JP2002540189A - ジアリール誘導体およびその医薬としての使用 - Google Patents
ジアリール誘導体およびその医薬としての使用Info
- Publication number
- JP2002540189A JP2002540189A JP2000607982A JP2000607982A JP2002540189A JP 2002540189 A JP2002540189 A JP 2002540189A JP 2000607982 A JP2000607982 A JP 2000607982A JP 2000607982 A JP2000607982 A JP 2000607982A JP 2002540189 A JP2002540189 A JP 2002540189A
- Authority
- JP
- Japan
- Prior art keywords
- dimethylphenyl
- hydroxy
- acid
- hydroxyphenoxy
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28010599A | 1999-03-29 | 1999-03-29 | |
US09/280,105 | 1999-03-29 | ||
PCT/EP2000/002683 WO2000058279A1 (en) | 1999-03-29 | 2000-03-27 | Diaryl derivatives and their use as medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002540189A true JP2002540189A (ja) | 2002-11-26 |
Family
ID=23071698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000607982A Pending JP2002540189A (ja) | 1999-03-29 | 2000-03-27 | ジアリール誘導体およびその医薬としての使用 |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1165502A1 (xx) |
JP (1) | JP2002540189A (xx) |
KR (1) | KR20010105394A (xx) |
CN (1) | CN1345309A (xx) |
AU (1) | AU4290800A (xx) |
BR (1) | BR0009431A (xx) |
CA (1) | CA2361016A1 (xx) |
CO (1) | CO5160290A1 (xx) |
CZ (1) | CZ20013449A3 (xx) |
HK (1) | HK1042692A1 (xx) |
HU (1) | HUP0200588A2 (xx) |
IL (1) | IL144637A0 (xx) |
MX (1) | MXPA01009843A (xx) |
NO (1) | NO20014702L (xx) |
NZ (1) | NZ514062A (xx) |
PE (1) | PE20001587A1 (xx) |
PL (1) | PL349355A1 (xx) |
RU (1) | RU2001126579A (xx) |
SK (1) | SK13812001A3 (xx) |
TR (1) | TR200102225T2 (xx) |
WO (1) | WO2000058279A1 (xx) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007512359A (ja) * | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
JP2017522329A (ja) * | 2014-08-14 | 2017-08-10 | 嘉▲興▼特科▲羅▼生物科技有限公司Technoderma Medicines Pte Ltd | 小分子化合物、その合成方法、及びその応用 |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2363145C (en) | 1999-03-01 | 2006-02-14 | Pfizer Products Inc. | Oxamic acids and derivatives as thyroid receptor ligands |
US6790978B2 (en) | 1999-03-29 | 2004-09-14 | Novartis Ag | Thyromimetic organic compounds |
MXPA02007929A (es) | 2000-02-17 | 2003-02-10 | Squibb Bristol Myers Co | Ligandos derivados de anilina para el receptor de la tiroides. |
IL151376A0 (en) * | 2000-03-31 | 2003-04-10 | Pfizer Prod Inc | Malonamic acids and derivatives thereof as thyroid receptor ligands |
US6664291B2 (en) | 2000-03-31 | 2003-12-16 | Pfizer, Inc. | Malonamic acids and derivatives thereof as thyroid receptor ligands |
WO2001085670A1 (fr) * | 2000-05-12 | 2001-11-15 | Kissei Pharmaceutical Co., Ltd. | Derives d'acide malonanilique, compositions medicinales les contenant et leur utilisation |
US6395784B1 (en) | 2000-06-07 | 2002-05-28 | Bristol-Myers Squibb Company | Benzamide ligands for the thyroid receptor |
DE10038007A1 (de) | 2000-08-04 | 2002-02-14 | Bayer Ag | Neue Amino-und Amido-Diphenylether für Arzneimittel |
DE10046029A1 (de) | 2000-09-18 | 2002-03-28 | Bayer Ag | Indazole |
AU2002223626A1 (en) * | 2000-10-20 | 2002-04-29 | Novartis Ag | Combinations of a thyromimetic compound and a statin |
CA2433100A1 (en) | 2000-12-27 | 2002-07-04 | Helmut Haning | Indole derivatives as ligands of thyroid receptors |
US6777442B2 (en) | 2001-03-12 | 2004-08-17 | Bayer Aktiengesellschaft | Diphenyl derivatives |
DE10122443A1 (de) * | 2001-05-09 | 2002-11-14 | Bayer Ag | Amido-Diphenyl-Derivate |
US6777443B2 (en) | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
ES2267945T3 (es) * | 2001-05-31 | 2007-03-16 | Pfizer Products Inc. | Uso medico de compuestos tiromimeticos para tratar la perdida del cabello y composiciones. |
DE10131462A1 (de) * | 2001-06-29 | 2003-01-09 | Bayer Ag | Phenol-Derivate |
EP1297833B1 (en) | 2001-09-26 | 2005-12-21 | Pfizer Products Inc. | Indole carboxylic acids as thyroid receptor ligands |
US6818766B2 (en) | 2002-10-02 | 2004-11-16 | Synthon Bv | Process for making bicalutamide and intermediates thereof |
WO2005105712A1 (en) * | 2004-05-05 | 2005-11-10 | Novo Nordisk A/S | Sulfonamide derivatives |
RU2416608C2 (ru) | 2004-08-06 | 2011-04-20 | Оцука Фармасьютикал Ко., Лтд. | Ароматическое соединение |
MX2007014502A (es) | 2005-05-26 | 2008-02-07 | Metabasis Therapeutics Inc | Tiromimeticos para el tratamiento de enfermedades del higado graso. |
MY146514A (en) | 2005-12-05 | 2012-08-15 | Otsuka Pharma Co Ltd | Diarylether derivatives as antitumor agents |
UA95978C2 (xx) | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Інгібітор активації stat3/5$ингибитор активации stat3/5 |
WO2009133834A1 (ja) * | 2008-04-28 | 2009-11-05 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有するケトアミド誘導体 |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
EP3541395A4 (en) | 2016-11-21 | 2020-07-01 | Viking Therapeutics, Inc. | GLYCOGENOSIS TREATMENT METHODS |
US11707472B2 (en) | 2017-06-05 | 2023-07-25 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis |
CN112135832A (zh) | 2018-03-22 | 2020-12-25 | 维京治疗公司 | 化合物的晶型和制备化合物的晶型的方法 |
TW202115029A (zh) * | 2019-07-31 | 2021-04-16 | 大陸商深圳微芯生物科技股份有限公司 | 雜環化合物及其用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE159515T1 (de) * | 1992-07-21 | 1997-11-15 | Ciba Geigy Ag | Oxamidsäure-derivate als hypocholesterämische mittel |
-
2000
- 2000-03-22 CO CO00020338A patent/CO5160290A1/es unknown
- 2000-03-27 JP JP2000607982A patent/JP2002540189A/ja active Pending
- 2000-03-27 WO PCT/EP2000/002683 patent/WO2000058279A1/en not_active Application Discontinuation
- 2000-03-27 MX MXPA01009843A patent/MXPA01009843A/es unknown
- 2000-03-27 EP EP00922557A patent/EP1165502A1/en not_active Withdrawn
- 2000-03-27 BR BR0009431-5A patent/BR0009431A/pt not_active Application Discontinuation
- 2000-03-27 PE PE2000000260A patent/PE20001587A1/es not_active Application Discontinuation
- 2000-03-27 CA CA002361016A patent/CA2361016A1/en not_active Abandoned
- 2000-03-27 KR KR1020017012250A patent/KR20010105394A/ko not_active Application Discontinuation
- 2000-03-27 CZ CZ20013449A patent/CZ20013449A3/cs unknown
- 2000-03-27 AU AU42908/00A patent/AU4290800A/en not_active Abandoned
- 2000-03-27 TR TR2001/02225T patent/TR200102225T2/xx unknown
- 2000-03-27 PL PL00349355A patent/PL349355A1/xx not_active Application Discontinuation
- 2000-03-27 HU HU0200588A patent/HUP0200588A2/hu unknown
- 2000-03-27 CN CN00805693A patent/CN1345309A/zh active Pending
- 2000-03-27 RU RU2001126579/04A patent/RU2001126579A/ru unknown
- 2000-03-27 IL IL14463700A patent/IL144637A0/xx unknown
- 2000-03-27 NZ NZ514062A patent/NZ514062A/xx not_active Application Discontinuation
- 2000-03-27 SK SK1381-2001A patent/SK13812001A3/sk unknown
-
2001
- 2001-09-27 NO NO20014702A patent/NO20014702L/no unknown
-
2002
- 2002-06-18 HK HK02104536.1A patent/HK1042692A1/zh unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007512359A (ja) * | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
JP2017522329A (ja) * | 2014-08-14 | 2017-08-10 | 嘉▲興▼特科▲羅▼生物科技有限公司Technoderma Medicines Pte Ltd | 小分子化合物、その合成方法、及びその応用 |
Also Published As
Publication number | Publication date |
---|---|
CA2361016A1 (en) | 2000-10-05 |
RU2001126579A (ru) | 2004-02-27 |
CZ20013449A3 (cs) | 2001-12-12 |
CO5160290A1 (es) | 2002-05-30 |
MXPA01009843A (es) | 2002-05-06 |
BR0009431A (pt) | 2002-01-08 |
IL144637A0 (en) | 2002-05-23 |
HUP0200588A2 (hu) | 2002-07-29 |
HK1042692A1 (zh) | 2002-08-23 |
SK13812001A3 (sk) | 2002-04-04 |
NZ514062A (en) | 2001-09-28 |
PE20001587A1 (es) | 2001-01-31 |
PL349355A1 (en) | 2002-07-15 |
AU4290800A (en) | 2000-10-16 |
EP1165502A1 (en) | 2002-01-02 |
CN1345309A (zh) | 2002-04-17 |
WO2000058279A1 (en) | 2000-10-05 |
TR200102225T2 (tr) | 2002-01-21 |
KR20010105394A (ko) | 2001-11-28 |
NO20014702D0 (no) | 2001-09-27 |
NO20014702L (no) | 2001-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20040907 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20050308 |