JP2003507040A5 - - Google Patents
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- Publication number
- JP2003507040A5 JP2003507040A5 JP2001517682A JP2001517682A JP2003507040A5 JP 2003507040 A5 JP2003507040 A5 JP 2003507040A5 JP 2001517682 A JP2001517682 A JP 2001517682A JP 2001517682 A JP2001517682 A JP 2001517682A JP 2003507040 A5 JP2003507040 A5 JP 2003507040A5
- Authority
- JP
- Japan
- Prior art keywords
- rotavirus
- vaccine composition
- antacid
- vaccine
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 26
- 229960005486 vaccine Drugs 0.000 description 23
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 15
- 241000702670 Rotavirus Species 0.000 description 15
- 229940069428 antacid Drugs 0.000 description 11
- 239000003159 antacid agent Substances 0.000 description 11
- 230000001458 anti-acid effect Effects 0.000 description 11
- 239000002773 nucleotide Substances 0.000 description 10
- 125000003729 nucleotide group Chemical group 0.000 description 10
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 9
- 230000002238 attenuated effect Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 241000700605 Viruses Species 0.000 description 5
- 229930024421 Adenine Natural products 0.000 description 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 4
- 108020004705 Codon Proteins 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 229960000643 adenine Drugs 0.000 description 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 229940113082 thymine Drugs 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000011345 viscous material Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 101100379079 Emericella variicolor andA gene Proteins 0.000 description 1
- 241000617996 Human rotavirus Species 0.000 description 1
- 206010067470 Rotavirus infection Diseases 0.000 description 1
- 229940124859 Rotavirus vaccine Drugs 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9919468.0A GB9919468D0 (en) | 1999-08-17 | 1999-08-17 | Vaccine |
| GB9919468.0 | 1999-08-17 | ||
| GBGB9927336.9A GB9927336D0 (en) | 1999-11-18 | 1999-11-18 | Vaccine |
| GB9927336.9 | 1999-11-18 | ||
| PCT/EP2000/007965 WO2001012797A2 (en) | 1999-08-17 | 2000-08-15 | Method of separating rotavirus variants and live attenuated rotavirus vaccine |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007211282A Division JP2007319164A (ja) | 1999-08-17 | 2007-08-14 | ワクチン |
| JP2010217093A Division JP5474720B2 (ja) | 1999-08-17 | 2010-09-28 | ワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003507040A JP2003507040A (ja) | 2003-02-25 |
| JP2003507040A5 true JP2003507040A5 (https=) | 2007-10-04 |
Family
ID=26315853
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001517682A Pending JP2003507040A (ja) | 1999-08-17 | 2000-08-15 | ワクチン |
| JP2007211282A Withdrawn JP2007319164A (ja) | 1999-08-17 | 2007-08-14 | ワクチン |
| JP2010217093A Expired - Lifetime JP5474720B2 (ja) | 1999-08-17 | 2010-09-28 | ワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007211282A Withdrawn JP2007319164A (ja) | 1999-08-17 | 2007-08-14 | ワクチン |
| JP2010217093A Expired - Lifetime JP5474720B2 (ja) | 1999-08-17 | 2010-09-28 | ワクチン |
Country Status (42)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200200420T2 (tr) * | 1999-08-17 | 2002-05-21 | Smithkline Beecham Biologicals S.A. | Aşı |
| US6592869B2 (en) | 1999-08-24 | 2003-07-15 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
| GB0020089D0 (en) * | 2000-08-15 | 2000-10-04 | Smithkline Beecham Biolog | Vaccine Composition |
| KR20030026654A (ko) * | 2001-09-26 | 2003-04-03 | 주식회사 씨트리 | 인간 로타바이러스의 활성을 저해하는 항체의 생산용 항원및 그의 제조방법과 이용 |
| WO2005021033A2 (en) * | 2003-09-02 | 2005-03-10 | Glaxosmithkline Biologicals S.A. | Vaccine |
| GB0414787D0 (en) | 2004-07-01 | 2004-08-04 | Glaxosmithkline Biolog Sa | Method |
| GB0503337D0 (en) * | 2005-02-17 | 2005-03-23 | Glaxosmithkline Biolog Sa | Compositions |
| WO2007020078A2 (en) * | 2005-08-17 | 2007-02-22 | Glaxosmithkline Biologicals S.A. | Rotavirus vaccine inducing heterotypic cross protection |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| KR101051986B1 (ko) * | 2006-09-28 | 2011-07-26 | 중앙대학교 산학협력단 | 인간로타바이러스 및 이를 이용한 백신 조성물 |
| DK2099485T3 (en) * | 2006-11-03 | 2018-05-22 | Alphavax Inc | Alphavirus and alphavirus replica particle formulations and associated methods |
| EP2236617A1 (en) | 2009-03-31 | 2010-10-06 | Leukocare Ag | Methods of terminal sterilization of biofunctional compositions |
| CN102695522B (zh) | 2009-05-12 | 2016-10-19 | 美国政府(由卫生和人类服务部、疾病控制和预防中心的部长所代表) | 新的人轮状病毒株和疫苗 |
| CN102470170B (zh) * | 2009-07-13 | 2015-03-18 | 巴拉特生物技术国际有限公司 | 用作轮状病毒疫苗的组合物及其方法 |
| FR2960781B1 (fr) * | 2010-06-07 | 2013-11-22 | Sanofi Pasteur | Preparation d'un vaccin oral sec stabilise, compose d'un virus vivant attenue |
| CN110227152A (zh) | 2012-04-23 | 2019-09-13 | 巴拉特生物技术国际有限公司 | 轮状病毒疫苗组合物及其制备方法 |
| NZ631348A (en) | 2012-08-27 | 2017-02-24 | Murdoch Childrens Res Inst | Modified human rotaviruses and uses therefor |
| CN106167518B (zh) * | 2015-05-21 | 2021-01-15 | 厦门大学 | 截短的轮状病毒vp4蛋白及其用途 |
| EP3359651A1 (en) | 2015-10-05 | 2018-08-15 | THE UNITED STATES OF AMERICA, represented by the S | Human rota virus g9p[6]strain and use as a vaccine |
| EP3373965A1 (en) * | 2015-11-09 | 2018-09-19 | CureVac AG | Rotavirus vaccines |
| MX2018007413A (es) * | 2015-12-18 | 2018-08-15 | Merck Sharp & Dohme | Formulaciones de vacuna contra rotavirus termicamente estable y metodos de uso de la misma. |
| MA44557B1 (fr) | 2016-06-16 | 2021-11-30 | Bharat Biotech Int Ltd | Vaccin contre le rotavirus sans tampon, stable en milieu acide, et d'un faible volume de dose à administrer |
| GB201614799D0 (en) | 2016-09-01 | 2016-10-19 | Glaxosmithkline Biologicals Sa | Compositions |
| CN110856493B (zh) * | 2018-08-20 | 2022-02-25 | 中国烟草总公司黑龙江省公司牡丹江烟草科学研究所 | 一种植物病毒弱毒疫苗组合物、弱毒疫苗保存方法及其应用 |
| WO2024242174A1 (ja) * | 2023-05-24 | 2024-11-28 | 国立大学法人大阪大学 | 一回感染性ロタウイルスおよびその利用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5927323B2 (ja) | 1976-10-12 | 1984-07-05 | 花王株式会社 | 歯みがき組成物 |
| US4341763A (en) * | 1981-03-10 | 1982-07-27 | Smithkline-Rit | Methods of vaccinating humans against rotavirus infection |
| US4571385A (en) * | 1983-06-27 | 1986-02-18 | The United States Of America As Represented By The Department Of Health And Human Services | Genetic reassortment of rotaviruses for production of vaccines and vaccine precursors |
| EP0152295B1 (en) | 1984-02-09 | 1991-03-20 | Royal Children's Hospital Research Foundation | Live attenuated human rotavirus vaccine and preparation thereof |
| US5626851A (en) * | 1987-11-30 | 1997-05-06 | The Wistar Institute Of Anatomy And Biology | Rotavirus reassortant vaccine |
| KR0171434B1 (ko) * | 1990-11-16 | 1999-02-01 | 윌리엄 케이. 슈버트 | 인체 로타바이러스, 백신 및 방법 |
| US5471385A (en) * | 1992-05-21 | 1995-11-28 | Tsubakimoto Chain Co. | Routeless guiding method for moving body |
| US5773009A (en) | 1994-04-15 | 1998-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Rotavirus strain G9P11 |
| WO1996001651A1 (en) | 1994-07-11 | 1996-01-25 | The Government Of The United States Of America, Represented By The Department Of Health And Human Services | Attenuated human rotavirus vaccine |
| US6403098B1 (en) | 1996-09-26 | 2002-06-11 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| US5932223A (en) | 1996-09-26 | 1999-08-03 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| WO1998013065A1 (en) * | 1996-09-26 | 1998-04-02 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| US6552024B1 (en) | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
| TR200200420T2 (tr) * | 1999-08-17 | 2002-05-21 | Smithkline Beecham Biologicals S.A. | Aşı |
-
2000
- 2000-08-15 TR TR2002/00420T patent/TR200200420T2/xx unknown
- 2000-08-15 OA OA1200200054A patent/OA12312A/en unknown
- 2000-08-15 BR BRPI0013357A patent/BRPI0013357B8/pt not_active IP Right Cessation
- 2000-08-15 NZ NZ517131A patent/NZ517131A/en not_active IP Right Cessation
- 2000-08-15 CA CA2379196A patent/CA2379196C/en not_active Expired - Lifetime
- 2000-08-15 IL IL14792600A patent/IL147926A0/xx not_active IP Right Cessation
- 2000-08-15 DE DE2000628390 patent/DE122006000026I1/de active Pending
- 2000-08-15 EA EA200200142A patent/EA005952B1/ru not_active IP Right Cessation
- 2000-08-15 CN CNB008143498A patent/CN100379451C/zh not_active Expired - Lifetime
- 2000-08-15 HU HU0203335A patent/HU228975B1/hu active Protection Beyond IP Right Term
- 2000-08-15 AP APAP/P/2002/002424A patent/AP1768A/en active
- 2000-08-15 DZ DZ003219A patent/DZ3219A1/fr active
- 2000-08-15 UA UA2002021196A patent/UA77388C2/uk unknown
- 2000-08-15 AR ARP000104215A patent/AR029643A1/es active IP Right Grant
- 2000-08-15 KR KR1020027002036A patent/KR100695599B1/ko not_active Expired - Lifetime
- 2000-08-15 US US10/049,192 patent/US7285280B1/en not_active Expired - Lifetime
- 2000-08-15 AT AT00958452T patent/ATE327765T1/de active
- 2000-08-15 HK HK02108459.5A patent/HK1046860B/en not_active IP Right Cessation
- 2000-08-15 PL PL354135A patent/PL205550B1/pl unknown
- 2000-08-15 JP JP2001517682A patent/JP2003507040A/ja active Pending
- 2000-08-15 MX MXPA02001648A patent/MXPA02001648A/es active IP Right Grant
- 2000-08-15 MY MYPI20003730 patent/MY133158A/en unknown
- 2000-08-15 WO PCT/EP2000/007965 patent/WO2001012797A2/en not_active Ceased
- 2000-08-15 ES ES00958452T patent/ES2260046T3/es not_active Expired - Lifetime
- 2000-08-15 SK SK243-2002A patent/SK287261B6/sk not_active IP Right Cessation
- 2000-08-15 PE PE2000000825A patent/PE20010487A1/es not_active Application Discontinuation
- 2000-08-15 CZ CZ20020522A patent/CZ302173B6/cs not_active IP Right Cessation
- 2000-08-15 EP EP00958452A patent/EP1212084B1/en not_active Expired - Lifetime
- 2000-08-15 DE DE60028390T patent/DE60028390T2/de not_active Expired - Lifetime
- 2000-08-15 AU AU69961/00A patent/AU767885B2/en not_active Expired
- 2000-08-15 PT PT00958452T patent/PT1212084E/pt unknown
- 2000-08-15 DK DK00958452T patent/DK1212084T3/da active
- 2000-08-15 SI SI200030846T patent/SI1212084T1/sl unknown
- 2000-08-16 UY UY26297A patent/UY26297A1/es not_active IP Right Cessation
- 2000-08-17 CO CO00061886A patent/CO5580165A1/es active IP Right Grant
- 2000-11-20 TW TW089124533A patent/TWI283270B/zh not_active IP Right Cessation
-
2002
- 2002-01-31 IL IL147926A patent/IL147926A/en active Protection Beyond IP Right Term
- 2002-02-15 NO NO20020763A patent/NO328112B1/no not_active IP Right Cessation
- 2002-02-15 MA MA26521A patent/MA25489A1/fr unknown
- 2002-02-15 BG BG106417A patent/BG65314B1/bg unknown
-
2006
- 2006-06-12 FR FR06C0018C patent/FR06C0018I2/fr active Active
- 2006-06-13 CY CY20061100784T patent/CY1106103T1/el unknown
- 2006-06-14 LU LU91251C patent/LU91251I2/fr unknown
- 2006-06-26 NL NL300233C patent/NL300233I2/nl unknown
- 2006-07-28 CY CY200600004C patent/CY2006004I2/el unknown
-
2007
- 2007-08-14 JP JP2007211282A patent/JP2007319164A/ja not_active Withdrawn
- 2007-08-22 US US11/843,256 patent/US7790179B2/en not_active Expired - Fee Related
- 2007-08-23 US US11/843,815 patent/US20080063662A1/en not_active Abandoned
- 2007-10-19 US US11/875,286 patent/US7790180B2/en not_active Expired - Fee Related
-
2008
- 2008-01-09 IL IL188686A patent/IL188686A0/en unknown
-
2010
- 2010-05-19 NO NO2010011C patent/NO2010011I2/no unknown
- 2010-09-28 JP JP2010217093A patent/JP5474720B2/ja not_active Expired - Lifetime
-
2013
- 2013-11-29 HU HUS1300072 patent/HUS1300072I1/hu unknown
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