CN1362956A - C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂 - Google Patents
C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂 Download PDFInfo
- Publication number
- CN1362956A CN1362956A CN01800316A CN01800316A CN1362956A CN 1362956 A CN1362956 A CN 1362956A CN 01800316 A CN01800316 A CN 01800316A CN 01800316 A CN01800316 A CN 01800316A CN 1362956 A CN1362956 A CN 1362956A
- Authority
- CN
- China
- Prior art keywords
- pyridyl
- furyl
- thienyl
- taxane
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17967000P | 2000-02-02 | 2000-02-02 | |
| US60/179,670 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362956A true CN1362956A (zh) | 2002-08-07 |
Family
ID=22657498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN01800316A Pending CN1362956A (zh) | 2000-02-02 | 2001-02-02 | C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US6359154B2 (https=) |
| EP (1) | EP1165549B1 (https=) |
| JP (1) | JP2003522168A (https=) |
| KR (1) | KR20020002417A (https=) |
| CN (1) | CN1362956A (https=) |
| AT (1) | ATE392422T1 (https=) |
| AU (1) | AU778991B2 (https=) |
| BR (1) | BR0104355A (https=) |
| CA (1) | CA2368510A1 (https=) |
| CZ (1) | CZ20013521A3 (https=) |
| DE (1) | DE60133600T2 (https=) |
| DK (1) | DK1165549T3 (https=) |
| ES (1) | ES2305056T3 (https=) |
| HK (1) | HK1047937A1 (https=) |
| HU (1) | HUP0200752A3 (https=) |
| IL (1) | IL145643A0 (https=) |
| MX (1) | MXPA01009923A (https=) |
| NO (1) | NO20014757L (https=) |
| NZ (1) | NZ514410A (https=) |
| PL (1) | PL350024A1 (https=) |
| PT (1) | PT1165549E (https=) |
| WO (1) | WO2001057028A1 (https=) |
| ZA (1) | ZA200108056B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019170092A1 (zh) * | 2018-03-06 | 2019-09-12 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1047937A1 (zh) * | 2000-02-02 | 2003-03-14 | 佛罗里达州立大学研究基金有限公司 | C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂 |
| CA2367661A1 (en) * | 2000-02-02 | 2001-08-09 | Robert A. Holton | Taxane formulations having improved solubility |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| BR0313197A (pt) | 2002-08-02 | 2005-08-09 | Immunogen Inc | Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
| DK0552041T3 (da) | 1992-01-15 | 2000-10-09 | Squibb & Sons Inc | Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| ATE253563T1 (de) * | 1993-02-05 | 2003-11-15 | Bryn Mawr College | Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US6100411A (en) | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| EP0788493A1 (en) | 1994-10-28 | 1997-08-13 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| WO1997009979A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| AU724499B2 (en) | 1996-05-06 | 2000-09-21 | Florida State University | 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| HK1047937A1 (zh) * | 2000-02-02 | 2003-03-14 | 佛罗里达州立大学研究基金有限公司 | C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂 |
-
2001
- 2001-02-02 HK HK03100171.8A patent/HK1047937A1/zh unknown
- 2001-02-02 ES ES01905421T patent/ES2305056T3/es not_active Expired - Lifetime
- 2001-02-02 MX MXPA01009923A patent/MXPA01009923A/es active IP Right Grant
- 2001-02-02 WO PCT/US2001/003592 patent/WO2001057028A1/en not_active Ceased
- 2001-02-02 PL PL01350024A patent/PL350024A1/xx not_active Application Discontinuation
- 2001-02-02 CN CN01800316A patent/CN1362956A/zh active Pending
- 2001-02-02 KR KR1020017012622A patent/KR20020002417A/ko not_active Abandoned
- 2001-02-02 DE DE60133600T patent/DE60133600T2/de not_active Expired - Fee Related
- 2001-02-02 CZ CZ20013521A patent/CZ20013521A3/cs unknown
- 2001-02-02 CA CA002368510A patent/CA2368510A1/en not_active Withdrawn
- 2001-02-02 PT PT01905421T patent/PT1165549E/pt unknown
- 2001-02-02 US US09/776,494 patent/US6359154B2/en not_active Expired - Fee Related
- 2001-02-02 IL IL14564301A patent/IL145643A0/xx unknown
- 2001-02-02 JP JP2001557860A patent/JP2003522168A/ja not_active Withdrawn
- 2001-02-02 BR BR0104355-2A patent/BR0104355A/pt not_active IP Right Cessation
- 2001-02-02 AT AT01905421T patent/ATE392422T1/de not_active IP Right Cessation
- 2001-02-02 AU AU33302/01A patent/AU778991B2/en not_active Ceased
- 2001-02-02 DK DK01905421T patent/DK1165549T3/da active
- 2001-02-02 HU HU0200752A patent/HUP0200752A3/hu unknown
- 2001-02-02 EP EP01905421A patent/EP1165549B1/en not_active Expired - Lifetime
- 2001-02-02 NZ NZ514410A patent/NZ514410A/en unknown
- 2001-10-01 NO NO20014757A patent/NO20014757L/no not_active Application Discontinuation
- 2001-10-01 ZA ZA200108056A patent/ZA200108056B/en unknown
-
2002
- 2002-02-06 US US10/071,924 patent/US6750245B2/en not_active Expired - Fee Related
-
2004
- 2004-06-14 US US10/867,275 patent/US20050020635A1/en not_active Abandoned
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019170092A1 (zh) * | 2018-03-06 | 2019-09-12 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用 |
| CN110227164B (zh) * | 2018-03-06 | 2021-11-23 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用 |
| CN113952464A (zh) * | 2018-03-06 | 2022-01-21 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其应用 |
| US11833128B2 (en) | 2018-03-06 | 2023-12-05 | Jiangsu Jibeier Pharmaceutical Co. Ltd. | Ketone carbonyl-containing hydrophobic antitumor drug and conjugate thereof as well as nano preparation containing conjugate, preparation method therefor, and application thereof |
| CN113952464B (zh) * | 2018-03-06 | 2024-10-15 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2368510A1 (en) | 2001-08-09 |
| EP1165549A1 (en) | 2002-01-02 |
| DK1165549T3 (da) | 2008-08-11 |
| US6359154B2 (en) | 2002-03-19 |
| AU778991B2 (en) | 2004-12-23 |
| US20030060638A1 (en) | 2003-03-27 |
| DE60133600T2 (de) | 2009-06-10 |
| ES2305056T3 (es) | 2008-11-01 |
| BR0104355A (pt) | 2002-01-02 |
| HK1047937A1 (zh) | 2003-03-14 |
| NO20014757D0 (no) | 2001-10-01 |
| MXPA01009923A (es) | 2003-08-01 |
| EP1165549B1 (en) | 2008-04-16 |
| ZA200108056B (en) | 2003-12-01 |
| DE60133600D1 (de) | 2008-05-29 |
| JP2003522168A (ja) | 2003-07-22 |
| ATE392422T1 (de) | 2008-05-15 |
| PL350024A1 (en) | 2002-10-21 |
| US20010051640A1 (en) | 2001-12-13 |
| US20050020635A1 (en) | 2005-01-27 |
| AU3330201A (en) | 2001-08-14 |
| HUP0200752A3 (en) | 2005-02-28 |
| US6750245B2 (en) | 2004-06-15 |
| NZ514410A (en) | 2005-01-28 |
| WO2001057028A1 (en) | 2001-08-09 |
| HUP0200752A2 (en) | 2002-10-28 |
| PT1165549E (pt) | 2008-06-20 |
| KR20020002417A (ko) | 2002-01-09 |
| NO20014757L (no) | 2001-11-29 |
| CZ20013521A3 (cs) | 2002-03-13 |
| IL145643A0 (en) | 2002-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1047937 Country of ref document: HK |
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| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |