JP2003522173A5 - - Google Patents
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- Publication number
- JP2003522173A5 JP2003522173A5 JP2001557865A JP2001557865A JP2003522173A5 JP 2003522173 A5 JP2003522173 A5 JP 2003522173A5 JP 2001557865 A JP2001557865 A JP 2001557865A JP 2001557865 A JP2001557865 A JP 2001557865A JP 2003522173 A5 JP2003522173 A5 JP 2003522173A5
- Authority
- JP
- Japan
- Prior art keywords
- furyl
- thienyl
- pyridyl
- alkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940123237 Taxane Drugs 0.000 description 16
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 6
- 125000000623 heterocyclic group Chemical group 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 4
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 description 4
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 4
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 4
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 4
- -1 carbamoyloxy Chemical group 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 3
- 125000002541 furyl group Chemical group 0.000 description 3
- 125000001544 thienyl group Chemical group 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17979300P | 2000-02-02 | 2000-02-02 | |
| US60/179,793 | 2000-02-02 | ||
| PCT/US2001/003633 WO2001057033A1 (en) | 2000-02-02 | 2001-02-02 | C10 carbamoyloxy substituted taxanes as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003522173A JP2003522173A (ja) | 2003-07-22 |
| JP2003522173A5 true JP2003522173A5 (enExample) | 2007-04-12 |
Family
ID=22658023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001557865A Withdrawn JP2003522173A (ja) | 2000-02-02 | 2001-02-02 | 抗腫瘍剤としてのｃ１０カルバモイルオキシ置換タキサン |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6596737B2 (enExample) |
| EP (1) | EP1165551B1 (enExample) |
| JP (1) | JP2003522173A (enExample) |
| KR (1) | KR20020000159A (enExample) |
| CN (1) | CN1362959A (enExample) |
| AT (1) | ATE401325T1 (enExample) |
| AU (1) | AU783422B2 (enExample) |
| BR (1) | BR0104352A (enExample) |
| CA (1) | CA2368541A1 (enExample) |
| CZ (1) | CZ20013520A3 (enExample) |
| DE (1) | DE60134814D1 (enExample) |
| HK (1) | HK1047936A1 (enExample) |
| HU (1) | HUP0200721A3 (enExample) |
| IL (1) | IL145640A (enExample) |
| MX (1) | MXPA01009921A (enExample) |
| NO (1) | NO20014760L (enExample) |
| NZ (1) | NZ514407A (enExample) |
| PL (1) | PL350331A1 (enExample) |
| WO (1) | WO2001057033A1 (enExample) |
| ZA (1) | ZA200108053B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL350075A1 (en) * | 2000-02-02 | 2002-11-04 | Univ Florida State Res Found | Taxane formulations having improved solubility |
| MXPA01009921A (es) * | 2000-02-02 | 2003-08-01 | Univ Florida State Res Found | Taxanos sustituidos como carbamoiloxilo en c10 como agentes antitumorales. |
| CN1712399B (zh) * | 2004-06-24 | 2010-08-11 | 中国医学科学院药物研究所 | 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途 |
| EP3252128B1 (en) * | 2006-04-03 | 2019-01-02 | Pharmatherm Chemicals Inc. | Thermal extraction method for producing a taxane extract |
| WO2011147330A1 (zh) | 2010-05-27 | 2011-12-01 | 中国医学科学院药物研究所 | 双功能共缀物的化学合成及抗肿瘤与抗肿瘤转移作用 |
| JP6959096B2 (ja) * | 2017-10-13 | 2021-11-02 | エイブリック株式会社 | 充放電制御回路及びこれを備えたバッテリ装置 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| ES2230790T3 (es) | 1992-01-15 | 2005-05-01 | E.R. SQUIBB & SONS, INC. | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos. |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| FR2691460B1 (fr) | 1992-05-21 | 1994-07-22 | Rhone Poulenc Rorer Sa | Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent. |
| CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| DE69424166T2 (de) | 1993-06-11 | 2000-10-05 | Pharmacia & Upjohn Co., Kalamazoo | Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US6100411A (en) * | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| WO1996013495A1 (en) * | 1994-10-28 | 1996-05-09 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| FR2732342B1 (fr) | 1995-04-03 | 1997-04-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2732968B1 (fr) | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| IL126856A0 (en) | 1996-05-06 | 1999-09-22 | Univ Florida State | 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| BR9710366A (pt) | 1996-07-15 | 1999-08-17 | Yakult Honsha Kk | Derivados de taxane e drogas que os contêm |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| JPH1192468A (ja) | 1997-09-17 | 1999-04-06 | Yakult Honsha Co Ltd | 新規なタキサン誘導体 |
| EP1044971A4 (en) * | 1997-12-19 | 2001-11-07 | Yakult Honsha Kk | TAXAN DERIVATIVES |
| JP2003026673A (ja) * | 1999-03-05 | 2003-01-29 | Asahi Kasei Corp | 骨形成促進剤 |
| PL350075A1 (en) * | 2000-02-02 | 2002-11-04 | Univ Florida State Res Found | Taxane formulations having improved solubility |
| MXPA01009921A (es) * | 2000-02-02 | 2003-08-01 | Univ Florida State Res Found | Taxanos sustituidos como carbamoiloxilo en c10 como agentes antitumorales. |
| EP1175414A1 (en) | 2000-02-02 | 2002-01-30 | Florida State University Research Foundation, Inc. | Taxane formulations having improved solubility |
| GB2370649B (en) * | 2000-11-09 | 2003-06-25 | Toppan Printing Co Ltd | Measurement of rate of transmission of a vapour through a sample |
-
2001
- 2001-02-02 MX MXPA01009921A patent/MXPA01009921A/es active IP Right Grant
- 2001-02-02 AT AT01905434T patent/ATE401325T1/de not_active IP Right Cessation
- 2001-02-02 NZ NZ51440701A patent/NZ514407A/xx unknown
- 2001-02-02 JP JP2001557865A patent/JP2003522173A/ja not_active Withdrawn
- 2001-02-02 KR KR1020017012573A patent/KR20020000159A/ko not_active Abandoned
- 2001-02-02 BR BR0104352-8A patent/BR0104352A/pt not_active IP Right Cessation
- 2001-02-02 AU AU33313/01A patent/AU783422B2/en not_active Ceased
- 2001-02-02 CZ CZ20013520A patent/CZ20013520A3/cs unknown
- 2001-02-02 CN CN01800317A patent/CN1362959A/zh active Pending
- 2001-02-02 PL PL01350331A patent/PL350331A1/xx not_active Application Discontinuation
- 2001-02-02 US US09/775,852 patent/US6596737B2/en not_active Expired - Fee Related
- 2001-02-02 CA CA002368541A patent/CA2368541A1/en not_active Withdrawn
- 2001-02-02 DE DE60134814T patent/DE60134814D1/de not_active Expired - Fee Related
- 2001-02-02 WO PCT/US2001/003633 patent/WO2001057033A1/en not_active Ceased
- 2001-02-02 HK HK03100170.9A patent/HK1047936A1/zh unknown
- 2001-02-02 HU HU0200721A patent/HUP0200721A3/hu unknown
- 2001-02-02 EP EP01905434A patent/EP1165551B1/en not_active Expired - Lifetime
- 2001-02-02 IL IL145640A patent/IL145640A/en not_active IP Right Cessation
- 2001-10-01 ZA ZA200108053A patent/ZA200108053B/en unknown
- 2001-10-01 NO NO20014760A patent/NO20014760L/no not_active Application Discontinuation
-
2003
- 2003-07-11 US US10/618,063 patent/US6906088B2/en not_active Expired - Fee Related
-
2005
- 2005-02-28 US US11/067,882 patent/US7230013B2/en not_active Expired - Fee Related
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