JP2002539072A5 - - Google Patents

Info

Publication number

JP2002539072A5

JP2002539072A5 JP2000565908A JP2000565908A JP2002539072A5 JP 2002539072 A5 JP2002539072 A5 JP 2002539072A5 JP 2000565908 A JP2000565908 A JP 2000565908A JP 2000565908 A JP2000565908 A JP 2000565908A JP 2002539072 A5 JP2002539072 A5 JP 2002539072A5

Authority

JP

Japan

Prior art keywords

egf

antagonist

formulated

package

growth factor

Prior art date

1999-08-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 102000001301 EGF receptor Human genes 0.000 description 31
• 108060006698 EGF receptor Proteins 0.000 description 31
• 239000005557 antagonist Substances 0.000 description 20
• 238000000034 method Methods 0.000 description 8
• 210000003097 mucus Anatomy 0.000 description 8
• 238000009472 formulation Methods 0.000 description 7
• 239000000203 mixture Substances 0.000 description 7
• 239000003814 drug Substances 0.000 description 6
• 238000001727 in vivo Methods 0.000 description 6
• 239000008194 pharmaceutical composition Substances 0.000 description 6
• 239000003795 chemical substances by application Substances 0.000 description 5
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 5
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 239000003172 expectorant agent Substances 0.000 description 4
• 230000001225 therapeutic effect Effects 0.000 description 4
• 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 4
• 239000005483 tyrosine kinase inhibitor Substances 0.000 description 4
• 150000004917 tyrosine kinase inhibitor derivatives Chemical group 0.000 description 4
• 101800003838 Epidermal growth factor Proteins 0.000 description 3
• 239000000443 aerosol Substances 0.000 description 3
• 230000000692 anti-sense effect Effects 0.000 description 3
• 229940124630 bronchodilator Drugs 0.000 description 3
• 239000003246 corticosteroid Substances 0.000 description 3
• 229940116977 epidermal growth factor Drugs 0.000 description 3
• 230000003419 expectorant effect Effects 0.000 description 3
• 238000010874 in vitro model Methods 0.000 description 3
• 230000000510 mucolytic effect Effects 0.000 description 3
• 230000000241 respiratory effect Effects 0.000 description 3
• 239000000243 solution Substances 0.000 description 3
• 102000009024 Epidermal Growth Factor Human genes 0.000 description 2
• 241000124008 Mammalia Species 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 230000009969 flowable effect Effects 0.000 description 2
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• 238000012216 screening Methods 0.000 description 2
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• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 108091000080 Phosphotransferase Proteins 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 208000006673 asthma Diseases 0.000 description 1
• 239000000168 bronchodilator agent Substances 0.000 description 1
• 229960001334 corticosteroids Drugs 0.000 description 1
• 229940112141 dry powder inhaler Drugs 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 229940066493 expectorants Drugs 0.000 description 1
• 210000002175 goblet cell Anatomy 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 229940043355 kinase inhibitor Drugs 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 229940071648 metered dose inhaler Drugs 0.000 description 1
• 229940066491 mucolytics Drugs 0.000 description 1
• 239000006199 nebulizer Substances 0.000 description 1
• 102000020233 phosphotransferase Human genes 0.000 description 1
• 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
• 102000004169 proteins and genes Human genes 0.000 description 1
• 108090000623 proteins and genes Proteins 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1