JP2003522173A - 抗腫瘍剤としてのｃ１０カルバモイルオキシ置換タキサン - Google Patents
抗腫瘍剤としてのｃ１０カルバモイルオキシ置換タキサンInfo
- Publication number
- JP2003522173A JP2003522173A JP2001557865A JP2001557865A JP2003522173A JP 2003522173 A JP2003522173 A JP 2003522173A JP 2001557865 A JP2001557865 A JP 2001557865A JP 2001557865 A JP2001557865 A JP 2001557865A JP 2003522173 A JP2003522173 A JP 2003522173A
- Authority
- JP
- Japan
- Prior art keywords
- pyridyl
- thienyl
- furyl
- taxane
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17979300P | 2000-02-02 | 2000-02-02 | |
| US60/179,793 | 2000-02-02 | ||
| PCT/US2001/003633 WO2001057033A1 (en) | 2000-02-02 | 2001-02-02 | C10 carbamoyloxy substituted taxanes as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003522173A true JP2003522173A (ja) | 2003-07-22 |
| JP2003522173A5 JP2003522173A5 (enExample) | 2007-04-12 |
Family
ID=22658023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001557865A Withdrawn JP2003522173A (ja) | 2000-02-02 | 2001-02-02 | 抗腫瘍剤としてのｃ１０カルバモイルオキシ置換タキサン |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6596737B2 (enExample) |
| EP (1) | EP1165551B1 (enExample) |
| JP (1) | JP2003522173A (enExample) |
| KR (1) | KR20020000159A (enExample) |
| CN (1) | CN1362959A (enExample) |
| AT (1) | ATE401325T1 (enExample) |
| AU (1) | AU783422B2 (enExample) |
| BR (1) | BR0104352A (enExample) |
| CA (1) | CA2368541A1 (enExample) |
| CZ (1) | CZ20013520A3 (enExample) |
| DE (1) | DE60134814D1 (enExample) |
| HK (1) | HK1047936A1 (enExample) |
| HU (1) | HUP0200721A3 (enExample) |
| IL (1) | IL145640A (enExample) |
| MX (1) | MXPA01009921A (enExample) |
| NO (1) | NO20014760L (enExample) |
| NZ (1) | NZ514407A (enExample) |
| PL (1) | PL350331A1 (enExample) |
| WO (1) | WO2001057033A1 (enExample) |
| ZA (1) | ZA200108053B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL350075A1 (en) * | 2000-02-02 | 2002-11-04 | Univ Florida State Res Found | Taxane formulations having improved solubility |
| MXPA01009921A (es) * | 2000-02-02 | 2003-08-01 | Univ Florida State Res Found | Taxanos sustituidos como carbamoiloxilo en c10 como agentes antitumorales. |
| CN1712399B (zh) * | 2004-06-24 | 2010-08-11 | 中国医学科学院药物研究所 | 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途 |
| EP3252128B1 (en) * | 2006-04-03 | 2019-01-02 | Pharmatherm Chemicals Inc. | Thermal extraction method for producing a taxane extract |
| WO2011147330A1 (zh) | 2010-05-27 | 2011-12-01 | 中国医学科学院药物研究所 | 双功能共缀物的化学合成及抗肿瘤与抗肿瘤转移作用 |
| JP6959096B2 (ja) * | 2017-10-13 | 2021-11-02 | エイブリック株式会社 | 充放電制御回路及びこれを備えたバッテリ装置 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| ES2230790T3 (es) | 1992-01-15 | 2005-05-01 | E.R. SQUIBB & SONS, INC. | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos. |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| FR2691460B1 (fr) | 1992-05-21 | 1994-07-22 | Rhone Poulenc Rorer Sa | Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent. |
| CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| DE69424166T2 (de) | 1993-06-11 | 2000-10-05 | Pharmacia & Upjohn Co., Kalamazoo | Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US6100411A (en) * | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| WO1996013495A1 (en) * | 1994-10-28 | 1996-05-09 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| FR2732342B1 (fr) | 1995-04-03 | 1997-04-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2732968B1 (fr) | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| IL126856A0 (en) | 1996-05-06 | 1999-09-22 | Univ Florida State | 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| BR9710366A (pt) | 1996-07-15 | 1999-08-17 | Yakult Honsha Kk | Derivados de taxane e drogas que os contêm |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| JPH1192468A (ja) | 1997-09-17 | 1999-04-06 | Yakult Honsha Co Ltd | 新規なタキサン誘導体 |
| EP1044971A4 (en) * | 1997-12-19 | 2001-11-07 | Yakult Honsha Kk | TAXAN DERIVATIVES |
| JP2003026673A (ja) * | 1999-03-05 | 2003-01-29 | Asahi Kasei Corp | 骨形成促進剤 |
| PL350075A1 (en) * | 2000-02-02 | 2002-11-04 | Univ Florida State Res Found | Taxane formulations having improved solubility |
| MXPA01009921A (es) * | 2000-02-02 | 2003-08-01 | Univ Florida State Res Found | Taxanos sustituidos como carbamoiloxilo en c10 como agentes antitumorales. |
| EP1175414A1 (en) | 2000-02-02 | 2002-01-30 | Florida State University Research Foundation, Inc. | Taxane formulations having improved solubility |
| GB2370649B (en) * | 2000-11-09 | 2003-06-25 | Toppan Printing Co Ltd | Measurement of rate of transmission of a vapour through a sample |
-
2001
- 2001-02-02 MX MXPA01009921A patent/MXPA01009921A/es active IP Right Grant
- 2001-02-02 AT AT01905434T patent/ATE401325T1/de not_active IP Right Cessation
- 2001-02-02 NZ NZ51440701A patent/NZ514407A/xx unknown
- 2001-02-02 JP JP2001557865A patent/JP2003522173A/ja not_active Withdrawn
- 2001-02-02 KR KR1020017012573A patent/KR20020000159A/ko not_active Abandoned
- 2001-02-02 BR BR0104352-8A patent/BR0104352A/pt not_active IP Right Cessation
- 2001-02-02 AU AU33313/01A patent/AU783422B2/en not_active Ceased
- 2001-02-02 CZ CZ20013520A patent/CZ20013520A3/cs unknown
- 2001-02-02 CN CN01800317A patent/CN1362959A/zh active Pending
- 2001-02-02 PL PL01350331A patent/PL350331A1/xx not_active Application Discontinuation
- 2001-02-02 US US09/775,852 patent/US6596737B2/en not_active Expired - Fee Related
- 2001-02-02 CA CA002368541A patent/CA2368541A1/en not_active Withdrawn
- 2001-02-02 DE DE60134814T patent/DE60134814D1/de not_active Expired - Fee Related
- 2001-02-02 WO PCT/US2001/003633 patent/WO2001057033A1/en not_active Ceased
- 2001-02-02 HK HK03100170.9A patent/HK1047936A1/zh unknown
- 2001-02-02 HU HU0200721A patent/HUP0200721A3/hu unknown
- 2001-02-02 EP EP01905434A patent/EP1165551B1/en not_active Expired - Lifetime
- 2001-02-02 IL IL145640A patent/IL145640A/en not_active IP Right Cessation
- 2001-10-01 ZA ZA200108053A patent/ZA200108053B/en unknown
- 2001-10-01 NO NO20014760A patent/NO20014760L/no not_active Application Discontinuation
-
2003
- 2003-07-11 US US10/618,063 patent/US6906088B2/en not_active Expired - Fee Related
-
2005
- 2005-02-28 US US11/067,882 patent/US7230013B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL145640A0 (en) | 2002-06-30 |
| ZA200108053B (en) | 2003-12-01 |
| IL145640A (en) | 2007-02-11 |
| WO2001057033A1 (en) | 2001-08-09 |
| US6596737B2 (en) | 2003-07-22 |
| US7230013B2 (en) | 2007-06-12 |
| BR0104352A (pt) | 2002-01-02 |
| NZ514407A (en) | 2004-12-24 |
| HUP0200721A2 (hu) | 2002-07-29 |
| EP1165551A1 (en) | 2002-01-02 |
| US6906088B2 (en) | 2005-06-14 |
| DE60134814D1 (de) | 2008-08-28 |
| NO20014760D0 (no) | 2001-10-01 |
| NO20014760L (no) | 2001-11-30 |
| HK1047936A1 (zh) | 2003-03-14 |
| PL350331A1 (en) | 2002-12-02 |
| KR20020000159A (ko) | 2002-01-04 |
| EP1165551B1 (en) | 2008-07-16 |
| US20050182098A1 (en) | 2005-08-18 |
| US20040034230A1 (en) | 2004-02-19 |
| US20020077341A1 (en) | 2002-06-20 |
| AU3331301A (en) | 2001-08-14 |
| CN1362959A (zh) | 2002-08-07 |
| CA2368541A1 (en) | 2001-08-09 |
| AU783422B2 (en) | 2005-10-27 |
| HUP0200721A3 (en) | 2005-02-28 |
| MXPA01009921A (es) | 2003-08-01 |
| ATE401325T1 (de) | 2008-08-15 |
| CZ20013520A3 (cs) | 2002-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070116 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070116 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20080110 |