|
US7393682B1
(en)
*
|
1993-03-19 |
2008-07-01 |
The Johns Hopkins University School Of Medicine |
Polynucleotides encoding promyostatin polypeptides
|
|
DK0733109T3
(da)
|
1993-12-07 |
2006-07-03 |
Genetics Inst Llc |
BMP-12, BMP-13 og seneinducerende præparater dermed
|
|
US6891082B2
(en)
*
|
1997-08-01 |
2005-05-10 |
The Johns Hopkins University School Of Medicine |
Transgenic non-human animals expressing a truncated activintype II receptor
|
|
US6656475B1
(en)
*
|
1997-08-01 |
2003-12-02 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
|
|
US7037501B2
(en)
|
2001-01-04 |
2006-05-02 |
Regents Of The University Of Minnesota |
Myostatin immnoconjugate
|
|
EP1790726B1
(en)
*
|
2001-02-08 |
2013-07-03 |
Wyeth LLC |
Modified and stabilized GDF propeptides and uses thereof
|
|
TW200526779A
(en)
*
|
2001-02-08 |
2005-08-16 |
Wyeth Corp |
Modified and stabilized GDF propeptides and uses thereof
|
|
US6734289B2
(en)
|
2001-03-29 |
2004-05-11 |
The University Of Chicago |
Gastrokines and derived peptides including inhibitors
|
|
US7629317B2
(en)
|
2001-03-29 |
2009-12-08 |
The University Of Chicago |
Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
|
|
DK1714982T3
(da)
|
2001-06-05 |
2009-05-04 |
Genetics Inst Llc |
Fremgangsmåde til rensning af stærkt anioniske proteiner
|
|
EP1404866B1
(en)
*
|
2001-07-11 |
2008-09-03 |
ORICO Limited |
Bioassay for myostatin
|
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
|
MXPA04008150A
(es)
|
2002-02-21 |
2005-06-17 |
Wyeth Corp |
Gasp1: una proteina que contiene dominio de folistatina.
|
|
MXPA04008149A
(es)
|
2002-02-21 |
2005-06-17 |
Wyeth Corp |
Proteinas que contienen dominios de folistatina.
|
|
US7261893B2
(en)
|
2002-10-22 |
2007-08-28 |
Wyeth |
Neutralizing antibodies against GDF-8 and uses therefor
|
|
EP2272864A3
(en)
*
|
2002-12-20 |
2011-02-16 |
Amgen Inc. |
Binding agents which inhibit myostatin
|
|
US7785587B2
(en)
|
2003-06-02 |
2010-08-31 |
Wyeth |
Therapeutic methods for muscular or neuromuscular disorders
|
|
WO2005094871A2
(en)
|
2004-03-26 |
2005-10-13 |
Acceleron Pharma Inc. |
Bmp-3 propeptides and related methods
|
|
JP4688483B2
(ja)
*
|
2004-04-15 |
2011-05-25 |
株式会社テクノネットワーク四国 |
フォリスタチン変異体ポリペプチド
|
|
WO2005113590A2
(en)
*
|
2004-05-12 |
2005-12-01 |
Acceleron Pharma Inc. |
Bmp10 propeptides and related methods
|
|
EP1771557B1
(en)
|
2004-06-24 |
2014-12-31 |
Acceleron Pharma Inc. |
GDF3 Propeptides and Related Methods
|
|
ES2551852T3
(es)
|
2004-07-23 |
2015-11-24 |
Acceleron Pharma Inc. |
Polipéptidos del receptor ActRII
|
|
CA2576734C
(en)
*
|
2004-07-29 |
2010-03-16 |
Schering-Plough Ltd. |
Use of alk 5 inhibitors to modulate or inhibit myostatin activity leading to increased lean tissue accretion in animals
|
|
BRPI0609449A2
(pt)
*
|
2005-03-23 |
2010-04-06 |
Wyeth Corp |
detecção de agentes de modulação de gdf-8
|
|
JP2008537777A
(ja)
*
|
2005-03-23 |
2008-09-25 |
ワイス |
Gdf−8調節剤に対する免疫応答の検出
|
|
US8017576B2
(en)
|
2005-05-10 |
2011-09-13 |
The University Of Chicago |
Methods and compositions to treat mucositis
|
|
PT2407486T
(pt)
|
2005-08-19 |
2018-02-21 |
Univ Pennsylvania |
Anticorpos antagonistas contra gdf-8 e utilizações no tratamento de ela e outros distúrbios associados a gdf-8
|
|
CN101277976B
(zh)
|
2005-10-06 |
2012-04-11 |
伊莱利利公司 |
抗肌抑制素抗体
|
|
UA92504C2
(en)
|
2005-10-12 |
2010-11-10 |
Эли Лилли Энд Компани |
Anti-myostatin monoclonal antibody
|
|
US8067562B2
(en)
|
2005-11-01 |
2011-11-29 |
Amgen Inc. |
Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
|
|
EA201692543A1
(ru)
|
2005-11-23 |
2017-08-31 |
Акселерон Фарма Инк. |
Антагонисты активина-actriia и их применение для стимулирования роста кости
|
|
US8128933B2
(en)
|
2005-11-23 |
2012-03-06 |
Acceleron Pharma, Inc. |
Method of promoting bone growth by an anti-activin B antibody
|
|
UA98308C2
(en)
|
2006-09-05 |
2012-05-10 |
Эли Лилли Энд Компани |
Anti-myostatin antibody
|
|
US8895016B2
(en)
|
2006-12-18 |
2014-11-25 |
Acceleron Pharma, Inc. |
Antagonists of activin-actriia and uses for increasing red blood cell levels
|
|
EP2468291B1
(en)
|
2006-12-18 |
2017-11-22 |
Acceleron Pharma, Inc. |
Activin-actrii antagonists and uses for increasing red blood cell levels
|
|
CA2677007A1
(en)
|
2007-02-01 |
2008-08-07 |
Acceleron Pharma Inc. |
Activin-actriia antagonists and uses for treating or preventing breast cancer
|
|
TWI782836B
(zh)
|
2007-02-02 |
2022-11-01 |
美商艾瑟勒朗法瑪公司 |
衍生自ActRIIB的變體與其用途
|
|
CA3039330C
(en)
|
2007-02-09 |
2021-11-09 |
Acceleron Pharma Inc. |
Activin-actriia antagonists and uses for promoting bone growth in cancer patients
|
|
US8501678B2
(en)
|
2007-03-06 |
2013-08-06 |
Atara Biotherapeutics, Inc. |
Variant activin receptor polypeptides and uses thereof
|
|
TWI573802B
(zh)
|
2007-03-06 |
2017-03-11 |
安美基公司 |
變異之活動素受體多肽及其用途
|
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
|
CN103877564A
(zh)
|
2007-09-18 |
2014-06-25 |
阿塞勒隆制药公司 |
活化素-actriia拮抗剂和减少或抑制fsh分泌的用途
|
|
KR100857861B1
(ko)
*
|
2007-10-15 |
2008-09-11 |
주식회사 바이오리더스 |
Myo-2 펩타이드 중합체와 마이오스타틴의 융합단백질표면발현용 벡터 및 상기 벡터로 형질전환된 미생물
|
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
|
JP5922928B2
(ja)
|
2008-08-14 |
2016-05-24 |
アクセルロン ファーマ, インコーポレイテッド |
赤血球レベルを高めるためのgdfトラップの使用
|
|
US8216997B2
(en)
|
2008-08-14 |
2012-07-10 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
|
|
ME02652B
(me)
|
2008-11-26 |
2017-06-20 |
Amgen Inc |
Stabilizovana varijanta aktivin iib receptora
|
|
EP2387412A4
(en)
|
2009-01-13 |
2013-04-03 |
Acceleron Pharma Inc |
PROCESS FOR INCREASING THE ADIPONECTIN MIRROR
|
|
CN102482339B
(zh)
|
2009-06-08 |
2015-06-17 |
阿塞勒隆制药公司 |
用于增加产热脂肪细胞的方法
|
|
EP2440577A4
(en)
|
2009-06-12 |
2013-01-23 |
Acceleron Pharma Inc |
SHORTEN ACTRIIB FC FUSION PROTEINS
|
|
ES2796121T3
(es)
|
2009-08-13 |
2020-11-25 |
Acceleron Pharma Inc |
Uso combinado de trampas de GDF y activadores del receptor de la eritropoyetina para aumentar los niveles de glóbulos rojos
|
|
KR20120082909A
(ko)
*
|
2009-10-01 |
2012-07-24 |
코비타 리미티드 |
합성 마이오스타틴 펩티드 길항제
|
|
CA2779472C
(en)
|
2009-11-03 |
2021-03-16 |
Acceleron Pharma Inc. |
The use of a composition comprising an activin type iib receptor polypeptide in the treatment of fatty liver disease
|
|
ES2658292T3
(es)
|
2009-11-17 |
2018-03-09 |
Acceleron Pharma, Inc. |
Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular
|
|
CN103298832A
(zh)
|
2010-11-08 |
2013-09-11 |
阿塞勒隆制药公司 |
Actriia结合剂及其用途
|
|
CA2852683A1
(en)
|
2011-10-17 |
2013-04-25 |
Acceleron Pharma, Inc. |
Methods and compositions for treating ineffective erythropoiesis
|
|
JP6145112B2
(ja)
|
2011-12-19 |
2017-06-07 |
アムジエン・インコーポレーテツド |
単独でのまたは化学療法と組み合わされた変異アクチビン受容体ポリペプチド、およびその使用
|
|
WO2013186719A1
(en)
|
2012-06-15 |
2013-12-19 |
Pfizer Inc. |
Improved antagonist antibodies against gdf-8 and uses therefor
|
|
ES2791778T3
(es)
|
2012-08-01 |
2020-11-05 |
Ikaika Therapeutics Llc |
Mitigación del daño tisular y la fibrosis a través de anticuerpos anti-LTBP4
|
|
MX2015004151A
(es)
|
2012-10-05 |
2015-07-06 |
Rigel Pharmaceuticals Inc |
Inhibidores del factor de diferenciacion de crecimiento-8 (gdf-8).
|
|
MX366336B
(es)
|
2012-11-02 |
2019-07-05 |
Celgene Corp |
Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros.
|
|
CA2899889A1
(en)
|
2013-02-01 |
2014-08-07 |
Santa Maria Biotherapeutics, Inc. |
Administration of an anti-activin-a compound to a subject
|
|
CA2911514A1
(en)
|
2013-05-06 |
2014-11-13 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
|
JP6649895B2
(ja)
|
2014-04-18 |
2020-02-19 |
アクセルロン ファーマ, インコーポレイテッド |
赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法
|
|
WO2015187977A1
(en)
|
2014-06-04 |
2015-12-10 |
Acceleron Pharma, Inc. |
Methods and compositions for treatment of disorders with follistatin polypeptides
|
|
AU2015274277B2
(en)
|
2014-06-13 |
2021-03-18 |
Acceleron Pharma, Inc. |
Methods and compositions for treating ulcers
|
|
MA41052A
(fr)
|
2014-10-09 |
2017-08-15 |
Celgene Corp |
Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
|
|
ES2895626T3
(es)
|
2014-11-21 |
2022-02-22 |
Rigel Pharmaceuticals Inc |
Derivados de imidazol condensados como inhibidores de TGF-beta
|
|
SMT202300166T1
(it)
|
2014-12-03 |
2023-07-20 |
Celgene Corp |
Antagonisti di attivina- actrii e usi per il trattamento di sindrome mielodisplastica
|
|
MA41119A
(fr)
|
2014-12-03 |
2017-10-10 |
Acceleron Pharma Inc |
Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
|
|
JP6800158B2
(ja)
|
2015-02-20 |
2020-12-16 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
Gdf−8阻害剤
|
|
EP3265454B1
(en)
|
2015-03-02 |
2020-02-26 |
Rigel Pharmaceuticals, Inc. |
Tgf-beta inhibitors
|
|
US11021468B2
(en)
|
2015-04-01 |
2021-06-01 |
Rigel Pharmaceuticals, Inc. |
TGF-ß inhibitors
|
|
EP3277673B1
(en)
|
2015-04-01 |
2022-05-04 |
Rigel Pharmaceuticals, Inc. |
Tgf-beta inhibitors
|
|
JP6810702B2
(ja)
|
2015-04-06 |
2021-01-06 |
アクセルロン ファーマ インコーポレイテッド |
シングルアームi型およびii型受容体融合タンパク質およびその使用
|
|
BR112017021510A2
(pt)
|
2015-04-06 |
2018-07-03 |
Acceleron Pharma Inc |
heteromultímeros do receptor tipo i e tipo ii da superfamília tgf-beta e sua utilização
|
|
MA41919A
(fr)
|
2015-04-06 |
2018-02-13 |
Acceleron Pharma Inc |
Hétéromultimères alk4:actriib et leurs utilisations
|
|
RS61881B1
(sr)
|
2015-04-22 |
2021-06-30 |
Biogen Ma Inc |
Novi hibridni actriib proteini zamke za ligand za lečenje bolesti gubljenja mišića
|
|
US11123430B2
(en)
|
2015-11-04 |
2021-09-21 |
Acceleron Pharma Inc. |
Methods for increasing red blood cell levels and treating ineffective erythropoiesis
|
|
CA3005975A1
(en)
|
2015-11-23 |
2017-06-01 |
Acceleron Pharma Inc. |
Methods for treating eye disorders
|
|
EP3439741A4
(en)
|
2016-04-06 |
2020-05-06 |
Acceleron Pharma Inc. |
ALK7 ANTAGONISTS AND USES THEREOF
|
|
AU2017296040C1
(en)
|
2016-07-15 |
2023-06-22 |
Acceleron Pharma Inc. |
Compositions and methods for treating pulmonary hypertension
|
|
MX2019001043A
(es)
|
2016-07-27 |
2019-09-26 |
Acceleron Pharma Inc |
Metodos y composiciones para el tratamiento de la mielofibrosis.
|
|
EP3522913A4
(en)
|
2016-10-05 |
2020-10-28 |
Acceleron Pharma Inc. |
ALK4 HETEROMULTIMERS: ACTRIIB AND THEIR USES
|
|
JP2019529509A
(ja)
|
2016-10-05 |
2019-10-17 |
アクセレロン ファーマ インコーポレーテッド |
腎臓疾患を治療するための組成物および方法
|
|
WO2018067874A1
(en)
|
2016-10-05 |
2018-04-12 |
Acceleron Pharma Inc. |
Variant actriib proteins and uses thereof
|
|
JOP20190085A1
(ar)
|
2016-10-20 |
2019-04-17 |
Biogen Ma Inc |
طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة
|
|
KR20210117271A
(ko)
|
2018-12-21 |
2021-09-28 |
노쓰웨스턴유니버시티 |
근막 손상 예방 및 치료를 위한 아넥신의 사용근각 손상 예방 및 치료를 위한 아넥신의 사용
|
|
WO2020139977A1
(en)
|
2018-12-26 |
2020-07-02 |
Northwestern University |
Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder
|
|
JP7715345B2
(ja)
*
|
2019-06-26 |
2025-07-30 |
神戸天然物化学株式会社 |
ミオスタチン遺伝子のmRNAの産生を抑制する核酸医薬
|