JP2002534505A5 - - Google Patents
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- Publication number
- JP2002534505A5 JP2002534505A5 JP2000593585A JP2000593585A JP2002534505A5 JP 2002534505 A5 JP2002534505 A5 JP 2002534505A5 JP 2000593585 A JP2000593585 A JP 2000593585A JP 2000593585 A JP2000593585 A JP 2000593585A JP 2002534505 A5 JP2002534505 A5 JP 2002534505A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- hydrogen
- alkyl
- unsubstituted
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 19
- 239000001257 hydrogen Substances 0.000 description 19
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 15
- 150000002431 hydrogen Chemical class 0.000 description 11
- -1 1-piperidyl Chemical group 0.000 description 9
- 150000001204 N-oxides Chemical class 0.000 description 9
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 9
- 229910052736 halogen Inorganic materials 0.000 description 7
- 150000002367 halogens Chemical group 0.000 description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 125000004076 pyridyl group Chemical class 0.000 description 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- BIVMWDQSMDXTCT-RYUDHWBXSA-N (1s,2s)-2-(3,4-dimethoxyphenyl)cyclohexan-1-amine Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](N)CCCC1 BIVMWDQSMDXTCT-RYUDHWBXSA-N 0.000 description 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- 125000000815 N-oxide group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000005530 alkylenedioxy group Chemical group 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100707.1 | 1999-01-15 | ||
| EP99100707 | 1999-01-15 | ||
| PCT/EP2000/000150 WO2000042017A1 (en) | 1999-01-15 | 2000-01-12 | Phenanthridine-n-oxides with pde-iv inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002534505A JP2002534505A (ja) | 2002-10-15 |
| JP2002534505A5 true JP2002534505A5 (enExample) | 2007-03-01 |
Family
ID=8237354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593585A Withdrawn JP2002534505A (ja) | 1999-01-15 | 2000-01-12 | 新規フェナントリジン−ｎ−オキシド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6538005B2 (enExample) |
| EP (1) | EP1147087B1 (enExample) |
| JP (1) | JP2002534505A (enExample) |
| AT (1) | ATE295352T1 (enExample) |
| AU (1) | AU2107700A (enExample) |
| CA (1) | CA2359404A1 (enExample) |
| DE (1) | DE60020079T2 (enExample) |
| DK (1) | DK1147087T3 (enExample) |
| ES (1) | ES2242594T3 (enExample) |
| PT (1) | PT1147087E (enExample) |
| SI (1) | SI1147087T1 (enExample) |
| WO (1) | WO2000042017A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU774868B2 (en) * | 1999-01-15 | 2004-07-08 | Takeda Gmbh | Phenylphenanthridines with PDE-IV inhibiting activity |
| US6630483B2 (en) | 2000-01-11 | 2003-10-07 | Altana Pharma Ag | Phenanthridine-N-oxides |
| DK1303506T3 (da) | 2000-07-14 | 2005-05-30 | Altana Pharma Ag | 6-heteroarylphenanthridiner |
| WO2002006239A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Phenanthridine n-oxides |
| US7423046B2 (en) | 2002-08-29 | 2008-09-09 | Nycomed Gmbh | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| ES2400823T3 (es) | 2004-02-18 | 2013-04-12 | Takeda Gmbh | Nuevas hidroxi-6-fenilfenantridinas sustituidas con guanidinilo como inhibidores eficaces de fosfodiesterasa (PDE) 4 |
| EP2589599B1 (en) | 2004-03-03 | 2014-06-25 | Takeda GmbH | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| CA2558391A1 (en) * | 2004-03-10 | 2005-09-22 | Altana Pharma Ag | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| EP1791847A2 (en) | 2004-09-08 | 2007-06-06 | Altana Pharma AG | Novel 3-thia-10-aza-phenanthrene derivatives |
| EP2295423B1 (en) | 2005-03-02 | 2013-10-02 | Takeda GmbH | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives |
| JP2008532980A (ja) * | 2005-03-09 | 2008-08-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミド置換された６−フェニルフェナントリジン |
| WO2009043784A1 (en) | 2007-10-04 | 2009-04-09 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
| US5475003A (en) * | 1994-03-03 | 1995-12-12 | Syntex (U.S.A.) Inc. | 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives |
| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
| KR100454781B1 (ko) | 1996-01-31 | 2005-04-08 | 알타나 파마 아게 | 신규한페난트리딘 |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| EP0889886B1 (de) * | 1996-03-26 | 2002-09-18 | ALTANA Pharma AG | Neue in 6-position substituierte phenanthridine |
| GB9622386D0 (en) * | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| EE03829B1 (et) | 1996-11-11 | 2002-08-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim |
| GB9626643D0 (en) | 1996-12-21 | 1997-02-12 | Astra Pharma Prod | Compounds |
| JP2001514640A (ja) | 1997-03-07 | 2001-09-11 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規のテトラゾール |
| DE69811492T2 (de) * | 1997-06-03 | 2004-02-05 | Altana Pharma Ag | Benzonaphthyridine |
| CZ293725B6 (cs) | 1997-07-25 | 2004-07-14 | Altana Pharma Ag | Tetrazolové deriváty |
| US6121279A (en) * | 1997-07-25 | 2000-09-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted 6-phenylphenanthridines |
| AU5970199A (en) | 1998-08-31 | 2000-03-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity |
-
2000
- 2000-01-12 EP EP00901089A patent/EP1147087B1/en not_active Expired - Lifetime
- 2000-01-12 CA CA002359404A patent/CA2359404A1/en not_active Abandoned
- 2000-01-12 DE DE60020079T patent/DE60020079T2/de not_active Expired - Fee Related
- 2000-01-12 AU AU21077/00A patent/AU2107700A/en not_active Abandoned
- 2000-01-12 JP JP2000593585A patent/JP2002534505A/ja not_active Withdrawn
- 2000-01-12 PT PT00901089T patent/PT1147087E/pt unknown
- 2000-01-12 ES ES00901089T patent/ES2242594T3/es not_active Expired - Lifetime
- 2000-01-12 SI SI200030717T patent/SI1147087T1/xx unknown
- 2000-01-12 AT AT00901089T patent/ATE295352T1/de not_active IP Right Cessation
- 2000-01-12 DK DK00901089T patent/DK1147087T3/da active
- 2000-01-12 WO PCT/EP2000/000150 patent/WO2000042017A1/en not_active Ceased
-
2001
- 2001-01-12 US US09/889,142 patent/US6538005B2/en not_active Expired - Fee Related
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