EA200100933A1 - Аминопиримидины в качестве ингибиторов сорбитолдегидрогеназы - Google Patents
Аминопиримидины в качестве ингибиторов сорбитолдегидрогеназыInfo
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- EA200100933A1 EA200100933A1 EA200100933A EA200100933A EA200100933A1 EA 200100933 A1 EA200100933 A1 EA 200100933A1 EA 200100933 A EA200100933 A EA 200100933A EA 200100933 A EA200100933 A EA 200100933A EA 200100933 A1 EA200100933 A1 EA 200100933A1
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
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- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Abstract
Данное изобретение относится к ингибирующим сорбитолдегидрогеназу соединениям общей формулы (I), где R, Rи Rтакие, как определено в материалах заявки. Данное изобретение также относится к фармацевтическим композициям, содержащим эти соединения, и к способам лечения или предупреждения диабетических осложнений, в частности диабетической невропатии, диабетической нефропатии, диабетической микроангиопатии, диабетической макроангиопатии и диабетической кардиомиопатии, при которых такие соединения вводят млекопитающему, страдающему диабетом и следовательно имеющему риск развития таких осложнений. Данное изобретение также относится к фармацевтическим композициям, содержащим комбинацию соединения формулы (I) по данному изобретению с ингибитором альдозоредуктазы, и к способам лечения или предупреждения диабетических осложнений с использованием таких композиций. Данное изобретение также относится к фармацевтическим композициям, содержащим комбинацию соединения формулы (I) по данному изобретению с ингибитором NHE-1 (натрий-водородного ионного обмена), и к способам лечения кардиомиопатии и других связанных с сердцем проблем с использованием таких композиций. Данное изобретение также относится к некоторым промежуточным соединениям, используемым в синтезе соединений формулы (I), и к способам получения этих промежуточных соединений.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12743799P | 1999-04-01 | 1999-04-01 | |
PCT/IB2000/000296 WO2000059510A1 (en) | 1999-04-01 | 2000-03-16 | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
Publications (2)
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EA200100933A1 true EA200100933A1 (ru) | 2002-04-25 |
EA004656B1 EA004656B1 (ru) | 2004-06-24 |
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Application Number | Title | Priority Date | Filing Date |
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EA200100933A EA004656B1 (ru) | 1999-04-01 | 2000-03-16 | Аминопиримидины в качестве ингибиторов сорбитолдегидрогеназы |
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US (5) | US6414149B1 (ru) |
EP (1) | EP1185275A1 (ru) |
JP (1) | JP3581103B2 (ru) |
KR (1) | KR20020005653A (ru) |
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AP (2) | AP2005003199A0 (ru) |
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CA (1) | CA2366858A1 (ru) |
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EA (1) | EA004656B1 (ru) |
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WO (1) | WO2000059510A1 (ru) |
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Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
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MXPA01009871A (es) * | 1999-04-01 | 2002-04-24 | Pfizer Prod Inc | Aminopiridinas como inhibidores de la sorbitol deshidrogenasa. |
WO2002032411A2 (en) * | 2000-10-18 | 2002-04-25 | Pfizer Products Inc. | Combination of statins and sorbitol dehydrogenase inhibitors |
SE0003795D0 (sv) * | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
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