JP2004523579A5 - - Google Patents
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- Publication number
- JP2004523579A5 JP2004523579A5 JP2002573044A JP2002573044A JP2004523579A5 JP 2004523579 A5 JP2004523579 A5 JP 2004523579A5 JP 2002573044 A JP2002573044 A JP 2002573044A JP 2002573044 A JP2002573044 A JP 2002573044A JP 2004523579 A5 JP2004523579 A5 JP 2004523579A5
- Authority
- JP
- Japan
- Prior art keywords
- hmg box
- molecule
- preparation
- therapeutic agent
- hmg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 208000019553 vascular disease Diseases 0.000 claims 3
- 102100029599 Advanced glycosylation end product-specific receptor Human genes 0.000 claims 2
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 claims 2
- 102000055207 HMGB1 Human genes 0.000 claims 2
- 108700010013 HMGB1 Proteins 0.000 claims 2
- 101150021904 HMGB1 gene Proteins 0.000 claims 2
- 101001061840 Homo sapiens Advanced glycosylation end product-specific receptor Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 210000002808 connective tissue Anatomy 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000004210 Pressure Ulcer Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 230000007838 tissue remodeling Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI000562A ITMI20010562A1 (it) | 2001-03-16 | 2001-03-16 | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| ITMI2001A000562 | 2001-03-16 | ||
| PCT/IT2002/000153 WO2002074337A1 (en) | 2001-03-16 | 2002-03-12 | Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004523579A JP2004523579A (ja) | 2004-08-05 |
| JP2004523579A5 true JP2004523579A5 (enExample) | 2005-08-18 |
| JP4822654B2 JP4822654B2 (ja) | 2011-11-24 |
Family
ID=11447291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573044A Expired - Fee Related JP4822654B2 (ja) | 2001-03-16 | 2002-03-12 | 血管疾患治療用ｈｍｇｂ１蛋白質インヒビタおよび／またはアンタゴニスト |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7754217B2 (enExample) |
| EP (1) | EP1368060B1 (enExample) |
| JP (1) | JP4822654B2 (enExample) |
| CN (2) | CN1537014B (enExample) |
| AT (1) | ATE468137T1 (enExample) |
| AU (1) | AU2002247977C1 (enExample) |
| CA (1) | CA2439530C (enExample) |
| DE (1) | DE60236413D1 (enExample) |
| DK (1) | DK1368060T3 (enExample) |
| ES (1) | ES2346408T3 (enExample) |
| IT (1) | ITMI20010562A1 (enExample) |
| MX (1) | MXPA03008364A (enExample) |
| PT (1) | PT1368060E (enExample) |
| WO (1) | WO2002074337A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7151082B2 (en) | 1999-02-11 | 2006-12-19 | The Feinstein Institute For Medical Research | Antagonists of HMG1 for treating inflammatory conditions |
| ITMI20010562A1 (it) * | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| BR0209689A (pt) * | 2001-05-15 | 2006-02-07 | Long Island Jewish Res Inst | Uso de fragmento de hmg como agente anti-inflamatório |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| DE60326453D1 (de) | 2002-07-03 | 2009-04-16 | Ct Cardiologico Monzino S P A | Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung |
| EP1579221A2 (de) * | 2003-01-03 | 2005-09-28 | Alcedo Biotech GmbH | Verwendungen von hmgb, hmgn, hmga proteinen |
| US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| AU2004272607B2 (en) | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
| ITRM20040058A1 (it) * | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
| PT1768677E (pt) * | 2004-07-02 | 2008-10-06 | Creabilis Therapeutics Spa | Ácidos nucleicos para o tratamento de patologias relacionadas com hmgb1 |
| US20090062187A1 (en) | 2004-07-20 | 2009-03-05 | Marco Bianchi | Use of Hmgb1 for Wound Healing |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| CA2579094C (en) | 2004-09-03 | 2014-12-02 | Creabilis Therapeutics S.P.A. | Use of polypeptides obtained through systematic mutations of single amino acids of human and non-human box-a of hmgb1 to prevent and/or antagonize pathologies induced by hmgb1 |
| US8129130B2 (en) | 2004-10-22 | 2012-03-06 | The Feinstein Institute For Medical Research | High affinity antibodies against HMGB1 and methods of use thereof |
| JP2008520552A (ja) | 2004-10-22 | 2008-06-19 | メディミューン，インコーポレーテッド | Ｈｍｇｂ１に対する高親和性の抗体およびその使用法 |
| ITRM20050032A1 (it) * | 2005-01-21 | 2006-07-22 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di inibire la patogenesi e la progressione della malattia aterosclerotica. |
| WO2006114805A2 (en) * | 2005-04-28 | 2006-11-02 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb2 and hmgb3 proteins for medical applications |
| WO2007011606A2 (en) | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| KR101379693B1 (ko) | 2005-08-25 | 2014-04-10 | 크리어빌리스 쎄라퓨틱스 에스.피.에이. | Ｋ-252ａ 및 그의 유도체의 중합체 컨쥬게이트 |
| WO2007031100A1 (en) * | 2005-09-14 | 2007-03-22 | Ostini, Marco | Active immunotherapy of life-threatening systemic inflammation |
| US20080311122A1 (en) | 2005-11-28 | 2008-12-18 | Medimmune, Llc | Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof |
| WO2007130725A2 (en) * | 2006-02-06 | 2007-11-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of hmgb1 for protection against ischemia reperfusion injury |
| JP2010503630A (ja) | 2006-09-15 | 2010-02-04 | クレアビリス・セラピューティクス・エスピーエー | ＨＭＧＢ１のＢｏｘ−ＡおよびＨＭＧＢ１のＢｏｘ−Ａ変異体のポリマー複合体 |
| US8470325B2 (en) | 2007-02-15 | 2013-06-25 | Kagoshima University | Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody |
| WO2009133943A1 (ja) | 2008-04-30 | 2009-11-05 | 株式会社ジェノミックス | 生体内機能的細胞の高効率採取法 |
| JP5660889B2 (ja) | 2008-04-30 | 2015-01-28 | 株式会社ジェノミックス | 末梢循環への骨髄由来多能性幹細胞動員薬 |
| WO2011007876A1 (ja) | 2009-07-16 | 2011-01-20 | Ｎｅｃソフト株式会社 | Ｈｍｇｂ１結合核酸分子およびその用途 |
| JP5467313B2 (ja) | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
| KR20120135190A (ko) | 2009-10-28 | 2012-12-12 | 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 | 골수 간엽계 및/또는 다능성 줄기세포의 혈중 동원(動員)에 의한 조직 재생 촉진제 |
| EP2632446B1 (en) | 2010-10-30 | 2018-12-12 | Oxford University Innovation Limited | Treatment for dupuytren's disease |
| EP3358011B1 (en) | 2011-04-26 | 2020-03-04 | StemRIM Inc. | Peptide for inducing regeneration of tissue and use thereof |
| US9561274B2 (en) | 2011-06-07 | 2017-02-07 | University Of Hawaii | Treatment and prevention of cancer with HMGB1 antagonists |
| US9244074B2 (en) * | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| JP6253589B2 (ja) | 2012-10-25 | 2017-12-27 | 株式会社ジェノミックス | Ｈｍｇｂ１断片を利用した新規心筋梗塞の治療法 |
| DK2913059T3 (en) | 2012-10-25 | 2018-06-25 | Genomix Co Ltd | Hitherto UNKNOWN PROCEDURE FOR TREATMENT OF SPINE INJURY USING HMGB1 FRAGMENT |
| MX2015009547A (es) | 2013-01-28 | 2015-11-25 | Evec Inc | Anticuerpo anti-hmgb1 humanizado o fragmento de union al antigeno del mismo. |
| IL242807A0 (en) | 2015-11-26 | 2016-04-21 | Novamed Ltd | Test facility |
| EP3386529A2 (en) | 2015-12-11 | 2018-10-17 | Ruprecht-Karls-Universität Heidelberg | Combined preparations of pkm2 modulators and hmgb1 |
| AU2018213671B2 (en) | 2017-01-27 | 2024-06-06 | Osaka University | Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure |
| AU2018376452A1 (en) | 2017-12-01 | 2020-06-25 | Osaka University | Ectodermal mesenchymal stem cells and method for producing same |
| EP3718561A4 (en) | 2017-12-01 | 2021-07-21 | Stemrim Inc. | Therapy for inflammatory bowel disease |
| US20210024594A1 (en) | 2018-02-08 | 2021-01-28 | StemRIM Inc. | Therapeutic Agent for Psoriasis |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| WO2021242180A1 (en) * | 2020-04-22 | 2021-12-02 | Chulalongkorn University | A composition and a method of rejuvenating dna and preventing dna damage |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US5470307A (en) * | 1994-03-16 | 1995-11-28 | Lindall; Arnold W. | Catheter system for controllably releasing a therapeutic agent at a remote tissue site |
| WO1997026913A1 (en) | 1996-01-26 | 1997-07-31 | The Trustees Of Columbia University In The City Of New York | A POLYPEPTIDE FROM LUNG EXTRACT WHICH BINDS AMYLOID-β PEPTIDE |
| US5864018A (en) | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| WO1997039121A1 (en) | 1996-04-16 | 1997-10-23 | Schering Aktiengesellschaft | Advanced glycosylation end-product receptor peptides and uses therefor |
| US6790443B2 (en) | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US6398808B1 (en) | 1999-06-15 | 2002-06-04 | Scimed Life Systems, Inc. | Localized delivery of genetic information from biostable materials |
| ITMI20010562A1 (it) * | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| BR0209689A (pt) * | 2001-05-15 | 2006-02-07 | Long Island Jewish Res Inst | Uso de fragmento de hmg como agente anti-inflamatório |
| ITRM20040058A1 (it) * | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
| US20090062187A1 (en) * | 2004-07-20 | 2009-03-05 | Marco Bianchi | Use of Hmgb1 for Wound Healing |
| WO2008137552A2 (en) * | 2007-05-02 | 2008-11-13 | Medimmune, Llc | Anti-rage antibodies and methods of use thereof |
-
2001
- 2001-03-16 IT IT2001MI000562A patent/ITMI20010562A1/it unknown
- 2001-03-16 US US10/471,641 patent/US7754217B2/en not_active Expired - Fee Related
-
2002
- 2002-03-12 EP EP02717057A patent/EP1368060B1/en not_active Expired - Lifetime
- 2002-03-12 ES ES02717057T patent/ES2346408T3/es not_active Expired - Lifetime
- 2002-03-12 WO PCT/IT2002/000153 patent/WO2002074337A1/en not_active Ceased
- 2002-03-12 AT AT02717057T patent/ATE468137T1/de active
- 2002-03-12 AU AU2002247977A patent/AU2002247977C1/en not_active Ceased
- 2002-03-12 CN CN028065670A patent/CN1537014B/zh not_active Expired - Fee Related
- 2002-03-12 PT PT02717057T patent/PT1368060E/pt unknown
- 2002-03-12 DE DE60236413T patent/DE60236413D1/de not_active Expired - Lifetime
- 2002-03-12 JP JP2002573044A patent/JP4822654B2/ja not_active Expired - Fee Related
- 2002-03-12 CN CN200910252323A patent/CN101773669A/zh active Pending
- 2002-03-12 DK DK02717057.0T patent/DK1368060T3/da active
- 2002-03-12 CA CA2439530A patent/CA2439530C/en not_active Expired - Fee Related
- 2002-03-12 MX MXPA03008364A patent/MXPA03008364A/es active IP Right Grant
-
2008
- 2008-01-02 US US11/968,506 patent/US8058239B2/en not_active Expired - Fee Related
-
2010
- 2010-02-17 US US12/707,264 patent/US20100297107A1/en not_active Abandoned
- 2010-02-17 US US12/707,222 patent/US20100172896A1/en not_active Abandoned
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