JP2003521528A - 食事補強剤、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製に使用する物質 - Google Patents

食事補強剤、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製に使用する物質

Info

Publication number
JP2003521528A
JP2003521528A JP2001556812A JP2001556812A JP2003521528A JP 2003521528 A JP2003521528 A JP 2003521528A JP 2001556812 A JP2001556812 A JP 2001556812A JP 2001556812 A JP2001556812 A JP 2001556812A JP 2003521528 A JP2003521528 A JP 2003521528A
Authority
JP
Japan
Prior art keywords
stevioside
substance
rebaudioside
insulin
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001556812A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003521528A5 (https=
Inventor
ハーマンセン，ケルダ
グレガーセン，セレン
イェッペセン，パー，ベンディクス
Original Assignee
ステヴィア，エイプス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ステヴィア，エイプス filed Critical ステヴィア，エイプス
Publication of JP2003521528A publication Critical patent/JP2003521528A/ja
Publication of JP2003521528A5 publication Critical patent/JP2003521528A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/62—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings
    • C07C13/66—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings the condensed ring system contains only four rings
    • C07C13/68—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings the condensed ring system contains only four rings with a bridged ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/86—Ring systems containing bridged rings containing four rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2001556812A 2000-02-01 2001-02-01 食事補強剤、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製に使用する物質 Withdrawn JP2003521528A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK200000163 2000-02-01
DKPA200000163 2000-02-01
PCT/DK2001/000075 WO2001056959A1 (en) 2000-02-01 2001-02-01 A substance for the use in a dietary supplementation or for the preparation of a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012112329A Division JP2012153721A (ja) 2000-02-01 2012-05-16 食事補強剤に使用するための、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製のための、物質

Publications (2)

Publication Number Publication Date
JP2003521528A true JP2003521528A (ja) 2003-07-15
JP2003521528A5 JP2003521528A5 (https=) 2009-06-25

Family

ID=8159060

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001556812A Withdrawn JP2003521528A (ja) 2000-02-01 2001-02-01 食事補強剤、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製に使用する物質
JP2012112329A Pending JP2012153721A (ja) 2000-02-01 2012-05-16 食事補強剤に使用するための、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製のための、物質

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012112329A Pending JP2012153721A (ja) 2000-02-01 2012-05-16 食事補強剤に使用するための、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製のための、物質

Country Status (8)

Country Link
US (5) US20030060428A1 (https=)
EP (2) EP1255718A1 (https=)
JP (2) JP2003521528A (https=)
CN (1) CN100475757C (https=)
AU (1) AU784422B2 (https=)
BR (1) BR0108043A (https=)
CA (2) CA2398445C (https=)
WO (1) WO2001056959A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505344A (ja) * 2007-12-03 2011-02-24 ディーエスエム アイピー アセッツ ビー．ブイ． ステビア抽出物またはステビア抽出物構成物質を含有する新規な栄養補給食品組成物およびその使用
WO2017018404A1 (ja) * 2015-07-27 2017-02-02 サントリーホールディングス株式会社 環状ジペプチド及び甘味料を含有する組成物
JP2019504819A (ja) * 2015-09-10 2019-02-21 キー ファーマ バイオメディカル インクＫｅｙ−Ｐｈａｒｍａ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃ． 心臓肥大および肺高血圧の治療用医薬の製造におけるカウラン化合物の使用
WO2020218382A1 (ja) * 2019-04-26 2020-10-29 サントリーホールディングス株式会社 Ｇｌｐ－１分泌促進剤
US11382911B2 (en) 2013-06-10 2022-07-12 Suntory Holdings Limited Plant extract containing diketopiperazine and method for producing same

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003521528A (ja) 2000-02-01 2003-07-15 ステヴィア，エイプス 食事補強剤、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製に使用する物質
BRPI0412189A (pt) * 2003-06-30 2006-08-22 Nestec Sa composição para tratar e/ou prevenir disfunções associadas à diabetes melito do tipo 2
AT502270B1 (de) * 2005-02-21 2007-07-15 Emakos Naturnahe Nahrungsmitte Verfahren zum modifizieren von steviosid durch austauschreaktionen
US8956677B2 (en) * 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with glucosamine and compositions sweetened therewith
KR20080071606A (ko) * 2005-11-23 2008-08-04 더 코카콜라 컴파니 시간 특성 및/또는 향미 특성이 개선된 인공 감미료조성물과 이들의 제제 방법 및 용도
US9144251B2 (en) * 2005-11-23 2015-09-29 The Coca-Cola Company High-potency sweetener composition with mineral and compositions sweetened therewith
AU2006318781B2 (en) * 2005-11-23 2012-11-01 The Coca-Cola Company Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
US8940350B2 (en) * 2005-11-23 2015-01-27 The Coca-Cola Company Cereal compositions comprising high-potency sweeteners
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20070116831A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company Dental Composition with High-Potency Sweetener
US8524304B2 (en) * 2005-11-23 2013-09-03 The Coca-Cola Company High-potency sweetener composition with probiotics/prebiotics and compositions sweetened therewith
US8956678B2 (en) * 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with preservative and compositions sweetened therewith
US8993027B2 (en) * 2005-11-23 2015-03-31 The Coca-Cola Company Natural high-potency tabletop sweetener compositions with improved temporal and/or flavor profile, methods for their formulation, and uses
US8524303B2 (en) * 2005-11-23 2013-09-03 The Coca-Cola Company High-potency sweetener composition with phytosterol and compositions sweetened therewith
US20070134391A1 (en) * 2005-11-23 2007-06-14 The Coca-Cola Company High-Potency Sweetener Composition for Treatment and/or Prevention of Autoimmune Disorders and Compositions Sweetened Therewith
US8940351B2 (en) * 2005-11-23 2015-01-27 The Coca-Cola Company Baked goods comprising high-potency sweetener
US8435588B2 (en) * 2005-11-23 2013-05-07 The Coca-Cola Company High-potency sweetener composition with an anti-inflammatory agent and compositions sweetened therewith
US20070116836A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition for Treatment and/or Prevention of Osteoporosis and Compositions Sweetened Therewith
US8367138B2 (en) * 2005-11-23 2013-02-05 The Coca-Cola Company Dairy composition with high-potency sweetener
US20070116822A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-potency sweetener composition with saponin and compositions sweetened therewith
EP2380566A3 (en) * 2006-09-15 2012-04-11 Stevia APS Treatment of insulin resistance or diseases associated with insulin resistance using steviol or isosteviol
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US9101161B2 (en) * 2006-11-02 2015-08-11 The Coca-Cola Company High-potency sweetener composition with phytoestrogen and compositions sweetened therewith
US20080107787A1 (en) * 2006-11-02 2008-05-08 The Coca-Cola Company Anti-Diabetic Composition with High-Potency Sweetener
EP2155769B1 (en) 2007-05-04 2012-06-27 Katholieke Universiteit Leuven KU Leuven Research & Development Tissue degeneration protection
WO2009071099A1 (en) * 2007-12-05 2009-06-11 Aarhus Universitet Elevation of the plasma hdl-cholesterol level
US8759405B2 (en) * 2009-07-21 2014-06-24 Dsm Ip Assets B.V. Stevia extract or steviol for hair care
WO2011033524A2 (en) 2009-08-04 2011-03-24 Laila Nutraceuticals Agents from ficus hispida for the amelioration of metabolic syndrome and related diseases
US20110189360A1 (en) * 2010-02-04 2011-08-04 Pepsico, Inc. Method to Increase Solubility Limit of Rebaudioside D in an Aqueous Solution
WO2012127287A2 (en) * 2011-03-18 2012-09-27 Febris Bio-Tech Limited Compositions and methods for treating multi-drug resistant malaria
EP2988754A1 (en) 2013-04-23 2016-03-02 Aarhus Universitet Compositions for use in restoring muscle glycogen and/or muscle mass
RU2525593C1 (ru) * 2013-05-24 2014-08-20 Государственное бюджетное образовательное учреждение дополнительного профессионального образования "Новокузнецкий государственный институт усовершенствования врачей" Министерства здравоохранения Российской Федерации Способ комплексного лечения артериальной гипертонии при метаболических нарушениях
TWI516474B (zh) 2013-05-27 2016-01-11 中央研究院 良薑化合物及其類似物之合成
MX2019004534A (es) 2016-10-20 2019-10-02 Coca Cola Co Glicosidos de diterpénicos aislados a partir de stevia, composiciones y métodos.
CN108159034B (zh) * 2018-02-12 2019-10-11 东南大学 异甜菊醇在制备治疗非酒精性脂肪性肝病药物中的应用
CN111357979A (zh) * 2019-12-26 2020-07-03 浙江欧谱生物科技有限公司 抑制高脂引起的肥胖及骨丢失的保健食品组合物及其应用
CN111233702A (zh) * 2020-01-20 2020-06-05 中国科学院昆明植物研究所 先花铃子香素a衍生物与其药物组合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06157302A (ja) * 1992-09-07 1994-06-03 Lab Monal 非インスリン依存性糖尿病治療を目的としたインスリン分泌刺激組成物
JP2002500677A (ja) * 1997-06-13 2002-01-08 ノボ ノルディスク アクティーゼルスカブ 新規ｎｉｄｄｍ療法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626441B1 (en) * 1983-10-06 1991-02-19 Dietetic frozen desserts containing aspartame
JPS63146813A (ja) * 1986-12-11 1988-06-18 Toa Nenryo Kogyo Kk ジテルペン系化合物を含んで成る制癌剤
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
EP0565785A1 (en) 1992-04-07 1993-10-20 Harry H. Leveen Use of glucose transport inhibitors for the treatment for acne
JPH0813251B2 (ja) * 1993-07-14 1996-02-14 長岡香料株式会社 鉄及び又はマグネシウム及び又はカルシウムを含む呈味改善液
CN1094580A (zh) * 1994-01-06 1994-11-09 贾玉海 降糖糊
US5545414A (en) * 1995-03-22 1996-08-13 Abbott Laboratories Cholesterol lowering food product
JPH08325156A (ja) * 1995-06-01 1996-12-10 Ichimaru Pharcos Co Ltd ステビオール配糖体含有皮膚外用剤及び飲食品
JPH0952825A (ja) * 1995-06-09 1997-02-25 Taisho Pharmaceut Co Ltd 解熱鎮痛剤
CN1148476A (zh) * 1995-10-20 1997-04-30 王国安 一种降糖保健食品添加剂及其配制方法
US7091183B1 (en) * 1996-12-03 2006-08-15 Boston Medical Center Corporation Specific antagonists for glucose-dependent insulinotropic polypeptide (GIP)
CN1065753C (zh) * 1996-12-04 2001-05-16 上海绿泰宝营养保健品有限公司 降糖冲剂及其制备方法
CN1062722C (zh) * 1997-04-04 2001-03-07 青岛海洋大学 双纤维降糖粉及其制造方法
US5980902A (en) * 1998-03-26 1999-11-09 Pharma Terra, Inc. Compositions for treating and preventing diabetes, impaired glucose tolerance and related symptoms, and methods for preparing and using such compositions
ATE264093T1 (de) * 1998-07-16 2004-04-15 Aaron Tabor Sojazubereitungen und deren verwendung zur gesundheitsförderung
US20030113390A1 (en) * 1998-11-25 2003-06-19 Hoie Lars Henrik Composition comprising soy protein, dietary fibers and a phytoestrogen compound and use thereof in the prevention and/or treatment of various diseases
JP2003521528A (ja) 2000-02-01 2003-07-15 ステヴィア，エイプス 食事補強剤、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製に使用する物質
EP1361870A2 (en) 2001-02-01 2003-11-19 Nutri Pharma ASA A substance for use in a dietary supplement or for the preparation of a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome
US20090232913A1 (en) 2005-05-02 2009-09-17 Momir Mikov Composition for the Control of Cholesterol Levels
WO2007047803A2 (en) * 2005-10-20 2007-04-26 Ghc Research Development Corporation Use of prolactin in the prophylactic treatment of cancer
EP2380566A3 (en) * 2006-09-15 2012-04-11 Stevia APS Treatment of insulin resistance or diseases associated with insulin resistance using steviol or isosteviol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06157302A (ja) * 1992-09-07 1994-06-03 Lab Monal 非インスリン依存性糖尿病治療を目的としたインスリン分泌刺激組成物
JP2002500677A (ja) * 1997-06-13 2002-01-08 ノボ ノルディスク アクティーゼルスカブ 新規ｎｉｄｄｍ療法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CELL SIGNALLING, vol. 10,10, JPN6011021572, 1998, pages 727 - 733, ISSN: 0001905962 *
CRAIG JOHN C, PHYTOCHEMISTRY, vol. V15, JPN5002021594, 1976, pages 1178, ISSN: 0001905963 *
DIABETOLOGIA, vol. 39, no. 1, JPN6011021571, 1996, pages 125, ISSN: 0001905961 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505344A (ja) * 2007-12-03 2011-02-24 ディーエスエム アイピー アセッツ ビー．ブイ． ステビア抽出物またはステビア抽出物構成物質を含有する新規な栄養補給食品組成物およびその使用
US11382911B2 (en) 2013-06-10 2022-07-12 Suntory Holdings Limited Plant extract containing diketopiperazine and method for producing same
WO2017018404A1 (ja) * 2015-07-27 2017-02-02 サントリーホールディングス株式会社 環状ジペプチド及び甘味料を含有する組成物
JPWO2017018404A1 (ja) * 2015-07-27 2018-05-17 サントリーホールディングス株式会社 環状ジペプチド及び甘味料を含有する組成物
US11219663B2 (en) 2015-07-27 2022-01-11 Suntory Holdings Limited Composition containing cyclic dipeptide and sweetening agent
AU2016299590B2 (en) * 2015-07-27 2022-09-01 Suntory Holdings Limited Composition containing cyclic dipeptide and sweetening agent
JP2019504819A (ja) * 2015-09-10 2019-02-21 キー ファーマ バイオメディカル インクＫｅｙ−Ｐｈａｒｍａ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃ． 心臓肥大および肺高血圧の治療用医薬の製造におけるカウラン化合物の使用
JP2021091714A (ja) * 2015-09-10 2021-06-17 キー ファーマ バイオメディカル インクＫｅｙ−Ｐｈａｒｍａ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃ． 心臓肥大および肺高血圧の治療用医薬の製造におけるカウラン化合物の使用
JP2021091713A (ja) * 2015-09-10 2021-06-17 キー ファーマ バイオメディカル インクＫｅｙ−Ｐｈａｒｍａ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃ． 心臓肥大および肺高血圧の治療用医薬の製造におけるカウラン化合物の使用
JP2021091712A (ja) * 2015-09-10 2021-06-17 キー ファーマ バイオメディカル インクＫｅｙ−Ｐｈａｒｍａ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃ． 心臓肥大および肺高血圧の治療用医薬の製造におけるカウラン化合物の使用
JP7179888B2 (ja) 2015-09-10 2022-11-29 キー ファーマ バイオメディカル インク 心臓肥大および肺高血圧の治療用医薬の製造におけるカウラン化合物の使用
WO2020218382A1 (ja) * 2019-04-26 2020-10-29 サントリーホールディングス株式会社 Ｇｌｐ－１分泌促進剤

Also Published As

Publication number Publication date
CN1416411A (zh) 2003-05-07
WO2001056959A1 (en) 2001-08-09
CA2398445A1 (en) 2001-08-09
EP1255718A1 (en) 2002-11-13
US20080318866A1 (en) 2008-12-25
JP2012153721A (ja) 2012-08-16
EP2330092A3 (en) 2012-07-25
AU3002801A (en) 2001-08-14
WO2001056959B1 (en) 2002-02-07
US9636314B2 (en) 2017-05-02
AU784422B2 (en) 2006-03-30
CA2398445C (en) 2012-04-03
US20080051341A1 (en) 2008-02-28
US20030060428A1 (en) 2003-03-27
US20140094408A1 (en) 2014-04-03
CN100475757C (zh) 2009-04-08
CA2762121A1 (en) 2001-08-09
US20050038126A1 (en) 2005-02-17
EP2330092A2 (en) 2011-06-08
BR0108043A (pt) 2003-04-01

Similar Documents

Publication Publication Date Title
JP2003521528A (ja) 食事補強剤、又は非インシュリン依存性糖尿病、高血圧及び／又は代謝症候群の治療のための薬剤の調製に使用する物質
US20040081712A1 (en) Substance for treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome
Matsuda et al. Inhibition of gastric emptying by triterpene saponin, momordin Ic, in mice: roles of blood glucose, capsaicin-sensitive sensory nerves, and central nervous system
US7674486B2 (en) Synergistic composition for the treatment of diabetes mellitus
JP2010511603A (ja) メタドキシンとニンニク油を含有するアルコール性脂肪肝並びに脂肪肝性肝炎の予防及び治療用薬学組成物
US6946151B2 (en) Therapeutic compositions
JPH04159223A (ja) 止瀉剤組成物
JP3507523B2 (ja) 糖質吸収抑制剤
WO1996012484A1 (en) Antianemic agent containing iron and difructose
US20040043442A1 (en) Use of betaine in functional products having blood pressure lowering effects
EP2274000B1 (fr) Composition pharmaceutique ou dietetique comprenant des extraits aqueux de nigella sativa et d'olea europea et/ou phyllantus amarus
JP3228534B2 (ja) 血中アルコール濃度低下用組成物
Rosenberg A Proved Case of Recovery from Fatty Metamorphosis of the Liver After Treatment with Lipocaic
JPH06504278A (ja) ヒトの高い血糖値を低下させる方法
JP5019708B2 (ja) 糖尿病の治療および予防用組成物
HK1156930A (en) Medicament comprising steviol or isosteviol for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome
CN105193869A (zh) 骨碎补及其提取物用于预防或治疗心衰的用途
JP2006206505A (ja) 糖尿病性腎症予防組成物
AU3069101A (en) Pharmaceutical preparation and method for treatment of diabetes
JP2004168766A (ja) α−グルコシダーゼ阻害剤
WO2005072064A2 (en) A preparation, process and a regenerative method and technioue for prevention, treatment and glycemic control of diabetes melletus
Nkanu et al. Antidiabetic potentials of herbal content of 1960 drink and effect on liver enzymes in streptozotocin-induced diabetic Wistar rats
JP2004262930A (ja) α−グルコシダーゼ阻害剤
JP2002119248A (ja) 肥満抑制組成物
JPH07126170A (ja) 糖質吸収抑制剤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080128

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090508

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110524

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110818

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110825

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111124

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20111125

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120124

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20120516

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120516

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20120516

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20120518

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20120516

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20120607

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20120629

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131219

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131225

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140123

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140129

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20140217