CN1351497A - 用作山梨醇脱氢酶抑制剂的氨基嘧啶类化合物 - Google Patents

用作山梨醇脱氢酶抑制剂的氨基嘧啶类化合物 Download PDF

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Publication number
CN1351497A
CN1351497A CN00807825A CN00807825A CN1351497A CN 1351497 A CN1351497 A CN 1351497A CN 00807825 A CN00807825 A CN 00807825A CN 00807825 A CN00807825 A CN 00807825A CN 1351497 A CN1351497 A CN 1351497A
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alkyl
alkoxy
optionally substituted
pyrimidin
hydroxy
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Chinese (zh)
Inventor
M·Y·朱－莫伊尔
J·A·姆利
B·L·米拉里
W·J·赞布罗斯吉
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Pfizer Products Inc
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Pfizer Products Inc
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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CN00807825A 1999-04-01 2000-03-16 用作山梨醇脱氢酶抑制剂的氨基嘧啶类化合物 Pending CN1351497A (zh)

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US12743799P 1999-04-01 1999-04-01
US60/127,437 1999-04-01

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CN103073506A (zh) * 2013-01-31 2013-05-01 黄河三角洲京博化工研究院有限公司 一种2-羟基-4,6-二甲基嘧啶盐酸盐的合成方法
CN101014587B (zh) * 2004-08-13 2013-12-18 神经能质公司 经取代的二芳基哌嗪基-吡啶类似物
CN103906750A (zh) * 2011-10-03 2014-07-02 欧洲筛选有限公司 作为选择性NK-3受体拮抗剂的新型手性N-酰基-5,6,7,(8-取代的)-四氢-[1,2,4]三唑并[4,3-a]吡嗪、药物组合物、用于NK-3受体介导的疾病中的方法及其手性合成
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CN101014587B (zh) * 2004-08-13 2013-12-18 神经能质公司 经取代的二芳基哌嗪基-吡啶类似物
CN101160287B (zh) * 2005-02-17 2011-08-03 安斯泰来制药株式会社 吡啶基非芳香族含氮杂环-1-羧酸酯衍生物
CN102046631A (zh) * 2008-03-31 2011-05-04 阳光医药工业有限公司 制备吗啡烷类似物的改良方法
CN101619063B (zh) * 2009-06-02 2011-08-10 华中师范大学 具有抗肿瘤活性的3,7,8-多取代吡啶并[4,3-d]嘧啶衍生物及制备
CN103906750A (zh) * 2011-10-03 2014-07-02 欧洲筛选有限公司 作为选择性NK-3受体拮抗剂的新型手性N-酰基-5,6,7,(8-取代的)-四氢-[1,2,4]三唑并[4,3-a]吡嗪、药物组合物、用于NK-3受体介导的疾病中的方法及其手性合成
CN103073506A (zh) * 2013-01-31 2013-05-01 黄河三角洲京博化工研究院有限公司 一种2-羟基-4,6-二甲基嘧啶盐酸盐的合成方法
CN103073506B (zh) * 2013-01-31 2015-03-11 京博农化科技股份有限公司 一种2-羟基-4,6-二甲基嘧啶盐酸盐的合成方法
CN110872302A (zh) * 2018-08-31 2020-03-10 沈阳中化农药化工研发有限公司 含嘧啶的螺环类化合物及其用途
CN110872302B (zh) * 2018-08-31 2022-09-27 沈阳中化农药化工研发有限公司 含嘧啶的螺环类化合物及其用途
CN113966396A (zh) * 2019-05-07 2022-01-21 迈阿密大学 遗传性神经病和相关障碍的治疗和检测

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