|
PL350884A1
(en)
*
|
1999-04-01 |
2003-02-10 |
Pfizer Prod Inc |
Aminopyrimidines as sorbitol dehydrogenase inhibitors
|
|
HUP0303497A3
(en)
*
|
2000-10-18 |
2006-02-28 |
Pfizer Prod Inc |
Pharmaceutical compositions containing combination of statins and sorbitol dehydrogenase inhibitors
|
|
SE0003795D0
(sv)
*
|
2000-10-20 |
2000-10-20 |
Astrazeneca Ab |
Pharmaceutically useful compounds
|
|
KR20030059290A
(ko)
*
|
2000-11-30 |
2003-07-07 |
화이자 프로덕츠 인코포레이티드 |
Ｇａｂａ 작용제 및 소르비톨 데하이드로게나제 억제제의혼합물
|
|
US20040180925A1
(en)
*
|
2000-12-27 |
2004-09-16 |
Kenji Matsuno |
Dipeptidylpeptidase-IV inhibitor
|
|
IL147696A0
(en)
*
|
2001-01-25 |
2002-08-14 |
Pfizer Prod Inc |
Combination therapy
|
|
EP1247809A3
(en)
|
2001-03-30 |
2003-12-17 |
Pfizer Products Inc. |
Triazine compounds useful as sorbitol dehydrogenase inhibitors
|
|
BR0209932A
(pt)
*
|
2001-05-22 |
2004-10-13 |
Neurogen Corp |
Composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, preparação farmacêutica embalada, métodos para modular ligação de mch a um receptor de mch e de mvc, para alterar a atividade de transdução de sinal de um receptor de mch em uma célula, para tratar uma doença ou distúrbio associado com a ativação de receptor de mch patogênico obesidade e para determinar a presença ou ausência de receptor de mch em uma amostra, e, uso de um composto
|
|
GB0127929D0
(en)
*
|
2001-11-21 |
2002-01-16 |
Celltech R&D Ltd |
Chemical compounds
|
|
BR0214967A
(pt)
*
|
2001-12-14 |
2005-05-10 |
Novo Nordisk As |
Composto, sal famaceuticamente aceitável, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratar um distúrbio de um paciente
|
|
AU2003249369A1
(en)
|
2002-06-21 |
2004-01-06 |
Cellular Genomics, Inc. |
Certain amino-substituted monocycles as kinase modulators
|
|
US7582635B2
(en)
|
2002-12-24 |
2009-09-01 |
Purdue Pharma, L.P. |
Therapeutic agents useful for treating pain
|
|
MY150088A
(en)
|
2003-05-19 |
2013-11-29 |
Irm Llc |
Immunosuppressant compounds and compositions
|
|
CN102174042B
(zh)
*
|
2003-05-19 |
2013-09-18 |
Irm有限责任公司 |
免疫抑制剂化合物和组合物
|
|
BRPI0410657A
(pt)
*
|
2003-06-12 |
2006-06-20 |
Novo Nordisk As |
composto, composição farmacêutica, uso de um composto, método para tratar um distúrbio de um paciente, e, processo para a preparação de um composto
|
|
CA2531619A1
(en)
*
|
2003-07-16 |
2005-01-27 |
Neurogen Corporation |
Biaryl piperazinyl-pyridine analogues
|
|
TWI290140B
(en)
*
|
2003-08-25 |
2007-11-21 |
Schering Corp |
2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders
|
|
SG146683A1
(en)
*
|
2003-09-17 |
2008-10-30 |
Janssen Pharmaceutica Nv |
Fused heterocyclic compounds as serotonin receptor modulators
|
|
WO2005037284A1
(en)
*
|
2003-10-15 |
2005-04-28 |
Pfizer Products Inc. |
Sorbitol dehydrogenase inhibitor and hypertensive agent combinations
|
|
WO2005047268A2
(en)
*
|
2003-11-10 |
2005-05-26 |
X-Ceptor Therapeutics, Inc. |
Substituted pyrimidine compositions and methods of use
|
|
WO2005110989A1
(en)
*
|
2004-04-07 |
2005-11-24 |
Neurogen Corporation |
Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
|
|
WO2005110982A2
(en)
*
|
2004-04-07 |
2005-11-24 |
Neurogen Corporation |
Substituted 1-benzyl-4-substituted piperazine analogues
|
|
TW200609219A
(en)
*
|
2004-06-17 |
2006-03-16 |
Neurogen Corp |
Aryl-substituted piperazine derivatives
|
|
MY145822A
(en)
*
|
2004-08-13 |
2012-04-30 |
Neurogen Corp |
Substituted biaryl piperazinyl-pyridine analogues
|
|
GB0420831D0
(en)
|
2004-09-17 |
2004-10-20 |
Glaxo Group Ltd |
Novel compounds
|
|
US20060128710A1
(en)
*
|
2004-12-09 |
2006-06-15 |
Chih-Hung Lee |
Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
|
|
MX2007010076A
(es)
|
2005-02-17 |
2007-10-16 |
Astellas Pharma Inc |
Derivado de heterociclico-1-carboxilato que contiene nitrogeno no aromatico de piridilo.
|
|
US7402596B2
(en)
|
2005-03-24 |
2008-07-22 |
Renovis, Inc. |
Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
|
|
JP2008540443A
(ja)
|
2005-05-04 |
2008-11-20 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン
|
|
EP1904491A2
(en)
|
2005-05-31 |
2008-04-02 |
Vertex Pharmaceuticals Incorporated |
Heterocycles useful as modulators of ion channels
|
|
EP1928461B1
(en)
*
|
2005-08-04 |
2012-01-04 |
Janssen Pharmaceutica NV |
Pyrimidine compounds as serotonin receptor modulators
|
|
US7598255B2
(en)
|
2005-08-04 |
2009-10-06 |
Janssen Pharmaceutica Nv |
Pyrimidine compounds as serotonin receptor modulators
|
|
JP2009504773A
(ja)
*
|
2005-08-19 |
2009-02-05 |
エラン ファーマシューティカルズ，インコーポレイテッド |
ガンマセクレターゼの架橋ｎ−二環式スルホンアミド阻害剤
|
|
WO2007070506A2
(en)
|
2005-12-14 |
2007-06-21 |
Amgen Inc. |
Diaza heterocyclic sulfonamide derivatives and their uses
|
|
US20100029688A1
(en)
*
|
2006-12-20 |
2010-02-04 |
Wood Harold B |
Bipiperidinyl compounds, compositions containing such compounds and methods of treatment
|
|
EP2142529B1
(en)
*
|
2007-04-27 |
2013-12-25 |
Purdue Pharma LP |
Trpv1 antagonists and uses thereof
|
|
CA2685121A1
(en)
|
2007-04-27 |
2008-11-06 |
Purdue Pharma L.P. |
Therapeutic agents useful for treating pain
|
|
BRPI0814182A2
(pt)
*
|
2007-08-02 |
2015-01-27 |
Recordati Ireland Ltd |
Compostos heterocíclocos inéditos como antagonistas de mglu5
|
|
JP2011516464A
(ja)
*
|
2008-03-31 |
2011-05-26 |
サン・ファーマシューティカル・インダストリーズ・リミテッド |
モルフィナン類似体の改良された調製方法
|
|
US8703962B2
(en)
*
|
2008-10-24 |
2014-04-22 |
Purdue Pharma L.P. |
Monocyclic compounds and their use as TRPV1 ligands
|
|
US8759362B2
(en)
*
|
2008-10-24 |
2014-06-24 |
Purdue Pharma L.P. |
Bicycloheteroaryl compounds and their use as TRPV1 ligands
|
|
EP2379505A4
(en)
*
|
2008-12-05 |
2012-10-17 |
Designmedix Inc |
MODIFIED CHLOROQUINE WITH SINGLE RING UNIT OR CONDENSED RING UNIT
|
|
EP2393780A1
(en)
*
|
2009-02-04 |
2011-12-14 |
Recordati Ireland Limited |
Heterocyclic derivatives as m-glu5 antagonists
|
|
TWI482771B
(zh)
*
|
2009-05-04 |
2015-05-01 |
Du Pont |
磺醯胺殺線蟲劑
|
|
CN101619063B
(zh)
*
|
2009-06-02 |
2011-08-10 |
华中师范大学 |
具有抗肿瘤活性的3,7,8-多取代吡啶并[4,3-d]嘧啶衍生物及制备
|
|
WO2011029633A1
(en)
*
|
2009-09-14 |
2011-03-17 |
Recordati Ireland Limited |
Heterocyclic mglu5 antagonists
|
|
AR080375A1
(es)
|
2010-03-05 |
2012-04-04 |
Sanofi Aventis |
Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
|
|
CA2793313C
(en)
|
2010-04-02 |
2018-01-23 |
Euroscreen Sa |
Nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders
|
|
US10065960B2
(en)
|
2010-04-02 |
2018-09-04 |
Ogeda Sa |
NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
|
|
US8921373B2
(en)
|
2010-06-22 |
2014-12-30 |
Shionogi & Co., Ltd. |
Compounds having TRPV1 antagonistic activity and uses thereof
|
|
ES2624845T3
(es)
|
2010-09-29 |
2017-07-17 |
Intervet International B.V. |
Compuestos de N-heteroarilo con unidad de puente cíclico para el tratamiento de enfermedades parasitarias
|
|
CN102572513A
(zh)
*
|
2010-12-13 |
2012-07-11 |
财团法人资讯工业策进会 |
网络协定电视互动系统、装置及其互动方法
|
|
RS55701B1
(sr)
|
2011-06-22 |
2017-07-31 |
Purdue Pharma Lp |
Trpv1 antagonisti koji uključuju dihidroksi supstituent i njihove upotrebe
|
|
US9394293B2
(en)
|
2011-08-10 |
2016-07-19 |
Purdue Pharma L.P. |
TRPV1 antagonists including dihydroxy substituent and uses thereof
|
|
CA2849751C
(en)
*
|
2011-10-03 |
2019-06-11 |
Euroscreen Sa |
Chiral n-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptormediated disorders and chiral synthesis thereof
|
|
US9567316B2
(en)
|
2012-03-07 |
2017-02-14 |
The Mclean Hospital Corporation |
Aminoquinoline derivatives and uses thereof
|
|
CN103073506B
(zh)
*
|
2013-01-31 |
2015-03-11 |
京博农化科技股份有限公司 |
一种2-羟基-4,6-二甲基嘧啶盐酸盐的合成方法
|
|
WO2014141110A2
(en)
*
|
2013-03-14 |
2014-09-18 |
Curadev Pharma Pvt. Ltd. |
Aminonitriles as kynurenine pathway inhibitors
|
|
HK1223096A1
(zh)
*
|
2013-09-25 |
2017-07-21 |
Vertex Pharmaceuticals Incorporated |
用作par-2信號通路抑制劑的咪唑並噠嗪
|
|
TWI651310B
(zh)
|
2014-02-20 |
2019-02-21 |
日商日本煙草產業股份有限公司 |
三化合物及其醫藥用途
|
|
FR3022784B1
(fr)
*
|
2014-06-26 |
2017-09-08 |
Ecole Normale Superieure Lyon |
Sondes moleculaires activables hydrosolubles, intermediaires pour leur synthese et procedes de detection associes
|
|
JP6469214B2
(ja)
|
2014-09-25 |
2019-02-13 |
オゲダ エス．エー． |
Ｎ−アシル−（３−置換）−（８−置換）−５，６−ジヒドロ−［１，２，４］トリアゾロ［４，３−ａ］ピラジンの新規キラル合成
|
|
US10100027B2
(en)
|
2014-09-26 |
2018-10-16 |
Changzhou Yinsheng Pharmaceutical Co., Ltd. |
Benzofuran analogue as NS4B inhibitor
|
|
US20170313665A1
(en)
|
2014-11-03 |
2017-11-02 |
Bayer Pharma Aktiengesellschaft |
Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
|
|
US20170057943A1
(en)
|
2015-08-17 |
2017-03-02 |
Japan Tobacco Inc. |
Hydroxytriazine compounds and pharmaceutical use thereof
|
|
JP2018525429A
(ja)
|
2015-08-28 |
2018-09-06 |
アッヴィ・インコーポレイテッド |
Ｓ１ｐ調節剤としての縮合複素環化合物
|
|
WO2017107754A1
(zh)
*
|
2015-12-22 |
2017-06-29 |
江苏恒瑞医药股份有限公司 |
苯并哌啶类衍生物、其制备方法及其在医药上的应用
|
|
US9988367B2
(en)
|
2016-05-03 |
2018-06-05 |
Bayer Pharma Aktiengesellschaft |
Amide-substituted pyridinyltriazole derivatives and uses thereof
|
|
EP3452457B1
(en)
|
2016-05-03 |
2020-03-18 |
Bayer Pharma Aktiengesellschaft |
Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
|
|
CA3056890A1
(en)
|
2017-03-17 |
2018-09-20 |
Regents Of The University Of Colorado, A Body Corporate |
Indazole inhibitors of fructokinase (khk) and methods of use in treating khk-mediated disorders or diseases
|
|
IL272246B2
(en)
|
2017-07-28 |
2026-01-01 |
Applied Therapeutics Inc |
History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
|
|
CN110872302B
(zh)
*
|
2018-08-31 |
2022-09-27 |
沈阳中化农药化工研发有限公司 |
含嘧啶的螺环类化合物及其用途
|
|
CN113840825A
(zh)
|
2019-04-01 |
2021-12-24 |
应用治疗公司 |
醛糖还原酶抑制剂
|
|
MX2021013511A
(es)
*
|
2019-05-07 |
2022-02-23 |
Univ Miami |
Tratamiento y deteccion de neuropatias heredadas y trastornos asociados.
|