JP2003508483A - 膜ミメティクスを用いた蛋白質性薬物の送達システム - Google Patents

膜ミメティクスを用いた蛋白質性薬物の送達システム

Info

Publication number
JP2003508483A
JP2003508483A JP2001521297A JP2001521297A JP2003508483A JP 2003508483 A JP2003508483 A JP 2003508483A JP 2001521297 A JP2001521297 A JP 2001521297A JP 2001521297 A JP2001521297 A JP 2001521297A JP 2003508483 A JP2003508483 A JP 2003508483A
Authority
JP
Japan
Prior art keywords
preparation
phospholipid
chloride
sodium
lecithin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2001521297A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003508483A5 (https=
Inventor
モーディ，パンカジュ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generex Pharmaceuticals Inc
Original Assignee
Generex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generex Pharmaceuticals Inc filed Critical Generex Pharmaceuticals Inc
Publication of JP2003508483A publication Critical patent/JP2003508483A/ja
Publication of JP2003508483A5 publication Critical patent/JP2003508483A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2001521297A 1999-09-07 2000-03-24 膜ミメティクスを用いた蛋白質性薬物の送達システム Ceased JP2003508483A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/391,664 1999-09-07
US09/391,664 US6290987B1 (en) 1998-09-27 1999-09-07 Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
PCT/CA2000/000323 WO2001017506A1 (en) 1999-09-07 2000-03-24 Proteinic drug delivery system using membrane mimetics

Publications (2)

Publication Number Publication Date
JP2003508483A true JP2003508483A (ja) 2003-03-04
JP2003508483A5 JP2003508483A5 (https=) 2007-05-10

Family

ID=23547478

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001521297A Ceased JP2003508483A (ja) 1999-09-07 2000-03-24 膜ミメティクスを用いた蛋白質性薬物の送達システム

Country Status (8)

Country Link
US (1) US6290987B1 (https=)
EP (1) EP1217988A1 (https=)
JP (1) JP2003508483A (https=)
AU (1) AU3412700A (https=)
CA (1) CA2383724C (https=)
MX (1) MXPA02002485A (https=)
NZ (1) NZ517499A (https=)
WO (1) WO2001017506A1 (https=)

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US6451286B1 (en) 1998-12-21 2002-09-17 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US7087215B2 (en) 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6375975B1 (en) * 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
FR2803202B1 (fr) * 2000-01-03 2004-04-16 Capsulis Compositions pharmaceutiques destinees a une adminstration par voie orale
GB0007150D0 (en) * 2000-03-24 2000-05-17 Lamellar Therapeutics Limited Immunotherapeutic methods and compositions
US6432383B1 (en) * 2000-03-30 2002-08-13 Generex Pharmaceuticals Incorporated Method for administering insulin
EP2206720A1 (en) 2000-04-12 2010-07-14 Human Genome Sciences, Inc. Albumin fusion proteins
CA2319928A1 (en) * 2000-09-18 2002-03-18 Vasogen Ireland Limited Apoptosis-mimicking synthetic entities and use thereof in medical treatments
TWI281407B (en) * 2000-09-18 2007-05-21 Vasogen Ireland Ltd Apoptosis-mimicking synthetic entities and use thereof in medical treatment
DE60226175T2 (de) * 2001-11-14 2009-07-09 Novavax, Inc. Mycobakterieller impfstoff
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
EP1480691A4 (en) * 2002-03-05 2007-11-28 Univ State Cleveland AGGLOMERATED PARTICLES FOR THE DISPOSAL OF A MEDICINAL PRODUCT IN AEROSOL FORM
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0322448D0 (en) * 2003-09-25 2003-10-29 Lamellar Therapeutics Ltd Using lamellar bodies to modify linear biological macro molecules
US20050238632A1 (en) * 2004-04-23 2005-10-27 Alburty David S Propellant formulations
CN100400097C (zh) * 2005-08-22 2008-07-09 上海医药工业研究院 一种胰岛素经鼻给药液体制剂
GB2430881B (en) 2005-10-06 2010-10-13 Ntnu Technology Transfer As Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity
EP2366787B1 (en) 2006-01-13 2019-12-11 The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services Codon optimized IL-15 and IL-15R-Alpha genes for expression in mammalian cells
GB0707096D0 (en) 2007-04-12 2007-05-23 Ntnu Technology Transfer As Method
KR20100044225A (ko) 2007-07-21 2010-04-29 알바니 몰레큘라 리써치, 인크. 5-피리디논 치환된 인다졸
KR20100098653A (ko) 2007-11-21 2010-09-08 디코드 제네틱스 이에이치에프 염증의 치료를 위한 바이아릴 ｐｄｅ４ 억제제
US8716308B2 (en) 2008-01-11 2014-05-06 Albany Molecular Research, Inc. (1-azinone)-substituted pyridoindoles
CN102112110A (zh) * 2008-06-06 2011-06-29 米尔纳医疗股份有限公司 用于RNAi试剂体内递送的新型组合物
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
WO2010059836A1 (en) 2008-11-20 2010-05-27 Decode Genetics Ehf Substituted aza-bridged bicyclics for cardiovascular and cns disease
AU2010207486B2 (en) 2009-01-26 2013-03-07 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
GB0904942D0 (en) 2009-03-23 2009-05-06 Ntnu Technology Transfer As Composition
GB0904941D0 (en) 2009-03-23 2009-05-06 Ntnu Technology Transfer As Composition
BR112012012945A2 (pt) 2009-11-25 2020-12-29 Arisgen Sa Composição de liberação mucosal, seu método de produção, complexo de peptídeo pré-formado, kit e uso de um agente ativo de peptídeo
US20130052221A1 (en) 2010-02-26 2013-02-28 The Govt. of the U.S, as represented by The Sec. of The Dept. of Health and Human Services Dna-protein vaccination protocols
US20120201857A1 (en) * 2010-03-17 2012-08-09 Pankaj Modi Transdermal delivery system for therapeutics
JP2021518413A (ja) 2018-03-20 2021-08-02 アイカーン スクール オブ メディシン アット マウント サイナイ キナーゼ阻害剤化合物及び組成物ならびに使用方法
AU2019334202A1 (en) 2018-09-06 2021-03-25 Innopharmascreen, Inc. Methods and compositions for treatment of asthma or parkinson's disease
WO2020142485A1 (en) 2018-12-31 2020-07-09 Icahn School Of Medicine At Mount Sinai Kinase inhibitor compounds and compositions and methods of use

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JPS5989633A (ja) * 1982-07-29 1984-05-23 チバ−ガイギ−・アクチエンゲゼルシヤフト 水性相中リポゾ−ムの製造方法
JPS6414A (en) * 1987-02-25 1989-01-05 Takeda Chem Ind Ltd Liposome preparation and production thereof
JPH02500360A (ja) * 1986-07-28 1990-02-08 リポソーム　テクノロジー，インコーポレイテッド 粘膜組織上での高い保持力を有するリポソーム
JPH0320214A (ja) * 1989-02-09 1991-01-29 L'oreal Sa 化粧品および製薬分野で用いることが出来る泡状物の調整方法とこの方法で得られる泡状物
JPH04360832A (ja) * 1991-06-07 1992-12-14 Asahi Chem Ind Co Ltd リポソーム製剤
WO1997010804A1 (en) * 1995-09-21 1997-03-27 Helene Curtis, Inc. Body wash composition to impart conditioning properties to skin
WO1997042938A1 (en) * 1996-05-14 1997-11-20 Biozone Laboratories, Inc. Delivery of biologically active material in a liposomal formulation for administration into the mouth

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US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation
US6193997B1 (en) * 1998-09-27 2001-02-27 Generex Pharmaceuticals Inc. Proteinic drug delivery system using membrane mimetics
US6271200B1 (en) * 1998-12-21 2001-08-07 Generex Pharmaceuticals Inc. Proteinic drug delivery system using aerosolized membrane-mimetic amphiphiles

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JPS5989633A (ja) * 1982-07-29 1984-05-23 チバ−ガイギ−・アクチエンゲゼルシヤフト 水性相中リポゾ−ムの製造方法
JPH02500360A (ja) * 1986-07-28 1990-02-08 リポソーム　テクノロジー，インコーポレイテッド 粘膜組織上での高い保持力を有するリポソーム
JPS6414A (en) * 1987-02-25 1989-01-05 Takeda Chem Ind Ltd Liposome preparation and production thereof
JPH0320214A (ja) * 1989-02-09 1991-01-29 L'oreal Sa 化粧品および製薬分野で用いることが出来る泡状物の調整方法とこの方法で得られる泡状物
JPH04360832A (ja) * 1991-06-07 1992-12-14 Asahi Chem Ind Co Ltd リポソーム製剤
WO1997010804A1 (en) * 1995-09-21 1997-03-27 Helene Curtis, Inc. Body wash composition to impart conditioning properties to skin
WO1997042938A1 (en) * 1996-05-14 1997-11-20 Biozone Laboratories, Inc. Delivery of biologically active material in a liposomal formulation for administration into the mouth

Also Published As

Publication number Publication date
AU3412700A (en) 2001-04-10
EP1217988A1 (en) 2002-07-03
MXPA02002485A (es) 2002-08-12
WO2001017506A1 (en) 2001-03-15
CA2383724A1 (en) 2001-03-15
US6290987B1 (en) 2001-09-18
NZ517499A (en) 2002-09-27
CA2383724C (en) 2012-05-08

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