JPS6475418A - Production of liposome - Google Patents
Production of liposomeInfo
- Publication number
- JPS6475418A JPS6475418A JP23009087A JP23009087A JPS6475418A JP S6475418 A JPS6475418 A JP S6475418A JP 23009087 A JP23009087 A JP 23009087A JP 23009087 A JP23009087 A JP 23009087A JP S6475418 A JPS6475418 A JP S6475418A
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- active substance
- water
- aqueous solvent
- liquid mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
PURPOSE:To obtain a liposome containing an active substance included therein in high concentration, by forming a liposome in an aqueous solvent, mixing with a water-soluble physiologically active substance, concentrating the liquid mixture by removing water therefrom and again forming a liposome. CONSTITUTION:A liposome is formed in an aqueous solvent using known method. The liposome suspension is mixed with a water-soluble physiologically active substance (e.g. hemoglobin) or its aqueous solution and the obtained liquid mixture is dehydrated and concentrated e.g. by ultrafiltration (preferably to a membrane component substance concentration of about 50-500mg/ml). A liposome is again formed from the concentrated liquid e.g. by high-pressure ejection, freezing and thawing treatment and ultrasonic treatment.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23009087A JPS6475418A (en) | 1987-09-14 | 1987-09-14 | Production of liposome |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23009087A JPS6475418A (en) | 1987-09-14 | 1987-09-14 | Production of liposome |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6475418A true JPS6475418A (en) | 1989-03-22 |
JPH0573726B2 JPH0573726B2 (en) | 1993-10-15 |
Family
ID=16902389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP23009087A Granted JPS6475418A (en) | 1987-09-14 | 1987-09-14 | Production of liposome |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6475418A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04504222A (en) * | 1989-01-18 | 1992-07-30 | ザ リポソーム カンパニー,インコーポレイテッド | Osmosis-dependent vesicles |
WO2002087540A1 (en) * | 2001-04-27 | 2002-11-07 | Horvath Istvan | Artificial blood made of hemoglobin encapsulated in liposomes |
JP2010508368A (en) * | 2006-11-07 | 2010-03-18 | メディゲーネ アクチエンゲゼルシャフト | Production of liposomes by single-pass process |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5782310A (en) * | 1980-11-11 | 1982-05-22 | Tanabe Seiyaku Co Ltd | Production of liposome preparation |
-
1987
- 1987-09-14 JP JP23009087A patent/JPS6475418A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5782310A (en) * | 1980-11-11 | 1982-05-22 | Tanabe Seiyaku Co Ltd | Production of liposome preparation |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04504222A (en) * | 1989-01-18 | 1992-07-30 | ザ リポソーム カンパニー,インコーポレイテッド | Osmosis-dependent vesicles |
WO2002087540A1 (en) * | 2001-04-27 | 2002-11-07 | Horvath Istvan | Artificial blood made of hemoglobin encapsulated in liposomes |
JP2010508368A (en) * | 2006-11-07 | 2010-03-18 | メディゲーネ アクチエンゲゼルシャフト | Production of liposomes by single-pass process |
Also Published As
Publication number | Publication date |
---|---|
JPH0573726B2 (en) | 1993-10-15 |
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