JP2002535285A5 - - Google Patents
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- JP2002535285A5 JP2002535285A5 JP2000594485A JP2000594485A JP2002535285A5 JP 2002535285 A5 JP2002535285 A5 JP 2002535285A5 JP 2000594485 A JP2000594485 A JP 2000594485A JP 2000594485 A JP2000594485 A JP 2000594485A JP 2002535285 A5 JP2002535285 A5 JP 2002535285A5
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- JP
- Japan
- Prior art keywords
- antibody
- preparation
- pharmaceutical composition
- inhibiting
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000016605 B-Cell Activating Factor Human genes 0.000 description 13
- 108010028006 B-Cell Activating Factor Proteins 0.000 description 13
- 210000003719 b-lymphocyte Anatomy 0.000 description 13
- 239000012634 fragment Substances 0.000 description 13
- 239000008194 pharmaceutical composition Substances 0.000 description 13
- 230000002401 inhibitory effect Effects 0.000 description 11
- 230000004663 cell proliferation Effects 0.000 description 7
- 208000030289 Lymphoproliferative disease Diseases 0.000 description 6
- 201000001268 lymphoproliferative syndrome Diseases 0.000 description 6
- 230000016784 immunoglobulin production Effects 0.000 description 5
- 208000023275 Autoimmune disease Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 208000026278 immune system disease Diseases 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000021766 negative regulation of B cell proliferation Effects 0.000 description 1
- 230000005401 negative regulation of immunoglobulin production Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11716999P | 1999-01-25 | 1999-01-25 | |
| US60/117,169 | 1999-01-25 | ||
| US14322899P | 1999-07-09 | 1999-07-09 | |
| US60/143,228 | 1999-07-09 | ||
| PCT/US2000/001788 WO2000043032A2 (en) | 1999-01-25 | 2000-01-25 | Baff, inhibitors thereof and their use in the modulation of b-cell response |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008303135A Division JP4955642B2 (ja) | 1999-01-25 | 2008-11-27 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012077812A Division JP2012126749A (ja) | 1999-01-25 | 2012-03-29 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002535285A JP2002535285A (ja) | 2002-10-22 |
| JP2002535285A5 true JP2002535285A5 (enExample) | 2009-01-22 |
| JP5066314B2 JP5066314B2 (ja) | 2012-11-07 |
Family
ID=26815006
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000594485A Expired - Lifetime JP5066314B2 (ja) | 1999-01-25 | 2000-01-25 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2008303135A Expired - Fee Related JP4955642B2 (ja) | 1999-01-25 | 2008-11-27 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012012379A Withdrawn JP2012087145A (ja) | 1999-01-25 | 2012-01-24 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012077812A Pending JP2012126749A (ja) | 1999-01-25 | 2012-03-29 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2014090152A Pending JP2014141527A (ja) | 1999-01-25 | 2014-04-24 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008303135A Expired - Fee Related JP4955642B2 (ja) | 1999-01-25 | 2008-11-27 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012012379A Withdrawn JP2012087145A (ja) | 1999-01-25 | 2012-01-24 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012077812A Pending JP2012126749A (ja) | 1999-01-25 | 2012-03-29 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2014090152A Pending JP2014141527A (ja) | 1999-01-25 | 2014-04-24 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6869605B2 (enExample) |
| EP (5) | EP2319527A3 (enExample) |
| JP (5) | JP5066314B2 (enExample) |
| KR (1) | KR100834809B1 (enExample) |
| CN (1) | CN100340292C (enExample) |
| AT (2) | ATE247482T1 (enExample) |
| AU (1) | AU762839B2 (enExample) |
| BR (1) | BR0007719A (enExample) |
| CA (1) | CA2360062A1 (enExample) |
| CY (2) | CY1107453T1 (enExample) |
| CZ (1) | CZ299819B6 (enExample) |
| DE (1) | DE60004635T2 (enExample) |
| DK (2) | DK1146892T3 (enExample) |
| EA (1) | EA006108B1 (enExample) |
| EE (1) | EE05699B1 (enExample) |
| ES (1) | ES2204528T3 (enExample) |
| HK (1) | HK1040628B (enExample) |
| HU (1) | HUP0105283A3 (enExample) |
| IL (3) | IL144202A0 (enExample) |
| IS (1) | IS5993A (enExample) |
| MX (1) | MXPA01007464A (enExample) |
| NO (2) | NO20013641L (enExample) |
| NZ (1) | NZ513284A (enExample) |
| PL (1) | PL198934B1 (enExample) |
| PT (2) | PT1415659E (enExample) |
| SI (1) | SI1146892T1 (enExample) |
| SK (1) | SK286665B6 (enExample) |
| TR (2) | TR200102147T2 (enExample) |
| WO (1) | WO2000043032A2 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US6689579B1 (en) | 1996-10-25 | 2004-02-10 | Human Genome Sciences, Inc. | Polynucleotides encoding neutrokine-α |
| US20030175208A1 (en) * | 1996-10-25 | 2003-09-18 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| EP0878552A1 (en) | 1997-05-13 | 1998-11-18 | Erasmus Universiteit Rotterdam | Molecular detection of chromosome aberrations |
| EP1078098A1 (en) | 1998-05-04 | 2001-02-28 | Dako A/S | Method and probes for the detection of chromosome aberrations |
| WO2001060397A1 (en) * | 2000-02-16 | 2001-08-23 | Genentech, Inc. | Uses of agonists and antagonists to modulate activity of tnf-related molecules |
| GB9828628D0 (en) | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Novel ligand |
| US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| CZ299819B6 (cs) | 1999-01-25 | 2008-12-03 | Biogen Idec Ma Inc. | Farmaceutické kompozice obsahující protilátky specifické pro rozpustný BAFF |
| US20050100548A1 (en) * | 2001-07-24 | 2005-05-12 | Biogen Idec Ma Inc. | BAFF, inhibitors thereof and their use in the modulation of B-cell response |
| US20030095967A1 (en) * | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| WO2000068378A1 (en) * | 1999-05-06 | 2000-11-16 | National Jewish Medical And Research Center | Tall-1 nucleic acid molecules, proteins, receptors and methods of use thereof |
| HK1043608B (en) | 1999-08-17 | 2007-12-07 | Biogen Ma Inc. | Baff receptor (bcma), an immunoregulatory agent |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| US7220840B2 (en) | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
| US7879328B2 (en) * | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| AU2001268427B2 (en) | 2000-06-16 | 2007-03-29 | Glaxosmithkline Intellectual Property Limited | Antibodies that immunospecifically bind to blys |
| AU2001288301A1 (en) * | 2000-08-18 | 2002-03-04 | Human Genome Sciences, Inc. | Binding polypeptides and methods based thereon |
| EP2267017A3 (en) * | 2000-08-18 | 2011-07-06 | Human Genome Sciences, Inc. | Binding polypeptides for B lymphocyte stimulator protein (BLyS) |
| UA83458C2 (uk) * | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| HU229910B1 (hu) * | 2001-05-11 | 2014-12-29 | Amgen Inc Thousand Oaks | A TALL-1-hez kötõdõ peptidek és rokon molekulák |
| PL403488A1 (pl) | 2001-05-24 | 2013-07-08 | Zymogenetics, Inc. | Zastosowanie bialka fuzyjnego TACI-immunoglobulina, bialko fuzyjne, czasteczka kwasu nukleinowego kodujaca bialko fuzyjne, kompozycja farmaceutyczna i sposób wytwarzania bialka fuzyjnego TACI-immunoglobulina |
| KR20040019105A (ko) * | 2001-08-03 | 2004-03-04 | 제넨테크, 인크. | ＴＡＣＩｓ 및 ＢＲ3 폴리펩티드 및 이의 용도 |
| AR035119A1 (es) | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
| AU2002356858A1 (en) * | 2001-10-24 | 2003-05-06 | National Jewish Medical And Research Center | Structure of tall-1 and its cognate receptor |
| AU2003221256A1 (en) * | 2002-02-21 | 2003-09-09 | Biogen Idec Ma Inc. | Use of bcma as an immunoregulatory agent |
| BR0313033A (pt) * | 2002-07-25 | 2007-07-10 | Genentech Inc | anticorpos, anticorpos monoclonais, linhagens de células de hibridoma, anticorpos receptores de anti-taci isolados, anticorpos anti -taci, métodos de modulação da atividade biológica |
| EP2311867A1 (en) | 2002-10-29 | 2011-04-20 | Anaphore, Inc. | Trimeric binding proteins for trimeric cytokines |
| US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
| WO2004074511A1 (en) * | 2003-02-21 | 2004-09-02 | Garvan Institute Of Medical Research | Diagnosis and treatment of baff-mediated autoimmune diseases and cancer |
| AU2004220078A1 (en) * | 2003-03-07 | 2004-09-23 | Xencor, Inc | BAFF mutants with at least one amino acid substitution and methods of their production |
| EP1608730B1 (en) | 2003-03-28 | 2013-11-06 | Biogen Idec MA Inc. | Truncated baff receptors |
| US20050163775A1 (en) * | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
| ES2537738T3 (es) * | 2003-06-05 | 2015-06-11 | Genentech, Inc. | Terapia de combinación para trastornos de células B |
| WO2005042009A1 (en) | 2003-10-20 | 2005-05-12 | Biogen Idec Ma Inc. | Therapeutic regimens for baff antagonists |
| WO2005075511A1 (en) | 2004-01-29 | 2005-08-18 | Genentech, Inc. | Variants of the extracellular domain of bcma and uses thereof |
| JP5570681B2 (ja) * | 2004-08-31 | 2014-08-13 | 興和株式会社 | 抗ヒトｂａｆｆ抗体 |
| NZ583905A (en) | 2004-10-13 | 2011-12-22 | Univ Washington | Use of BAFF to Treat Sepsis |
| EP1844069A4 (en) * | 2005-01-28 | 2009-05-20 | Apollo Life Sciences Ltd | MOLECULES AND CHIMESE MOLECULES THEREOF |
| US20080254030A1 (en) * | 2005-01-28 | 2008-10-16 | Charles Mackay | Use of Baff to Treat Th2-Mediated Conditions |
| EP1883424A2 (en) * | 2005-05-18 | 2008-02-06 | Biogen Idec Inc. | Methods for treating fibrotic conditions |
| KR20080056714A (ko) | 2005-08-09 | 2008-06-23 | 지모제넥틱스, 인코포레이티드 | ＴＡＣＩ―Ｉｇ 융합 분자를 사용하여 Ｂ―세포 악성종양을치료하는 방법 |
| US8808696B2 (en) | 2005-08-09 | 2014-08-19 | Ares Trading S.A. | Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules |
| US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| KR20080074120A (ko) * | 2005-10-13 | 2008-08-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 자가항체 양성 질환 환자의 치료에 유용한 방법 및 조성물 |
| CA2629306A1 (en) | 2005-11-23 | 2007-05-31 | Genentech, Inc. | Methods and compositions related to b cell assays |
| WO2007123765A2 (en) | 2006-03-31 | 2007-11-01 | Human Genome Sciences Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| WO2007134326A2 (en) | 2006-05-15 | 2007-11-22 | Ares Trading S.A. | Methods for treating autoimmune diseases using a taci-ig fusion molecule |
| EP2396035A4 (en) * | 2009-02-12 | 2012-09-12 | Human Genome Sciences Inc | USE OF ANTAGONISTS OF THE B-LYMPHOCYTE STIMULATOR PROTEIN TO PROMOTE TRANSPLANT TOLERANCE |
| JP5938352B2 (ja) * | 2010-03-11 | 2016-06-22 | ギリアード コネチカット， インコーポレイテッド | イミダゾピリジンｓｙｋ阻害剤 |
| WO2013171296A1 (en) | 2012-05-16 | 2013-11-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Diagnostic and treatment of sarcoidosis |
| CZ2012561A3 (cs) * | 2012-08-22 | 2013-10-23 | Masarykova Univerzita | B-bunecný aktivující faktor pro zvýsení sliznicní imunity kojencu a prípravek jej obsahující |
| PH12022550138A1 (en) | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| US9688767B2 (en) | 2013-03-15 | 2017-06-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method of predicting survival time in myocardial infarction patients by measuring BAFF levels |
| KR101493592B1 (ko) | 2013-04-29 | 2015-02-17 | 부산대학교 산학협력단 | Ｓｏｃｓ3 단백질을 이용한 ｂａｆｆ 연관 면역질환 치료제 스크리닝 방법 |
| MY183188A (en) | 2013-11-19 | 2021-02-18 | Regeneron Pharma | Non-human animals having a humanized b-cell activating factor gene |
| TWI662037B (zh) | 2013-12-23 | 2019-06-11 | 美商基利科學股份有限公司 | 脾酪胺酸激酶抑制劑 |
| US10435474B2 (en) | 2013-12-24 | 2019-10-08 | Ossianix, Inc. | Baff selective binding compounds and related methods |
| CA2934965A1 (en) | 2014-01-31 | 2016-03-17 | Boehringer Ingelheim International Gmbh | Novel anti-baff antibodies |
| AR104368A1 (es) | 2015-04-03 | 2017-07-19 | Lilly Co Eli | Anticuerpos biespecíficos anti-cd20- / anti-baff |
| WO2016205714A1 (en) * | 2015-06-19 | 2016-12-22 | University Of Louisville Research Foundation, Inc. | Immunomodulation for the long term prevention and treatment of autoimmune diseases and foreign tissue rejection |
| CN107328620B (zh) * | 2017-06-23 | 2020-06-05 | 浙江普罗亭健康科技有限公司 | 用于流式细胞技术的封闭缓冲液及试剂盒 |
| US20220133788A1 (en) * | 2017-12-19 | 2022-05-05 | The Johns Hopkins University | Baff therapy to promote anti-tumor immunity |
| WO2019210168A1 (en) * | 2018-04-26 | 2019-10-31 | University Of Virginia Patent Foundation | Compositions and methods for treating abdominal aortic aneurysm |
| AU2020225455A1 (en) | 2019-02-22 | 2021-09-09 | Kronos Bio, Inc. | Solid forms of condensed pyrazines as Syk inhibitors |
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| CZ299819B6 (cs) | 1999-01-25 | 2008-12-03 | Biogen Idec Ma Inc. | Farmaceutické kompozice obsahující protilátky specifické pro rozpustný BAFF |
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| WO2000068378A1 (en) | 1999-05-06 | 2000-11-16 | National Jewish Medical And Research Center | Tall-1 nucleic acid molecules, proteins, receptors and methods of use thereof |
| EP1259544B1 (en) * | 2000-02-11 | 2011-08-24 | Biogen Idec MA Inc. | Heterologous polypeptide of the tnf family |
| AU2001268427B2 (en) | 2000-06-16 | 2007-03-29 | Glaxosmithkline Intellectual Property Limited | Antibodies that immunospecifically bind to blys |
| EP1309718A4 (en) | 2000-08-15 | 2004-08-25 | Human Genome Sciences Inc | Neutrokine-alpha and neutrokine-alpha splice variant |
| WO2003055979A2 (en) | 2001-11-16 | 2003-07-10 | Human Genome Sciences, Inc. | ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO BLyS |
-
2000
- 2000-01-25 CZ CZ20012696A patent/CZ299819B6/cs not_active IP Right Cessation
- 2000-01-25 EA EA200100822A patent/EA006108B1/ru not_active IP Right Cessation
- 2000-01-25 MX MXPA01007464A patent/MXPA01007464A/es active IP Right Grant
- 2000-01-25 PL PL349772A patent/PL198934B1/pl unknown
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- 2000-01-25 EP EP00909970A patent/EP1146892B1/en not_active Revoked
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2001
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2008
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2009
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