JP2003518136A5 - - Google Patents
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- Publication number
- JP2003518136A5 JP2003518136A5 JP2001547172A JP2001547172A JP2003518136A5 JP 2003518136 A5 JP2003518136 A5 JP 2003518136A5 JP 2001547172 A JP2001547172 A JP 2001547172A JP 2001547172 A JP2001547172 A JP 2001547172A JP 2003518136 A5 JP2003518136 A5 JP 2003518136A5
- Authority
- JP
- Japan
- Prior art keywords
- piperidinyl
- amino
- benzamide
- diethyl
- hydroxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 125000001246 bromo group Chemical group Br* 0.000 description 5
- 125000001309 chloro group Chemical group Cl* 0.000 description 5
- 125000001153 fluoro group Chemical group F* 0.000 description 5
- 125000001072 heteroaryl group Chemical group 0.000 description 5
- 125000002346 iodo group Chemical group I* 0.000 description 5
- 125000001424 substituent group Chemical group 0.000 description 5
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 4
- 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 150000002431 hydrogen Chemical group 0.000 description 2
- 125000002883 imidazolyl group Chemical group 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 208000020431 spinal cord injury Diseases 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 125000001425 triazolyl group Chemical group 0.000 description 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 description 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 description 1
- ZNUIIBUGODHZMS-UHFFFAOYSA-N 4-(n-(1-benzylpiperidin-4-yl)-2-bromo-5-hydroxyanilino)-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=CC=C(O)C=1)Br)C1CCN(CC=2C=CC=CC=2)CC1 ZNUIIBUGODHZMS-UHFFFAOYSA-N 0.000 description 1
- BWLIJEAKIOLWFP-UHFFFAOYSA-N 4-(n-(1-benzylpiperidin-4-yl)-2-chloro-5-hydroxyanilino)-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=CC=C(O)C=1)Cl)C1CCN(CC=2C=CC=CC=2)CC1 BWLIJEAKIOLWFP-UHFFFAOYSA-N 0.000 description 1
- ZLTZCMNKTGITGP-UHFFFAOYSA-N 4-(n-(1-benzylpiperidin-4-yl)-2-fluoro-5-hydroxyanilino)-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=CC=C(O)C=1)F)C1CCN(CC=2C=CC=CC=2)CC1 ZLTZCMNKTGITGP-UHFFFAOYSA-N 0.000 description 1
- PWAHBRNWPAQLDU-UHFFFAOYSA-N 4-(n-(1-benzylpiperidin-4-yl)-5-hydroxy-2-iodoanilino)-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=CC=C(O)C=1)I)C1CCN(CC=2C=CC=CC=2)CC1 PWAHBRNWPAQLDU-UHFFFAOYSA-N 0.000 description 1
- WILATYUMLLLBFE-UHFFFAOYSA-N 4-(n-[1-[(2,4-dichlorophenyl)methyl]piperidin-4-yl]-3-hydroxyanilino)-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(O)C=CC=1)C1CCN(CC=2C(=CC(Cl)=CC=2)Cl)CC1 WILATYUMLLLBFE-UHFFFAOYSA-N 0.000 description 1
- SRFARMYXBYDWBL-UHFFFAOYSA-N 4-(n-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-hydroxyanilino)-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(O)C=CC=1)C1CCN(CC=2C=CC(Cl)=CC=2)CC1 SRFARMYXBYDWBL-UHFFFAOYSA-N 0.000 description 1
- RBFDCFLNWXKHFK-UHFFFAOYSA-N C(C)N(C(C1=CC=C(C=C1)N(C1=CC(=CC=C1)O)C1CCN(CC1)CC1=CC=C(C=C1)Br)=O)CC.C(C)N(C(C1=CC=C(C=C1)N(C1CCN(CC1)CC1=CC=C(C=C1)I)C1=CC(=CC=C1)O)=O)CC Chemical compound C(C)N(C(C1=CC=C(C=C1)N(C1=CC(=CC=C1)O)C1CCN(CC1)CC1=CC=C(C=C1)Br)=O)CC.C(C)N(C(C1=CC=C(C=C1)N(C1CCN(CC1)CC1=CC=C(C=C1)I)C1=CC(=CC=C1)O)=O)CC RBFDCFLNWXKHFK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- DBDFCAIWUBMWBJ-UHFFFAOYSA-N n,n-diethyl-4-(3-hydroxy-n-[1-(thiophen-3-ylmethyl)piperidin-4-yl]anilino)benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(O)C=CC=1)C1CCN(CC2=CSC=C2)CC1 DBDFCAIWUBMWBJ-UHFFFAOYSA-N 0.000 description 1
- GMVFOJKDXATNNM-UHFFFAOYSA-N n,n-diethyl-4-(3-hydroxy-n-[1-[(4-methylphenyl)methyl]piperidin-4-yl]anilino)benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(O)C=CC=1)C1CCN(CC=2C=CC(C)=CC=2)CC1 GMVFOJKDXATNNM-UHFFFAOYSA-N 0.000 description 1
- CTGRANPRWGTGNZ-UHFFFAOYSA-N n,n-diethyl-4-(3-hydroxy-n-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]anilino)benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(O)C=CC=1)C1CCN(CC=2C=CC(=CC=2)C(F)(F)F)CC1 CTGRANPRWGTGNZ-UHFFFAOYSA-N 0.000 description 1
- MPFKAGVQJDJAAD-UHFFFAOYSA-N n,n-diethyl-4-(n-[1-(furan-3-ylmethyl)piperidin-4-yl]-3-hydroxyanilino)benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(O)C=CC=1)C1CCN(CC2=COC=C2)CC1 MPFKAGVQJDJAAD-UHFFFAOYSA-N 0.000 description 1
- DMEADXCOOZTKBV-UHFFFAOYSA-N n,n-diethyl-4-(n-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]-3-hydroxyanilino)benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(O)C=CC=1)C1CCN(CC=2C=CC(F)=CC=2)CC1 DMEADXCOOZTKBV-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 208000016702 sympathetic nervous system disease Diseases 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904675A SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Novel compounds |
| SE9904675-7 | 1999-12-20 | ||
| PCT/SE2000/002560 WO2001046263A1 (en) | 1999-12-20 | 2000-12-15 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003518136A JP2003518136A (ja) | 2003-06-03 |
| JP2003518136A5 true JP2003518136A5 (OSRAM) | 2008-02-07 |
Family
ID=20418211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001547172A Abandoned JP2003518136A (ja) | 1999-12-20 | 2000-12-15 | 新規な化合物 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6875777B2 (OSRAM) |
| EP (1) | EP1242406B1 (OSRAM) |
| JP (1) | JP2003518136A (OSRAM) |
| KR (1) | KR20020062351A (OSRAM) |
| CN (1) | CN1185227C (OSRAM) |
| AT (1) | ATE261957T1 (OSRAM) |
| AU (1) | AU775648B2 (OSRAM) |
| BG (1) | BG106807A (OSRAM) |
| BR (1) | BR0016594A (OSRAM) |
| CA (1) | CA2394864A1 (OSRAM) |
| CO (1) | CO5271645A1 (OSRAM) |
| CZ (1) | CZ20022123A3 (OSRAM) |
| DE (1) | DE60009148T2 (OSRAM) |
| DK (1) | DK1242406T3 (OSRAM) |
| EE (1) | EE200200338A (OSRAM) |
| ES (1) | ES2215786T3 (OSRAM) |
| HK (1) | HK1048629B (OSRAM) |
| HU (1) | HUP0300295A3 (OSRAM) |
| IL (1) | IL150210A0 (OSRAM) |
| IS (1) | IS6419A (OSRAM) |
| MX (1) | MXPA02006064A (OSRAM) |
| NO (1) | NO20022919L (OSRAM) |
| NZ (1) | NZ519987A (OSRAM) |
| PL (1) | PL355843A1 (OSRAM) |
| PT (1) | PT1242406E (OSRAM) |
| RU (1) | RU2002114346A (OSRAM) |
| SE (1) | SE9904675D0 (OSRAM) |
| SK (1) | SK8842002A3 (OSRAM) |
| TR (1) | TR200401433T4 (OSRAM) |
| UA (1) | UA72287C2 (OSRAM) |
| WO (1) | WO2001046263A1 (OSRAM) |
| ZA (1) | ZA200204257B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0101771D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101770D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101769D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| US7229994B2 (en) | 2001-05-18 | 2007-06-12 | Astrazeneca Ab | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
| SE0101773D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| US8575169B2 (en) | 2001-10-29 | 2013-11-05 | Versi Group, Llc | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
| EP1450807B1 (en) * | 2001-10-29 | 2013-12-25 | Versi Group, LLC | Method of treating depression with delta receptor agonist compounds |
| US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| MX2007001240A (es) | 2004-08-02 | 2007-03-23 | Astrazeneca Ab | Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas. |
| CN101128447A (zh) * | 2005-02-28 | 2008-02-20 | 阿斯利康(瑞典)有限公司 | 二芳基甲基哌嗪衍生物，其制备及其用途 |
| EP4333821A4 (en) * | 2021-05-04 | 2025-07-09 | Texas A & M Univ Sys | SARS-COV-2 INHIBITORS |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091096A (en) | 1976-03-19 | 1978-05-23 | Eli Lilly And Company | Dinitroanilines for the control of phytopathogens |
| EG12406A (en) | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| SE441448B (sv) | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
| DE3200304A1 (de) | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| DE3563964D1 (en) | 1984-10-16 | 1988-09-01 | Synthelabo | Piperidine derivatives, their preparation and their therapeutical application |
| KR940003491B1 (ko) | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
| YU150489A (sh) | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| US5854245A (en) | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| AU2009799A (en) | 1997-12-24 | 1999-07-19 | Ortho-Mcneil Pharmaceutical, Inc. | 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor |
| AU756983B2 (en) | 1998-03-10 | 2003-01-30 | Research Triangle Institute | Novel opiate compounds, methods of making and methods of use |
| US6436959B1 (en) * | 1998-12-23 | 2002-08-20 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)]aminobenzamides |
-
1999
- 1999-12-20 SE SE9904675A patent/SE9904675D0/xx unknown
-
2000
- 2000-12-15 JP JP2001547172A patent/JP2003518136A/ja not_active Abandoned
- 2000-12-15 EE EEP200200338A patent/EE200200338A/xx unknown
- 2000-12-15 KR KR1020027007837A patent/KR20020062351A/ko not_active Withdrawn
- 2000-12-15 NZ NZ519987A patent/NZ519987A/en unknown
- 2000-12-15 RU RU2002114346/04A patent/RU2002114346A/ru not_active Application Discontinuation
- 2000-12-15 UA UA2002064616A patent/UA72287C2/uk unknown
- 2000-12-15 HK HK03100303.9A patent/HK1048629B/en not_active IP Right Cessation
- 2000-12-15 DE DE60009148T patent/DE60009148T2/de not_active Expired - Fee Related
- 2000-12-15 EP EP00989097A patent/EP1242406B1/en not_active Expired - Lifetime
- 2000-12-15 SK SK884-2002A patent/SK8842002A3/sk unknown
- 2000-12-15 CA CA002394864A patent/CA2394864A1/en not_active Abandoned
- 2000-12-15 CZ CZ20022123A patent/CZ20022123A3/cs unknown
- 2000-12-15 PL PL00355843A patent/PL355843A1/xx not_active Application Discontinuation
- 2000-12-15 AT AT00989097T patent/ATE261957T1/de not_active IP Right Cessation
- 2000-12-15 MX MXPA02006064A patent/MXPA02006064A/es active IP Right Grant
- 2000-12-15 AU AU25644/01A patent/AU775648B2/en not_active Ceased
- 2000-12-15 TR TR2004/01433T patent/TR200401433T4/xx unknown
- 2000-12-15 WO PCT/SE2000/002560 patent/WO2001046263A1/en not_active Ceased
- 2000-12-15 BR BR0016594-8A patent/BR0016594A/pt not_active IP Right Cessation
- 2000-12-15 IL IL15021000A patent/IL150210A0/xx unknown
- 2000-12-15 DK DK00989097T patent/DK1242406T3/da active
- 2000-12-15 PT PT00989097T patent/PT1242406E/pt unknown
- 2000-12-15 US US10/149,982 patent/US6875777B2/en not_active Expired - Fee Related
- 2000-12-15 HU HU0300295A patent/HUP0300295A3/hu unknown
- 2000-12-15 CN CNB00819064XA patent/CN1185227C/zh not_active Expired - Fee Related
- 2000-12-15 ES ES00989097T patent/ES2215786T3/es not_active Expired - Lifetime
- 2000-12-19 CO CO00096315A patent/CO5271645A1/es not_active Application Discontinuation
-
2002
- 2002-05-28 ZA ZA200204257A patent/ZA200204257B/en unknown
- 2002-06-10 BG BG106807A patent/BG106807A/xx unknown
- 2002-06-12 IS IS6419A patent/IS6419A/is unknown
- 2002-06-18 NO NO20022919A patent/NO20022919L/no not_active Application Discontinuation
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