JP2003519651A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003519651A5 JP2003519651A5 JP2001551456A JP2001551456A JP2003519651A5 JP 2003519651 A5 JP2003519651 A5 JP 2003519651A5 JP 2001551456 A JP2001551456 A JP 2001551456A JP 2001551456 A JP2001551456 A JP 2001551456A JP 2003519651 A5 JP2003519651 A5 JP 2003519651A5
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- drug
- particles
- solid
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 36
- 239000003814 drug Substances 0.000 description 22
- 239000002904 solvent Substances 0.000 description 22
- 239000002245 particle Substances 0.000 description 17
- 239000007787 solid Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 13
- 239000000463 material Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- 239000002861 polymer material Substances 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 229920002732 Polyanhydride Polymers 0.000 description 2
- 239000012867 bioactive agent Substances 0.000 description 2
- 229920000249 biocompatible polymer Polymers 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000005191 phase separation Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 238000012696 Interfacial polycondensation Methods 0.000 description 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- -1 poly (Hydroxy Chemical group 0.000 description 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920001306 poly(lactide-co-caprolactone) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17619300P | 2000-01-14 | 2000-01-14 | |
| US60/176,193 | 2000-01-14 | ||
| PCT/US2001/001183 WO2001051032A2 (en) | 2000-01-14 | 2001-01-12 | Micronized freeze-dried particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519651A JP2003519651A (ja) | 2003-06-24 |
| JP2003519651A5 true JP2003519651A5 (https=) | 2008-02-28 |
Family
ID=22643372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551456A Pending JP2003519651A (ja) | 2000-01-14 | 2001-01-12 | 微紛化凍結乾燥粒子 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1246609B1 (https=) |
| JP (1) | JP2003519651A (https=) |
| AT (1) | ATE462413T1 (https=) |
| AU (1) | AU773735B2 (https=) |
| CA (1) | CA2397404C (https=) |
| DE (1) | DE60141680D1 (https=) |
| WO (1) | WO2001051032A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8652504B2 (en) | 2005-09-22 | 2014-02-18 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2809309B1 (fr) * | 2000-05-23 | 2004-06-11 | Mainelab | Microspheres a liberation prolongee pour administration injectable |
| CA2456806C (en) | 2001-08-08 | 2011-10-18 | Brown University Research Foundation | Methods for micronization of hydrophobic drugs |
| WO2003049701A2 (en) * | 2001-12-10 | 2003-06-19 | Spherics, Inc. | Methods and products useful in the formation and isolation of microparticles |
| US20050152980A1 (en) * | 2002-03-13 | 2005-07-14 | Michael Ausborn | Pharmeutical microparticles |
| SI21222A (sl) * | 2002-05-28 | 2003-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek za pripravo nanodelcev |
| US7670627B2 (en) * | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| JP2006199589A (ja) * | 2003-09-03 | 2006-08-03 | Ltt Bio-Pharma Co Ltd | 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤 |
| WO2006088647A1 (en) * | 2005-02-17 | 2006-08-24 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| ES2363342T3 (es) * | 2003-12-19 | 2011-08-01 | Alk-Abelló A/S | Procedimiento para criogranulación y almacenamiento de alérgenos. |
| RU2006126051A (ru) | 2003-12-19 | 2008-01-27 | Альк-Абелло А/С (Dk) | Способы получения партии активного фармацевтического ингредиента, контейнер, содержащий криогранулы аллергенного продукта, и криогранула аллергенного продукта |
| KR101411100B1 (ko) * | 2006-01-23 | 2014-07-08 | 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘, 엘티디. | 친지성 약물을 함유하는 나노캡슐을 포함하는 미소구체 |
| EP3179985A1 (en) | 2014-08-14 | 2017-06-21 | Brown University | Compositions for stabilizing and delivering proteins |
| CN108379243A (zh) * | 2018-03-22 | 2018-08-10 | 福州大学 | 一种载基因多孔磁性微球的制备方法 |
| CN115005320B (zh) * | 2022-05-07 | 2023-09-05 | 中国农业大学 | 一种具有长效饱腹感的酪蛋白粉的制备方法及所得产物 |
| CN116982619A (zh) * | 2023-08-04 | 2023-11-03 | 洛阳奇泓生物科技有限公司 | 丙交酯-Nisin固体分散体及其制备 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0225162B1 (en) * | 1985-11-27 | 1992-01-22 | Ethicon, Inc. | Inhibition of post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug |
| ATE76311T1 (de) * | 1986-08-19 | 1992-06-15 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und zytokinen. |
| US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
| EP0840623B1 (en) * | 1995-07-21 | 2007-07-18 | Brown University Research Foundation | Compositions for gene therapy comprising nucleic acid loaded polymeric microparticles |
| US6190702B1 (en) * | 1996-03-28 | 2001-02-20 | Takeda Chemical Industries, Ltd. | Sustained-released material prepared by dispersing a lyophilized polypeptide in an oil phase |
| DE69819145T2 (de) * | 1997-04-17 | 2004-08-19 | Amgen Inc., Thousand Oaks | Bioabbaubare mikropartikeln mit verzögerter wirkstofffreisetzung |
| JP3918248B2 (ja) * | 1997-09-26 | 2007-05-23 | ソニー株式会社 | 固体撮像素子およびその駆動方法 |
-
2001
- 2001-01-12 CA CA002397404A patent/CA2397404C/en not_active Expired - Lifetime
- 2001-01-12 WO PCT/US2001/001183 patent/WO2001051032A2/en not_active Ceased
- 2001-01-12 JP JP2001551456A patent/JP2003519651A/ja active Pending
- 2001-01-12 AT AT01902059T patent/ATE462413T1/de not_active IP Right Cessation
- 2001-01-12 AU AU27902/01A patent/AU773735B2/en not_active Ceased
- 2001-01-12 EP EP01902059A patent/EP1246609B1/en not_active Expired - Lifetime
- 2001-01-12 DE DE60141680T patent/DE60141680D1/de not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8652504B2 (en) | 2005-09-22 | 2014-02-18 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1343480B1 (en) | Induced phase transition method for the production of microparticles containing hydrophobic active agents | |
| Ansary et al. | Biodegradable poly (D, L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs-A review. | |
| JP2003519651A5 (https=) | ||
| Truong-Le et al. | Stabilization challenges and formulation strategies associated with oral biologic drug delivery systems | |
| EP0857081B1 (en) | Preparation of peptide containing biodegradable microspheres by melt process | |
| EP0914095B1 (en) | Method for fabricating polymer-based controlled-release devices | |
| CN101528206B (zh) | 制备用于缓释的、具有改善的可分散性和可注射性的微球的方法 | |
| US5753234A (en) | Single-shot vaccine formulation | |
| AU2003304108B2 (en) | Nanoparticulate bioactive agents | |
| US6455074B1 (en) | Methods for fabricating polymer-based controlled release devices | |
| US7691412B2 (en) | Prolonged release biodegradable microspheres and method for preparing same | |
| JPH09510477A (ja) | 薬剤移送用ポリマーミクロ粒子 | |
| HU224008B1 (hu) | Kapszulázási eljárás | |
| CN112972388B (zh) | 卡利拉嗪释放制剂 | |
| JP3841309B2 (ja) | 流動床乾燥工程を含んでなるミクロスフェアの製造方法 | |
| HU221308B1 (en) | Process for producing microcapsules | |
| Kim et al. | Albumin loaded microsphere of amphiphilic poly (ethylene glycol)/poly (α-ester) multiblock copolymer | |
| CN103269689B (zh) | 含有生理活性肽的微粒及其制备方法和包括该微粒的药物组合物 | |
| JP2004517146A (ja) | 生物活性物質カプセル化生分解性高分子の微粒子および該微粒子を含有する徐放性医薬配合物 | |
| CN1771912B (zh) | 用于口服给药的蛋白多肽类复合物纳米粒及其制法 | |
| CN104825399A (zh) | 包载康普瑞丁磷酸二钠的反胶束-微球缓释制剂及其制备方法 | |
| Yeo et al. | Recent advances in microencapsulation technology |