JP2006510636A5 - - Google Patents
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- Publication number
- JP2006510636A5 JP2006510636A5 JP2004557712A JP2004557712A JP2006510636A5 JP 2006510636 A5 JP2006510636 A5 JP 2006510636A5 JP 2004557712 A JP2004557712 A JP 2004557712A JP 2004557712 A JP2004557712 A JP 2004557712A JP 2006510636 A5 JP2006510636 A5 JP 2006510636A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclohexyl
- compound
- phenyl
- methyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(c(cc1)ccc1-c1cc(N([C@](CC2)CC[C@@]2O)C(C(CC2)CCC2Cl)=O)c(C(O)=O)[s]1)=O Chemical compound *C(c(cc1)ccc1-c1cc(N([C@](CC2)CC[C@@]2O)C(C(CC2)CCC2Cl)=O)c(C(O)=O)[s]1)=O 0.000 description 2
- HWYFKCSXDHOHRG-UHFFFAOYSA-N CC(CC1)CCC1C(N(C(CC1)CCC1(C)O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O Chemical compound CC(CC1)CCC1C(N(C(CC1)CCC1(C)O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O HWYFKCSXDHOHRG-UHFFFAOYSA-N 0.000 description 1
- PWKUJELUZICZFM-WYDVDPGPSA-N CC(CC1)CCC1C(N(C(CCC1)C[C@@H]1O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O Chemical compound CC(CC1)CCC1C(N(C(CCC1)C[C@@H]1O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O PWKUJELUZICZFM-WYDVDPGPSA-N 0.000 description 1
- PWKUJELUZICZFM-GXVYMARFSA-N CC(CC1)CCC1C(N(C(CCC1)C[C@H]1O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O Chemical compound CC(CC1)CCC1C(N(C(CCC1)C[C@H]1O)c1c(C(O)=O)[s]c(-c2ccccc2)c1)=O PWKUJELUZICZFM-GXVYMARFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43196402P | 2002-12-10 | 2002-12-10 | |
| US60/431,964 | 2002-12-10 | ||
| PCT/CA2003/001912 WO2004052885A1 (en) | 2002-12-10 | 2003-12-09 | Compounds and methods for the treatment or prevention of flavivirus infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006510636A JP2006510636A (ja) | 2006-03-30 |
| JP2006510636A5 true JP2006510636A5 (https=) | 2006-12-14 |
| JP4926403B2 JP4926403B2 (ja) | 2012-05-09 |
Family
ID=42828817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004557712A Expired - Fee Related JP4926403B2 (ja) | 2002-12-10 | 2003-12-09 | フラビウイルス感染の処置もしくは予防のための化合物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1569929B9 (https=) |
| JP (1) | JP4926403B2 (https=) |
| AT (1) | ATE466856T1 (https=) |
| AU (1) | AU2003291885A1 (https=) |
| BR (1) | BR0316771A (https=) |
| CA (1) | CA2508990C (https=) |
| DK (1) | DK1569929T3 (https=) |
| MX (1) | MXPA05006196A (https=) |
| NZ (1) | NZ540799A (https=) |
| WO (1) | WO2004052885A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004061746A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| BRPI0610283A2 (pt) | 2005-05-13 | 2010-10-19 | Virochem Pharma Inc | composto, uso do mesmo na preparação de um medicamento para o tratamento ou prevenção de uma infecção por vìrus de hepatite c, composição farmacêutica e combinação farmacêutica |
| PE20070814A1 (es) * | 2005-12-22 | 2007-08-16 | Smithkline Beecham Corp | Compuestos derivados de 2-carboxitiofeno como inhibidores de la polimerasa del virus de la hepatitis c (hcv) |
| WO2008017688A1 (en) * | 2006-08-11 | 2008-02-14 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti-viral agents |
| WO2008043791A2 (en) * | 2006-10-13 | 2008-04-17 | Smithkline Beecham Corporation | Thiophene derivatives for treating hepatitis c |
| CA2670260A1 (en) * | 2006-11-15 | 2008-05-22 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of flavivirus infections |
| ES2381410T3 (es) | 2007-05-04 | 2012-05-28 | Vertex Pharmceuticals Incorporated | Terapia de combinación paa el tratamiento de infecciones por VHC |
| GB0712393D0 (en) * | 2007-06-26 | 2007-08-01 | Smithkline Beecham Corp | Compounds |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9095572B2 (en) | 2009-01-09 | 2015-08-04 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| EP2385829B1 (en) | 2009-01-09 | 2018-08-01 | Board of Regents of the University of Texas System | Pro-neurogenic compounds |
| WO2011011303A1 (en) | 2009-07-21 | 2011-01-27 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| ES2559437T3 (es) * | 2009-09-09 | 2016-02-12 | Gilead Sciences, Inc. | Inhibidores de virus de la familia Flaviviridae |
| JP2013512247A (ja) * | 2009-11-25 | 2013-04-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染症の治療または予防のための５−アルキニル−チオフェン−２−カルボン酸誘導体およびそれらの使用 |
| AP3576A (en) | 2010-01-15 | 2016-02-08 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
| CA2785563C (en) | 2010-01-15 | 2019-05-14 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| WO2012006070A1 (en) * | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
| AU2011292040A1 (en) * | 2010-08-17 | 2013-03-07 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of Flaviviridae viral infections |
| EP2651906A4 (en) | 2010-12-17 | 2014-06-25 | Cocrystal Discovery Inc | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE |
| AU2012280959B2 (en) * | 2011-07-13 | 2015-08-06 | Gilead Sciences, Inc. | Thiophen-2-carboxylic acid derivatives useful as inhibitors of Flaviviridae viruses |
| WO2013016492A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Thiophene compounds |
| WO2014055142A1 (en) | 2012-06-20 | 2014-04-10 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| AU2013305591B2 (en) | 2012-08-24 | 2017-04-13 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
| WO2015070234A2 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective compounds and use thereof |
| TWI731854B (zh) | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | Ｃ型肝炎病毒聚合酶之抑制劑 |
| MX2020011912A (es) | 2018-05-09 | 2021-01-29 | Cocrystal Pharma Inc | Terapia de combinacion para el tratamiento del virus de la hepatitis c (vhc). |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995005170A1 (en) * | 1993-08-13 | 1995-02-23 | Warner-Lambert Company | Methods of inhibiting hiv and inhibiting the activation of hiv |
| US5734081A (en) * | 1994-08-05 | 1998-03-31 | Warner-Lambert Company | Arylthio compounds |
| KR20020060160A (ko) * | 1999-08-12 | 2002-07-16 | 파마시아 이탈리아 에스.피.에이. | 3(5)-아미노-피라졸 유도체, 이의 제조 방법 및항종양제로서의 이의 용도 |
| US20030096737A1 (en) * | 2001-04-19 | 2003-05-22 | Anita Diu-Hercend | Caspase inhibitors and uses thereof |
| US6887877B2 (en) * | 2001-06-11 | 2005-05-03 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
| CN101624391A (zh) * | 2001-06-11 | 2010-01-13 | 病毒化学医药公司 | 用作黄病毒感染抗病毒剂的噻吩衍生物 |
-
2003
- 2003-12-09 JP JP2004557712A patent/JP4926403B2/ja not_active Expired - Fee Related
- 2003-12-09 EP EP03767343A patent/EP1569929B9/en not_active Expired - Lifetime
- 2003-12-09 AU AU2003291885A patent/AU2003291885A1/en not_active Abandoned
- 2003-12-09 WO PCT/CA2003/001912 patent/WO2004052885A1/en not_active Ceased
- 2003-12-09 DK DK03767343.1T patent/DK1569929T3/da active
- 2003-12-09 MX MXPA05006196A patent/MXPA05006196A/es active IP Right Grant
- 2003-12-09 AT AT03767343T patent/ATE466856T1/de active
- 2003-12-09 CA CA2508990A patent/CA2508990C/en not_active Expired - Fee Related
- 2003-12-09 NZ NZ540799A patent/NZ540799A/en not_active IP Right Cessation
- 2003-12-09 BR BR0316771-2A patent/BR0316771A/pt not_active IP Right Cessation
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