JPS6414A - Liposome preparation and production thereof - Google Patents
Liposome preparation and production thereofInfo
- Publication number
- JPS6414A JPS6414A JP3912988A JP3912988A JPS6414A JP S6414 A JPS6414 A JP S6414A JP 3912988 A JP3912988 A JP 3912988A JP 3912988 A JP3912988 A JP 3912988A JP S6414 A JPS6414 A JP S6414A
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- liposome
- acyl group
- phospholipid
- drug component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To obtain the titled preparation having prolonged elimination time in blood and exhibiting improved continuing remedying effect of a drug component, by sealing a drug component in a liposome having a membrane composed of a phospholipid having saturated acyl group as the acyl group and a specific anionic surfactant as the membrane-constituting components.
CONSTITUTION: A liposome membrane is produced by using an emulsion or dispersion of (A) a phospholipid having saturated acyl group as the acyl group, preferably a glycerophospholipid or sphingophospholipid wherein both of the two saturated acyl groups are 12W18C saturated alkyl groups and (B) an aqueous liquid containing an anionic surfactant (preferably having sulfuric acid group or sulfonic acid group) having a Krafft point of ≥37°C at a concentration higher than the critical micelle concentration. A drug component is sealed in the liposome membrane to obtain the objective liposome preparation. The amount of the surfactant is preferably 0.5W50pts.wt., especially 5W20pts.wt. per 100pts.wt. of the phospholipid and the phase-transition temperature of the obtained membrane is adjusted to preferably 37W60°C, especially 40W55°C.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63039129A JP2611307B2 (en) | 1987-02-25 | 1988-02-22 | Liposome preparation and method for producing the same |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4344287 | 1987-02-25 | ||
JP62-43442 | 1987-02-25 | ||
JP63039129A JP2611307B2 (en) | 1987-02-25 | 1988-02-22 | Liposome preparation and method for producing the same |
Publications (3)
Publication Number | Publication Date |
---|---|
JPS6414A true JPS6414A (en) | 1989-01-05 |
JPH0114A JPH0114A (en) | 1989-01-05 |
JP2611307B2 JP2611307B2 (en) | 1997-05-21 |
Family
ID=26378459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63039129A Expired - Fee Related JP2611307B2 (en) | 1987-02-25 | 1988-02-22 | Liposome preparation and method for producing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2611307B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01238539A (en) * | 1989-01-12 | 1989-09-22 | Reiko Kosaka | Composition having remedying effect on dermatopathy |
JPH03106821A (en) * | 1989-09-20 | 1991-05-07 | Denki Kagaku Kogyo Kk | Antitumor agent |
JP2003508483A (en) * | 1999-09-07 | 2003-03-04 | ジェネレクス ファーマシューティカルズ インコーポレイテッド | Delivery system for proteinaceous drugs using membrane mimetics |
WO2009125816A1 (en) * | 2008-04-09 | 2009-10-15 | 株式会社 資生堂 | Vesicle and cosmetic containing the same |
CN115501917A (en) * | 2022-11-01 | 2022-12-23 | 航天科工(长沙)新材料研究院有限公司 | Nano gold catalyst and preparation method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5989633A (en) * | 1982-07-29 | 1984-05-23 | チバ−ガイギ−・アクチエンゲゼルシヤフト | Manufacture of liposome in aqueous phase |
-
1988
- 1988-02-22 JP JP63039129A patent/JP2611307B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5989633A (en) * | 1982-07-29 | 1984-05-23 | チバ−ガイギ−・アクチエンゲゼルシヤフト | Manufacture of liposome in aqueous phase |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01238539A (en) * | 1989-01-12 | 1989-09-22 | Reiko Kosaka | Composition having remedying effect on dermatopathy |
JPH03106821A (en) * | 1989-09-20 | 1991-05-07 | Denki Kagaku Kogyo Kk | Antitumor agent |
JP2003508483A (en) * | 1999-09-07 | 2003-03-04 | ジェネレクス ファーマシューティカルズ インコーポレイテッド | Delivery system for proteinaceous drugs using membrane mimetics |
WO2009125816A1 (en) * | 2008-04-09 | 2009-10-15 | 株式会社 資生堂 | Vesicle and cosmetic containing the same |
CN115501917A (en) * | 2022-11-01 | 2022-12-23 | 航天科工(长沙)新材料研究院有限公司 | Nano gold catalyst and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
JP2611307B2 (en) | 1997-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
LAPS | Cancellation because of no payment of annual fees |