JP2003508543A5 - - Google Patents
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- Publication number
- JP2003508543A5 JP2003508543A5 JP2001522252A JP2001522252A JP2003508543A5 JP 2003508543 A5 JP2003508543 A5 JP 2003508543A5 JP 2001522252 A JP2001522252 A JP 2001522252A JP 2001522252 A JP2001522252 A JP 2001522252A JP 2003508543 A5 JP2003508543 A5 JP 2003508543A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- betulinic acid
- acid derivative
- composition
- endothelial cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 13
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 description 8
- 210000002889 endothelial cell Anatomy 0.000 description 5
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- -1 elixir Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000003606 umbilical vein Anatomy 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN1999/000043 WO2001018029A1 (en) | 1999-09-09 | 1999-09-09 | Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003508543A JP2003508543A (ja) | 2003-03-04 |
| JP2003508543A5 true JP2003508543A5 (enExample) | 2006-10-19 |
Family
ID=11076668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522252A Pending JP2003508543A (ja) | 1999-09-09 | 1999-09-09 | 抗脈管形成活性を有する新規なベツリン酸誘導体、該誘導体を調整する方法、および腫瘍に関連する脈管形成を処置するためのそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1218402B1 (enExample) |
| JP (1) | JP2003508543A (enExample) |
| KR (1) | KR100618100B1 (enExample) |
| CN (1) | CN1152046C (enExample) |
| AT (1) | ATE267837T1 (enExample) |
| AU (1) | AU780148B2 (enExample) |
| BR (1) | BR9917495A (enExample) |
| CA (1) | CA2384433C (enExample) |
| DE (1) | DE69917684T2 (enExample) |
| ES (1) | ES2224735T3 (enExample) |
| WO (1) | WO2001018029A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2319653T3 (es) | 2003-02-11 | 2009-05-11 | Novelix Pharmaceuticals, Inc. | Medicamento para la inhibicion del crecimiento de tumores. |
| RU2276980C1 (ru) * | 2005-03-01 | 2006-05-27 | Институт химии и химической технологии СО РАН (ИХХТ СО РАН) | Капилляроукрепляющее средство |
| US20090023698A1 (en) * | 2005-03-29 | 2009-01-22 | Krasutsky Pavel A | Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid |
| GB0604535D0 (en) | 2006-03-07 | 2006-04-12 | Sndv Sprl | Betulonic acid derivatives |
| CZ301158B6 (cs) * | 2008-09-01 | 2009-11-18 | Univerzita Karlova v Praze, Prírodovedecká fakulta | Deriváty triterpenoidu pro lécbu nádorových onemocnení a farmaceutická kompozice je obsahující |
| KR101061911B1 (ko) * | 2009-04-01 | 2011-09-02 | 주식회사 페라온 | 페길레이션된 베튤린 유도체 및 그를 포함하는 화장료 조성물 |
| CN102603858B (zh) * | 2012-03-02 | 2014-07-02 | 东北林业大学 | 桦木醇的含氮杂环衍生物、制备方法及用途 |
| US9637516B2 (en) | 2012-12-31 | 2017-05-02 | Hetero Research Foundation | Betulinic acid proline derivatives as HIV inhibitors |
| CN104910239B (zh) * | 2014-03-14 | 2018-12-07 | 中国科学院上海药物研究所 | 五环三萜类化合物及其制备方法、药物组合物和用途 |
| US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
| MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
| US10370405B2 (en) | 2015-03-16 | 2019-08-06 | Hetero Labs Limited | C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors |
| CN109517022B (zh) * | 2017-09-18 | 2022-09-13 | 中国科学院上海药物研究所 | 五环三萜类化合物及其制备方法、药物组合物和用途 |
| CN109700760B (zh) * | 2019-03-07 | 2021-04-06 | 南京中医药大学 | 一种白桦脂酸纳米混悬剂及其制备方法 |
| WO2022007765A1 (zh) * | 2020-07-07 | 2022-01-13 | 中国科学院上海药物研究所 | 一类五环三萜类碳苷化合物及其制备方法和用途 |
| CN113135974B (zh) * | 2021-03-24 | 2022-05-06 | 广东工业大学 | 白桦脂醇衍生物及其在制备抗肿瘤药物中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1415601A (en) * | 1973-03-14 | 1975-11-26 | Biorex Laboratories Ltd | Dihydrobetulinic acid derivatives |
| JPS6417431A (en) * | 1987-07-13 | 1989-01-20 | Nec Corp | Manufacture of semiconductor integrated circuit device |
| JP2694048B2 (ja) * | 1991-05-09 | 1997-12-24 | 日立建機株式会社 | 建設機械の油圧駆動装置 |
| FR2683531B1 (fr) * | 1991-11-13 | 1993-12-31 | Rhone Poulenc Rorer Sa | Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| US5962527A (en) * | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
| US5869535A (en) * | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
| US5679828A (en) * | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
-
1999
- 1999-09-09 BR BR9917495-2A patent/BR9917495A/pt not_active IP Right Cessation
- 1999-09-09 ES ES99963658T patent/ES2224735T3/es not_active Expired - Lifetime
- 1999-09-09 AT AT99963658T patent/ATE267837T1/de not_active IP Right Cessation
- 1999-09-09 DE DE69917684T patent/DE69917684T2/de not_active Expired - Fee Related
- 1999-09-09 CN CNB998169404A patent/CN1152046C/zh not_active Expired - Fee Related
- 1999-09-09 WO PCT/IN1999/000043 patent/WO2001018029A1/en not_active Ceased
- 1999-09-09 JP JP2001522252A patent/JP2003508543A/ja active Pending
- 1999-09-09 AU AU20001/00A patent/AU780148B2/en not_active Ceased
- 1999-09-09 EP EP99963658A patent/EP1218402B1/en not_active Expired - Lifetime
- 1999-09-09 CA CA002384433A patent/CA2384433C/en not_active Expired - Fee Related
- 1999-09-09 KR KR1020027003120A patent/KR100618100B1/ko not_active Expired - Fee Related
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