JP2003520044A5 - - Google Patents
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- JP2003520044A5 JP2003520044A5 JP2001553367A JP2001553367A JP2003520044A5 JP 2003520044 A5 JP2003520044 A5 JP 2003520044A5 JP 2001553367 A JP2001553367 A JP 2001553367A JP 2001553367 A JP2001553367 A JP 2001553367A JP 2003520044 A5 JP2003520044 A5 JP 2003520044A5
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- 241000700605 Viruses Species 0.000 description 15
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 230000002519 immonomodulatory Effects 0.000 description 3
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 3
- 210000004881 tumor cells Anatomy 0.000 description 3
- 210000004443 Dendritic Cells Anatomy 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006011 modification reaction Methods 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 108010029697 CD40 Ligand Proteins 0.000 description 1
- 102100003729 CD40LG Human genes 0.000 description 1
- 102000001327 Chemokine CCL5 Human genes 0.000 description 1
- 108010055166 Chemokine CCL5 Proteins 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 101710021191 ICP34.5 Proteins 0.000 description 1
- 101710011281 MDV056 Proteins 0.000 description 1
- 101710004289 RRM1 Proteins 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 102000006601 Thymidine Kinase Human genes 0.000 description 1
- 108020004440 Thymidine Kinase Proteins 0.000 description 1
- 101700012273 UL43 Proteins 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 210000004027 cells Anatomy 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000002601 intratumoral Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000003362 replicative Effects 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
Description
【特許請求の範囲】
【請求項１】
免疫調節タンパク質をコードする遺伝子を含み、機能的ICP34.5をコードする遺伝子及び機能的ICP47をコードする遺伝子が欠失し、かつ腫瘍細胞中で複製能力のあるヘルペスウイルス。
【請求項２】
免疫調節遺伝子がサイトカイン、ケモカイン又はＴ細胞増殖を制御可能なタンパク質である、請求項１に記載のウイルス。
【請求項３】
前記サイトカインがGM-CSFであり、前記ケモカインがRANTESであり、又は前記タンパク質がB7.1、B7.2若しくはCD40Lである、請求項２に記載のウイルス。
【請求項４】
２種以上の免疫調節タンパク質をコードする、請求項１〜３のいずれか１項に記載のウイルス。
【請求項５】
ICP6、グリコプロテインH又はチミジンキナーゼをコードする機能的遺伝子をさらに欠失した、請求項１〜４のいずれか１項に記載のウイルス。
【請求項６】
樹状細胞の機能を阻害する能力のあるタンパク質の機能的コピーをコードする遺伝子をさらに欠失した、請求項１〜５のいずれか１項に記載のウイルス。
【請求項７】
樹状細胞の機能を阻害する能力のある前記タンパク質がUL43又はvhsである、請求項６に記載のウイルス。
【請求項８】
単純ヘルペスウイルスI型又はII型の株である、請求項１〜７のいずれか１項に記載のウイルス。
【請求項９】
非実験室ウイルス株である、請求項１〜８のいずれか１項に記載のウイルス。
【請求項１０】
前記非実験室株が、
(a) 改変されていない前駆株をその宿主から単離してからの培養期間が１年以下のものであるか；又は
(b) 改変されていない前駆株をその宿主から単離してからの連続継代のサイクルが100サイクル以下のものであるか；又は
(c) 腫瘍細胞に感染するかもしくは腫瘍細胞内で複製する能力、腫瘍細胞を死滅させる能力、又は組織内の細胞間で伝染する能力が、等価な改変を有する参照の実験室株よりも優れているものであるか；又は
(d) (c)に規定する１以上の特性について、実質的には、改変されていない前駆株の能力を有するものである；
ことを特徴とする、請求項９に記載のウイルス。
【請求項１１】
前記(c)に記載のより優れている能力が、統計的に有意に優れた能力であるか、又は前記(d)に記載の能力が、実質的に等しい能力であるか、もしくは統計的に有意差がない能力であることを特徴とする、請求項１０に記載のウイルス。
【請求項１２】
非実験室株がHSV株であり、請求項８に記載の参照株が非実験室株に等価な改変を施したHSV1 17+株、HSV1 F株、又はHSV1 KOS株である、請求項１０又は１１に記載のウイルス。
【請求項１３】
European Collection of Cell Cultures(ECACC)に仮受託番号01010209として寄託されているHSV1 JS1株に由来する、請求項１〜１２のいずれか１項に記載のウイルス。
【請求項１４】
請求項１〜１３のいずれか１項に記載のヘルペスウイルスを含む癌を治療するための薬剤。
【請求項１５】
腫瘍内直接接種用である、請求項１４に記載の薬剤。
【請求項１６】
有効成分としての請求項１〜１３のいずれか１項に記載のウイルス及び製薬上許容しうる担体又は希釈剤を含む医薬組成物。
【請求項１７】
European Collection of Cell Cultures(ECACC)に仮受託番号01010209として寄託されているHSV1 JS1株、又はそれから誘導されたHSV1株。
【請求項１】
免疫調節タンパク質をコードする遺伝子を含み、機能的ICP34.5をコードする遺伝子及び機能的ICP47をコードする遺伝子が欠失し、かつ腫瘍細胞中で複製能力のあるヘルペスウイルス。
【請求項２】
免疫調節遺伝子がサイトカイン、ケモカイン又はＴ細胞増殖を制御可能なタンパク質である、請求項１に記載のウイルス。
【請求項３】
前記サイトカインがGM-CSFであり、前記ケモカインがRANTESであり、又は前記タンパク質がB7.1、B7.2若しくはCD40Lである、請求項２に記載のウイルス。
【請求項４】
２種以上の免疫調節タンパク質をコードする、請求項１〜３のいずれか１項に記載のウイルス。
【請求項５】
ICP6、グリコプロテインH又はチミジンキナーゼをコードする機能的遺伝子をさらに欠失した、請求項１〜４のいずれか１項に記載のウイルス。
【請求項６】
樹状細胞の機能を阻害する能力のあるタンパク質の機能的コピーをコードする遺伝子をさらに欠失した、請求項１〜５のいずれか１項に記載のウイルス。
【請求項７】
樹状細胞の機能を阻害する能力のある前記タンパク質がUL43又はvhsである、請求項６に記載のウイルス。
【請求項８】
単純ヘルペスウイルスI型又はII型の株である、請求項１〜７のいずれか１項に記載のウイルス。
【請求項９】
非実験室ウイルス株である、請求項１〜８のいずれか１項に記載のウイルス。
【請求項１０】
前記非実験室株が、
(a) 改変されていない前駆株をその宿主から単離してからの培養期間が１年以下のものであるか；又は
(b) 改変されていない前駆株をその宿主から単離してからの連続継代のサイクルが100サイクル以下のものであるか；又は
(c) 腫瘍細胞に感染するかもしくは腫瘍細胞内で複製する能力、腫瘍細胞を死滅させる能力、又は組織内の細胞間で伝染する能力が、等価な改変を有する参照の実験室株よりも優れているものであるか；又は
(d) (c)に規定する１以上の特性について、実質的には、改変されていない前駆株の能力を有するものである；
ことを特徴とする、請求項９に記載のウイルス。
【請求項１１】
前記(c)に記載のより優れている能力が、統計的に有意に優れた能力であるか、又は前記(d)に記載の能力が、実質的に等しい能力であるか、もしくは統計的に有意差がない能力であることを特徴とする、請求項１０に記載のウイルス。
【請求項１２】
非実験室株がHSV株であり、請求項８に記載の参照株が非実験室株に等価な改変を施したHSV1 17+株、HSV1 F株、又はHSV1 KOS株である、請求項１０又は１１に記載のウイルス。
【請求項１３】
European Collection of Cell Cultures(ECACC)に仮受託番号01010209として寄託されているHSV1 JS1株に由来する、請求項１〜１２のいずれか１項に記載のウイルス。
【請求項１４】
請求項１〜１３のいずれか１項に記載のヘルペスウイルスを含む癌を治療するための薬剤。
【請求項１５】
腫瘍内直接接種用である、請求項１４に記載の薬剤。
【請求項１６】
有効成分としての請求項１〜１３のいずれか１項に記載のウイルス及び製薬上許容しうる担体又は希釈剤を含む医薬組成物。
【請求項１７】
European Collection of Cell Cultures(ECACC)に仮受託番号01010209として寄託されているHSV1 JS1株、又はそれから誘導されたHSV1株。
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0001475.3 | 2000-01-21 | ||
| GB0001475A GB0001475D0 (en) | 2000-01-21 | 2000-01-21 | Virus strains |
| GB0002854A GB0002854D0 (en) | 2000-02-08 | 2000-02-08 | Virus strains |
| GB0002854.8 | 2000-02-08 | ||
| GB0100288A GB0100288D0 (en) | 2001-01-05 | 2001-01-05 | Virus strains |
| GB0100288.0 | 2001-01-05 | ||
| GB0100430.8 | 2001-01-06 | ||
| GB0100430A GB0100430D0 (en) | 2001-01-06 | 2001-01-06 | Virus strains |
| PCT/GB2001/000225 WO2001053505A2 (en) | 2000-01-21 | 2001-01-22 | Herpes virus strains for gene therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520044A JP2003520044A (ja) | 2003-07-02 |
| JP2003520044A5 true JP2003520044A5 (ja) | 2008-02-14 |
| JP4810042B2 JP4810042B2 (ja) | 2011-11-09 |
Family
ID=27447756
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001553368A Expired - Lifetime JP4921669B2 (ja) | 2000-01-21 | 2001-01-22 | ウイルス株 |
| JP2001553367A Expired - Lifetime JP4810042B2 (ja) | 2000-01-21 | 2001-01-22 | ヘルペスウイルス株 |
| JP2011238257A Pending JP2012072156A (ja) | 2000-01-21 | 2011-10-31 | ウイルス株 |
| JP2015138227A Expired - Lifetime JP6424145B2 (ja) | 2000-01-21 | 2015-07-10 | ウイルス株 |
| JP2017037827A Pending JP2017132779A (ja) | 2000-01-21 | 2017-03-01 | ウイルス株 |
| JP2018218735A Expired - Lifetime JP6644378B2 (ja) | 2000-01-21 | 2018-11-22 | ウイルス株 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001553368A Expired - Lifetime JP4921669B2 (ja) | 2000-01-21 | 2001-01-22 | ウイルス株 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011238257A Pending JP2012072156A (ja) | 2000-01-21 | 2011-10-31 | ウイルス株 |
| JP2015138227A Expired - Lifetime JP6424145B2 (ja) | 2000-01-21 | 2015-07-10 | ウイルス株 |
| JP2017037827A Pending JP2017132779A (ja) | 2000-01-21 | 2017-03-01 | ウイルス株 |
| JP2018218735A Expired - Lifetime JP6644378B2 (ja) | 2000-01-21 | 2018-11-22 | ウイルス株 |
Country Status (22)
| Country | Link |
|---|---|
| US (12) | US7063835B2 (ja) |
| EP (4) | EP1252322B2 (ja) |
| JP (6) | JP4921669B2 (ja) |
| KR (2) | KR100768408B1 (ja) |
| CN (2) | CN1418255A (ja) |
| AT (2) | ATE282708T1 (ja) |
| AU (2) | AU2001226951B8 (ja) |
| BE (1) | BE2016C033I2 (ja) |
| BR (3) | BRPI0107737B8 (ja) |
| CA (2) | CA2398335C (ja) |
| CY (2) | CY2016020I1 (ja) |
| DE (2) | DE60115600T2 (ja) |
| DK (2) | DK1252323T3 (ja) |
| ES (2) | ES2233600T5 (ja) |
| FR (1) | FR16C0026I2 (ja) |
| GB (2) | GB2374873C (ja) |
| HK (2) | HK1047451B (ja) |
| IL (4) | IL150677A0 (ja) |
| LU (2) | LU93100I2 (ja) |
| NL (2) | NL300820I2 (ja) |
| PT (1) | PT1252322E (ja) |
| WO (2) | WO2001053506A2 (ja) |
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| WO2002076216A1 (en) * | 2001-03-27 | 2002-10-03 | Medigene, Inc. | Viral vectors and their use in therapeutic methods |
| GB0203285D0 (en) | 2002-02-12 | 2002-03-27 | Brown Susanne M | An herpes simplex virus complex |
| JP2004099584A (ja) | 2002-05-02 | 2004-04-02 | Keio Gijuku | Ｈｓｖを用いた抗腫瘍剤 |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| GB0317511D0 (en) * | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
| GB0326798D0 (en) * | 2003-11-17 | 2003-12-24 | Crusade Lab Ltd | Methods for generating mutant virus |
| US7897146B2 (en) | 2003-11-17 | 2011-03-01 | Crusade Laboratories Limited | Treatment using herpes simplex virus |
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| JP5522884B2 (ja) * | 2004-03-31 | 2014-06-18 | 具紀 藤堂 | ウイルス療法の抗癌作用増強剤、癌の予防または治療方法 |
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