KR100618100B1 - 항맥관형성 활성을 가지는 새로운 베툴린산 유도체,이러한 유도체의 제조 방법 및 종양 관련 맥관형성증의치료를 위한 이들의 용도 - Google Patents

항맥관형성 활성을 가지는 새로운 베툴린산 유도체,이러한 유도체의 제조 방법 및 종양 관련 맥관형성증의치료를 위한 이들의 용도 Download PDF

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Publication number
KR100618100B1
KR100618100B1 KR1020027003120A KR20027003120A KR100618100B1 KR 100618100 B1 KR100618100 B1 KR 100618100B1 KR 1020027003120 A KR1020027003120 A KR 1020027003120A KR 20027003120 A KR20027003120 A KR 20027003120A KR 100618100 B1 KR100618100 B1 KR 100618100B1
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South Korea
Prior art keywords
betulinic acid
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derivatives
pharmaceutical composition
acid derivatives
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Korean (ko)
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KR20020092908A (ko
Inventor
재기마누
라마도스선더
라젠드란프라빈
아메드시디퀴모하매드잠쉐드
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다브르 리서치 파운데이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020027003120A 1999-09-09 1999-09-09 항맥관형성 활성을 가지는 새로운 베툴린산 유도체,이러한 유도체의 제조 방법 및 종양 관련 맥관형성증의치료를 위한 이들의 용도 Expired - Fee Related KR100618100B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN1999/000043 WO2001018029A1 (en) 1999-09-09 1999-09-09 Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis

Publications (2)

Publication Number Publication Date
KR20020092908A KR20020092908A (ko) 2002-12-12
KR100618100B1 true KR100618100B1 (ko) 2006-08-29

Family

ID=11076668

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027003120A Expired - Fee Related KR100618100B1 (ko) 1999-09-09 1999-09-09 항맥관형성 활성을 가지는 새로운 베툴린산 유도체,이러한 유도체의 제조 방법 및 종양 관련 맥관형성증의치료를 위한 이들의 용도

Country Status (11)

Country Link
EP (1) EP1218402B1 (enExample)
JP (1) JP2003508543A (enExample)
KR (1) KR100618100B1 (enExample)
CN (1) CN1152046C (enExample)
AT (1) ATE267837T1 (enExample)
AU (1) AU780148B2 (enExample)
BR (1) BR9917495A (enExample)
CA (1) CA2384433C (enExample)
DE (1) DE69917684T2 (enExample)
ES (1) ES2224735T3 (enExample)
WO (1) WO2001018029A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1594885T1 (sl) 2003-02-11 2009-06-30 Novelix Pharmaceuticals Inc Zdravilo za inhibiranje rasti tumorjev
RU2276980C1 (ru) * 2005-03-01 2006-05-27 Институт химии и химической технологии СО РАН (ИХХТ СО РАН) Капилляроукрепляющее средство
US20090023698A1 (en) * 2005-03-29 2009-01-22 Krasutsky Pavel A Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
GB0604535D0 (en) 2006-03-07 2006-04-12 Sndv Sprl Betulonic acid derivatives
CZ2008528A3 (cs) * 2008-09-01 2009-11-18 Univerzita Karlova v Praze, Prírodovedecká fakulta Deriváty triterpenoidu pro lécbu nádorových onemocnení a farmaceutická kompozice je obsahující
KR101061911B1 (ko) * 2009-04-01 2011-09-02 주식회사 페라온 페길레이션된 베튤린 유도체 및 그를 포함하는 화장료 조성물
CN102603858B (zh) * 2012-03-02 2014-07-02 东北林业大学 桦木醇的含氮杂环衍生物、制备方法及用途
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
CN104910239B (zh) * 2014-03-14 2018-12-07 中国科学院上海药物研究所 五环三萜类化合物及其制备方法、药物组合物和用途
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
CN109517022B (zh) 2017-09-18 2022-09-13 中国科学院上海药物研究所 五环三萜类化合物及其制备方法、药物组合物和用途
CN109700760B (zh) * 2019-03-07 2021-04-06 南京中医药大学 一种白桦脂酸纳米混悬剂及其制备方法
JP2023533557A (ja) * 2020-07-07 2023-08-03 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ 五環性トリテルペノイドｃ－グリコシド、その製造方法及び使用
CN113135974B (zh) * 2021-03-24 2022-05-06 广东工业大学 白桦脂醇衍生物及其在制备抗肿瘤药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415601A (en) * 1973-03-14 1975-11-26 Biorex Laboratories Ltd Dihydrobetulinic acid derivatives
JPS6417431A (en) * 1987-07-13 1989-01-20 Nec Corp Manufacture of semiconductor integrated circuit device
JP2694048B2 (ja) * 1991-05-09 1997-12-24 日立建機株式会社 建設機械の油圧駆動装置
FR2683531B1 (fr) * 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5869535A (en) * 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) * 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5679828A (en) * 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor

Also Published As

Publication number Publication date
AU780148B2 (en) 2005-03-03
EP1218402B1 (en) 2004-05-26
WO2001018029A1 (en) 2001-03-15
EP1218402A1 (en) 2002-07-03
CA2384433A1 (en) 2001-03-15
CA2384433C (en) 2007-10-23
CN1152046C (zh) 2004-06-02
DE69917684T2 (de) 2005-07-21
BR9917495A (pt) 2002-06-11
KR20020092908A (ko) 2002-12-12
ES2224735T3 (es) 2005-03-01
AU2000100A (en) 2001-04-10
JP2003508543A (ja) 2003-03-04
CN1373769A (zh) 2002-10-09
ATE267837T1 (de) 2004-06-15
DE69917684D1 (de) 2004-07-01

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