JP2006510636A5 - - Google Patents
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- Publication number
- JP2006510636A5 JP2006510636A5 JP2004557712A JP2004557712A JP2006510636A5 JP 2006510636 A5 JP2006510636 A5 JP 2006510636A5 JP 2004557712 A JP2004557712 A JP 2004557712A JP 2004557712 A JP2004557712 A JP 2004557712A JP 2006510636 A5 JP2006510636 A5 JP 2006510636A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclohexyl
- compound
- phenyl
- methyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(c(cc1)ccc1-c1cc(N([C@](CC2)CC[C@@]2O)C(C(CC2)CCC2Cl)=O)c(C(O)=O)[s]1)=O Chemical compound *C(c(cc1)ccc1-c1cc(N([C@](CC2)CC[C@@]2O)C(C(CC2)CCC2Cl)=O)c(C(O)=O)[s]1)=O 0.000 description 2
- HWYFKCSXDHOHRG-UHFFFAOYSA-N CC(CC1)CCC1C(N(C(CC1)CCC1(C)O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O Chemical compound CC(CC1)CCC1C(N(C(CC1)CCC1(C)O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O HWYFKCSXDHOHRG-UHFFFAOYSA-N 0.000 description 1
- PWKUJELUZICZFM-WYDVDPGPSA-N CC(CC1)CCC1C(N(C(CCC1)C[C@@H]1O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O Chemical compound CC(CC1)CCC1C(N(C(CCC1)C[C@@H]1O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O PWKUJELUZICZFM-WYDVDPGPSA-N 0.000 description 1
- PWKUJELUZICZFM-GXVYMARFSA-N CC(CC1)CCC1C(N(C(CCC1)C[C@H]1O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O Chemical compound CC(CC1)CCC1C(N(C(CCC1)C[C@H]1O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O PWKUJELUZICZFM-GXVYMARFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43196402P | 2002-12-10 | 2002-12-10 | |
| US60/431,964 | 2002-12-10 | ||
| PCT/CA2003/001912 WO2004052885A1 (en) | 2002-12-10 | 2003-12-09 | Compounds and methods for the treatment or prevention of flavivirus infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006510636A JP2006510636A (ja) | 2006-03-30 |
| JP2006510636A5 true JP2006510636A5 (https=) | 2006-12-14 |
| JP4926403B2 JP4926403B2 (ja) | 2012-05-09 |
Family
ID=42828817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004557712A Expired - Fee Related JP4926403B2 (ja) | 2002-12-10 | 2003-12-09 | フラビウイルス感染の処置もしくは予防のための化合物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1569929B9 (https=) |
| JP (1) | JP4926403B2 (https=) |
| AT (1) | ATE466856T1 (https=) |
| AU (1) | AU2003291885A1 (https=) |
| BR (1) | BR0316771A (https=) |
| CA (1) | CA2508990C (https=) |
| DK (1) | DK1569929T3 (https=) |
| MX (1) | MXPA05006196A (https=) |
| NZ (1) | NZ540799A (https=) |
| WO (1) | WO2004052885A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004061746A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| WO2006119646A1 (en) | 2005-05-13 | 2006-11-16 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| PE20070814A1 (es) * | 2005-12-22 | 2007-08-16 | Smithkline Beecham Corp | Compuestos derivados de 2-carboxitiofeno como inhibidores de la polimerasa del virus de la hepatitis c (hcv) |
| WO2008017688A1 (en) * | 2006-08-11 | 2008-02-14 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti-viral agents |
| WO2008043791A2 (en) * | 2006-10-13 | 2008-04-17 | Smithkline Beecham Corporation | Thiophene derivatives for treating hepatitis c |
| JP5290186B2 (ja) | 2006-11-15 | 2013-09-18 | ヴァイロケム ファーマ インコーポレイテッド | フラビウイルス感染症の治療または予防用のチオフェン類似体 |
| EP2142215B1 (en) | 2007-05-04 | 2012-03-07 | Vertex Pharmceuticals Incorporated | Combination therapy for the treatment of hcv infection |
| GB0712393D0 (en) * | 2007-06-26 | 2007-08-01 | Smithkline Beecham Corp | Compounds |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| CA2748813C (en) | 2009-01-09 | 2018-07-10 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| AU2010276441B2 (en) | 2009-07-21 | 2015-07-02 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| WO2011031669A1 (en) * | 2009-09-09 | 2011-03-17 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| EP2504329A1 (en) | 2009-11-25 | 2012-10-03 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
| MX2012008211A (es) | 2010-01-15 | 2012-08-08 | Gilead Sciences Inc | Inhibidores de virus flaviviridae. |
| US8524764B2 (en) | 2010-01-15 | 2013-09-03 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| WO2012006070A1 (en) * | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
| CA2804161A1 (en) | 2010-07-07 | 2012-01-12 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| EP2606041A2 (en) * | 2010-08-17 | 2013-06-26 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flaviviridae viral infections |
| US8771665B2 (en) | 2010-12-17 | 2014-07-08 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis C virus polymerase |
| PT2734515E (pt) | 2011-07-13 | 2016-03-11 | Gilead Sciences Inc | Derivados de ácido tiofen-2-carboxílico úteis como inibidores de vírus flaviviridae |
| AU2012286853A1 (en) | 2011-07-26 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Thiophene compounds |
| WO2014055142A1 (en) | 2012-06-20 | 2014-04-10 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| CA2882826A1 (en) | 2012-08-24 | 2014-02-27 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
| EP3068388A4 (en) | 2013-11-11 | 2017-04-12 | Board of Regents of the University of Texas System | Neuroprotective compounds and use thereof |
| TWI731854B (zh) | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | Ｃ型肝炎病毒聚合酶之抑制劑 |
| KR20210018806A (ko) | 2018-05-09 | 2021-02-18 | 코크리스탈 파마, 아이엔씨. | Hcv의 치료를 위한 병용 요법 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995005170A1 (en) * | 1993-08-13 | 1995-02-23 | Warner-Lambert Company | Methods of inhibiting hiv and inhibiting the activation of hiv |
| US5734081A (en) * | 1994-08-05 | 1998-03-31 | Warner-Lambert Company | Arylthio compounds |
| WO2001012189A1 (en) * | 1999-08-12 | 2001-02-22 | Pharmacia Italia S.P.A. | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| US20030096737A1 (en) * | 2001-04-19 | 2003-05-22 | Anita Diu-Hercend | Caspase inhibitors and uses thereof |
| US6881741B2 (en) * | 2001-06-11 | 2005-04-19 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
| WO2002100846A1 (en) * | 2001-06-11 | 2002-12-19 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
-
2003
- 2003-12-09 MX MXPA05006196A patent/MXPA05006196A/es active IP Right Grant
- 2003-12-09 EP EP03767343A patent/EP1569929B9/en not_active Expired - Lifetime
- 2003-12-09 JP JP2004557712A patent/JP4926403B2/ja not_active Expired - Fee Related
- 2003-12-09 BR BR0316771-2A patent/BR0316771A/pt not_active IP Right Cessation
- 2003-12-09 DK DK03767343.1T patent/DK1569929T3/da active
- 2003-12-09 CA CA2508990A patent/CA2508990C/en not_active Expired - Fee Related
- 2003-12-09 WO PCT/CA2003/001912 patent/WO2004052885A1/en not_active Ceased
- 2003-12-09 AT AT03767343T patent/ATE466856T1/de active
- 2003-12-09 NZ NZ540799A patent/NZ540799A/en not_active IP Right Cessation
- 2003-12-09 AU AU2003291885A patent/AU2003291885A1/en not_active Abandoned
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