PL350331A1 - C10 carbamoyloxy substituted taxanes as antitumor agents - Google Patents
C10 carbamoyloxy substituted taxanes as antitumor agentsInfo
- Publication number
- PL350331A1 PL350331A1 PL01350331A PL35033101A PL350331A1 PL 350331 A1 PL350331 A1 PL 350331A1 PL 01350331 A PL01350331 A PL 01350331A PL 35033101 A PL35033101 A PL 35033101A PL 350331 A1 PL350331 A1 PL 350331A1
- Authority
- PL
- Poland
- Prior art keywords
- antitumor agents
- substituted taxanes
- carbamoyloxy substituted
- carbamoyloxy
- taxanes
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title abstract 2
- -1 carbamoyloxy Chemical group 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17979300P | 2000-02-02 | 2000-02-02 | |
| PCT/US2001/003633 WO2001057033A1 (en) | 2000-02-02 | 2001-02-02 | C10 carbamoyloxy substituted taxanes as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL350331A1 true PL350331A1 (en) | 2002-12-02 |
Family
ID=22658023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL01350331A PL350331A1 (en) | 2000-02-02 | 2001-02-02 | C10 carbamoyloxy substituted taxanes as antitumor agents |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6596737B2 (enExample) |
| EP (1) | EP1165551B1 (enExample) |
| JP (1) | JP2003522173A (enExample) |
| KR (1) | KR20020000159A (enExample) |
| CN (1) | CN1362959A (enExample) |
| AT (1) | ATE401325T1 (enExample) |
| AU (1) | AU783422B2 (enExample) |
| BR (1) | BR0104352A (enExample) |
| CA (1) | CA2368541A1 (enExample) |
| CZ (1) | CZ20013520A3 (enExample) |
| DE (1) | DE60134814D1 (enExample) |
| HK (1) | HK1047936A1 (enExample) |
| HU (1) | HUP0200721A3 (enExample) |
| IL (1) | IL145640A (enExample) |
| MX (1) | MXPA01009921A (enExample) |
| NO (1) | NO20014760L (enExample) |
| NZ (1) | NZ514407A (enExample) |
| PL (1) | PL350331A1 (enExample) |
| WO (1) | WO2001057033A1 (enExample) |
| ZA (1) | ZA200108053B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6638973B2 (en) * | 2000-02-02 | 2003-10-28 | Fsu Research Foundation, Inc. | Taxane formulations |
| NZ514407A (en) * | 2000-02-02 | 2004-12-24 | Univ Florida State Res Found | C10 carbamoyloxy substituted taxanes as antitumor agents |
| CN1712399B (zh) * | 2004-06-24 | 2010-08-11 | 中国医学科学院药物研究所 | 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途 |
| CN101460473A (zh) * | 2006-04-03 | 2009-06-17 | 药物热化学品公司 | 热提取方法和产物 |
| KR101477194B1 (ko) | 2010-05-27 | 2014-12-29 | 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 | 이중기능 복합체의 화학합성 및 항 종양과 항 종양 전이 작용 |
| JP6959096B2 (ja) * | 2017-10-13 | 2021-11-02 | エイブリック株式会社 | 充放電制御回路及びこれを備えたバッテリ装置 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| SG46582A1 (en) | 1991-09-23 | 1998-02-20 | Univ Florida State | 10-Desacetoxytaxol derivatives |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| ATE280240T1 (de) | 1992-01-15 | 2004-11-15 | Squibb & Sons Inc | Enzymatische verfahren zur aüftrennüng von enantiomeren-mischungen nützlich als zwischenprodukte zur herstellung von taxanen |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| FR2691460B1 (fr) | 1992-05-21 | 1994-07-22 | Rhone Poulenc Rorer Sa | Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent. |
| CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| DK0703909T3 (da) | 1993-06-11 | 2000-09-11 | Upjohn Co | Delta6,7-taxoler, antineoplastisk anvendelse og farmaceutiske præparater indeholdende dem |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US6100411A (en) * | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| WO1996013495A1 (en) | 1994-10-28 | 1996-05-09 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| FR2732342B1 (fr) | 1995-04-03 | 1997-04-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2732968B1 (fr) | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| EP0927175A4 (en) | 1996-05-06 | 2002-05-22 | Univ Florida State | 1-DEOXYBACCATIN III, 1-DEOXYTAXOL AND 1-DEOXYTAXOL ANALOG AND METHOD FOR THE PRODUCTION THEREOF |
| CN1097044C (zh) | 1996-07-15 | 2002-12-25 | 亚库尔特株式会社总社 | 紫杉烷衍生物以及含有该衍生物的药物 |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| JPH1192468A (ja) * | 1997-09-17 | 1999-04-06 | Yakult Honsha Co Ltd | 新規なタキサン誘導体 |
| AU758418B2 (en) * | 1997-12-19 | 2003-03-20 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives |
| JP2003026673A (ja) * | 1999-03-05 | 2003-01-29 | Asahi Kasei Corp | 骨形成促進剤 |
| US6638973B2 (en) * | 2000-02-02 | 2003-10-28 | Fsu Research Foundation, Inc. | Taxane formulations |
| NZ514407A (en) * | 2000-02-02 | 2004-12-24 | Univ Florida State Res Found | C10 carbamoyloxy substituted taxanes as antitumor agents |
| IL145635A0 (en) | 2000-02-02 | 2002-06-30 | Univ Florida State Res Found | Taxane formulations having improved solubility |
| GB2370649B (en) * | 2000-11-09 | 2003-06-25 | Toppan Printing Co Ltd | Measurement of rate of transmission of a vapour through a sample |
-
2001
- 2001-02-02 NZ NZ51440701A patent/NZ514407A/xx unknown
- 2001-02-02 BR BR0104352-8A patent/BR0104352A/pt not_active IP Right Cessation
- 2001-02-02 MX MXPA01009921A patent/MXPA01009921A/es active IP Right Grant
- 2001-02-02 CZ CZ20013520A patent/CZ20013520A3/cs unknown
- 2001-02-02 CA CA002368541A patent/CA2368541A1/en not_active Withdrawn
- 2001-02-02 HK HK03100170.9A patent/HK1047936A1/zh unknown
- 2001-02-02 PL PL01350331A patent/PL350331A1/xx not_active Application Discontinuation
- 2001-02-02 US US09/775,852 patent/US6596737B2/en not_active Expired - Fee Related
- 2001-02-02 JP JP2001557865A patent/JP2003522173A/ja not_active Withdrawn
- 2001-02-02 CN CN01800317A patent/CN1362959A/zh active Pending
- 2001-02-02 WO PCT/US2001/003633 patent/WO2001057033A1/en not_active Ceased
- 2001-02-02 DE DE60134814T patent/DE60134814D1/de not_active Expired - Fee Related
- 2001-02-02 AT AT01905434T patent/ATE401325T1/de not_active IP Right Cessation
- 2001-02-02 AU AU33313/01A patent/AU783422B2/en not_active Ceased
- 2001-02-02 IL IL145640A patent/IL145640A/en not_active IP Right Cessation
- 2001-02-02 KR KR1020017012573A patent/KR20020000159A/ko not_active Abandoned
- 2001-02-02 EP EP01905434A patent/EP1165551B1/en not_active Expired - Lifetime
- 2001-02-02 HU HU0200721A patent/HUP0200721A3/hu unknown
- 2001-10-01 NO NO20014760A patent/NO20014760L/no not_active Application Discontinuation
- 2001-10-01 ZA ZA200108053A patent/ZA200108053B/en unknown
-
2003
- 2003-07-11 US US10/618,063 patent/US6906088B2/en not_active Expired - Fee Related
-
2005
- 2005-02-28 US US11/067,882 patent/US7230013B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO20014760L (no) | 2001-11-30 |
| ATE401325T1 (de) | 2008-08-15 |
| NZ514407A (en) | 2004-12-24 |
| EP1165551B1 (en) | 2008-07-16 |
| IL145640A (en) | 2007-02-11 |
| JP2003522173A (ja) | 2003-07-22 |
| US7230013B2 (en) | 2007-06-12 |
| HUP0200721A2 (hu) | 2002-07-29 |
| AU783422B2 (en) | 2005-10-27 |
| US6596737B2 (en) | 2003-07-22 |
| HUP0200721A3 (en) | 2005-02-28 |
| CN1362959A (zh) | 2002-08-07 |
| DE60134814D1 (de) | 2008-08-28 |
| US20050182098A1 (en) | 2005-08-18 |
| HK1047936A1 (zh) | 2003-03-14 |
| EP1165551A1 (en) | 2002-01-02 |
| WO2001057033A1 (en) | 2001-08-09 |
| CA2368541A1 (en) | 2001-08-09 |
| US20040034230A1 (en) | 2004-02-19 |
| BR0104352A (pt) | 2002-01-02 |
| CZ20013520A3 (cs) | 2002-03-13 |
| ZA200108053B (en) | 2003-12-01 |
| AU3331301A (en) | 2001-08-14 |
| KR20020000159A (ko) | 2002-01-04 |
| US6906088B2 (en) | 2005-06-14 |
| MXPA01009921A (es) | 2003-08-01 |
| NO20014760D0 (no) | 2001-10-01 |
| IL145640A0 (en) | 2002-06-30 |
| US20020077341A1 (en) | 2002-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |