CN1152046C - 新的桦木酸衍生物,该衍生物的制备方法及其在治疗与血管生成有关肿瘤中的应用 - Google Patents

新的桦木酸衍生物,该衍生物的制备方法及其在治疗与血管生成有关肿瘤中的应用 Download PDF

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Publication number
CN1152046C
CN1152046C CNB998169404A CN99816940A CN1152046C CN 1152046 C CN1152046 C CN 1152046C CN B998169404 A CNB998169404 A CN B998169404A CN 99816940 A CN99816940 A CN 99816940A CN 1152046 C CN1152046 C CN 1152046C
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China
Prior art keywords
betulinic acid
derivatives
och
ococ
derivative
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Expired - Fee Related
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CNB998169404A
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English (en)
Chinese (zh)
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CN1373769A (zh
Inventor
M
M·杰吉
S·拉曼多斯
P·拉詹德恩
M·J·阿曼德斯迪奎
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Dabur Research Foundation
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Dabur Research Foundation
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
CNB998169404A 1999-09-09 1999-09-09 新的桦木酸衍生物,该衍生物的制备方法及其在治疗与血管生成有关肿瘤中的应用 Expired - Fee Related CN1152046C (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN1999/000043 WO2001018029A1 (en) 1999-09-09 1999-09-09 Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis

Publications (2)

Publication Number Publication Date
CN1373769A CN1373769A (zh) 2002-10-09
CN1152046C true CN1152046C (zh) 2004-06-02

Family

ID=11076668

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998169404A Expired - Fee Related CN1152046C (zh) 1999-09-09 1999-09-09 新的桦木酸衍生物,该衍生物的制备方法及其在治疗与血管生成有关肿瘤中的应用

Country Status (11)

Country Link
EP (1) EP1218402B1 (enExample)
JP (1) JP2003508543A (enExample)
KR (1) KR100618100B1 (enExample)
CN (1) CN1152046C (enExample)
AT (1) ATE267837T1 (enExample)
AU (1) AU780148B2 (enExample)
BR (1) BR9917495A (enExample)
CA (1) CA2384433C (enExample)
DE (1) DE69917684T2 (enExample)
ES (1) ES2224735T3 (enExample)
WO (1) WO2001018029A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113135974A (zh) * 2021-03-24 2021-07-20 广东工业大学 白桦脂醇衍生物及其在制备抗肿瘤药物中的应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1594885T1 (sl) 2003-02-11 2009-06-30 Novelix Pharmaceuticals Inc Zdravilo za inhibiranje rasti tumorjev
RU2276980C1 (ru) * 2005-03-01 2006-05-27 Институт химии и химической технологии СО РАН (ИХХТ СО РАН) Капилляроукрепляющее средство
US20090023698A1 (en) * 2005-03-29 2009-01-22 Krasutsky Pavel A Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
GB0604535D0 (en) 2006-03-07 2006-04-12 Sndv Sprl Betulonic acid derivatives
CZ2008528A3 (cs) * 2008-09-01 2009-11-18 Univerzita Karlova v Praze, Prírodovedecká fakulta Deriváty triterpenoidu pro lécbu nádorových onemocnení a farmaceutická kompozice je obsahující
KR101061911B1 (ko) * 2009-04-01 2011-09-02 주식회사 페라온 페길레이션된 베튤린 유도체 및 그를 포함하는 화장료 조성물
CN102603858B (zh) * 2012-03-02 2014-07-02 东北林业大学 桦木醇的含氮杂环衍生物、制备方法及用途
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
CN104910239B (zh) * 2014-03-14 2018-12-07 中国科学院上海药物研究所 五环三萜类化合物及其制备方法、药物组合物和用途
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
CN109517022B (zh) 2017-09-18 2022-09-13 中国科学院上海药物研究所 五环三萜类化合物及其制备方法、药物组合物和用途
CN109700760B (zh) * 2019-03-07 2021-04-06 南京中医药大学 一种白桦脂酸纳米混悬剂及其制备方法
JP2023533557A (ja) * 2020-07-07 2023-08-03 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ 五環性トリテルペノイドｃ－グリコシド、その製造方法及び使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415601A (en) * 1973-03-14 1975-11-26 Biorex Laboratories Ltd Dihydrobetulinic acid derivatives
JPS6417431A (en) * 1987-07-13 1989-01-20 Nec Corp Manufacture of semiconductor integrated circuit device
JP2694048B2 (ja) * 1991-05-09 1997-12-24 日立建機株式会社 建設機械の油圧駆動装置
FR2683531B1 (fr) * 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5869535A (en) * 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) * 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5679828A (en) * 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113135974A (zh) * 2021-03-24 2021-07-20 广东工业大学 白桦脂醇衍生物及其在制备抗肿瘤药物中的应用
CN113135974B (zh) * 2021-03-24 2022-05-06 广东工业大学 白桦脂醇衍生物及其在制备抗肿瘤药物中的应用

Also Published As

Publication number Publication date
AU780148B2 (en) 2005-03-03
EP1218402B1 (en) 2004-05-26
WO2001018029A1 (en) 2001-03-15
EP1218402A1 (en) 2002-07-03
CA2384433A1 (en) 2001-03-15
CA2384433C (en) 2007-10-23
DE69917684T2 (de) 2005-07-21
BR9917495A (pt) 2002-06-11
KR20020092908A (ko) 2002-12-12
ES2224735T3 (es) 2005-03-01
AU2000100A (en) 2001-04-10
JP2003508543A (ja) 2003-03-04
CN1373769A (zh) 2002-10-09
ATE267837T1 (de) 2004-06-15
DE69917684D1 (de) 2004-07-01
KR100618100B1 (ko) 2006-08-29

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