linda Arterburn | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| US8324277B2 (en) | 2007-08-01 | 2012-12-04 | University of Pittsburgh—of the Commonwealth System of Higher Education | Nitrated-fatty acids modulation of type II diabetes |
| CA2699483A1 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
| KR20150115959A (ko) * | 2007-10-12 | 2015-10-14 | 레솔빅스 파마슈티칼즈, 인코퍼레이티드 | 안과 질환의 치료를 위한 옥실리핀 화합물 |
| US20110027841A1 (en) * | 2007-12-21 | 2011-02-03 | Martek Biosciences Corporation | Method for preparation of oxylipins |
| CN102083787A (zh) | 2008-05-01 | 2011-06-01 | 康普雷克萨公司 | 乙烯基取代的脂肪酸 |
| US20140024713A1 (en) | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| EP2324827A4 (en) * | 2008-08-22 | 2012-04-25 | Mochida Pharm Co Ltd | THERAPEUTIC ACTIVE FOR ANCA-ASSOCIATED VASCULITIDES |
| US8927747B2 (en) * | 2008-09-16 | 2015-01-06 | The Brigham And Women's Hospital, Inc. | 14-hydroxy-docosahexaenoic acid compounds |
| US20110190242A1 (en) * | 2008-09-23 | 2011-08-04 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| WO2010095706A1 (ja) | 2009-02-20 | 2010-08-26 | 国立大学法人東京大学 | 新規抗炎症性化合物 |
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| JP2013500966A (ja) * | 2009-07-31 | 2013-01-10 | ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 抗炎症剤としての脂肪酸 |
| US8686167B2 (en) | 2009-10-02 | 2014-04-01 | Complexa, Inc. | Heteroatom containing substituted fatty acids |
| US20130137767A1 (en) * | 2010-02-02 | 2013-05-30 | Dsm Ip Assets B.V. | Methods and Compositions for Treating Arthritis with Docosahexaenoic Acid |
| WO2012023254A1 (ja) * | 2010-08-19 | 2012-02-23 | 国立大学法人 東京大学 | オメガ３系脂肪酸由来の新規抗炎症性代謝物 |
| WO2013028501A1 (en) | 2011-08-19 | 2013-02-28 | The University Of Utah Research Foundation | Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system |
| FR2979824A1 (fr) * | 2011-09-13 | 2013-03-15 | Vetinnov | Composition a usage humain ou veterinaire. |
| JP5969186B2 (ja) * | 2011-09-15 | 2016-08-17 | 出光興産株式会社 | Ｇｐｒ１１９アゴニスト並びにそれを含むインスリン分泌促進剤、血糖降下剤および糖尿病の治療または予防剤 |
| WO2013044176A2 (en) * | 2011-09-23 | 2013-03-28 | University Of Southern California | Methods and compositions for the treatment of ischemic stroke |
| JP6173352B2 (ja) | 2012-02-15 | 2017-08-02 | アニダ ファーマ インコーポレイテッド | 筋萎縮性側索硬化症の治療方法 |
| CN110478342A (zh) | 2012-05-10 | 2019-11-22 | 索卢泰克斯Na有限责任公司 | 含有天然专门促消退介质及其前体的具有抗炎活性的油 |
| GB201213484D0 (en) * | 2012-07-30 | 2012-09-12 | Dignity Sciences Ltd | Pharmaceutical compositions comprising 15-OHEPA and methods of using the same |
| PL2887923T3 (pl) | 2012-08-24 | 2023-08-14 | Sun Pharmaceutical Industries Limited | Preparat okulistyczny polioksylipidu lub polioksylowego kwasu tłuszczowego i leczenie chorób oczu |
| GB201301626D0 (en) * | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| AU2014218666B2 (en) * | 2013-02-22 | 2018-11-01 | University Of Southern California | Methods for treatment of ophthalmic diseases and disorders |
| JP6295278B2 (ja) | 2013-02-28 | 2018-03-14 | アニダ ファーマ インコーポレイテッド | 聴器毒性を治療する方法 |
| EP3068757B1 (en) | 2013-11-15 | 2019-02-27 | DS Biopharma Limited | Lysine salt of 15-hydroxy-8(z),11(z),13(e)-eicosatrienoic acid |
| MX2016008953A (es) * | 2014-01-10 | 2017-02-02 | Dignity Sciences Ltd | Composiciones farmaceuticas que comprenden i5-hidroxi-eicosa- 5,8,11,13,17-pentaenoico ( 15-hepe ) y metodos para tratar el asma y trastornos pulmonares que usan las mismas. |
| WO2015185698A1 (en) | 2014-06-04 | 2015-12-10 | Dignity Sciences Limited | Pharmaceutical compositions comprising dgla and use of same |
| MA41120A (fr) | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| ES2895062T3 (es) | 2015-03-18 | 2022-02-17 | Forsyth Dental Infirmary For Children | Métodos para estabilizar placas ateroscleróticas usando lipoxinas, resolvinas y análogos de las mismas |
| JP2018524274A (ja) | 2015-05-13 | 2018-08-30 | ディーエス バイオファーマ リミテッド | １５−オキソ−ｅｐａまたは１５−オキソ−ｄｇｌａを含む組成物、ならびにその作製及び使用方法 |
| BR112018000254A2 (pt) | 2015-07-07 | 2018-09-04 | H Lundbeck As | inibidores de pde9 com cadeia principal de imidazotriazinona e cadeia principal de imidazopirazinona para o tratamento de doenças periféricas |
| JP2018520197A (ja) * | 2015-07-21 | 2018-07-26 | アフィミューン リミテッド | 癌及び神経疾患の治療または予防において使用するための、１５−ｈｅｐｅを含む組成物 |
| WO2017041094A1 (en) | 2015-09-03 | 2017-03-09 | Solutex Na Llc | Compositions comprising omega-3 fatty acids, 17-hdha and 18- hepe and methods of using same |
| IL258476B2 (en) | 2015-10-02 | 2023-04-01 | Complexa Inc | Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids |
| WO2017077528A2 (en) * | 2015-11-02 | 2017-05-11 | Salzman Lovelace Investments, Ltd. | Methods and pharmaceutical compositions for treatment of lung inflammation |
| JP2018532809A (ja) | 2015-11-10 | 2018-11-08 | サン ファーマ グローバル エフジーイー | 局所製剤およびその使用 |
| CN113230244A (zh) | 2015-12-18 | 2021-08-10 | 艾菲穆恩有限公司 | 包含15-hepe的组合物及其使用方法 |
| US11903998B2 (en) | 2016-05-27 | 2024-02-20 | Forsyth Dental Infirmary For Children | Compositions and methods of treating cancer using lipid agonists and receptors thereof |
| JP6906047B2 (ja) | 2016-06-03 | 2021-07-21 | テティス・ファーマシューティカルズ・エルエルシー | 特異的炎症収束性メディエーターの塩に関連する組成物及び方法 |
| CN105924338B (zh) * | 2016-06-17 | 2019-03-01 | 中科瑞奥能源科技股份有限公司 | 丁醇尾气回收工艺与系统 |
| EP3475442B1 (en) * | 2016-06-23 | 2024-10-23 | The Regents of The University of Michigan | 12(s)-hydroxyeicosatrienoic acid compounds and their use as therapeutic agents |
| CA3055093A1 (en) | 2017-03-09 | 2018-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
| WO2019182191A1 (ko) | 2018-03-21 | 2019-09-26 | 경북대학교 산학협력단 | C0x2 아세틸화제를 유효성분으로 포함하는 퇴행성 신경질환의 예방 또는 치료용 약학적 조성물 |
| HUE065709T2 (hu) | 2018-05-25 | 2024-06-28 | Cardurion Pharmaceuticals Inc | 6-[(3S,4S)-4-metil-1-(pirimidin-2-ilmetil)pirrolidin-3-il]-3-tetrahidropirán-4-il-7H-imidazo[1,5-a] pirazin-8-on vegyület monohidrát és kristályos formái |
| MA53501A (fr) | 2018-08-31 | 2021-07-07 | Imara Inc | Inhibiteurs de pde9 pour le traitement de la drépanocytose |
| WO2020076578A1 (en) | 2018-10-09 | 2020-04-16 | University Of Rochester | Treatment of vulvovaginal disorders |
| AU2019387329B2 (en) * | 2018-11-30 | 2025-05-15 | Evonik Operations Gmbh | Preparation comprising a probiotic strain of the genus bacillus megaterium and a polyunsaturated fatty acid component |
| EP3946308A4 (en) * | 2019-04-04 | 2022-12-14 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Very-long-chain polyunsaturated fatty acids, elovanoid hydroxylated derivatives, and methods of use |
| WO2021054778A1 (ko) * | 2019-09-20 | 2021-03-25 | 경북대학교 산학협력단 | Cox2 단백질의 아세틸화 검출용 항체 및 이의 용도 |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
| BR112022020012A2 (pt) * | 2020-04-03 | 2022-12-13 | Afimmune Ltd | Composições que compreendem 15-hepe e métodos de tratamento ou prevenção de distúrbios hematológicos e/ou doenças relacionadas |
| CN112511569B (zh) * | 2021-02-07 | 2021-05-11 | 杭州筋斗腾云科技有限公司 | 网络资源访问请求的处理方法、系统及计算机设备 |
| KR20240150603A (ko) | 2022-03-03 | 2024-10-15 | 테티스 파마수티컬스 엘엘씨 | 특수화된 해소촉진 매개체의 시클로덱스트린 복합체 |
| WO2025023183A1 (ja) * | 2023-07-21 | 2025-01-30 | 国立大学法人大阪大学 | 炎症性腸疾患を抑制する脂肪酸代謝産物 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US466701A (en) * | 1892-01-05 | Hiram ezkiel payne | ||
| US4201211A (en) | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| GB2033745B (en) * | 1978-05-26 | 1983-08-17 | Wellcome Found | Fatty acid and derivatives thereof for use in treatment or prophylaxis of thromboembolic conditions |
| US4442099A (en) | 1981-11-27 | 1984-04-10 | Research Corporation | Leukotriene analogues |
| US4567290A (en) | 1981-11-27 | 1986-01-28 | Research Corporation | Leukotriene analogues |
| US4576758A (en) | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
| US4759880A (en) | 1984-09-27 | 1988-07-26 | Research Corporation | Alkanoarachidonic acids |
| GB8507058D0 (en) | 1985-03-19 | 1985-04-24 | Efamol Ltd | Pharmaceutical & dietary compositions |
| US4710521A (en) | 1986-07-25 | 1987-12-01 | The Celotex Corporation | Catalyst mixtures for polyisocyanurate foam |
| US4810424A (en) * | 1987-10-09 | 1989-03-07 | The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University | Method for the recovery of 12-(S)-hydroxyeicosapentaenoic acid from the red alga murrayella periclados |
| US5136501A (en) | 1989-05-26 | 1992-08-04 | Reuters Limited | Anonymous matching system |
| AU8083691A (en) * | 1990-05-07 | 1991-11-27 | Barry I. Bockow | Methods and preparations of stable, deodorized oils and pharmaceutical compositions thereof |
| JPH0425036A (ja) | 1990-05-16 | 1992-01-28 | Mitsubishi Electric Corp | マイクロ波半導体装置 |
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| US5087790A (en) | 1991-06-12 | 1992-02-11 | University Of Southern California | Method for olefination of carbonyl compounds using titanocene derivatives |
| SG44524A1 (en) | 1991-06-24 | 1997-12-19 | Adelaide Children S Hospital | Methods and compositions of treating malaria and other diseases |
| US5177046A (en) | 1991-09-20 | 1993-01-05 | Air Products And Chemicals, Inc. | Amine-boron adducts as reduced odor catalyst compositions for the production of polyurethanes |
| JPH05186342A (ja) * | 1992-01-10 | 1993-07-27 | Fujirebio Inc | 免疫調節作用を併せもつ抗炎症剤 |
| US5409955A (en) | 1993-05-13 | 1995-04-25 | Bockow; Barry I. | Compositions and methods for inhibiting uterine contractility |
| US6887901B1 (en) | 1993-06-15 | 2005-05-03 | Brigham & Women's Hospital, Inc. | Lipoxin compounds and their use in treating cell proliferative disorders |
| US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| US5411988A (en) * | 1993-10-27 | 1995-05-02 | Bockow; Barry I. | Compositions and methods for inhibiting inflammation and adhesion formation |
| US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
| JP2536436B2 (ja) | 1993-11-19 | 1996-09-18 | 日本電気株式会社 | モ―ルド型半導体装置 |
| US6030917A (en) | 1996-07-23 | 2000-02-29 | Symyx Technologies, Inc. | Combinatorial synthesis and analysis of organometallic compounds and catalysts |
| US5752238A (en) | 1994-11-03 | 1998-05-12 | Intel Corporation | Consumer-driven electronic information pricing mechanism |
| US5594732A (en) | 1995-03-03 | 1997-01-14 | Intecom, Incorporated | Bridging and signalling subsystems and methods for private and hybrid communications systems including multimedia systems |
| US5801280A (en) | 1995-04-07 | 1998-09-01 | Sumitomo Chemical Company, Limited | Processes for preparing optically active alcohols and optically active amines |
| US5845265A (en) | 1995-04-26 | 1998-12-01 | Mercexchange, L.L.C. | Consignment nodes |
| US5756789A (en) | 1995-06-08 | 1998-05-26 | Texaco, Inc. | Synthesis of metal--containing aluminophosphates with layered structure |
| CA2182851A1 (en) | 1995-08-15 | 1997-02-16 | August Masaru Watanabe | Method for treating substance abuse withdrawal |
| US5709855A (en) * | 1995-09-22 | 1998-01-20 | Bockow; Barry I. | Compositions of spirulina algae and omega fatty acids for treatment of inflammation and pain |
| US5870717A (en) | 1995-11-13 | 1999-02-09 | International Business Machines Corporation | System for ordering items over computer network using an electronic catalog |
| US5789441A (en) * | 1996-02-15 | 1998-08-04 | Virocell Inc. | Leukotriene B4 as an antiviral and anti-neoplastic agent |
| BR9708574A (pt) | 1996-04-12 | 1999-08-03 | Searle & Co | Derivados benzeno sulfonamida substituídos como pródrogas de inibidores cox-2 |
| US5878400A (en) | 1996-06-17 | 1999-03-02 | Trilogy Development Group, Inc. | Method and apparatus for pricing products in multi-level product and organizational groups |
| US5842040A (en) | 1996-06-18 | 1998-11-24 | Storage Technology Corporation | Policy caching method and apparatus for use in a communication device based on contents of one data unit in a subset of related data units |
| EP0923544B1 (en) | 1996-06-28 | 2008-10-15 | University of Southern California | Method for the synthesis of amines and amino acids with organoboron derivatives |
| US5890138A (en) | 1996-08-26 | 1999-03-30 | Bid.Com International Inc. | Computer auction system |
| US5861399A (en) * | 1996-07-17 | 1999-01-19 | Heart Care Partners | Methods and compositions for the rapid and enduring relief of inadequate myocardial function |
| US5896379A (en) | 1996-08-26 | 1999-04-20 | Motorola, Inc. | Network node for packet switching with selective data processing and method therefor |
| US5912006A (en) * | 1996-08-28 | 1999-06-15 | Eboc, Inc. | Compositions and methods for alleviating discomforting menstrual pain |
| US5946467A (en) | 1996-09-20 | 1999-08-31 | Novell, Inc. | Application-level, persistent packeting apparatus and method |
| US20020055539A1 (en) | 1996-10-02 | 2002-05-09 | Bockow Barry I. | Compositions and methods for treating cardiovascular conditions |
| US6201022B1 (en) * | 1997-03-27 | 2001-03-13 | Myorx, Inc. | Methods for treating neurotransmitter-mediated pain syndromes by topically administering an omega fatty acid |
| US6008205A (en) | 1997-04-04 | 1999-12-28 | The Brigham & Women's Hospital, Inc. | Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses |
| AU6959898A (en) * | 1997-04-11 | 1998-11-11 | David J. Grainger | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
| US6428990B1 (en) | 1997-04-11 | 2002-08-06 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US5878423A (en) | 1997-04-21 | 1999-03-02 | Bellsouth Corporation | Dynamically processing an index to create an ordered set of questions |
| US6030715A (en) | 1997-10-09 | 2000-02-29 | The University Of Southern California | Azlactone-related dopants in the emissive layer of an OLED |
| US6259699B1 (en) | 1997-12-30 | 2001-07-10 | Nexabit Networks, Llc | System architecture for and method of processing packets and/or cells in a common switch |
| AU3843999A (en) * | 1998-05-07 | 1999-11-23 | Elan Corporation, Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
| US6377937B1 (en) | 1998-05-28 | 2002-04-23 | Paskowitz Associates | Method and system for more effective communication of characteristics data for products and services |
| US6069109A (en) | 1998-07-01 | 2000-05-30 | Union Carbide Chemicals & Plastics Technology Corporation | Process for the production of half-sandwich transition metal based catalyst precursors |
| US6336138B1 (en) | 1998-08-25 | 2002-01-01 | Hewlett-Packard Company | Template-driven approach for generating models on network services |
| WO2000024510A1 (en) | 1998-10-23 | 2000-05-04 | University Of Southern California | Combinatorial approach to chiral reagents or catalysts having amine or amino alcohol ligands |
| US6336105B1 (en) | 1998-11-16 | 2002-01-01 | Trade Access Inc. | System and method for representing data and providing electronic non-repudiation in a negotiations system |
| DE19855426A1 (de) * | 1998-12-02 | 2000-06-08 | Wolfgang Langhoff | Mittel zur Therapie und Prophylaxe von rheumatisch-arthritischen Erkrankungen und zur Prophylaxe von cardiovaskulären Erkrankungen |
| US6272474B1 (en) | 1999-02-08 | 2001-08-07 | Crisostomo B. Garcia | Method for monitoring and trading stocks via the internet displaying bid/ask trade bars |
| US6397212B1 (en) | 1999-03-04 | 2002-05-28 | Peter Biffar | Self-learning and self-personalizing knowledge search engine that delivers holistic results |
| AU780114B2 (en) | 1999-03-18 | 2005-03-03 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| WO2000054767A1 (en) | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alfa) initiated neutrophil response |
| EP1165809A2 (en) | 1999-03-18 | 2002-01-02 | The Brigham And Women's Hospital, Inc. | Leukotriene b4 receptor transgenic mammals |
| ES2246230T3 (es) | 1999-03-18 | 2006-02-16 | The Brigham And Women's Hospital, Inc. | Compuestos de lipoxina y su utilizacion. |
| US6427132B1 (en) | 1999-08-31 | 2002-07-30 | Accenture Llp | System, method and article of manufacture for demonstrating E-commerce capabilities via a simulation on a network |
| US6415270B1 (en) | 1999-09-03 | 2002-07-02 | Omnihub, Inc. | Multiple auction coordination method and system |
| IL151299A0 (en) | 2000-02-16 | 2003-04-10 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
| US6473314B1 (en) | 2000-08-03 | 2002-10-29 | Powerwave Technologies, Inc. | RF power amplifier assembly employing multi-layer RF blocking filter |
| US20020074162A1 (en) | 2000-12-15 | 2002-06-20 | Bor-Ray Su | Substrate layout method and structure for reducing cross talk of adjacent signals |
| JP2005508282A (ja) | 2001-03-02 | 2005-03-31 | ザ・ブリガム・アンド・ウイメンズ・ホスピタル | 新規な脈管形成抑制剤としてのリポキシン類似物 |
| US20040044028A1 (en) | 2001-03-30 | 2004-03-04 | Obukowicz Mark G. | Combinations of omega-3 fatty acids and cyclooxygenase-2 inhibitors for treatment or prevention of cardiovascular disease and treatment or prevention of cancer |
| WO2003039533A1 (en) | 2001-11-06 | 2003-05-15 | The Brigham And Women's Hospital, Inc. | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| WO2003051350A1 (en) | 2001-12-18 | 2003-06-26 | The Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| WO2003053423A2 (en) | 2001-12-18 | 2003-07-03 | The Brigham And Women's Hospital | Inhibition or prevention of infection by bacteria with epa, dha or analogs |
| US7582785B2 (en) | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| SI2022775T1 (sl) * | 2002-04-01 | 2015-03-31 | University Of Southern California | Trihidroksi polinenasiäśeni eikosanoidi |
| DE60318456T2 (de) | 2002-06-17 | 2008-12-24 | Resolvyx Pharmaceuticals, Bedford | ANALOGA VON OMEGA-3-PUFAs ABGELEITETEN LIPIDMEDIATOREN UND ANWENDUNGSVERFAHREN |
| DK2216318T3 (en) | 2002-08-12 | 2018-12-10 | Brigham & Womens Hospital | Resolvins: Bio templates for therapeutic interventions |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004078143A2 (en) | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| AU2004263164A1 (en) | 2003-08-05 | 2005-02-17 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Neuroprotection protects against cellular apoptosis, neural stroke damage, alzheimer's disease and retinal degeneration |
| EP1755537A4 (en) | 2004-04-14 | 2009-12-09 | Univ Boston | METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA |
| US20060293288A1 (en) | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
| WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| WO2008011085A1 (en) | 2006-07-19 | 2008-01-24 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of mucositis |
-
2001
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