JP2002535014A5 - - Google Patents
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- JP2002535014A5 JP2002535014A5 JP2000596180A JP2000596180A JP2002535014A5 JP 2002535014 A5 JP2002535014 A5 JP 2002535014A5 JP 2000596180 A JP2000596180 A JP 2000596180A JP 2000596180 A JP2000596180 A JP 2000596180A JP 2002535014 A5 JP2002535014 A5 JP 2002535014A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- oligonucleotide
- sequence
- combination
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091034117 Oligonucleotide Proteins 0.000 description 43
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 13
- 102100038358 Prostate-specific antigen Human genes 0.000 description 13
- 150000007523 nucleic acids Chemical group 0.000 description 13
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 108020004707 nucleic acids Proteins 0.000 description 11
- 102000039446 nucleic acids Human genes 0.000 description 11
- 230000000295 complement effect Effects 0.000 description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 108700024394 Exon Proteins 0.000 description 5
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 5
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 108020004999 messenger RNA Proteins 0.000 description 3
- 102100038356 Kallikrein-2 Human genes 0.000 description 2
- 101710176220 Kallikrein-2 Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11764099P | 1999-01-28 | 1999-01-28 | |
| US60/117,640 | 1999-01-28 | ||
| PCT/US2000/002270 WO2000044940A2 (en) | 1999-01-28 | 2000-01-28 | Nucleic acid sequences for detecting genetic markers for cancer in a biological sample |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002535014A JP2002535014A (ja) | 2002-10-22 |
| JP2002535014A5 true JP2002535014A5 (enExample) | 2007-03-15 |
| JP4495349B2 JP4495349B2 (ja) | 2010-07-07 |
Family
ID=22374015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000596180A Expired - Fee Related JP4495349B2 (ja) | 1999-01-28 | 2000-01-28 | 癌の遺伝マーカーを生物学的サンプルにおいて検出するための核酸配列 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US6551778B1 (enExample) |
| EP (1) | EP1151142A2 (enExample) |
| JP (1) | JP4495349B2 (enExample) |
| AU (1) | AU767587B2 (enExample) |
| CA (1) | CA2360073C (enExample) |
| WO (1) | WO2000044940A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3981416B2 (ja) * | 1997-04-10 | 2007-09-26 | ユニバーシティ メディカル センター ナイメーヘン | Ｐｃａ３タンパク質、ｐｃａ３遺伝子、及びこれらの用途 |
| CA2360073C (en) * | 1999-01-28 | 2011-01-18 | Gen-Probe Incorporated | Probes and primers for detecting prostate specific antigen (psa) in a biological sample |
| AU7636400A (en) | 1999-09-29 | 2001-04-30 | Diagnocure Inc. | Pca3 messenger rna species in benign and malignant prostate tissues |
| EP1368471A2 (en) * | 2000-11-21 | 2003-12-10 | Diadexus, Inc. | Compositions and methods relating to prostate specific genes and proteins |
| AU2003209127A1 (en) * | 2002-02-11 | 2003-09-04 | Auburn University | High-sensitivity real-time polymerase chain reaction for detection of nucleic acids |
| ES2427853T3 (es) | 2003-02-07 | 2013-11-04 | Diagnocure Inc. | Procedimiento para detectar cáncer de próstata en una muestra |
| AU2004201842A1 (en) * | 2003-05-01 | 2004-11-18 | Veridex, Llc | Intraoperative lymph node assay |
| CA2491067A1 (en) | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| US20070130694A1 (en) * | 2005-12-12 | 2007-06-14 | Michaels Emily W | Textile surface modification composition |
| WO2008080029A2 (en) | 2006-12-21 | 2008-07-03 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
| US20110091883A1 (en) * | 2009-02-18 | 2011-04-21 | Helicos Biosciences Corporation | Methods for analyzing minute cellular nucleic acids |
| US9080973B2 (en) * | 2009-04-22 | 2015-07-14 | Wisconsin Alumni Research Foundation | Analyte detection using liquid crystals |
| EP2449132B1 (en) | 2009-07-01 | 2015-05-13 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
| WO2012015765A2 (en) * | 2010-07-27 | 2012-02-02 | Genomic Health, Inc. | Method for using gene expression to determine prognosis of prostate cancer |
| AU2011301804B2 (en) | 2010-09-16 | 2015-07-16 | Gen-Probe Incorporated | Capture probes immobilizable via L-nucleotide tail |
| AU2011323478B2 (en) | 2010-11-01 | 2015-09-10 | Gen-Probe Incorporated | Integrated capture and amplification of target nucleic acid for sequencing |
| US10655165B2 (en) | 2012-02-01 | 2020-05-19 | Gen-Probe Incorporated | Asymmetric hairpin target capture oligomers |
| KR101933752B1 (ko) | 2012-03-05 | 2018-12-28 | 오와이 아크틱 파트너스 에이비 | 전립선 암의 위험성 및 전립선 부피를 예측하는 방법 및 장치 |
| US12326453B2 (en) | 2014-03-28 | 2025-06-10 | Opko Diagnostics, Llc | Compositions and methods for active surveillance of prostate cancer |
| ES2964706T3 (es) | 2014-03-28 | 2024-04-09 | Opko Diagnostics Llc | Composiciones y métodos relacionados con el diagnóstico de cáncer de próstata |
| HUE055020T2 (hu) | 2015-03-27 | 2021-11-29 | Opko Diagnostics Llc | Prosztata-antigén szabványok és azok felhasználása |
| DE202017007130U1 (de) * | 2016-04-27 | 2019-08-29 | Gen-Probe Inc. | Lysereagenz für Blutzellen |
| CN111518170A (zh) * | 2020-05-09 | 2020-08-11 | 新乡医学院 | 基于fret的psa荧光探针、制备方法及其应用 |
| EP4493716A1 (en) | 2022-03-15 | 2025-01-22 | Diagenode S.A. | Detection of methylation status of a dna sample |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3725010A (en) * | 1971-08-23 | 1973-04-03 | Beckman Instruments Inc | Apparatus for automatically performing chemical processes |
| US5283174A (en) | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5851764A (en) | 1990-10-25 | 1998-12-22 | The Trustees Of Columbia University In The City Of New York | Human prostate tumor inducing gene-1 and uses thereof |
| AU662906B2 (en) | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
| WO1993022461A1 (en) | 1992-05-06 | 1993-11-11 | Gen-Probe Incorporated | Nucleic acid sequence amplification method, composition and kit |
| US5786148A (en) | 1996-11-05 | 1998-07-28 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a novel prostate-specific kallikrein |
| US5674682A (en) * | 1992-10-29 | 1997-10-07 | Thomas Jefferson University | Nucleic acid primers for detecting micrometastasis of prostate cancer |
| DE69332642T2 (de) | 1992-10-29 | 2003-10-02 | Thomas Jefferson University, Philadelphia | Methoden zur detektion von mikrometastasen bei prostata-krebs |
| JP4204642B2 (ja) | 1992-11-05 | 2009-01-07 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 前立腺に特異的な膜抗原 |
| US5516639A (en) | 1993-07-22 | 1996-05-14 | Mayo Foundation For Medical Education And Research | Antibodies specific for human prostate glandular kallkrein |
| US6103237A (en) * | 1993-07-22 | 2000-08-15 | Hybritech Incorporated | Stable variant hK2 polypeptide |
| US6569432B1 (en) * | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
| FR2714062B1 (fr) * | 1993-12-22 | 1996-02-16 | Bio Merieux | Promoteur modifié pour ARN polymérase, sa préparation et ses applications. |
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| WO1995028498A1 (en) * | 1994-04-15 | 1995-10-26 | The Trustees Of Columbia University In The City Of New York | Method for molecular staging of prostate cancer |
| AU699748B2 (en) * | 1994-05-10 | 1998-12-10 | Hybritech Incorporated | Recombinant HK2 polypeptide |
| WO1996021042A2 (en) * | 1995-01-04 | 1996-07-11 | Trustees Of Boston University | Primers for the pcr amplification of metastatic sequences |
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| JP2001526522A (ja) * | 1995-02-24 | 2001-12-18 | スローン−ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 前立腺特異的膜抗原およびその使用 |
| US5773292A (en) | 1995-06-05 | 1998-06-30 | Cornell University | Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood |
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| WO1997007242A1 (en) | 1995-08-16 | 1997-02-27 | Steven Lehrer | Method for detecting circulating breast cancer cells |
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| US6479263B1 (en) * | 1996-11-14 | 2002-11-12 | Baylor College Of Medicine | Method for detection of micrometastatic prostate cancer |
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| CA2218754A1 (en) | 1996-11-15 | 1998-05-15 | Eli Lilly And Company | Recombinant psa expression vectors and assays using the same |
| US6100444A (en) | 1997-02-11 | 2000-08-08 | University Of Rochester Medical Center | Prostate specific regulatory nucleic acid sequences and transgenic non-human animals expressing prostate specific antigen |
| US6620922B1 (en) * | 1997-02-25 | 2003-09-16 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6630305B1 (en) * | 1999-11-12 | 2003-10-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US7033827B2 (en) * | 1997-02-25 | 2006-04-25 | Corixa Corporation | Prostate-specific polynucleotide compositions |
| US6759515B1 (en) * | 1997-02-25 | 2004-07-06 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| WO1998040513A1 (en) | 1997-03-11 | 1998-09-17 | Ferrari Anna C | Method of detecting prostate cancer metastasis |
| US6475727B1 (en) * | 1997-04-11 | 2002-11-05 | Micromet Gesellschaft Fur Biomedizinische Forschung Mbh | Primers and methods for the detection of disseminated tumor cells |
| CA2286090C (en) | 1997-04-30 | 2013-01-08 | Hybritech Incorporated | Forms of prostate specific antigen and methods for their detection |
| AU8259798A (en) * | 1997-06-20 | 1999-01-04 | George G Klee | Method for detection of breast cancer |
| US5817798A (en) * | 1997-09-17 | 1998-10-06 | Abbott Laboratories | Rapid RNA isolation procedure in the presence of a transition metal ion |
| US20030215803A1 (en) * | 2000-12-07 | 2003-11-20 | Garcia Pablo Dominguez | Human genes and gene expression products isolated from human prostate |
| US8101349B2 (en) * | 1997-12-23 | 2012-01-24 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells and their methods of use II |
| JP2000069969A (ja) | 1998-08-28 | 2000-03-07 | Hitachi Chem Co Ltd | プライマーＤＮＡ及びこれを用いる前立腺特異抗原をコードするｍＲＮＡの検出方法 |
| CA2360073C (en) * | 1999-01-28 | 2011-01-18 | Gen-Probe Incorporated | Probes and primers for detecting prostate specific antigen (psa) in a biological sample |
| AU2686200A (en) * | 1999-02-18 | 2000-09-04 | Compugen Ltd. | Novel nucleic acid and amino acid sequences |
| WO2000053747A1 (en) | 1999-03-11 | 2000-09-14 | Mount Sinai Hospital | Sialic acid-binding ig-like lectin (siglec) gene; ob-binding protein like (ob-bpl) |
| AU4484400A (en) | 1999-04-23 | 2000-11-10 | University Of Washington | Prostate-specific polynucleotides, polypeptides and their methods of use |
| AU5416700A (en) | 1999-05-20 | 2000-12-12 | Fahri Saatcioglu | Differentially expressed genes in prostate cancer |
| AU2001241541A1 (en) * | 2000-02-17 | 2001-08-27 | Millennium Predictive Medicine, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer |
| ES2546450T3 (es) | 2000-04-07 | 2015-09-23 | Eiken Kagaku Kabushiki Kaisha | Método para amplificar y detectar un ácido nucleico usando ácido nucleico bicatenario como molde |
| AU2001248188A1 (en) | 2000-04-10 | 2001-10-23 | Aventis Pasteur Limited | Immunogenic peptides derived from prostate-specific antigen (psa) and uses thereof |
| JP4683811B2 (ja) | 2000-05-01 | 2011-05-18 | 栄研化学株式会社 | 核酸合成反応産物の検出方法 |
| CN1810992B (zh) * | 2001-06-18 | 2010-09-08 | 荣研化学株式会社 | 有效检测双链核酸的方法 |
| JP2005519606A (ja) * | 2002-03-14 | 2005-07-07 | エグゾニ・テラピューティック・ソシエテ・アノニム | ヒトカリクレイン−２及びカリクレイン−３のバリアント並びにそれらの使用 |
| US7348142B2 (en) * | 2002-03-29 | 2008-03-25 | Veridex, Lcc | Cancer diagnostic panel |
| ES2427853T3 (es) * | 2003-02-07 | 2013-11-04 | Diagnocure Inc. | Procedimiento para detectar cáncer de próstata en una muestra |
| US20040223885A1 (en) * | 2003-05-06 | 2004-11-11 | Keen Randy E. | Apparatus for the automated synthesis of polynucleotides |
| US20060008468A1 (en) * | 2004-06-17 | 2006-01-12 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
-
2000
- 2000-01-28 CA CA2360073A patent/CA2360073C/en not_active Expired - Fee Related
- 2000-01-28 US US09/493,491 patent/US6551778B1/en not_active Expired - Lifetime
- 2000-01-28 JP JP2000596180A patent/JP4495349B2/ja not_active Expired - Fee Related
- 2000-01-28 AU AU34755/00A patent/AU767587B2/en not_active Ceased
- 2000-01-28 WO PCT/US2000/002270 patent/WO2000044940A2/en not_active Ceased
- 2000-01-28 EP EP00913284A patent/EP1151142A2/en not_active Withdrawn
-
2002
- 2002-10-17 US US10/273,707 patent/US6811985B2/en not_active Expired - Lifetime
-
2004
- 2004-10-28 US US10/978,145 patent/US7267956B2/en not_active Expired - Lifetime
-
2007
- 2007-08-13 US US11/838,168 patent/US20080026398A1/en not_active Abandoned
-
2008
- 2008-02-14 US US12/031,489 patent/US20090035773A1/en not_active Abandoned
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