JP2003522168A5 - - Google Patents
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- Publication number
- JP2003522168A5 JP2003522168A5 JP2001557860A JP2001557860A JP2003522168A5 JP 2003522168 A5 JP2003522168 A5 JP 2003522168A5 JP 2001557860 A JP2001557860 A JP 2001557860A JP 2001557860 A JP2001557860 A JP 2001557860A JP 2003522168 A5 JP2003522168 A5 JP 2003522168A5
- Authority
- JP
- Japan
- Prior art keywords
- taxane
- furyl
- hydrogen
- coox
- thienyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940123237 Taxane Drugs 0.000 description 18
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 18
- -1 carbamoyloxy Chemical group 0.000 description 15
- 229910052739 hydrogen Inorganic materials 0.000 description 9
- 239000001257 hydrogen Substances 0.000 description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 9
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 7
- 125000000623 heterocyclic group Chemical group 0.000 description 6
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 description 5
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 description 5
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 description 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 2
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 description 2
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 241000023320 Luma <angiosperm> Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17967000P | 2000-02-02 | 2000-02-02 | |
| US60/179,670 | 2000-02-02 | ||
| PCT/US2001/003592 WO2001057028A1 (en) | 2000-02-02 | 2001-02-02 | C7 carbamoyloxy substituted taxanes as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003522168A JP2003522168A (ja) | 2003-07-22 |
| JP2003522168A5 true JP2003522168A5 (https=) | 2007-03-15 |
Family
ID=22657498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001557860A Withdrawn JP2003522168A (ja) | 2000-02-02 | 2001-02-02 | 抗腫瘍剤としてのｃ７カルバモイルオキシ置換タキサン |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US6359154B2 (https=) |
| EP (1) | EP1165549B1 (https=) |
| JP (1) | JP2003522168A (https=) |
| KR (1) | KR20020002417A (https=) |
| CN (1) | CN1362956A (https=) |
| AT (1) | ATE392422T1 (https=) |
| AU (1) | AU778991B2 (https=) |
| BR (1) | BR0104355A (https=) |
| CA (1) | CA2368510A1 (https=) |
| CZ (1) | CZ20013521A3 (https=) |
| DE (1) | DE60133600T2 (https=) |
| DK (1) | DK1165549T3 (https=) |
| ES (1) | ES2305056T3 (https=) |
| HK (1) | HK1047937A1 (https=) |
| HU (1) | HUP0200752A3 (https=) |
| IL (1) | IL145643A0 (https=) |
| MX (1) | MXPA01009923A (https=) |
| NO (1) | NO20014757L (https=) |
| NZ (1) | NZ514410A (https=) |
| PL (1) | PL350024A1 (https=) |
| PT (1) | PT1165549E (https=) |
| WO (1) | WO2001057028A1 (https=) |
| ZA (1) | ZA200108056B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1047937A1 (zh) * | 2000-02-02 | 2003-03-14 | 佛罗里达州立大学研究基金有限公司 | C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂 |
| CA2367661A1 (en) * | 2000-02-02 | 2001-08-09 | Robert A. Holton | Taxane formulations having improved solubility |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| BR0313197A (pt) | 2002-08-02 | 2005-08-09 | Immunogen Inc | Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico |
| CN110227164B (zh) | 2018-03-06 | 2021-11-23 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
| DK0552041T3 (da) | 1992-01-15 | 2000-10-09 | Squibb & Sons Inc | Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| ATE253563T1 (de) * | 1993-02-05 | 2003-11-15 | Bryn Mawr College | Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US6100411A (en) | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| EP0788493A1 (en) | 1994-10-28 | 1997-08-13 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| WO1997009979A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| AU724499B2 (en) | 1996-05-06 | 2000-09-21 | Florida State University | 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| HK1047937A1 (zh) * | 2000-02-02 | 2003-03-14 | 佛罗里达州立大学研究基金有限公司 | C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂 |
-
2001
- 2001-02-02 HK HK03100171.8A patent/HK1047937A1/zh unknown
- 2001-02-02 ES ES01905421T patent/ES2305056T3/es not_active Expired - Lifetime
- 2001-02-02 MX MXPA01009923A patent/MXPA01009923A/es active IP Right Grant
- 2001-02-02 WO PCT/US2001/003592 patent/WO2001057028A1/en not_active Ceased
- 2001-02-02 PL PL01350024A patent/PL350024A1/xx not_active Application Discontinuation
- 2001-02-02 CN CN01800316A patent/CN1362956A/zh active Pending
- 2001-02-02 KR KR1020017012622A patent/KR20020002417A/ko not_active Abandoned
- 2001-02-02 DE DE60133600T patent/DE60133600T2/de not_active Expired - Fee Related
- 2001-02-02 CZ CZ20013521A patent/CZ20013521A3/cs unknown
- 2001-02-02 CA CA002368510A patent/CA2368510A1/en not_active Withdrawn
- 2001-02-02 PT PT01905421T patent/PT1165549E/pt unknown
- 2001-02-02 US US09/776,494 patent/US6359154B2/en not_active Expired - Fee Related
- 2001-02-02 IL IL14564301A patent/IL145643A0/xx unknown
- 2001-02-02 JP JP2001557860A patent/JP2003522168A/ja not_active Withdrawn
- 2001-02-02 BR BR0104355-2A patent/BR0104355A/pt not_active IP Right Cessation
- 2001-02-02 AT AT01905421T patent/ATE392422T1/de not_active IP Right Cessation
- 2001-02-02 AU AU33302/01A patent/AU778991B2/en not_active Ceased
- 2001-02-02 DK DK01905421T patent/DK1165549T3/da active
- 2001-02-02 HU HU0200752A patent/HUP0200752A3/hu unknown
- 2001-02-02 EP EP01905421A patent/EP1165549B1/en not_active Expired - Lifetime
- 2001-02-02 NZ NZ514410A patent/NZ514410A/en unknown
- 2001-10-01 NO NO20014757A patent/NO20014757L/no not_active Application Discontinuation
- 2001-10-01 ZA ZA200108056A patent/ZA200108056B/en unknown
-
2002
- 2002-02-06 US US10/071,924 patent/US6750245B2/en not_active Expired - Fee Related
-
2004
- 2004-06-14 US US10/867,275 patent/US20050020635A1/en not_active Abandoned
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