JP2003055360A5 - - Google Patents
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- Publication number
- JP2003055360A5 JP2003055360A5 JP2001233149A JP2001233149A JP2003055360A5 JP 2003055360 A5 JP2003055360 A5 JP 2003055360A5 JP 2001233149 A JP2001233149 A JP 2001233149A JP 2001233149 A JP2001233149 A JP 2001233149A JP 2003055360 A5 JP2003055360 A5 JP 2003055360A5
- Authority
- JP
- Japan
- Prior art keywords
- thienyl
- pyridyl
- furyl
- taxane
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940123237 Taxane Drugs 0.000 description 12
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 12
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 9
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 8
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 description 7
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 7
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 6
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
- 125000001183 hydrocarbyl group Chemical group 0.000 description 6
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 125000000304 alkynyl group Chemical group 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002354471A CA2354471A1 (en) | 2001-07-31 | 2001-07-31 | C10 ester substituted taxanes |
| JP2001233149A JP2003055360A (ja) | 2001-07-31 | 2001-08-01 | Ｃ１０エステル置換タキサン |
| EP01118728A EP1285920A1 (en) | 2001-07-31 | 2001-08-06 | C10 Ester sustituted taxanes as antitumor agents |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002354471A CA2354471A1 (en) | 2001-07-31 | 2001-07-31 | C10 ester substituted taxanes |
| JP2001233149A JP2003055360A (ja) | 2001-07-31 | 2001-08-01 | Ｃ１０エステル置換タキサン |
| EP01118728A EP1285920A1 (en) | 2001-07-31 | 2001-08-06 | C10 Ester sustituted taxanes as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003055360A JP2003055360A (ja) | 2003-02-26 |
| JP2003055360A5 true JP2003055360A5 (enExample) | 2008-09-18 |
Family
ID=27808193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001233149A Pending JP2003055360A (ja) | 2001-07-31 | 2001-08-01 | Ｃ１０エステル置換タキサン |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1285920A1 (enExample) |
| JP (1) | JP2003055360A (enExample) |
| CA (1) | CA2354471A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1810968A3 (en) * | 2003-09-25 | 2007-08-08 | Tapestry Pharmaceuticals, Inc. | 9, 10-a, a-OH-taxane analogs and methods for production thereof |
| US7745650B2 (en) | 2003-09-25 | 2010-06-29 | Tapestry Pharmaceuticals, Inc | 9,10-α,α-OH-taxane analogs and methods for production thereof |
| CN1303077C (zh) | 2004-01-16 | 2007-03-07 | 桂林晖昂生化药业有限责任公司 | 合成紫杉烷的制备工艺 |
| PE20050693A1 (es) * | 2004-02-13 | 2005-09-27 | Univ Florida State Res Found | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| CN101274924B (zh) * | 2007-03-27 | 2010-11-10 | 中国科学院大连化学物理研究所 | 一种制备紫杉醇及其衍生物的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US102404A (en) * | 1870-04-26 | Improvement in alphabetical indexes | ||
| US5250683A (en) * | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
| US5200534A (en) * | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| FR2696461B1 (fr) * | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent. |
| JPH07177879A (ja) * | 1993-07-27 | 1995-07-18 | Nippon Steel Corp | 微生物によるタキソール及びその類縁化合物の製造法 |
| US6100411A (en) * | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| JPH10508022A (ja) * | 1994-10-28 | 1998-08-04 | ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク | タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用 |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| ATE196844T1 (de) * | 1996-05-22 | 2000-10-15 | Protarga Inc | Zusammensetzungen die konjugate von cis- docosahexaenoic-säure und taxotere enthalten |
| AU710156B2 (en) * | 1996-07-15 | 1999-09-16 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives and drugs containing the same |
| JPH1192468A (ja) * | 1997-09-17 | 1999-04-06 | Yakult Honsha Co Ltd | 新規なタキサン誘導体 |
| AU758418B2 (en) * | 1997-12-19 | 2003-03-20 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives |
| JP2003026673A (ja) * | 1999-03-05 | 2003-01-29 | Asahi Kasei Corp | 骨形成促進剤 |
| US6638973B2 (en) * | 2000-02-02 | 2003-10-28 | Fsu Research Foundation, Inc. | Taxane formulations |
| BR0104354A (pt) * | 2000-02-02 | 2002-01-02 | Univ Florida State Res Found | Taxanos substituìdos com éster c10 |
| IT1319168B1 (it) * | 2000-03-17 | 2003-09-26 | Indena Spa | Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono. |
-
2001
- 2001-07-31 CA CA002354471A patent/CA2354471A1/en not_active Abandoned
- 2001-08-01 JP JP2001233149A patent/JP2003055360A/ja active Pending
- 2001-08-06 EP EP01118728A patent/EP1285920A1/en not_active Withdrawn
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