JPS6475418A - Production of liposome - Google Patents

Production of liposome

Info

Publication number
JPS6475418A
JPS6475418A JP23009087A JP23009087A JPS6475418A JP S6475418 A JPS6475418 A JP S6475418A JP 23009087 A JP23009087 A JP 23009087A JP 23009087 A JP23009087 A JP 23009087A JP S6475418 A JPS6475418 A JP S6475418A
Authority
JP
Japan
Prior art keywords
liposome
active substance
water
aqueous solvent
liquid mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP23009087A
Other languages
Japanese (ja)
Other versions
JPH0573726B2 (en
Inventor
Keisuke Sakaguchi
Yoshitaka Ogata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP23009087A priority Critical patent/JPS6475418A/en
Publication of JPS6475418A publication Critical patent/JPS6475418A/en
Publication of JPH0573726B2 publication Critical patent/JPH0573726B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

PURPOSE:To obtain a liposome containing an active substance included therein in high concentration, by forming a liposome in an aqueous solvent, mixing with a water-soluble physiologically active substance, concentrating the liquid mixture by removing water therefrom and again forming a liposome. CONSTITUTION:A liposome is formed in an aqueous solvent using known method. The liposome suspension is mixed with a water-soluble physiologically active substance (e.g. hemoglobin) or its aqueous solution and the obtained liquid mixture is dehydrated and concentrated e.g. by ultrafiltration (preferably to a membrane component substance concentration of about 50-500mg/ml). A liposome is again formed from the concentrated liquid e.g. by high-pressure ejection, freezing and thawing treatment and ultrasonic treatment.
JP23009087A 1987-09-14 1987-09-14 Production of liposome Granted JPS6475418A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP23009087A JPS6475418A (en) 1987-09-14 1987-09-14 Production of liposome

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23009087A JPS6475418A (en) 1987-09-14 1987-09-14 Production of liposome

Publications (2)

Publication Number Publication Date
JPS6475418A true JPS6475418A (en) 1989-03-22
JPH0573726B2 JPH0573726B2 (en) 1993-10-15

Family

ID=16902389

Family Applications (1)

Application Number Title Priority Date Filing Date
JP23009087A Granted JPS6475418A (en) 1987-09-14 1987-09-14 Production of liposome

Country Status (1)

Country Link
JP (1) JPS6475418A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04504222A (en) * 1989-01-18 1992-07-30 ザ　リポソーム　カンパニー，インコーポレイテッド Osmosis-dependent vesicles
WO2002087540A1 (en) * 2001-04-27 2002-11-07 Horvath Istvan Artificial blood made of hemoglobin encapsulated in liposomes
JP2010508368A (en) * 2006-11-07 2010-03-18 メディゲーネ アクチエンゲゼルシャフト Production of liposomes by single-pass process

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5782310A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5782310A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04504222A (en) * 1989-01-18 1992-07-30 ザ　リポソーム　カンパニー，インコーポレイテッド Osmosis-dependent vesicles
WO2002087540A1 (en) * 2001-04-27 2002-11-07 Horvath Istvan Artificial blood made of hemoglobin encapsulated in liposomes
JP2010508368A (en) * 2006-11-07 2010-03-18 メディゲーネ アクチエンゲゼルシャフト Production of liposomes by single-pass process

Also Published As

Publication number Publication date
JPH0573726B2 (en) 1993-10-15

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