JP2002543121A5 - - Google Patents
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- Publication number
- JP2002543121A5 JP2002543121A5 JP2000614991A JP2000614991A JP2002543121A5 JP 2002543121 A5 JP2002543121 A5 JP 2002543121A5 JP 2000614991 A JP2000614991 A JP 2000614991A JP 2000614991 A JP2000614991 A JP 2000614991A JP 2002543121 A5 JP2002543121 A5 JP 2002543121A5
- Authority
- JP
- Japan
- Prior art keywords
- medicine
- aliphatic
- aryl
- group
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003814 drug Substances 0.000 description 32
- -1 benzodiazepine compound Chemical class 0.000 description 9
- 125000003118 aryl group Chemical group 0.000 description 8
- 230000001684 chronic effect Effects 0.000 description 8
- 125000001931 aliphatic group Chemical group 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000003463 hyperproliferative effect Effects 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 229940049706 benzodiazepine Drugs 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 208000026278 immune system disease Diseases 0.000 description 4
- 230000004968 inflammatory condition Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 125000005843 halogen group Chemical group 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000006664 bond formation reaction Methods 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 206010025135 lupus erythematosus Diseases 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 125000006574 non-aromatic ring group Chemical group 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Chemical group 0.000 description 2
- 239000011593 sulfur Chemical group 0.000 description 2
- 229910052717 sulfur Chemical group 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13176199P | 1999-04-30 | 1999-04-30 | |
| US60/131,761 | 1999-04-30 | ||
| US16551199P | 1999-11-15 | 1999-11-15 | |
| US60/165,511 | 1999-11-15 | ||
| US19185500P | 2000-03-24 | 2000-03-24 | |
| US60/191,855 | 2000-03-24 | ||
| PCT/US2000/011599 WO2000066106A2 (en) | 1999-04-30 | 2000-04-27 | Use of benzodiazepines for treating autoimmune diseases induced by apoptosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002543121A JP2002543121A (ja) | 2002-12-17 |
| JP2002543121A5 true JP2002543121A5 (enExample) | 2007-06-21 |
| JP5127096B2 JP5127096B2 (ja) | 2013-01-23 |
Family
ID=27384197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000614991A Expired - Lifetime JP5127096B2 (ja) | 1999-04-30 | 2000-04-27 | アポトーシスにより誘導される自己免疫疾患を処置するためのベンゾジアゼピンの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US7125866B1 (enExample) |
| EP (4) | EP2062583B1 (enExample) |
| JP (1) | JP5127096B2 (enExample) |
| AT (2) | ATE258439T1 (enExample) |
| AU (2) | AU782447C (enExample) |
| CA (1) | CA2372150C (enExample) |
| DE (2) | DE60042425D1 (enExample) |
| DK (1) | DK1143946T3 (enExample) |
| ES (1) | ES2214273T3 (enExample) |
| IL (2) | IL146222A0 (enExample) |
| MX (1) | MXPA01011052A (enExample) |
| PT (1) | PT1143946E (enExample) |
| WO (1) | WO2000066106A2 (enExample) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2785803B1 (fr) * | 1998-11-17 | 2005-03-25 | Sanofi Sa | Utilisation d'une substance se liant au recepteur peripherique des benzodiazepines dans le traitement des stress cutanes |
| US20050113460A1 (en) * | 1999-04-30 | 2005-05-26 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| EP2062583B1 (en) | 1999-04-30 | 2012-12-26 | The Regents of the University of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
| US20060025388A1 (en) | 1999-04-30 | 2006-02-02 | Glick Gary D | Compositions and methods relating to novel compounds and targets thereof |
| US20040176358A1 (en) * | 1999-04-30 | 2004-09-09 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US7144880B2 (en) | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
| US20030119029A1 (en) * | 1999-04-30 | 2003-06-26 | Regents Of The University Of Michigan | Compositions and methods relating to novel benzodiazepine compounds and targets thereof |
| US7276348B2 (en) | 1999-04-30 | 2007-10-02 | Regents Of The University Of Michigan | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| AU2002332560B2 (en) * | 2001-08-15 | 2006-01-19 | The Regents Of The University Of Michigan | Compositions and methods relating to novel benzodiazepine compounds and targets thereof |
| NZ532463A (en) | 2001-11-13 | 2007-02-23 | Dimensional Pharm Inc | Substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer |
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| AU2004255153B2 (en) * | 2003-05-01 | 2007-11-22 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| WO2004100885A2 (en) * | 2003-05-09 | 2004-11-25 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
| JP2007516149A (ja) | 2003-05-21 | 2007-06-21 | アレックザ ファーマシューティカルズ， インコーポレイテッド | 基板温度の均一性を制御する方法、および、内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット |
| US20050120397A1 (en) * | 2003-11-24 | 2005-06-02 | Hermann Steller | Compounds and methods for regulation of spermatid differentiation |
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| US20050272723A1 (en) * | 2004-04-27 | 2005-12-08 | The Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| EP1781360A1 (en) | 2004-08-12 | 2007-05-09 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| US20060052369A1 (en) * | 2004-09-07 | 2006-03-09 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| WO2006074358A1 (en) | 2005-01-03 | 2006-07-13 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| WO2007053193A2 (en) * | 2005-06-01 | 2007-05-10 | The Regents Of The University Of Michigan | Unsolvated benzodiazepine compositions and methods |
| KR20080040032A (ko) * | 2005-09-02 | 2008-05-07 | 티보텍 파마슈티칼즈 리미티드 | Ｈｃｖ 저해제로서의 벤조디아제핀 |
| US8039616B2 (en) | 2005-09-19 | 2011-10-18 | Astrazeneca Ab | Benzodiazepine derivatives for treating hepatitis C infection |
| US20070105844A1 (en) * | 2005-10-26 | 2007-05-10 | Regents Of The University Of Michigan | Therapeutic compositions and methods |
| AU2006308655B2 (en) * | 2005-11-01 | 2010-09-23 | The Regents Of The University Of Michigan | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| SI2001849T1 (sl) | 2006-03-29 | 2015-02-27 | F. Hoffmann-La Roche Ag | Derivati piridina in pirimidina kot antagonisti mglur2 |
| US7759338B2 (en) * | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
| WO2007146167A1 (en) * | 2006-06-09 | 2007-12-21 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US20100021928A1 (en) * | 2006-06-26 | 2010-01-28 | Technion Research & Development Foundation Ltd. | Methods and kits for diagnosing cancer |
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| JP5383513B2 (ja) | 2007-03-09 | 2014-01-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 化合物およびその標的に関連する組成物ならびに方法 |
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| RU2010122902A (ru) | 2007-11-06 | 2011-12-20 | Дзе Риджентс оф дзе Юниверсити оф Мичиган (US) | Бензодиапениноновые соединения, применимые в лечении кожных состояний |
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| EP2352724B1 (en) | 2008-09-11 | 2015-04-22 | The Regents of the University of Michigan | Aryl guanidine f1f0-atpase inhibitors and their medical use |
| US8604023B2 (en) | 2009-04-17 | 2013-12-10 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
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| US8815845B2 (en) | 2009-11-17 | 2014-08-26 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| CA2780333C (en) | 2009-11-17 | 2016-05-24 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| CN102190631B (zh) * | 2010-03-10 | 2014-10-29 | 中国人民解放军63975部队 | 苯二氮卓化合物的制备方法 |
| TWI530489B (zh) | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯二氮呯酮化合物 |
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-
2000
- 2000-04-27 EP EP09003224A patent/EP2062583B1/en not_active Expired - Lifetime
- 2000-04-27 EP EP00928586A patent/EP1143946B1/en not_active Expired - Lifetime
- 2000-04-27 PT PT00928586T patent/PT1143946E/pt unknown
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- 2000-04-27 IL IL14622200A patent/IL146222A0/xx active IP Right Grant
- 2000-04-27 DE DE60042425T patent/DE60042425D1/de not_active Expired - Lifetime
- 2000-04-27 EP EP03027484A patent/EP1398033B1/en not_active Expired - Lifetime
- 2000-04-27 DK DK00928586T patent/DK1143946T3/da active
- 2000-04-27 MX MXPA01011052A patent/MXPA01011052A/es active IP Right Grant
- 2000-04-27 US US09/700,101 patent/US7125866B1/en not_active Expired - Lifetime
- 2000-04-27 EP EP10011671A patent/EP2359831A3/en not_active Withdrawn
- 2000-04-27 WO PCT/US2000/011599 patent/WO2000066106A2/en not_active Ceased
- 2000-04-27 JP JP2000614991A patent/JP5127096B2/ja not_active Expired - Lifetime
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2001
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2005
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2006
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2007
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