JP2003508429A5 - - Google Patents
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- Publication number
- JP2003508429A5 JP2003508429A5 JP2001519896A JP2001519896A JP2003508429A5 JP 2003508429 A5 JP2003508429 A5 JP 2003508429A5 JP 2001519896 A JP2001519896 A JP 2001519896A JP 2001519896 A JP2001519896 A JP 2001519896A JP 2003508429 A5 JP2003508429 A5 JP 2003508429A5
- Authority
- JP
- Japan
- Prior art keywords
- tramadol
- medicament
- salt
- treatment
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 description 27
- 239000003814 drug Substances 0.000 description 19
- 150000003839 salts Chemical class 0.000 description 16
- 238000004519 manufacturing process Methods 0.000 description 14
- 229960004380 tramadol Drugs 0.000 description 11
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 11
- 235000021092 sugar substitutes Nutrition 0.000 description 10
- 239000003765 sweetening agent Substances 0.000 description 10
- 239000013543 active substance Substances 0.000 description 9
- 239000002552 dosage form Substances 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 7
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 6
- 206010046543 Urinary incontinence Diseases 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 229940109275 cyclamate Drugs 0.000 description 5
- 208000007848 Alcoholism Diseases 0.000 description 4
- 208000024172 Cardiovascular disease Diseases 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 206010013654 Drug abuse Diseases 0.000 description 4
- 208000007882 Gastritis Diseases 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 description 4
- 229960005164 acesulfame Drugs 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 206010001584 alcohol abuse Diseases 0.000 description 4
- 208000025746 alcohol use disease Diseases 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
- 208000020016 psychiatric disease Diseases 0.000 description 4
- 208000023504 respiratory system disease Diseases 0.000 description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 4
- 229940081974 saccharin Drugs 0.000 description 4
- 235000019204 saccharin Nutrition 0.000 description 4
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 4
- 208000011117 substance-related disease Diseases 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 229960003107 tramadol hydrochloride Drugs 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 208000014617 hemorrhoid Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- PPKXEPBICJTCRU-UHFFFAOYSA-N [2-hydroxy-2-(3-methoxyphenyl)cyclohexyl]methyl-dimethylazanium;chloride Chemical compound Cl.COC1=CC=CC(C2(O)C(CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19940740.1 | 1999-08-31 | ||
| DE19940740A DE19940740A1 (de) | 1999-08-31 | 1999-08-31 | Pharmazeutische Salze |
| PCT/EP2000/007526 WO2001015682A1 (de) | 1999-08-31 | 2000-08-03 | Pharmazeutische tramadolsalze |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003508429A JP2003508429A (ja) | 2003-03-04 |
| JP2003508429A5 true JP2003508429A5 (https=) | 2011-06-16 |
Family
ID=7919846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001519896A Ceased JP2003508429A (ja) | 1999-08-31 | 2000-08-03 | 医薬用トラマドール塩 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6723343B2 (https=) |
| EP (1) | EP1207868B1 (https=) |
| JP (1) | JP2003508429A (https=) |
| KR (1) | KR100730502B1 (https=) |
| CN (1) | CN1200700C (https=) |
| AR (1) | AR025426A1 (https=) |
| AT (1) | ATE359064T1 (https=) |
| AU (1) | AU781852B2 (https=) |
| BR (1) | BR0015048A (https=) |
| CA (1) | CA2386690C (https=) |
| CO (1) | CO5190689A1 (https=) |
| CY (1) | CY1107675T1 (https=) |
| CZ (1) | CZ301259B6 (https=) |
| DE (2) | DE19940740A1 (https=) |
| DK (1) | DK1207868T3 (https=) |
| ES (1) | ES2284523T3 (https=) |
| HK (1) | HK1047229B (https=) |
| HU (1) | HUP0302131A2 (https=) |
| IL (2) | IL148406A0 (https=) |
| MX (1) | MXPA02002024A (https=) |
| MY (1) | MY127683A (https=) |
| NO (1) | NO329625B1 (https=) |
| NZ (1) | NZ517366A (https=) |
| PE (1) | PE20010531A1 (https=) |
| PL (1) | PL212105B1 (https=) |
| PT (1) | PT1207868E (https=) |
| RU (1) | RU2292876C2 (https=) |
| SI (1) | SI1207868T1 (https=) |
| SK (1) | SK285987B6 (https=) |
| UY (1) | UY26320A1 (https=) |
| WO (1) | WO2001015682A1 (https=) |
| ZA (1) | ZA200202536B (https=) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10108308A1 (de) | 2001-02-21 | 2002-08-29 | Gruenenthal Gmbh | Verfahren zur Isolierung und Reinigung von (1RS,2RS)-2[(Dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol |
| US20050176790A1 (en) * | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| US20060177381A1 (en) * | 2002-02-15 | 2006-08-10 | Howard Brooks-Korn | Opiopathies |
| MXPA04008100A (es) * | 2002-02-21 | 2005-06-17 | Biovail Lab Int Srl | Formulaciones de liberacion modificada de al menos una forma de tramadol. |
| US8128957B1 (en) | 2002-02-21 | 2012-03-06 | Valeant International (Barbados) Srl | Modified release compositions of at least one form of tramadol |
| US20050182056A9 (en) * | 2002-02-21 | 2005-08-18 | Seth Pawan | Modified release formulations of at least one form of tramadol |
| EP1492511B3 (fr) | 2002-04-09 | 2012-05-02 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| EP1364649A1 (en) * | 2002-05-23 | 2003-11-26 | Cilag AG | Adduct of topiramate and tramadol hydrochioride and uses thereof |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US10004729B2 (en) | 2002-07-05 | 2018-06-26 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| US7399488B2 (en) * | 2002-07-05 | 2008-07-15 | Collegium Pharmaceutical, Inc. | Abuse-deterrent pharmaceutical compositions of opiods and other drugs |
| US8557291B2 (en) * | 2002-07-05 | 2013-10-15 | Collegium Pharmaceutical, Inc. | Abuse-deterrent pharmaceutical compositions of opioids and other drugs |
| US8840928B2 (en) * | 2002-07-05 | 2014-09-23 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| US8487002B2 (en) | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
| TWI319713B (en) | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| EP1658054B1 (de) * | 2003-08-06 | 2007-06-27 | Grünenthal GmbH | Gegen missbrauch gesicherte darreichungsform |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE102004020220A1 (de) * | 2004-04-22 | 2005-11-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US20070048228A1 (en) * | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
| CA2916869A1 (en) * | 2004-06-12 | 2005-12-29 | Jane C. Hirsh | Abuse-deterrent drug formulations |
| DE102004032103A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| NZ565108A (en) | 2005-07-07 | 2011-10-28 | Farnam Co Inc | Sustained release pharmaceutical compositions for highly water soluble drugs |
| PT1931346E (pt) | 2005-09-09 | 2012-08-14 | Angelini Labopharm Llc | Composição de trazodona para administração uma vez por dia |
| WO2007048219A2 (en) | 2005-09-09 | 2007-05-03 | Labopharm Inc. | Sustained drug release composition |
| EP1785412A1 (en) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Tramadol recovery process |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| GB0712101D0 (en) * | 2007-06-22 | 2007-08-01 | Therapeutics Ltd E | Treatment of depression |
| JP2011506374A (ja) * | 2007-12-12 | 2011-03-03 | ウルティモルフィクス・テクノロジーズ・ベー・フェー | テノホビルジソプロキシルの固形物 |
| CN101467984B (zh) * | 2007-12-25 | 2012-05-23 | 上海医药工业研究院 | 一种曲马多鼻用凝胶剂及其制备方法和用途 |
| CA2713128C (en) | 2008-01-25 | 2016-04-05 | Gruenenthal Gmbh | Pharmaceutical dosage form |
| US7935817B2 (en) * | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
| AU2009243681B2 (en) | 2008-05-09 | 2013-12-19 | Grunenthal Gmbh | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
| GB0811024D0 (en) * | 2008-06-17 | 2008-07-23 | E Therapeutics Plc | Sustained release treatment of depression |
| US20100003322A1 (en) * | 2008-07-03 | 2010-01-07 | Lai Felix S | Enteric coated hydrophobic matrix formulation |
| KR101738369B1 (ko) | 2009-07-22 | 2017-05-22 | 그뤼넨탈 게엠베하 | 핫 멜트 압출된 제어 방출 투여형 |
| CN102639118B (zh) | 2009-07-22 | 2015-07-29 | 格吕伦塔尔有限公司 | 氧化稳定的抗干扰剂型 |
| US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| ES2606227T3 (es) | 2010-02-03 | 2017-03-23 | Grünenthal GmbH | Preparación de una composición farmacéutica en polvo mediante una extrusora |
| BR112013005194A2 (pt) | 2010-09-02 | 2016-05-03 | Gruenenthal Gmbh | forma de dosagem resistente à violação compreendendo sal inorgânico |
| TWI516286B (zh) | 2010-09-02 | 2016-01-11 | 歌林達股份有限公司 | 含陰離子聚合物之抗破碎劑型 |
| US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
| EA201400172A1 (ru) | 2011-07-29 | 2014-06-30 | Грюненталь Гмбх | Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства |
| BR112014001091A2 (pt) | 2011-07-29 | 2017-02-14 | Gruenenthal Gmbh | comprimido resistente à adulteração que fornece liberação imediata do fármaco |
| MX356421B (es) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico. |
| EP2838512B1 (en) | 2012-04-18 | 2018-08-22 | Grünenthal GmbH | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
| EP3003279A1 (en) | 2013-05-29 | 2016-04-13 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
| BR112016000194A8 (pt) | 2013-07-12 | 2019-12-31 | Gruenenthal Gmbh | forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila |
| EP3073994A1 (en) | 2013-11-26 | 2016-10-05 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| WO2015173195A1 (en) | 2014-05-12 | 2015-11-19 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
| EA201692388A1 (ru) | 2014-05-26 | 2017-05-31 | Грюненталь Гмбх | Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы |
| US9192613B1 (en) * | 2014-10-14 | 2015-11-24 | Sapere Ip, Llc | Treatment method for primary premature ejaculation |
| WO2016170097A1 (en) | 2015-04-24 | 2016-10-27 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
| JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
| US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
| IL267689B2 (en) | 2016-12-31 | 2025-05-01 | Bioxcel Therapeutics Inc | Use of sublingual dexmedetomidine for the treatment of agitation |
| GR1009629B (el) | 2018-02-20 | 2019-10-25 | Laboserve Φαρμακευτικη Βιομηχανια Α.Ε. | Ποσιμα διαλυματα που περιλαμβανουν τραμαδολη |
| GR1009630B (el) | 2018-03-14 | 2019-10-25 | Laboserve Φαρμακευτικη Βιομηχανια Α.Ε. | Ποσιμα διαλυματα που περιλαμβανουν τραμαδολη και ακεταμινοφαινη |
| BR112020026672A2 (pt) | 2018-06-27 | 2021-03-30 | Bioxcel Therapeutics, Inc. | Formulações de filme contendo dexmedetomidina e métodos para produzi-las |
| BR112022000992A2 (pt) | 2019-07-19 | 2022-06-14 | Arx Llc | Regimes de tratamento de dexmedetomidina não sedantes |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
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| US6054296A (en) * | 1988-10-24 | 2000-04-25 | Symbicom Ab | 66 kDa antigen from Borrelia |
| US3652589A (en) | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| NZ210386A (en) * | 1983-12-09 | 1987-11-27 | Sterling Drug Inc | Saccharine salts and dentrifice compositions |
| CA1260941A (en) * | 1983-12-09 | 1989-09-26 | Sanofi | Bis¬4-(substituted-amino)-1-pyridinium|alkane saccharin salts and process of preparation thereof |
| CA2077637C (en) * | 1991-09-06 | 2007-01-09 | Robert B. Raffa | Compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone and their use |
| US5837277A (en) * | 1992-06-04 | 1998-11-17 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
| US5330760A (en) * | 1992-08-27 | 1994-07-19 | Sterling Winthrop Inc. | Effervescent antacid |
| DE19530575A1 (de) * | 1995-08-19 | 1997-02-20 | Gruenenthal Gmbh | Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz |
| US5919826A (en) * | 1996-10-24 | 1999-07-06 | Algos Pharmaceutical Corporation | Method of alleviating pain |
| AU6747698A (en) * | 1997-04-11 | 1998-11-11 | Nippon Shinyaku Co. Ltd. | Remedies for frequent urination and urinary incontinence |
| ATE284211T1 (de) * | 1997-11-06 | 2004-12-15 | Lannacher Heilmittel | Orale retard-präparation enthaltend tramadol sowie verfahren zu ihrer herstellung |
| EP1107738A4 (en) * | 1998-08-27 | 2003-01-22 | Bristol Myers Squibb Co | Novel pharmaceutical salt form |
| US6165512A (en) * | 1998-10-30 | 2000-12-26 | Fuisz Technologies Ltd. | Dosage forms containing taste masked active agents |
| PL213323B1 (pl) * | 1999-08-20 | 2013-02-28 | Ortho Mcneil Pharm Inc | Kompozycja farmaceutyczna i jej zastosowanie |
| ES2226886T3 (es) * | 1999-08-31 | 2005-04-01 | Grunenthal Gmbh | Forma de administracion de accion retardada que contiene sacarinato de tramadol. |
| DE19940944B4 (de) * | 1999-08-31 | 2006-10-12 | Grünenthal GmbH | Retardierte, orale, pharmazeutische Darreichungsformen |
| US20020119193A1 (en) * | 2000-08-18 | 2002-08-29 | Le Trang T. | Oral fast-melt formulation of a cyclooxygenase-2 inhibitor |
-
1999
- 1999-08-31 DE DE19940740A patent/DE19940740A1/de not_active Withdrawn
-
2000
- 2000-08-03 PL PL354238A patent/PL212105B1/pl not_active IP Right Cessation
- 2000-08-03 NZ NZ517366A patent/NZ517366A/en not_active IP Right Cessation
- 2000-08-03 MY MYPI20003557A patent/MY127683A/en unknown
- 2000-08-03 SI SI200030952T patent/SI1207868T1/sl unknown
- 2000-08-03 SK SK235-2002A patent/SK285987B6/sk not_active IP Right Cessation
- 2000-08-03 DE DE50014244T patent/DE50014244D1/de not_active Expired - Lifetime
- 2000-08-03 AU AU69921/00A patent/AU781852B2/en not_active Ceased
- 2000-08-03 CZ CZ20020674A patent/CZ301259B6/cs not_active IP Right Cessation
- 2000-08-03 KR KR1020027002634A patent/KR100730502B1/ko not_active Expired - Fee Related
- 2000-08-03 EP EP00958375A patent/EP1207868B1/de not_active Expired - Lifetime
- 2000-08-03 WO PCT/EP2000/007526 patent/WO2001015682A1/de not_active Ceased
- 2000-08-03 AT AT00958375T patent/ATE359064T1/de active
- 2000-08-03 JP JP2001519896A patent/JP2003508429A/ja not_active Ceased
- 2000-08-03 DK DK00958375T patent/DK1207868T3/da active
- 2000-08-03 HU HU0302131A patent/HUP0302131A2/hu unknown
- 2000-08-03 BR BR0015048-7A patent/BR0015048A/pt not_active Application Discontinuation
- 2000-08-03 MX MXPA02002024A patent/MXPA02002024A/es active IP Right Grant
- 2000-08-03 CN CNB008121591A patent/CN1200700C/zh not_active Expired - Fee Related
- 2000-08-03 RU RU2002106748/15A patent/RU2292876C2/ru not_active IP Right Cessation
- 2000-08-03 HK HK02108598.7A patent/HK1047229B/zh not_active IP Right Cessation
- 2000-08-03 ES ES00958375T patent/ES2284523T3/es not_active Expired - Lifetime
- 2000-08-03 IL IL14840600A patent/IL148406A0/xx active IP Right Grant
- 2000-08-03 PT PT00958375T patent/PT1207868E/pt unknown
- 2000-08-03 CA CA002386690A patent/CA2386690C/en not_active Expired - Fee Related
- 2000-08-25 PE PE2000000873A patent/PE20010531A1/es not_active Application Discontinuation
- 2000-08-28 AR ARP000104480A patent/AR025426A1/es unknown
- 2000-08-28 CO CO00064190A patent/CO5190689A1/es not_active Application Discontinuation
- 2000-08-31 UY UY26320A patent/UY26320A1/es not_active Application Discontinuation
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2002
- 2002-02-27 IL IL148406A patent/IL148406A/en not_active IP Right Cessation
- 2002-02-27 NO NO20020974A patent/NO329625B1/no not_active IP Right Cessation
- 2002-02-28 US US10/084,682 patent/US6723343B2/en not_active Expired - Fee Related
- 2002-03-28 ZA ZA200202536A patent/ZA200202536B/xx unknown
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2007
- 2007-06-18 CY CY20071100802T patent/CY1107675T1/el unknown
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