JP2003040874A5 - - Google Patents
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- Publication number
- JP2003040874A5 JP2003040874A5 JP2002163198A JP2002163198A JP2003040874A5 JP 2003040874 A5 JP2003040874 A5 JP 2003040874A5 JP 2002163198 A JP2002163198 A JP 2002163198A JP 2002163198 A JP2002163198 A JP 2002163198A JP 2003040874 A5 JP2003040874 A5 JP 2003040874A5
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- slurry
- crystalline compound
- antisolvent
- wet cake
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3738597P | 1997-02-05 | 1997-02-05 | |
| US60/037,385 | 1997-02-05 | ||
| GB9706046.1 | 1997-03-24 | ||
| GBGB9706046.1A GB9706046D0 (en) | 1997-03-24 | 1997-03-24 | Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent |
| US4280797P | 1997-04-08 | 1997-04-08 | |
| US60/042,807 | 1997-04-08 | ||
| GBGB9709348.8A GB9709348D0 (en) | 1997-05-07 | 1997-05-07 | Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent |
| GB9709348.8 | 1997-05-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53319098A Division JP3418626B2 (ja) | 1997-02-05 | 1998-02-02 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010202879A Division JP5295190B2 (ja) | 1997-02-05 | 2010-09-10 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003040874A JP2003040874A (ja) | 2003-02-13 |
| JP2003040874A5 true JP2003040874A5 (https=) | 2005-08-04 |
Family
ID=27451618
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53319098A Expired - Lifetime JP3418626B2 (ja) | 1997-02-05 | 1998-02-02 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
| JP2002163198A Withdrawn JP2003040874A (ja) | 1997-02-05 | 2002-06-04 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
| JP2010202879A Expired - Lifetime JP5295190B2 (ja) | 1997-02-05 | 2010-09-10 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
| JP2013089216A Pending JP2013139484A (ja) | 1997-02-05 | 2013-04-22 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
| JP2015146631A Expired - Lifetime JP6126172B2 (ja) | 1997-02-05 | 2015-07-24 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
| JP2017002745A Pending JP2017061575A (ja) | 1997-02-05 | 2017-01-11 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53319098A Expired - Lifetime JP3418626B2 (ja) | 1997-02-05 | 1998-02-02 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010202879A Expired - Lifetime JP5295190B2 (ja) | 1997-02-05 | 2010-09-10 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
| JP2013089216A Pending JP2013139484A (ja) | 1997-02-05 | 2013-04-22 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
| JP2015146631A Expired - Lifetime JP6126172B2 (ja) | 1997-02-05 | 2015-07-24 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
| JP2017002745A Pending JP2017061575A (ja) | 1997-02-05 | 2017-01-11 | 逆溶媒を使用する逆転写酵素阻害剤の結晶化方法 |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0975609B1 (https=) |
| JP (6) | JP3418626B2 (https=) |
| KR (1) | KR100573192B1 (https=) |
| CN (2) | CN1073991C (https=) |
| AT (1) | ATE486065T1 (https=) |
| AU (1) | AU738545C (https=) |
| CA (1) | CA2279198C (https=) |
| CZ (2) | CZ297535B6 (https=) |
| DE (1) | DE69841972D1 (https=) |
| EA (1) | EA001805B1 (https=) |
| EE (1) | EE03827B1 (https=) |
| HU (1) | HU229087B1 (https=) |
| IL (1) | IL130715A (https=) |
| NO (1) | NO320128B1 (https=) |
| NZ (1) | NZ336510A (https=) |
| PL (1) | PL197740B1 (https=) |
| SK (1) | SK284935B6 (https=) |
| WO (1) | WO1998033782A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU229087B1 (en) * | 1997-02-05 | 2013-07-29 | Merck Sharp & Dohme | Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent |
| AR011731A1 (es) * | 1997-05-16 | 2000-08-30 | Merck & Co Inc | Un proceso de reaccion de adicion enantioselectiva eficiente utilizando un reactivo de organozinc. |
| US20010014352A1 (en) | 1998-05-27 | 2001-08-16 | Udit Batra | Compressed tablet formulation |
| HRP990182A2 (en) * | 1998-06-11 | 2000-02-29 | Du Pont Pharm Co | Crystalline efavirenz |
| GB9828721D0 (en) * | 1998-12-24 | 1999-02-17 | Glaxo Group Ltd | Novel apparatus and process |
| WO2006018853A2 (en) | 2004-08-19 | 2006-02-23 | Hetero Drugs Limited | Novel polymorphs of efavirenz |
| WO2008108630A1 (en) * | 2007-03-02 | 2008-09-12 | Ultimorphix Technologies B.V. | Polymorphic forms of efavirenz |
| US8318930B2 (en) * | 2007-12-24 | 2012-11-27 | Matrix Laboratories Limited | Process for preparing polymorphic forms of (S)-6-chloro-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one |
| US8383811B2 (en) | 2008-12-22 | 2013-02-26 | Hetero Research Foundation | Process for preparing efavirenz polymorph |
| DE102009041443A1 (de) | 2009-09-16 | 2011-03-31 | Archimica Gmbh | Salze des 6-Chlor-4-(cyclopropylethinyl)-1,4-dihydro-4-(trifluormethyl)-2H-3,1-benzoxazin-2-ons und deren Synthese, Aufreinigung und Anwendung als Vorstufen für Efavirenz |
| EP2471783A1 (en) | 2010-12-23 | 2012-07-04 | Esteve Química, S.A. | Novel polymorphic form of efavirenz |
| CN103508973B (zh) * | 2012-06-25 | 2016-04-27 | 上海迪赛诺药业有限公司 | 制备依非韦伦i型结晶的方法 |
| CN105037175B (zh) * | 2014-07-18 | 2017-02-22 | 盐城迪赛诺制药有限公司 | 一种用于提高依非韦伦中间体光学纯度的方法 |
| US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| SG10201913990RA (en) | 2015-10-16 | 2020-03-30 | Abbvie Inc | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
| CN114195761B (zh) * | 2021-12-23 | 2023-04-14 | 浙江普洛家园药业有限公司 | 一种高纯度西他沙星3/2水合物的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1282405C (en) * | 1984-05-21 | 1991-04-02 | Michael R. Violante | Method for making uniformly sized particles from water-insoluble organic compounds |
| US5665720A (en) * | 1992-08-07 | 1997-09-09 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
| IL106507A (en) * | 1992-08-07 | 1997-11-20 | Merck & Co Inc | Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type |
| WO1995020389A1 (en) * | 1994-01-28 | 1995-08-03 | Merck & Co., Inc. | Benzoxazinones as inhibitors of hiv reverse transcriptase |
| US5663467A (en) * | 1995-01-23 | 1997-09-02 | Merck & Co., Inc. | Synthesis of cyclopropylacetylene |
| US5633405A (en) * | 1995-05-25 | 1997-05-27 | Merck & Co., Inc. | Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one |
| HU229087B1 (en) * | 1997-02-05 | 2013-07-29 | Merck Sharp & Dohme | Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent |
| AU6876898A (en) * | 1997-04-07 | 1998-10-30 | Du Pont Pharmaceuticals Company | Asymmetric synthesis of benzoxazinones via new intermediates |
-
1998
- 1998-02-02 HU HU0001313A patent/HU229087B1/hu unknown
- 1998-02-02 CN CN98802171A patent/CN1073991C/zh not_active Expired - Lifetime
- 1998-02-02 DE DE69841972T patent/DE69841972D1/de not_active Expired - Lifetime
- 1998-02-02 EA EA199900720A patent/EA001805B1/ru not_active IP Right Cessation
- 1998-02-02 PL PL334478A patent/PL197740B1/pl unknown
- 1998-02-02 NZ NZ336510A patent/NZ336510A/en not_active IP Right Cessation
- 1998-02-02 EP EP98904853A patent/EP0975609B1/en not_active Expired - Lifetime
- 1998-02-02 CN CNB011227095A patent/CN1191242C/zh not_active Expired - Lifetime
- 1998-02-02 EE EEP199900341A patent/EE03827B1/xx unknown
- 1998-02-02 WO PCT/US1998/001999 patent/WO1998033782A1/en not_active Ceased
- 1998-02-02 CZ CZ0276599A patent/CZ297535B6/cs not_active IP Right Cessation
- 1998-02-02 SK SK1055-99A patent/SK284935B6/sk not_active IP Right Cessation
- 1998-02-02 AT AT98904853T patent/ATE486065T1/de active
- 1998-02-02 IL IL13071598A patent/IL130715A/xx not_active IP Right Cessation
- 1998-02-02 JP JP53319098A patent/JP3418626B2/ja not_active Expired - Lifetime
- 1998-02-02 CZ CZ20040883A patent/CZ304186B6/cs not_active IP Right Cessation
- 1998-02-02 CA CA002279198A patent/CA2279198C/en not_active Expired - Lifetime
- 1998-02-02 KR KR1019997006985A patent/KR100573192B1/ko not_active Expired - Lifetime
- 1998-02-02 AU AU62632/98A patent/AU738545C/en not_active Expired
-
1999
- 1999-08-04 NO NO19993779A patent/NO320128B1/no not_active IP Right Cessation
-
2002
- 2002-06-04 JP JP2002163198A patent/JP2003040874A/ja not_active Withdrawn
-
2010
- 2010-09-10 JP JP2010202879A patent/JP5295190B2/ja not_active Expired - Lifetime
-
2013
- 2013-04-22 JP JP2013089216A patent/JP2013139484A/ja active Pending
-
2015
- 2015-07-24 JP JP2015146631A patent/JP6126172B2/ja not_active Expired - Lifetime
-
2017
- 2017-01-11 JP JP2017002745A patent/JP2017061575A/ja active Pending
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