ATE462413T1 - Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln - Google Patents
Verfahren zur herstellung von mikronisierte gefriergetrocknete partikelnInfo
- Publication number
- ATE462413T1 ATE462413T1 AT01902059T AT01902059T ATE462413T1 AT E462413 T1 ATE462413 T1 AT E462413T1 AT 01902059 T AT01902059 T AT 01902059T AT 01902059 T AT01902059 T AT 01902059T AT E462413 T1 ATE462413 T1 AT E462413T1
- Authority
- AT
- Austria
- Prior art keywords
- agent
- particles
- mixture
- drug
- macromolecular
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 7
- 239000003795 chemical substances by application Substances 0.000 abstract 6
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000011159 matrix material Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000000463 material Substances 0.000 abstract 2
- 239000011859 microparticle Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000004581 coalescence Methods 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17619300P | 2000-01-14 | 2000-01-14 | |
| PCT/US2001/001183 WO2001051032A2 (en) | 2000-01-14 | 2001-01-12 | Micronized freeze-dried particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE462413T1 true ATE462413T1 (de) | 2010-04-15 |
Family
ID=22643372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01902059T ATE462413T1 (de) | 2000-01-14 | 2001-01-12 | Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1246609B1 (https=) |
| JP (1) | JP2003519651A (https=) |
| AT (1) | ATE462413T1 (https=) |
| AU (1) | AU773735B2 (https=) |
| CA (1) | CA2397404C (https=) |
| DE (1) | DE60141680D1 (https=) |
| WO (1) | WO2001051032A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2809309B1 (fr) * | 2000-05-23 | 2004-06-11 | Mainelab | Microspheres a liberation prolongee pour administration injectable |
| CA2456806C (en) | 2001-08-08 | 2011-10-18 | Brown University Research Foundation | Methods for micronization of hydrophobic drugs |
| WO2003049701A2 (en) * | 2001-12-10 | 2003-06-19 | Spherics, Inc. | Methods and products useful in the formation and isolation of microparticles |
| US20050152980A1 (en) * | 2002-03-13 | 2005-07-14 | Michael Ausborn | Pharmeutical microparticles |
| SI21222A (sl) * | 2002-05-28 | 2003-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek za pripravo nanodelcev |
| US7670627B2 (en) * | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| JP2006199589A (ja) * | 2003-09-03 | 2006-08-03 | Ltt Bio-Pharma Co Ltd | 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤 |
| WO2006088647A1 (en) * | 2005-02-17 | 2006-08-24 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| ES2363342T3 (es) * | 2003-12-19 | 2011-08-01 | Alk-Abelló A/S | Procedimiento para criogranulación y almacenamiento de alérgenos. |
| RU2006126051A (ru) | 2003-12-19 | 2008-01-27 | Альк-Абелло А/С (Dk) | Способы получения партии активного фармацевтического ингредиента, контейнер, содержащий криогранулы аллергенного продукта, и криогранула аллергенного продукта |
| JP5178520B2 (ja) | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | 固体ポリマー送達組成物およびその使用法 |
| KR101411100B1 (ko) * | 2006-01-23 | 2014-07-08 | 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘, 엘티디. | 친지성 약물을 함유하는 나노캡슐을 포함하는 미소구체 |
| EP3179985A1 (en) | 2014-08-14 | 2017-06-21 | Brown University | Compositions for stabilizing and delivering proteins |
| CN108379243A (zh) * | 2018-03-22 | 2018-08-10 | 福州大学 | 一种载基因多孔磁性微球的制备方法 |
| CN115005320B (zh) * | 2022-05-07 | 2023-09-05 | 中国农业大学 | 一种具有长效饱腹感的酪蛋白粉的制备方法及所得产物 |
| CN116982619A (zh) * | 2023-08-04 | 2023-11-03 | 洛阳奇泓生物科技有限公司 | 丙交酯-Nisin固体分散体及其制备 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0225162B1 (en) * | 1985-11-27 | 1992-01-22 | Ethicon, Inc. | Inhibition of post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug |
| ATE76311T1 (de) * | 1986-08-19 | 1992-06-15 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und zytokinen. |
| US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
| EP0840623B1 (en) * | 1995-07-21 | 2007-07-18 | Brown University Research Foundation | Compositions for gene therapy comprising nucleic acid loaded polymeric microparticles |
| US6190702B1 (en) * | 1996-03-28 | 2001-02-20 | Takeda Chemical Industries, Ltd. | Sustained-released material prepared by dispersing a lyophilized polypeptide in an oil phase |
| DE69819145T2 (de) * | 1997-04-17 | 2004-08-19 | Amgen Inc., Thousand Oaks | Bioabbaubare mikropartikeln mit verzögerter wirkstofffreisetzung |
| JP3918248B2 (ja) * | 1997-09-26 | 2007-05-23 | ソニー株式会社 | 固体撮像素子およびその駆動方法 |
-
2001
- 2001-01-12 CA CA002397404A patent/CA2397404C/en not_active Expired - Lifetime
- 2001-01-12 WO PCT/US2001/001183 patent/WO2001051032A2/en not_active Ceased
- 2001-01-12 JP JP2001551456A patent/JP2003519651A/ja active Pending
- 2001-01-12 AT AT01902059T patent/ATE462413T1/de not_active IP Right Cessation
- 2001-01-12 AU AU27902/01A patent/AU773735B2/en not_active Ceased
- 2001-01-12 EP EP01902059A patent/EP1246609B1/en not_active Expired - Lifetime
- 2001-01-12 DE DE60141680T patent/DE60141680D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2397404C (en) | 2008-12-02 |
| EP1246609B1 (en) | 2010-03-31 |
| WO2001051032A3 (en) | 2002-03-28 |
| AU2790201A (en) | 2001-07-24 |
| CA2397404A1 (en) | 2001-07-19 |
| WO2001051032A2 (en) | 2001-07-19 |
| AU773735B2 (en) | 2004-06-03 |
| EP1246609A2 (en) | 2002-10-09 |
| DE60141680D1 (de) | 2010-05-12 |
| JP2003519651A (ja) | 2003-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |