AU783422B2 - C10 carbamoyloxy substituted taxanes as antitumor agents - Google Patents

C10 carbamoyloxy substituted taxanes as antitumor agents Download PDF

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Publication number
AU783422B2
AU783422B2 AU33313/01A AU3331301A AU783422B2 AU 783422 B2 AU783422 B2 AU 783422B2 AU 33313/01 A AU33313/01 A AU 33313/01A AU 3331301 A AU3331301 A AU 3331301A AU 783422 B2 AU783422 B2 AU 783422B2
Authority
AU
Australia
Prior art keywords
substituted
taxane
phenyl
pyridyl
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU33313/01A
Other languages
English (en)
Other versions
AU3331301A (en
Inventor
Weishuo Fang
Robert A. Holton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University Research Foundation Inc
Original Assignee
Florida State University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University Research Foundation Inc filed Critical Florida State University Research Foundation Inc
Publication of AU3331301A publication Critical patent/AU3331301A/en
Application granted granted Critical
Publication of AU783422B2 publication Critical patent/AU783422B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
AU33313/01A 2000-02-02 2001-02-02 C10 carbamoyloxy substituted taxanes as antitumor agents Ceased AU783422B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17979300P 2000-02-02 2000-02-02
US60/179793 2000-02-02
PCT/US2001/003633 WO2001057033A1 (en) 2000-02-02 2001-02-02 C10 carbamoyloxy substituted taxanes as antitumor agents

Publications (2)

Publication Number Publication Date
AU3331301A AU3331301A (en) 2001-08-14
AU783422B2 true AU783422B2 (en) 2005-10-27

Family

ID=22658023

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33313/01A Ceased AU783422B2 (en) 2000-02-02 2001-02-02 C10 carbamoyloxy substituted taxanes as antitumor agents

Country Status (20)

Country Link
US (3) US6596737B2 (enExample)
EP (1) EP1165551B1 (enExample)
JP (1) JP2003522173A (enExample)
KR (1) KR20020000159A (enExample)
CN (1) CN1362959A (enExample)
AT (1) ATE401325T1 (enExample)
AU (1) AU783422B2 (enExample)
BR (1) BR0104352A (enExample)
CA (1) CA2368541A1 (enExample)
CZ (1) CZ20013520A3 (enExample)
DE (1) DE60134814D1 (enExample)
HK (1) HK1047936A1 (enExample)
HU (1) HUP0200721A3 (enExample)
IL (1) IL145640A (enExample)
MX (1) MXPA01009921A (enExample)
NO (1) NO20014760L (enExample)
NZ (1) NZ514407A (enExample)
PL (1) PL350331A1 (enExample)
WO (1) WO2001057033A1 (enExample)
ZA (1) ZA200108053B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL350075A1 (en) * 2000-02-02 2002-11-04 Univ Florida State Res Found Taxane formulations having improved solubility
MXPA01009921A (es) * 2000-02-02 2003-08-01 Univ Florida State Res Found Taxanos sustituidos como carbamoiloxilo en c10 como agentes antitumorales.
CN1712399B (zh) * 2004-06-24 2010-08-11 中国医学科学院药物研究所 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途
EP3252128B1 (en) * 2006-04-03 2019-01-02 Pharmatherm Chemicals Inc. Thermal extraction method for producing a taxane extract
WO2011147330A1 (zh) 2010-05-27 2011-12-01 中国医学科学院药物研究所 双功能共缀物的化学合成及抗肿瘤与抗肿瘤转移作用
JP6959096B2 (ja) * 2017-10-13 2021-11-02 エイブリック株式会社 充放電制御回路及びこれを備えたバッテリ装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0524093A1 (fr) * 1991-07-16 1993-01-20 Aventis Pharma S.A. Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent
WO1996013495A1 (en) * 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
WO1997032578A1 (en) * 1996-03-04 1997-09-12 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
ES2230790T3 (es) 1992-01-15 2005-05-01 E.R. SQUIBB & SONS, INC. Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos.
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
FR2691460B1 (fr) 1992-05-21 1994-07-22 Rhone Poulenc Rorer Sa Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent.
CA2109861C (en) 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
DE69424166T2 (de) 1993-06-11 2000-10-05 Pharmacia & Upjohn Co., Kalamazoo Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
FR2732342B1 (fr) 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732968B1 (fr) 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
CA2231837A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
IL126856A0 (en) 1996-05-06 1999-09-22 Univ Florida State 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
BR9710366A (pt) 1996-07-15 1999-08-17 Yakult Honsha Kk Derivados de taxane e drogas que os contêm
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
JPH1192468A (ja) 1997-09-17 1999-04-06 Yakult Honsha Co Ltd 新規なタキサン誘導体
EP1044971A4 (en) * 1997-12-19 2001-11-07 Yakult Honsha Kk TAXAN DERIVATIVES
JP2003026673A (ja) * 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
PL350075A1 (en) * 2000-02-02 2002-11-04 Univ Florida State Res Found Taxane formulations having improved solubility
MXPA01009921A (es) * 2000-02-02 2003-08-01 Univ Florida State Res Found Taxanos sustituidos como carbamoiloxilo en c10 como agentes antitumorales.
EP1175414A1 (en) 2000-02-02 2002-01-30 Florida State University Research Foundation, Inc. Taxane formulations having improved solubility
GB2370649B (en) * 2000-11-09 2003-06-25 Toppan Printing Co Ltd Measurement of rate of transmission of a vapour through a sample

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0524093A1 (fr) * 1991-07-16 1993-01-20 Aventis Pharma S.A. Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent
WO1996013495A1 (en) * 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
WO1997032578A1 (en) * 1996-03-04 1997-09-12 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
IL145640A0 (en) 2002-06-30
ZA200108053B (en) 2003-12-01
IL145640A (en) 2007-02-11
WO2001057033A1 (en) 2001-08-09
US6596737B2 (en) 2003-07-22
US7230013B2 (en) 2007-06-12
BR0104352A (pt) 2002-01-02
NZ514407A (en) 2004-12-24
HUP0200721A2 (hu) 2002-07-29
EP1165551A1 (en) 2002-01-02
US6906088B2 (en) 2005-06-14
DE60134814D1 (de) 2008-08-28
NO20014760D0 (no) 2001-10-01
NO20014760L (no) 2001-11-30
HK1047936A1 (zh) 2003-03-14
PL350331A1 (en) 2002-12-02
KR20020000159A (ko) 2002-01-04
EP1165551B1 (en) 2008-07-16
US20050182098A1 (en) 2005-08-18
US20040034230A1 (en) 2004-02-19
US20020077341A1 (en) 2002-06-20
AU3331301A (en) 2001-08-14
CN1362959A (zh) 2002-08-07
CA2368541A1 (en) 2001-08-09
HUP0200721A3 (en) 2005-02-28
JP2003522173A (ja) 2003-07-22
MXPA01009921A (es) 2003-08-01
ATE401325T1 (de) 2008-08-15
CZ20013520A3 (cs) 2002-03-13

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