CA2439530C - Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases - Google Patents
Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases Download PDFInfo
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- CA2439530C CA2439530C CA2439530A CA2439530A CA2439530C CA 2439530 C CA2439530 C CA 2439530C CA 2439530 A CA2439530 A CA 2439530A CA 2439530 A CA2439530 A CA 2439530A CA 2439530 C CA2439530 C CA 2439530C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI000562A ITMI20010562A1 (it) | 2001-03-16 | 2001-03-16 | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| ITMI2001A000562 | 2001-03-16 | ||
| PCT/IT2002/000153 WO2002074337A1 (en) | 2001-03-16 | 2002-03-12 | Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2439530A1 CA2439530A1 (en) | 2002-09-26 |
| CA2439530C true CA2439530C (en) | 2016-11-08 |
Family
ID=11447291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2439530A Expired - Fee Related CA2439530C (en) | 2001-03-16 | 2002-03-12 | Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7754217B2 (enExample) |
| EP (1) | EP1368060B1 (enExample) |
| JP (1) | JP4822654B2 (enExample) |
| CN (2) | CN1537014B (enExample) |
| AT (1) | ATE468137T1 (enExample) |
| AU (1) | AU2002247977C1 (enExample) |
| CA (1) | CA2439530C (enExample) |
| DE (1) | DE60236413D1 (enExample) |
| DK (1) | DK1368060T3 (enExample) |
| ES (1) | ES2346408T3 (enExample) |
| IT (1) | ITMI20010562A1 (enExample) |
| MX (1) | MXPA03008364A (enExample) |
| PT (1) | PT1368060E (enExample) |
| WO (1) | WO2002074337A1 (enExample) |
Families Citing this family (46)
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| US7151082B2 (en) | 1999-02-11 | 2006-12-19 | The Feinstein Institute For Medical Research | Antagonists of HMG1 for treating inflammatory conditions |
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| ITMI20010562A1 (it) * | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| HUP0500042A3 (en) * | 2001-05-15 | 2010-01-28 | Long Island Jewish Res Inst | Use of hmg fragments as anti-inflammatory agents |
| US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| ATE424416T1 (de) | 2002-07-03 | 2009-03-15 | San Raffaele Centro Fond | Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung |
| WO2004061456A2 (de) * | 2003-01-03 | 2004-07-22 | Alcedo Biotech Gmbh | Verwendungen von hmgb, hmgn, hmga proteinen |
| US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| CA2882022A1 (en) | 2003-09-11 | 2005-03-24 | Walter Newman | Monoclonal antibodies against hmgb1 |
| ITRM20040058A1 (it) * | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
| PT1768677E (pt) * | 2004-07-02 | 2008-10-06 | Creabilis Therapeutics Spa | Ácidos nucleicos para o tratamento de patologias relacionadas com hmgb1 |
| US20090062187A1 (en) | 2004-07-20 | 2009-03-05 | Marco Bianchi | Use of Hmgb1 for Wound Healing |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| EP1797118A2 (en) * | 2004-09-03 | 2007-06-20 | Creabilis Therapeutics S.P.A. | Protease resistant human and non-human hmgb1 box-a mutants and their therapeutic/diagnostic use |
| WO2007001422A2 (en) | 2004-10-22 | 2007-01-04 | Medimmune, Inc. | High affinity antibodies against hmgb1 and methods of use thereof |
| US8129130B2 (en) | 2004-10-22 | 2012-03-06 | The Feinstein Institute For Medical Research | High affinity antibodies against HMGB1 and methods of use thereof |
| ITRM20050032A1 (it) * | 2005-01-21 | 2006-07-22 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di inibire la patogenesi e la progressione della malattia aterosclerotica. |
| WO2006114805A2 (en) * | 2005-04-28 | 2006-11-02 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb2 and hmgb3 proteins for medical applications |
| US20100040608A1 (en) | 2005-07-18 | 2010-02-18 | Marie Wahren-Herlenius | Use of HMGB1 antagonists for the treatment of inflammatory skin conditions |
| AU2006284096B2 (en) | 2005-08-25 | 2012-03-29 | Avro Life Sciences, Inc. | Polymer conjugates of K-252a and derivatives thereof |
| WO2007031100A1 (en) * | 2005-09-14 | 2007-03-22 | Ostini, Marco | Active immunotherapy of life-threatening systemic inflammation |
| CA2631212A1 (en) | 2005-11-28 | 2007-07-05 | Medimmune, Llc | Antagonists of hmgb1 and/or rage and methods of use thereof |
| US7829097B2 (en) * | 2006-02-06 | 2010-11-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of HMGB1 for protection against ischemia reperfusion injury |
| CA2663300C (en) | 2006-09-15 | 2014-10-07 | Creabilis Therapeutics S.P.A. | Polymer conjugates of box-a of hmgb1 and box-a variants of hmgb1 |
| US8470325B2 (en) | 2007-02-15 | 2013-06-25 | Kagoshima University | Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody |
| RU2519714C2 (ru) | 2008-04-30 | 2014-06-20 | Дженомикс Ко., Лтд. | Средство для вовлечения происходящей из костного мозга плюрипотентной стволовой клетки в периферический кровоток |
| WO2009133943A1 (ja) | 2008-04-30 | 2009-11-05 | 株式会社ジェノミックス | 生体内機能的細胞の高効率採取法 |
| JP5582580B2 (ja) * | 2009-07-16 | 2014-09-03 | Ｎｅｃソリューションイノベータ株式会社 | Ｈｍｇｂ１結合核酸分子およびその用途 |
| JP5467313B2 (ja) * | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
| CN102711777B (zh) | 2009-10-28 | 2015-04-15 | 吉诺米克斯股份有限公司 | 利用骨髓间充质干细胞和/或多能干细胞的血中动员的组织再生促进剂 |
| CA2847197C (en) | 2010-10-30 | 2020-11-03 | Isis Innovation Limited | Treatment for dupuytren's disease |
| DK2703487T3 (en) | 2011-04-26 | 2018-09-10 | Genomix Co Ltd | TIME TO INDUCTION Tissue Regeneration and its Use |
| US9244074B2 (en) * | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| WO2012170742A2 (en) | 2011-06-07 | 2012-12-13 | University Of Hawaii | Treatment and prevention of cancer with hmgb1 antagonists |
| RU2647467C2 (ru) | 2012-10-25 | 2018-03-15 | Дженомикс Ко., Лтд. | Новый способ лечения инфаркта миокарда с применением фрагмента hmgb1 |
| EP2913059B1 (en) | 2012-10-25 | 2018-04-11 | Genomix Co., Ltd. | Novel method for treating spinal cord injury using hmgb1 fragment |
| MX2015009547A (es) | 2013-01-28 | 2015-11-25 | Evec Inc | Anticuerpo anti-hmgb1 humanizado o fragmento de union al antigeno del mismo. |
| IL242807A0 (en) * | 2015-11-26 | 2016-04-21 | Novamed Ltd | Test facility |
| US11274132B2 (en) | 2015-12-11 | 2022-03-15 | Ruprecht-Karls-Universität Heidelberg | Combined preparations of PKM2 modulators and HMGB1 |
| BR112019014921A2 (pt) | 2017-01-27 | 2020-03-31 | StemRIM Inc. | Agente terapêutico para miocardiopatia, infarto antigo do miocárdio e insuficiência cardíaca crônica |
| EP3719117A4 (en) | 2017-12-01 | 2021-11-03 | Stemrim Inc. | EECTODERMAL MESENCHYMAL STEM CELLS AND METHOD FOR PRODUCING THEM |
| US11298403B2 (en) | 2017-12-01 | 2022-04-12 | StemRIM Inc. | Therapeutic agent for inflammatory bowel disease |
| US20210024594A1 (en) | 2018-02-08 | 2021-01-28 | StemRIM Inc. | Therapeutic Agent for Psoriasis |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| CN115361966B (zh) * | 2020-04-22 | 2025-09-16 | 朱拉隆功大学 | 使dna恢复活力和防止dna损伤的组合物以及方法 |
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| US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US5470307A (en) * | 1994-03-16 | 1995-11-28 | Lindall; Arnold W. | Catheter system for controllably releasing a therapeutic agent at a remote tissue site |
| WO1997026913A1 (en) | 1996-01-26 | 1997-07-31 | The Trustees Of Columbia University In The City Of New York | A POLYPEPTIDE FROM LUNG EXTRACT WHICH BINDS AMYLOID-β PEPTIDE |
| US5864018A (en) * | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| WO1997039121A1 (en) | 1996-04-16 | 1997-10-23 | Schering Aktiengesellschaft | Advanced glycosylation end-product receptor peptides and uses therefor |
| US6790443B2 (en) | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US6398808B1 (en) | 1999-06-15 | 2002-06-04 | Scimed Life Systems, Inc. | Localized delivery of genetic information from biostable materials |
| ITMI20010562A1 (it) * | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| HUP0500042A3 (en) * | 2001-05-15 | 2010-01-28 | Long Island Jewish Res Inst | Use of hmg fragments as anti-inflammatory agents |
| ITRM20040058A1 (it) * | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
| US20090062187A1 (en) * | 2004-07-20 | 2009-03-05 | Marco Bianchi | Use of Hmgb1 for Wound Healing |
| WO2008137552A2 (en) * | 2007-05-02 | 2008-11-13 | Medimmune, Llc | Anti-rage antibodies and methods of use thereof |
-
2001
- 2001-03-16 IT IT2001MI000562A patent/ITMI20010562A1/it unknown
- 2001-03-16 US US10/471,641 patent/US7754217B2/en not_active Expired - Fee Related
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2002
- 2002-03-12 EP EP02717057A patent/EP1368060B1/en not_active Expired - Lifetime
- 2002-03-12 CN CN028065670A patent/CN1537014B/zh not_active Expired - Fee Related
- 2002-03-12 AU AU2002247977A patent/AU2002247977C1/en not_active Ceased
- 2002-03-12 DK DK02717057.0T patent/DK1368060T3/da active
- 2002-03-12 CN CN200910252323A patent/CN101773669A/zh active Pending
- 2002-03-12 ES ES02717057T patent/ES2346408T3/es not_active Expired - Lifetime
- 2002-03-12 CA CA2439530A patent/CA2439530C/en not_active Expired - Fee Related
- 2002-03-12 MX MXPA03008364A patent/MXPA03008364A/es active IP Right Grant
- 2002-03-12 AT AT02717057T patent/ATE468137T1/de active
- 2002-03-12 DE DE60236413T patent/DE60236413D1/de not_active Expired - Lifetime
- 2002-03-12 JP JP2002573044A patent/JP4822654B2/ja not_active Expired - Fee Related
- 2002-03-12 PT PT02717057T patent/PT1368060E/pt unknown
- 2002-03-12 WO PCT/IT2002/000153 patent/WO2002074337A1/en not_active Ceased
-
2008
- 2008-01-02 US US11/968,506 patent/US8058239B2/en not_active Expired - Fee Related
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2010
- 2010-02-17 US US12/707,222 patent/US20100172896A1/en not_active Abandoned
- 2010-02-17 US US12/707,264 patent/US20100297107A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1537014B (zh) | 2012-04-25 |
| JP2004523579A (ja) | 2004-08-05 |
| AU2002247977B8 (en) | 2007-03-15 |
| AU2002247977C1 (en) | 2008-09-18 |
| WO2002074337A1 (en) | 2002-09-26 |
| AU2002247977B2 (en) | 2006-12-14 |
| US20100297107A1 (en) | 2010-11-25 |
| DK1368060T3 (da) | 2010-08-30 |
| ES2346408T3 (es) | 2010-10-15 |
| EP1368060A1 (en) | 2003-12-10 |
| EP1368060B1 (en) | 2010-05-19 |
| AU2002247977A2 (en) | 2004-02-26 |
| ITMI20010562A1 (it) | 2002-09-16 |
| DE60236413D1 (de) | 2010-07-01 |
| US8058239B2 (en) | 2011-11-15 |
| US7754217B2 (en) | 2010-07-13 |
| US20100172896A1 (en) | 2010-07-08 |
| PT1368060E (pt) | 2010-08-24 |
| HK1069316A1 (en) | 2005-05-20 |
| AU2002247977A1 (en) | 2002-10-03 |
| MXPA03008364A (es) | 2004-11-12 |
| US20080171052A1 (en) | 2008-07-17 |
| US20040136979A1 (en) | 2004-07-15 |
| CN1537014A (zh) | 2004-10-13 |
| ATE468137T1 (de) | 2010-06-15 |
| CA2439530A1 (en) | 2002-09-26 |
| CN101773669A (zh) | 2010-07-14 |
| WO2002074337A8 (en) | 2003-08-28 |
| JP4822654B2 (ja) | 2011-11-24 |
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Effective date: 20190312 |